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We have reported a case of fungal splenic abscess caused by Blastomyces dermatitidis. Splenic abscess is an uncommon disorder, and fungus as the causative organism is rare. The diagnosis of splenic abscess can be rapidly made with radionuclide and CT scanning and ultrasonography. Splenectomy with appropriate antifungal chemotherapy is the currently recommended therapy.

In diagnosing and treating small malignant lesions of the eyelids, physicians should be alert for possible extension of the cancer into the orbit, endangering not only the patient's sight but his life as well. Important signs and symptoms include bone thickening, disturbances of ocular motility, intermittent epiphora, and positive results of radiologic studies. From histopathologic study of the resected carcinomatous tissues, it is apparent that the creeping, cicatrizing, ulcerated, and invasive patterns of basal cell carcinoma predominate in this group of eyelid tumors, all of which are aggressive lesions; however, the histologic type is quite variable and no definite trends can be established.

ConclusionIn 3 series of experiments employing 675 BALB/c, 108 C57BR/cd and 50 C57BL/6 mice, the first of double isografts of EO771 mammary carcinoma acquired an altered enhanced status comparable with that of the second of double isografts and each of the double isografts had 9 times the homotransplantability (24%) of single control isografts (2.7%). Within the conditions of the experiment neither size, nor age of the isograft was of importance. The altered enhanced status was abiding as determined by serial homotransplantability without further treatment.