1,361 results on '"D’Andrea, V."'
Search Results
2. Abstract P5-08-09: Does Breast Inflammation Contribute to Lymphedema Risk in Patients Treated with Axillary Lymph Node Dissection?
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Andrea V. Barrio, Giacomo Montagna, Varadan Sevilimedu, Ethan Gomez, Dilip Giri, Babak Mehrara, and Monica Morrow
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Cancer Research ,Oncology - Abstract
Background Chronic inflammatory responses initiated by lymphatic injury play a key role in the pathophysiology of secondary lymphedema. However, it is unclear if baseline inflammation or ethnic/racial variability in inflammatory responses increase lymphedema risk. Crown-like structures of the breast (CLS-B), consisting of macrophages engulfing necrotic adipocytes, are a marker of systemic inflammation and have been implicated in the pathogenesis of breast cancer, but their role in lymphedema development is unknown. Here we determine whether baseline differences in inflammation, characterized by the presence of CLS-B, contributed to lymphedema risk in a diverse cohort of patients treated with ALND. Methods Patients ≥ 18 years undergoing ALND were enrolled in a prospective lymphedema screening study. Body mass index (BMI) and volumetric arm measurements (perometer) were performed at baseline, postoperatively, and every 6 months. Breast tissue obtained at definitive surgery was assessed for CLS-B with CD-68 IHC stain in non-tumor breast tissue. Inflammation severity was determined by number of CLS-B/cm2, with the median used to differentiate between mild and severe inflammation. Lymphedema was defined as a relative arm volume change of ≥10%. Lymphedema incidence was assessed using competing risk analysis and compared between patients with and without CLS-B. Uni- and multivariable analysis was performed to identify factors associated with lymphedema development. Results Between 11/2016-03/2020, 304 ALND patients were enrolled; 281 had at least 6 months of follow-up and were included in the study. Eleven percent self-identified as Asian, 20% Black, 6% Hispanic, and 60% White. Median age was 48 years; median BMI was 26.3 kg/m2, with higher BMI observed in Black and Hispanic women compared to Asian and White women (p < 0.001). Overall, 54% had CLS-B, with severe inflammation (> 0.4 CLS-B/cm2) identified in 71 (25%) patients. CLS-B presence correlated with BMI (36% [BMI < 25], 63% [BMI 25-30], 70% [BMI > 30], p < 0.001) and varied across racial/ethnic groups, with a higher prevalence in Black and Hispanic women (68% [Black], 69% [Hispanic] vs 59% [Asian], 46% [White], p = 0.03) (Table). Inflammation severity did not differ by race/ethnicity (p = 0.11). At 2.1 years median follow-up (IQR 1.6-3.1), 66 women developed lymphedema, with a 2-year lymphedema rate of 21.3% (95% CI 16.4-26.8). Lymphedema incidence was higher among Black and Hispanic women, compared to Asian and White women (2-year rate: 33.8% [Black], 31% [Hispanic], 17.4% [Asian], 18.2% [White], p = 0.002), and was higher among women with CLS-B (2-year rate: 28.2% [CLS-B] vs 12.9% [no CLS-B], p = 0.02). On multivariable analysis, Black race (White [referent]: HR 2.85, 95% CI 1.4-5.8; p = 0.03), receipt of NAC (upfront surgery [referent]: HR 2.46, 95% CI 1.04-5.8, p = 0.04) and older age (HR 1.03, 95% CI 1.01-1.06 per 1-year increase; p = 0.009) were independently associated with lymphedema development, while CLS-B was not (HR 1.37, 95% CI 0.81-2.34, p = 0.2). Conclusions In a prospective cohort of patients treated with ALND, Black race, receipt of NAC, and increasing age, but not CLS-B, were independently associated with lymphedema risk. However, the higher CLS-B prevalence in Black women suggests that they may have a propensity for increased inflammation, which may in part be contributing to the higher lymphedema risk observed, but is likely not the only inflammatory mechanism that modulates risk. Table. Clinical characteristics of study cohort stratified by the presence of CLS-B Citation Format: Andrea V. Barrio, Giacomo Montagna, Varadan Sevilimedu, Ethan Gomez, Dilip Giri, Babak Mehrara, Monica Morrow. Does Breast Inflammation Contribute to Lymphedema Risk in Patients Treated with Axillary Lymph Node Dissection? [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-08-09.
