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9 results on '"Dal Santo F"'

2. EPP1399. The mediating role of impulsivity in the relationship between suicidal behaviour and early traumatic experiences in depressed subjects

Author

Dal Santo, F., Carballo, J. J., Velasco Iglesias, Ángela, Jiménez Treviño, Luis, Rodríguez Revuelta, Julia, Martínez Cao, Clara, Caro Cañizares, Irene, Fuente Tomás, Lorena de la, Menéndez Miranda, Isabel, González Blanco, Leticia, García-Portilla González, María Paz, Bobes, Julio, and Saiz Martínez, Pilar Alejandra

Abstract

European Congress of Psychiatry (29th. 2021. Virtual)

Published
2021

3. O306. Association of traumatic events in childhood, impulsivity and decision-making with previous suicide attempt and/or current suicidal ideation in adult patients with major depressive disorder

Author

Roman, A., Rodríguez Revuelta, Julia, Dal Santo, F., García Álvarez, Leticia, Fuente Tomás, Lorena de la, Martínez Cao, Clara, Jiménez Treviño, Luis, González Blanco, Leticia, García-Portilla González, María Paz, Bobes, Julio, and Saiz Martínez, Pilar Alejandra

Abstract

European Congress of Psychiatry (29th. 2021. Virtual)

Published
2021

9. Searching for bridges between psychopathology and real-world functioning in first-episode psychosis: A network analysis from the OPTiMiSE trial

Author

Dal Santo, Francesco, Fonseca-Pedrero, Eduardo, García-Portilla, María Paz, González-Blanco, Leticia, Sáiz, Pilar A., Galderisi, Silvana, Giordano, Giulia Maria, Bobes, Julio, http://orcid.org/0000-0002-9879-6443, http://orcid.org/0000-0003-3643-1622, http://orcid.org/0000-0002-5705-4523, http://orcid.org/0000-0002-1592-7656, http://orcid.org/0000-0003-2187-4033, Dal Santo, F., Fonseca-Pedrero, E., Garcia-Portilla, M. P., Gonzalez-Blanco, L., Saiz, P. A., Galderisi, S., Giordano, G. M., and Bobes, J.

Subjects
Psychiatric Status Rating Scales, Adult, Male, Real-world functioning, Clinical Trials as Topic, Psychopathology, Bridge node, Network analysi, Middle Aged, Psychiatric Status Rating Scale, Psychotic Disorder, Psychiatry and Mental health, Cognition, Psychotic Disorders, First-episode psychosi, Schizophrenia, Humans, Female, Human
Abstract

BackgroundNetwork analysis has been used to explore the interplay between psychopathology and functioning in psychosis, but no study has used dedicated statistical techniques to focus on the bridge symptoms connecting these domains. The current study aims to estimate the network of depressive, negative, and positive symptoms, general psychopathology, and real-world functioning in people with first-episode schizophrenia or schizophreniform disorder, focusing on bridge nodes.MethodsBaseline data from the OPTiMiSE trial were analyzed. The sample included 446 participants (age 40.0 ± 10.9 years, 70% males). The network was estimated with a Gaussian graphical model, using scores on individual items of the positive and negative syndrome scale (PANSS), the Calgary depression scale for schizophrenia, and the personal and social performance scale. Stability, strength centrality, expected influence (EI), predictability, and bridge centrality statistics were computed. The top 20% scoring nodes on bridge strength were selected as bridge nodes.ResultsNodes from different rating scales assessing similar psychopathological and functioning constructs tended to cluster together in the estimated network. The most central nodes (EI) were Delusions, Emotional Withdrawal, Depression, and Depressed Mood. Bridge nodes included Depression, Conceptual Disorganization, Active Social Avoidance, Delusions, Stereotyped Thinking, Poor Impulse Control, Guilty Feelings, Unusual Thought Content, and Hostility. Most of the bridge nodes belonged to the general psychopathology subscale of the PANSS. Depression (G6) was the bridge node with the highest value.ConclusionsThe current study provides novel insights for understanding the complex phenotype of psychotic disorders and the mechanisms underlying the development and maintenance of comorbidity and functional impairment after psychosis onset.

Published
2022

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