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- 2023
3. Interplay of Immunosuppression and Immunotherapy Among Patients With Cancer and COVID-19
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Ziad, Bakouny, Chris, Labaki, Punita, Grover, Joy, Awosika, Shuchi, Gulati, Chih-Yuan, Hsu, Saif I, Alimohamed, Babar, Bashir, Stephanie, Berg, Mehmet A, Bilen, Daniel, Bowles, Cecilia, Castellano, Aakash, Desai, Arielle, Elkrief, Omar E, Eton, Leslie A, Fecher, Daniel, Flora, Matthew D, Galsky, Margaret E, Gatti-Mays, Alicia, Gesenhues, Michael J, Glover, Dharmesh, Gopalakrishnan, Shilpa, Gupta, Thorvardur R, Halfdanarson, Brandon, Hayes-Lattin, Mohamed, Hendawi, Emily, Hsu, Clara, Hwang, Roman, Jandarov, Chinmay, Jani, Douglas B, Johnson, Monika, Joshi, Hina, Khan, Shaheer A, Khan, Natalie, Knox, Vadim S, Koshkin, Amit A, Kulkarni, Daniel H, Kwon, Sara, Matar, Rana R, McKay, Sanjay, Mishra, Feras A, Moria, Amanda, Nizam, Nora L, Nock, Taylor K, Nonato, Justin, Panasci, Lauren, Pomerantz, Andrew J, Portuguese, Destie, Provenzano, Matthew, Puc, Yuan J, Rao, Terence D, Rhodes, Gregory J, Riely, Jacob J, Ripp, Andrea V, Rivera, Erika, Ruiz-Garcia, Andrew L, Schmidt, Adam J, Schoenfeld, Gary K, Schwartz, Sumit A, Shah, Justin, Shaya, Suki, Subbiah, Lisa M, Tachiki, Matthew D, Tucker, Melissa, Valdez-Reyes, Lisa B, Weissmann, Michael T, Wotman, Elizabeth M, Wulff-Burchfield, Zhuoer, Xie, Yuanchu James, Yang, Michael A, Thompson, Dimpy P, Shah, Jeremy L, Warner, Yu, Shyr, Toni K, Choueiri, Trisha M, Wise-Draper, and Catherine, Stratton
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Cancer Research ,Oncology - Abstract
ImportanceCytokine storm due to COVID-19 can cause high morbidity and mortality and may be more common in patients with cancer treated with immunotherapy (IO) due to immune system activation.ObjectiveTo determine the association of baseline immunosuppression and/or IO-based therapies with COVID-19 severity and cytokine storm in patients with cancer.Design, Setting, and ParticipantsThis registry-based retrospective cohort study included 12 046 patients reported to the COVID-19 and Cancer Consortium (CCC19) registry from March 2020 to May 2022. The CCC19 registry is a centralized international multi-institutional registry of patients with COVID-19 with a current or past diagnosis of cancer. Records analyzed included patients with active or previous cancer who had a laboratory-confirmed infection with SARS-CoV-2 by polymerase chain reaction and/or serologic findings.ExposuresImmunosuppression due to therapy; systemic anticancer therapy (IO or non-IO).Main Outcomes and MeasuresThe primary outcome was a 5-level ordinal scale of COVID-19 severity: no complications; hospitalized without requiring oxygen; hospitalized and required oxygen; intensive care unit admission and/or mechanical ventilation; death. The secondary outcome was the occurrence of cytokine storm.ResultsThe median age of the entire cohort was 65 years (interquartile range [IQR], 54-74) years and 6359 patients were female (52.8%) and 6598 (54.8%) were non-Hispanic White. A total of 599 (5.0%) patients received IO, whereas 4327 (35.9%) received non-IO systemic anticancer therapies, and 7120 (59.1%) did not receive any antineoplastic regimen within 3 months prior to COVID-19 diagnosis. Although no difference in COVID-19 severity and cytokine storm was found in the IO group compared with the untreated group in the total cohort (adjusted odds ratio [aOR], 0.80; 95% CI, 0.56-1.13, and aOR, 0.89; 95% CI, 0.41-1.93, respectively), patients with baseline immunosuppression treated with IO (vs untreated) had worse COVID-19 severity and cytokine storm (aOR, 3.33; 95% CI, 1.38-8.01, and aOR, 4.41; 95% CI, 1.71-11.38, respectively). Patients with immunosuppression receiving non-IO therapies (vs untreated) also had worse COVID-19 severity (aOR, 1.79; 95% CI, 1.36-2.35) and cytokine storm (aOR, 2.32; 95% CI, 1.42-3.79).Conclusions and RelevanceThis cohort study found that in patients with cancer and COVID-19, administration of systemic anticancer therapies, especially IO, in the context of baseline immunosuppression was associated with severe clinical outcomes and the development of cytokine storm.Trial RegistrationClinicalTrials.gov Identifier: NCT04354701
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- 2023
4. Adherence to COVID‐19 health protocols in an online news context in the Philippines: A manifest content analysis
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Tyrone Gabriel D. Sundiam, Julia Czarina A. Sy, Daniel Joseph E. Berdida, Patricia Yssabel R. Talampas, Hazel Abigail A. Suillan, Eloisa Andrea V. Sumangil, Angela Mariz E. Sunga, Samantha Nicole T. Sy Juco, and Kyle Catherine Talastas
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Public Health, Environmental and Occupational Health ,General Nursing - Published
- 2023
5. Viviendas paradigmáticas en manta: comprendidas entre los años 1960 – 1980
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Denisse E. Zambrano Calderero, Joel S. Lapo Vicente, José M. Espinoza Macías, Andrea V. Intriago Landázuri, and Fabricio A. Ormaza García
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General Medicine - Abstract
La lectura de la arquitectura de una ciudad permite entender rasgos de su historia, evolución y desarrollo. Especialmente si el lugar cuenta con obras de carácter paradigmático que afianza y aportan a la identidad de su colectivo. Este texto es la sintesis de un estudio, donde se analizaron dos viviendas construidas en Manta-Ecuador entre los años 1960 – 1980, para efectos al presente articulo, se opto por citar solo una. Se pretende demostrar el valor arquitectónico de la vivienda “Cevallos”, que evidencia su función como artefacto cultural, así como la innovación técnica que representa, de manera que la memoria de esta obra y su autor no se pierda. Se llevó a cabo la investigación en tres niveles: exploratorio, descriptivo y deductivo. La metodología aplicada incluye análisis descriptivo, crítico y fenomenológico en base a estudios afines al tema. Como resultado, se comprobó que Manta cuenta con obras arquitectónicas de carácter paradigmática, el problema es la carencia de su conocimiento, el 56% de los encuestados desconocían de su existencia influyendo de manera negativa, dejándolas en el olvido y consigo una muestra de identidad del lugar, en respuesta a la problemática se plantea una matriz para la calificación de una arquitectura paradigmática.
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- 2023
6. Explainable Rules and Heuristics in AI Algorithm Recommendation Approaches—A Systematic Literature Review and Mapping Study
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Francisco Jos�Garc韆-Pe馻lvo, Andrea V醶quez-Ingelmo, and Alicia Garc韆-Holgado
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Modeling and Simulation ,Software ,Computer Science Applications - Published
- 2023
7. Efficient method of arsenic removal from water based on photocatalytic oxidation by a plasmonic–magnetic nanosystem
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María Y. Paredes, Luciana P. Martinez, Beatriz C. Barja, M. Claudia Marchi, Matías Herran, Gustavo Grinblat, Andrea V. Bragas, Emiliano Cortés, and Alberto F. Scarpettini
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Materials Science (miscellaneous) ,General Environmental Science - Abstract
Arsenic is one of the most toxic elements in natural waters since prolonged exposure to this metalloid can cause chronic damage to health.
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- 2023
8. Revisiting carboxylic group functionalization of silica sol–gel materials
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M. Verónica Rivas, María J. Arenas Muñetón, Andrea V. Bordoni, M. Verónica Lombardo, Carla C. Spagnuolo, and Alejandro Wolosiuk
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Biomedical Engineering ,General Materials Science ,General Chemistry ,General Medicine - Abstract
In this review we present characterization and synthetic chemistry guidelines for obtaining COOH-based alkoxysilanes aiming at SiO2 modification. Applications of these derivatized materials related to biology and medicine are also discussed.
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- 2023
9. Reducing Volatile Anesthetic Waste Using a Commercial Electronic Health Record Clinical Decision Support Tool to Lower Fresh Gas Flows
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Andrea V. Olmos, David Robinowitz, John R. Feiner, Catherine L. Chen, and Seema Gandhi
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Anesthesiology and Pain Medicine - Published
- 2022
10. Situational engagement experiences: Measurement options and theory testing
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Jingxian Jiang, Gary D. Ellis, Andrea V. Ettekal, and Chad Nelson
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Marketing - Published
- 2022
11. 'As de sauer que todo el rreyno tenía quatro rreys, quatro partes': Organización política y representación espacial en el Mapamundi del reino de las Indias de Felipe Guamán Poma de Ayala
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Andrea V. López Salas
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General Engineering - Published
- 2022
12. Searching for Heavy Dark Matter near the Planck Mass with XENON1T
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Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.
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High Energy Physics - Experiment (hep-ex) ,Physics - Instrumentation and Detectors ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,High Energy Physics - Experiment - Abstract
Multiple viable theoretical models predict heavy dark matter particles with a mass close to the Planck mass, a range relatively unexplored by current experimental measurements. We use 219.4 days of data collected with the XENON1T experiment to conduct a blind search for signals from Multiply-Interacting Massive Particles (MIMPs). Their unique track signature allows a targeted analysis with only 0.05 expected background events from muons. Following unblinding, we observe no signal candidate events. This work places strong constraints on spin-independent interactions of dark matter particles with a mass between 1$\times$10$^{12}\,$GeV/c$^2$ and 2$\times$10$^{17}\,$GeV/c$^2$. In addition, we present the first exclusion limits on spin-dependent MIMP-neutron and MIMP-proton cross-sections for dark matter particles with masses close to the Planck scale., Comment: 7 pages, 6 figures
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- 2023
13. Cosmogenic background simulations for the DARWIN observatory at different underground locations
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Adrover, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antunovic, B., Aprile, E., Babicz, M., Bajpai, D., Barberio, E., Baudis, L., Bazyk, M., Bell, N., Bellagamba, L., Biondi, R., Biondi, Y., Bismark, A., Boehm, C., Breskin, A., Brookes, E. J., Brown, A., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Chauvin, A., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Decowski, M. P., Deisting, A., Di Gangi, P., Diglio, S., Doerenkamp, M., Drexlin, G., Eitel, K., Elykov, A., Engel, R., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Garroum, N., Ghosh, S., Girard, F., Glade-Beucke, R., Glück, F., Grandi, L., Grigat, J., Größle, R., Guan, H., Guida, M., Hammann, R., Hannen, V., Hansmann-Menzemer, S., Hargittai, N., Hasegawa, T., Hils, C., Higuera, A., Hiraoka, K., Hoetzsch, L., Iacovacci, M., Itow, Y., Jakob, J., Jörg, F., Kara, M., Kavrigin, P., Kazama, S., Keller, M., Kilminster, B., Kleifges, M., Kobayashi, M., Kopec, A., von Krosigk, B., Kuger, F., Landsman, H., Lang, R. F., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Lombardi, F., Loizeau, J., Luce, T., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Undagoitia, T. Marrodán, Lopes, J. A. M., Marignetti, F., Martens, K., Masbou, J., Mastroianni, S., Milutinovic, S., Miuchi, K., Miyata, R., Molinario, A., Monteiro, C. M. B., Morå, K., Morteau, E., Mosbacher, Y., Müller, J., Murra, M., Newstead, J. L., Ni, K., Oberlack, U. G., Ostrovskiy, I., Paetsch, B., Pandurovic, M., Pellegrini, Q., Peres, R., Pienaar, J., Pierre, M., Piotter, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qin, J., Silva, M. Rajado, García, D. Ramírez, Razeto, A., Sakamoto, S., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. dos, Sartorelli, G., Scaffidi, A., Schulte, P., Schultz-Coulon, H. -C., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Sharma, S., Shen, W., Silva, M., Simgen, H., Singh, R., Solmaz, M., Stanley, O., Steidl, M., Tan, P. L., Terliuk, A., Thers, D., Thümmler, T., Tönnies, F., Toschi, F., Trinchero, G., Trotta, R., Tunnell, C., Urquijo, P., Valerius, K., Vecchi, S., Vetter, S., Volta, G., Vorkapic, D., Wang, W., Weerman, K. M., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, J., Wolf, T., Wu, V. H. S., Wurm, M., Xing, Y., Yamashita, M., Ye, J., Zavattini, G., and Zuber, K.
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Physics - Instrumentation and Detectors ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) - Abstract
Xenon dual-phase time projections chambers (TPCs) have proven to be a successful technology in studying physical phenomena that require low-background conditions. With 40t of liquid xenon (LXe) in the TPC baseline design, DARWIN will have a high sensitivity for the detection of particle dark matter, neutrinoless double beta decay ($0\nu\beta\beta$), and axion-like particles (ALPs). Although cosmic muons are a source of background that cannot be entirely eliminated, they may be greatly diminished by placing the detector deep underground. In this study, we used Monte Carlo simulations to model the cosmogenic background expected for the DARWIN observatory at four underground laboratories: Laboratori Nazionali del Gran Sasso (LNGS), Sanford Underground Research Facility (SURF), Laboratoire Souterrain de Modane (LSM) and SNOLAB. We determine the production rates of unstable xenon isotopes and tritium due to muon-included neutron fluxes and muon-induced spallation. These are expected to represent the dominant contributions to cosmogenic backgrounds and thus the most relevant for site selection.
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- 2023
14. Low-energy calibration of XENON1T with an internal $$^{{\textbf {37}}}$$ <math> <msup> <mrow></mrow> <mn>37</mn> </msup> </math> Ar source
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Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J., Antochi, V., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T., Cai, C., Capelli, C., Cardoso, J., Cichon, D., Colijn, A., Conrad, J., Cuenca-García, J., Cussonneau, J., D’Andrea, V., Decowski, M., Gangi, P., Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Sanchez-Lucas, P., Santos, J., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., Zhu, T., Geppert, C., and Riemer, J.
- Abstract
A low-energy electronic recoil calibration of XENON1T, a dual-phase xenon time projection chamber, with an internal $${}^{37}$$ 37 Ar source was performed. This calibration source features a 35-day half-life and provides two mono-energetic lines at 2.82 keV and 0.27 keV. The photon yield and electron yield at 2.82 keV are measured to be ( $$32.3\,\pm \,0.3$$ 32.3 ± 0.3 ) photons/keV and ( $$40.6\,\pm \,0.5$$ 40.6 ± 0.5 ) electrons/keV, respectively, in agreement with other measurements and with NEST predictions. The electron yield at 0.27 keV is also measured and it is ( $$68.0^{+6.3}_{-3.7}$$ 68 . 0 - 3.7 + 6.3 ) electrons/keV. The $${}^{37}$$ 37 Ar calibration confirms that the detector is well-understood in the energy region close to the detection threshold, with the 2.82 keV line reconstructed at ( $$2.83\,\pm \,0.02$$ 2.83 ± 0.02 ) keV, which further validates the model used to interpret the low-energy electronic recoil excess previously reported by XENON1T. The ability to efficiently remove argon with cryogenic distillation after the calibration proves that $${}^{37}$$ 37 Ar can be considered as a regular calibration source for multi-tonne xenon detectors.
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- 2023
15. Search for events in XENON1T associated with Gravitational Waves
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XENON Collaboration, Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antoń, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Decowski, M. P., Di Gangi, P., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Carlos, D. G. Layos, Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M, Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C, Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Shi, J., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.
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High Energy Physics - Experiment (hep-ex) ,Physics - Instrumentation and Detectors ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,High Energy Physics - Experiment - Abstract
We perform a blind search for particle signals in the XENON1T dark matter detector that occur close in time to gravitational wave signals in the LIGO and Virgo observatories. No particle signal is observed in the nuclear recoil, electronic recoil, CE$\nu$NS, and S2-only channels within $\pm$ 500 seconds of observations of the gravitational wave signals GW170104, GW170729, GW170817, GW170818, and GW170823. We use this null result to constrain mono-energetic neutrinos and Beyond Standard Model particles emitted in the closest coalescence GW170817, a binary neutron star merger. We set new upper limits on the fluence (time-integrated flux) of coincident neutrinos down to 17 keV at 90% confidence level. Furthermore, we constrain the product of coincident fluence and cross section of Beyond Standard Model particles to be less than $10^{-29}$ cm$^2$/cm$^2$ in the [5.5-210] keV energy range at 90% confidence level.
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- 2023
16. Risk Factors and Racial and Ethnic Disparities in Patients With Breast Cancer-Related Lymphedema
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Giacomo Montagna, Jennifer Zhang, Varadan Sevilimedu, Jillian Charyn, Kelly Abbate, Ethan A. Gomez, Babak Mehrara, Monica Morrow, and Andrea V. Barrio
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Adult ,Cancer Research ,Sentinel Lymph Node Biopsy ,Brief Report ,Breast Neoplasms ,Cohort Studies ,Oncology ,Risk Factors ,Axilla ,Ethnicity ,Humans ,Lymph Node Excision ,Female ,Lymphedema ,Prospective Studies - Abstract
IMPORTANCE: Risk factors for breast cancer–related lymphedema (BCRL) after axillary lymph node dissection (ALND) are poorly understood. OBJECTIVE: To evaluate rates of and risk factors associated with BCRL in a prospective cohort of women treated with ALND. DESIGN, SETTING, AND PARTICIPANTS: This prospective BCRL screening study performed at a tertiary cancer center enrolled women with breast cancer 18 years and older undergoing breast surgery and unilateral ALND in the primary setting or after sentinel lymph node biopsy. EXPOSURES: Risk of BCRL during the first 2 years after ALND and radiotherapy. MAIN OUTCOMES AND MEASURES: Patients were prospectively evaluated with arm volume (perometer) measurements, and BCRL was defined as a relative volume change of 10% or greater from baseline. Cumulative incidence of BCRL was assessed using competing risk analysis. Risk factors for BCRL were assessed on univariate and multivariable analyses. RESULTS: From November 2016 to March 2020, 304 patients were enrolled; 276 had at least 1 longitudinal measurement. Median (IQR) age was 48 (40-57) years; median (IQR) body mass index, calculated as weight in kilograms divided by height in meters squared, was 26.4 (22.5-31.2). Of the 276 patients included in the analysis, 29 (11%) self-identified as Asian, 55 (20%) as Black, 16 (6%) as Hispanic, 166 (60%) as White, and 10 (3%) as unknown race and ethnicity; 70% received neoadjuvant chemotherapy (NAC); 93% received nodal irradiation. The 24-month BCRL rate was 23.8% (95% CI, 17.9%-29.8%), with significant variation by race and ethnicity (24-month rate: 37.2% [Black], 27.7% [Hispanic], 22.5% [Asian], and 19.8% [White]; P = .004). The BCRL rates were also higher among patients receiving NAC vs up-front surgery (24-month rate: 29.3% vs 11.1%; P = .01). On multivariable analysis, Black race and Hispanic ethnicity (compared with White race) (odds ratio [OR], 3.88; 95% CI, 2.14-7.08 and OR, 3.01; 95% CI, 1.10-7.62, respectively; P
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- 2023
17. Omission of Intraoperative Frozen Section May Reduce Axillary Overtreatment Among Clinically Node-Negative Patients Having Upfront Mastectomy
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Austin D. Williams, Atif J. Khan, Varadan Sevilimedu, Andrea V. Barrio, Monica Morrow, and Anita Mamtani
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Oncology ,Surgery - Published
- 2022
18. Aquatic Walking and Swimming Kinematics of Neonate and Juvenile Epaulette Sharks
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Marianne E, Porter, Andrea V, Hernandez, Connor R, Gervais, and Jodie L, Rummer
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Animal Science and Zoology ,Plant Science - Abstract
The epaulette shark, Hemiscyllium ocellatum, is a small, reef-dwelling, benthic shark that—using its paired fins—can walk, both in and out of water. Within the reef flats, this species experiences short periods of elevated CO2 and hypoxia as well as fluctuating temperatures as reef flats become isolated with the outgoing tide. Past studies have shown that this species is robust (i.e., respiratory and metabolic performance, behavior) to climate change-relevant elevated CO2 levels as well as hypoxia and anoxia tolerant. However, epaulette shark embryos reared under ocean warming conditions hatch earlier and smaller, with altered patterns and coloration, and with higher metabolic costs than their current-day counterparts. Findings to date suggest that this species has adaptations to tolerate some, but perhaps not all, of the challenging conditions predicted for the 21st century. As such, the epaulette shark is emerging as a model system to understand vertebrate physiology in changing oceans. Yet, few studies have investigated the kinematics of walking and swimming, which may be vital to their biological fitness, considering their habitat and propensity for challenging environmental conditions. Given that neonates retain embryonic nutrition via an internalized yolk sac, resulting in a bulbous abdomen, while juveniles actively forage for worms, crustaceans, and small fishes, we hypothesized that difference in body shape over early ontogeny would affect locomotor performance. To test this, we examined neonate and juvenile locomotor kinematics during the three aquatic gaits they utilize—slow-to-medium walking, fast walking, and swimming—using 13 anatomical landmarks along the fins, girdles, and body midline. We found that differences in body shape did not alter kinematics between neonates and juveniles. Overall velocity, fin rotation, axial bending, and tail beat frequency and amplitude were consistent between early life stages. Data suggest that the locomotor kinematics are maintained between neonate and juvenile epaulette sharks, even as their feeding strategy changes. Studying epaulette shark locomotion allows us to understand this—and perhaps related—species’ ability to move within and away from challenging conditions in their habitats. Such locomotor traits may not only be key to survival, in general, as a small, benthic mesopredator (i.e., movements required to maneuver into small reef crevices to avoid aerial and aquatic predators), but also be related to their sustained physiological performance under challenging environmental conditions, including those associated with climate change—a topic worthy of future investigation.
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- 2022
19. Neoadjuvant Chemotherapy for Breast Cancer In the Elderly: Are We Accomplishing Our Treatment Goals?
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Austin D. Williams, Chau T. Dang, Varadan Sevilimedu, Monica Morrow, and Andrea V. Barrio
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Oncology ,Surgery - Published
- 2022
20. Biological traits of Ascogaster quadridentata an endoparasitoid of the codling moth
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Carmen M. Hernández, Andrea V. Andorno, and Eduardo N. Botto
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Insect Science ,Plant Science - Published
- 2022
21. A NOVEL NITRIC OXIDE-RELEASING GEL FOR DIABETIC WOUNDS
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Yukun Liu, Songxue Guo, Shuyi Wei, Huan Wang, Yong Liu, Andrea V. Moscoso, Zina Ribkovskaia, Tsvetelina Lazarova, Steven Riesinger, Dennis P. Orgill, and Mihail Climov
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- 2022
22. Association Between Life's Simple 7 and Biomarkers of Cardiovascular Disease: Aldosterone, Interleukin‐6, C‐Reactive Protein
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Yan Emily Yuan, Andrea V. Haas, Gordon H. Williams, Herman Taylor, Ellen W. Seely, and Gail K. Adler
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Cardiology and Cardiovascular Medicine - Abstract
Background To promote ideal cardiovascular health, the American Heart Association recommends adhering to Life's Simple 7 (LS7)—achieving healthy targets for body mass index, physical activity, dietary intake, blood pressure, fasting plasma glucose, and cholesterol, along with smoking abstinence. Poorer achievement of LS7 (lower score) has been associated with the development of hypertension and cardiovascular disease. However, less is known about the associations between LS7 and specific biomarkers linked to cardiovascular health: aldosterone, CRP (C‐reactive protein), and IL‐6 (interleukin‐6). Methods and Results We analyzed 379 individuals (age 18–66 years) from the HyperPATH (International Hypertensive Pathotype), who were maintained on ≥200 mEq of sodium daily for 1 week. We calculated a 14‐point summative LS7 score according to participants' baseline data. Based on the range of LS7 score in this population (3–14), we classified participants as “inadequate” (3–6), “average” (7–10), and “optimal” (11–14). Regression analyses found that a higher LS7 score group was associated with lower levels of serum and urinary aldosterone ( P trend P trend =0.001, respectively), lower plasma renin activity ( P trend P trend =0.023). Being in the “optimal” LS7 score group was associated with lower serum CRP ( P trend =0.001) and IL‐6 ( P trend =0.001). Conclusions A higher LS7 score was associated with a lower activity of the renin‐angiotensin‐aldosterone system and lower levels of the inflammatory markers CRP and IL‐6. These findings offer a possible link between ideal cardiovascular health targets and biomarkers known to play a central role in the development of cardiovascular disease.
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- 2023
23. Strategies to avoid mastectomy skin-flap necrosis during nipple-sparing mastectomy
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Tracy-Ann Moo, Jonas A Nelson, Varadan Sevilimedu, Jillian Charyn, Tiana V Le, Robert J Allen, Babak J Mehrara, Andrea V Barrio, Deborah M Capko, Melissa Pilewskie, Alexandra S Heerdt, Audree B Tadros, Mary L Gemignani, Monica Morrow, and Virgilio Sacchini
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Surgery - Abstract
Background Nipple-sparing mastectomy is associated with a higher risk of mastectomy skin-flap necrosis than conventional skin-sparing mastectomy. There are limited prospective data examining modifiable intraoperative factors that contribute to skin-flap necrosis after nipple-sparing mastectomy. Methods Data on consecutive patients undergoing nipple-sparing mastectomy between April 2018 and December 2020 were recorded prospectively. Relevant intraoperative variables were documented by both breast and plastic surgeons at the time of surgery. The presence and extent of nipple and/or skin-flap necrosis was documented at the first postoperative visit. Necrosis treatment and outcome was documented at 8–10 weeks after surgery. The association of clinical and intraoperative variables with nipple and skin-flap necrosis was analysed, and significant variables were included in a multivariable logistic regression analysis with backward selection. Results Some 299 patients underwent 515 nipple-sparing mastectomies (54.8 per cent (282 of 515) prophylactic, 45.2 per cent therapeutic). Overall, 23.3 per cent of breasts (120 of 515) developed nipple or skin-flap necrosis; 45.8 per cent of these (55 of 120) had nipple necrosis only. Among 120 breasts with necrosis, 22.5 per cent had superficial, 60.8 per cent had partial, and 16.7 per cent had full-thickness necrosis. On multivariable logistic regression analysis, significant modifiable intraoperative predictors of necrosis included sacrificing the second intercostal perforator (P = 0.006), greater tissue expander fill volume (P < 0.001), and non-lateral inframammary fold incision placement (P = 0.003). Conclusion Modifiable intraoperative factors that may decrease the likelihood of necrosis after nipple-sparing mastectomy include incision placement in the lateral inframammary fold, preserving the second intercostal perforating vessel, and minimizing tissue expander fill volume.
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- 2023
24. IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models
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Janneke E. Jaspers, Jonathan F. Khan, William D. Godfrey, Andrea V. Lopez, Metamia Ciampricotti, Charles M. Rudin, and Renier J. Brentjens
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General Medicine - Published
- 2023
25. Distribution of gestational age at birth by maternal and infant characteristics in <scp>U</scp> . <scp>S</scp> . birth certificate data: Informing gestational age assumptions when clinical estimates are not available
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Andrea V. Margulis, Brian Calingaert, Alison T. Kawai, Elena Rivero‐Ferrer, and Mary S. Anthony
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Epidemiology ,Pharmacology (medical) - Published
- 2023
26. Safety guidelines for youth agricultural work in the United States: A description of the development and updating process
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Andrea V. R. Swenson, Marsha Salzwedel, Cassandra Peltier, and Barbara C. Lee
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Public Health, Environmental and Occupational Health - Abstract
To reduce the prevalence of youth injuries and fatalities in agricultural settings, safety professionals considered developing a guideline-focused intervention for how and when youth should conduct farm chores. In 1996, the process to create guidelines started, which then expanded to include professionals from the United States, Canada, and Mexico. This team used a consensus driven approach to develop the guidelines and launch the North American Guidelines for Children’s Agricultural Tasks. By 2015, research related to the published guidelines indicated a need to incorporate new empirical evidence and develop dissemination plans based on new technologies. The process for updating the guidelines was supported by a 16-person steering committee and used content experts and technical advisors. The process yielded updated and new guidelines, now called Agricultural Youth Work Guidelines. This report responds to request for further details on the development and update of the guidelines and describes the genesis of the guidelines as an intervention, the process for creating guidelines, recognition of the need to update guidelines based on research, and the process for updating guidelines to assist in others engaged in similar types of interventions.
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- 2023
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27. Detector signal characterization with a Bayesian network in XENONnT
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XENON Collaboration, Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.
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High Energy Physics - Experiment (hep-ex) ,FOS: Physical sciences ,High Energy Physics - Experiment - Abstract
We developed a detector signal characterization model based on a Bayesian network trained on the waveform attributes generated by a dual-phase xenon time projection chamber. By performing inference on the model, we produced a quantitative metric of signal characterization and demonstrate that this metric can be used to determine whether a detector signal is sourced from a scintillation or an ionization process. We describe the method and its performance on electronic-recoil (ER) data taken during the first science run of the XENONnT dark matter experiment. We demonstrate the first use of a Bayesian network in a waveform-based analysis of detector signals. This method resulted in a 3% increase in ER event selection efficiency with a simultaneously effective rejection of events outside of the region of interest. The findings of this analysis are consistent with the previous analysis from XENONnT, namely a background-only fit of the ER data., 10 pages, 6 figures
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- 2023
28. Figure S1 from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
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Sequences of CAR T cells with mCD8 signal peptide annotated in orange, scFv annotated in red, myc tag annotated in highlighted gray, mCD28 transmembrane and intracellular annotated in purple, mZeta annotated in green, IRES annotated in pink, mIL12 annotated in black, and m4-1BB annotated in yellow.
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- 2023
29. Figure S2 from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
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(A) Media from in vitro co-culture of CAR T cells with EL4mCD19 tumor cells was assessed for IL12p70 on day 7 after CAR T cell treatment. Data shown is mean +/- s.e.m. of two independent experiments. (B) EL4mCD19 tumor bearing C57BL/6 mice, pretreated with 250mg/kg per mouse of cyclophosphamide day -3, treated i.v. with CAR T cells day 0. Significance determined bylong-rank Mantel-Cox Test, with 95% confidence interval (n=3 per group). *p=0.0224 m1928� compared to m1928� + cyclophosphamide and *p=0.0295 m19� compared to m19� + cyclophosphamide (C) Flow cytometry demonstrating CD25 expression on CAR T cells prior to injection in terms of percentage and representative flow cytometry plot (ns by ordinary one-way ANOVA). Data shown is mean +/- s.e.m. of three independent experiments (n=3 per group). (D) CAR T cells were co-cultured with EL4mCD19 tumor cells and assessed for cytotoxicity 4 hours later, using a luciferase killing assay. m1928�, m19�IL-12, and m1928�IL-12 CAR T cells showed significantly increased cytotoxicity compared to m19� CAR T cells at E:T ratios of 2:1, 1:1, and 0.5:1. There was no difference in tumor lysis between 19�12 and m1928�IL-12 CAR T cells (*p=
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- 2023
30. Figure S3 from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
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(A) CAR T cells were co-cultured with EL4mCD19 tumor cells and then assessed for cytotoxicity 4 hours later, using a luciferase killing assay. There was no difference in tumor lysis between CAR T cells and vex-GFP tagged CAR T cells (two-way ANOVA). Data shown is representative of two independent experiments. (B) Flow cytometry gating strategy to determine CD8+ and CD4+ ratio and PD-1, TIM-3, and LAG-3 inhibitory receptor expression.
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- 2023
31. Data from Optimization of T-cell Receptor–Modified T Cells for Cancer Therapy
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Renier J. Brentjens, Christopher A. Klebanoff, Smita S. Chandran, Andrea V. Lopez, Terence J. Purdon, Sarwish Rafiq, and Dylan J. Drakes
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T-cell receptor (TCR)–modified T-cell gene therapy can target a variety of extracellular and intracellular tumor-associated antigens, yet has had little clinical success. A potential explanation for limited antitumor efficacy is a lack of T-cell activation in vivo. We postulated that expression of proinflammatory cytokines in TCR-modified T cells would activate T cells and enhance antitumor efficacy. We demonstrate that expression of interleukin 18 (IL18) in tumor-directed TCR-modified T cells provides a superior proinflammatory signal than expression of interleukin 12 (IL12). Tumor-targeted T cells secreting IL18 promote persistent and functional effector T cells and a proinflammatory tumor microenvironment. Together, these effects augmented overall survival of mice in the pmel-1 syngeneic tumor model. When combined with sublethal irradiation, IL18-secreting pmel-1 T cells were able to eradicate tumors, whereas IL12-secreting pmel-1 T cells caused toxicity in mice through excessive cytokine secretion. In another xenograft tumor model, IL18 secretion enhanced the persistence and antitumor efficacy of NY-ESO-1–reactive TCR-modified human T cells as well as overall survival of tumor-bearing mice. These results demonstrate a rationale for optimizing the efficacy of TCR-modified T-cell cancer therapy through expression of IL18.See related commentary by Wijewarnasuriya et al., p. 732
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- 2023
32. Supplementary Figure Legends from Optimization of T-cell Receptor–Modified T Cells for Cancer Therapy
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Renier J. Brentjens, Christopher A. Klebanoff, Smita S. Chandran, Andrea V. Lopez, Terence J. Purdon, Sarwish Rafiq, and Dylan J. Drakes
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Supplementary Data Figure Legends
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- 2023
33. Figure S4 from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
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(A) CAR T cells, day 5 after infusion, were characterized by flow cytometry in terms of percentage and representative plots. m1928�IL-12 CAR T cells expressed higher levels of inhibitory receptors, PD-1 (*p=0.0015) and LAG-3 (*p=0.0491) and showed a trend toward higher levels of TIM-3 (*p=0.1715). Data obtained is mean +/- s.e.m. of three independent experiments analyzed by unpaired t test. (B) Representative flow cytometry plots of PD-1, LAG-3, and TIM-3 inhibitory receptor expression of CAR T cells referenced in Figure 2B.
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- 2023
34. Figure S6 from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
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(A) B cells were assessed for CD80 expression by flow cytometry through peripheral blood. *p=0.048 unpaired t test of BM and *p=0.0233 unpaired t test of spleen. Data shown is mean +/- s.e.m. of two independent experiments. (B) Luminex data showing IL-4 secreting from EL4mCD19 tumor cells. Data shown is mean +/- s.e.m. of two independent experiments. *p=0.002 by unpaired t test. (C) Flow cytometry demonstrating lack of CD28 expression on CD28-/- T cells. Data shown is representative of two independent experiments. (D) CAR T cells were co-cultured with EL4mCD19 tumor cells and then assessed for cytotoxicity 4 hours later, using a luciferase killing assay. There was no difference in tumor lysis between CD28-/- or wildtype transduced CAR T cells. Data shown is mean +/- s.e.m. of two independent experiments.
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- 2023
35. Data from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
- Abstract
Although clinical responses with CD19-targeting chimeric antigen receptor (CAR) T-cell treatment have been observed in patients with certain hematologic malignancies, high rates of disease relapse highlight the necessity to understand and improve mechanisms of CAR T-cell failure. Because T-cell dysfunction is thought to contribute to CAR T-cell treatment failure, understanding what mechanisms drive T cells into this dysfunctional state may aid optimal design of efficacious CAR T cells. Dysfunctional CAR T cells have been characterized as having upregulated inhibitory receptors and decreased cytolytic capabilities. Previous studies have identified a role for sustained CAR CD3ζ signaling in CAR T-cell dysfunction. Here, we demonstrate a mechanism that drives dysfunction in CAR T cells through excessive costimulation. Fully activated CD19-targeted CAR T cells were rendered dysfunctional upon stimulation with both endogenous CD28 stimulation and CAR-mediated CD28 costimulation. Costimulation-driven dysfunction of CAR T cells was demonstrated in a syngeneic immunocompetent mouse model, in which CAR T cells were activated with signals 1 (CD3ζ), 2 (CD28), and 3 (IL12). Thus, we show that CAR T-cell dysfunction can be driven through excessive CD28 and 4-1BB costimulation.See related article by Drakes et al., p. 743
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- 2023
36. Supplementary Figure Legends from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
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Figure Legends
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- 2023
37. Figure S5 from Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells
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Renier J. Brentjens, Sarwish Rafiq, Andrea V. Lopez, Christina Bebernitz, and Dinali Wijewarnasuriya
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(A) CAR T cells, day 0 before infusion, were characterized by flow cytometry. Data shown is mean +/- s.e.m. of three independent experiments. "ns" (not significant) by unpaired t test. (B) Representative flow cytometry plots of CAR T cell CD8+ and CD4+ ratios day 5 after infusion referenced in Figure 2D. (C) Representative flow cytometry plots of PD-1, LAG-3, and TIM-3 inhibitory receptor expression of CD8+ CAR T cells referenced in Figure 2E. (D) CAR T cells, day 5 after infusion, were characterized by flow cytometry. m1928�IL-12 CAR T cells, gated on CD8+ T cells, expressed higher levels of double positive inhibitory receptors, LAG-3;TIM-3 (*p=0.0397) and LAG-3;PD-1 (*p=0.001), and showed a trend toward higher levels of TIM-3;PD-1 (*p=0.0563). Data obtained is mean +/- s.e.m. of three independent experiments analyzed by unpaired t test.
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- 2023
38. Supplementary Figures 1-8 from Optimization of T-cell Receptor–Modified T Cells for Cancer Therapy
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Renier J. Brentjens, Christopher A. Klebanoff, Smita S. Chandran, Andrea V. Lopez, Terence J. Purdon, Sarwish Rafiq, and Dylan J. Drakes
- Abstract
Supplementary Figures 1-8
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- 2023
39. Association between primary Spanish language and quality of intrapartum care among Latina women: a secondary analysis of the Listening to Mothers in California survey
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Valdez, Jessica J, Jackson, Andrea V, and Marshall, Cassondra
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Spanish-speaking ,Patient-centered ,Mothers ,Multilingualism ,Language barriers ,Reproductive health and childbirth ,Nursing ,Intrapartum ,California ,Limited English ,Paediatrics and Reproductive Medicine ,Latina ,Pregnancy ,Clinical Research ,Humans ,Obstetrics & Reproductive Medicine ,Limited English proficiency ,Language ,Contraception/Reproduction ,Quality of care ,Infant ,Obstetrics and Gynecology ,Hispanic or Latino ,Newborn ,Public Health and Health Services ,Female ,Maternal care ,proficiency - Abstract
Background Language barriers play significant roles in quality of healthcare. Limited studies have examined the relationships between Spanish language and quality of intrapartum care. The objective was to determine the association between primary Spanish language and quality of intrapartum care so as to further inform best practices for non-English speaking patients in the labor and delivery setting. Methods We used the 2016 Listening to Mothers in California survey data, which included a statewide representative sample of women who gave birth in hospitals. Our analytical sample included 1202 Latina women. Multivariable logistic regression was used to examine the association between primary language (monolingual English vs. monolingual Spanish vs. bilingual Spanish/English) and perceived discrimination due to language, perceived pressure for medical interventions, and mistreatment during labor, adjusting for maternal sociodemographics and other maternal and neonatal factors. Results Over one-third of the study population spoke English (35.6%), less than one-third spoke Spanish (29.1%), and greater than one-third spoke bilingual Spanish/English (35.3%). Overall, 5.4% of Latina women perceived discrimination due to language spoken, 23.1% perceived pressure for any medical intervention, and 10.1% experienced either form of mistreatment. Compared to English-speakers, Spanish-speakers were significantly more likely to report discrimination due to language (aOR 4.36; 95% CI 1.15–16.59), but were significantly less likely to experience pressure for certain medical interventions (labor induction or cesarean delivery) during labor (aOR 0.34; 95% CI 0.15–0.79 for induction; aOR 0.44; 95% CI 0.18–0.97 for cesarean delivery). Bilingual Spanish/English-speakers also significantly reported discrimination due to language to a lesser extent than monolingual Spanish-speakers (aOR 3.37; 95% CI 1.12–10.13). Any form of Spanish language (monolingual or bilingual) was not significantly associated with mistreatment. Conclusions Spanish language may contribute to experiences of discrimination during intrapartum care among Latina women. Future research is needed to explore perceptions of pressure, discrimination and mistreatment, among patients with limited English proficiency.
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- 2023
40. First Dark Matter Search with Nuclear Recoils from the XENONnT Experiment
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XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.
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High Energy Physics - Experiment (hep-ex) ,High Energy Physics - Phenomenology ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,High Energy Physics - Phenomenology (hep-ph) ,Physics - Instrumentation and Detectors ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,High Energy Physics - Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report on the first search for nuclear recoils from dark matter in the form of weakly interacting massive particles (WIMPs) with the XENONnT experiment which is based on a two-phase time projection chamber with a sensitive liquid xenon mass of $5.9$~t. During the approximately 1.1 tonne-year exposure used for this search, the intrinsic $^{85}$Kr and $^{222}$Rn concentrations in the liquid target were reduced to unprecedentedly low levels, giving an electronic recoil background rate of $(15.8\pm1.3)~\mathrm{events}/(\mathrm{t\cdot y \cdot keV})$ in the region of interest. A blind analysis of nuclear recoil events with energies between $3.3$~keV and $60.5$~keV finds no significant excess. This leads to a minimum upper limit on the spin-independent WIMP-nucleon cross section of $2.58\times 10^{-47}~\mathrm{cm}^2$ for a WIMP mass of $28~\mathrm{GeV}/c^2$ at $90\%$ confidence level. Limits for spin-dependent interactions are also provided. Both the limit and the sensitivity for the full range of WIMP masses analyzed here improve on previous results obtained with the XENON1T experiment for the same exposure., Limit points are included in the submission file
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- 2023
41. What does One Health want? Feminist, posthuman, and anti-colonial possibilities
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Lauren E. Van Patter, Julia Linares-Roake, and Andrea V. Breen
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General Medicine - Abstract
What does One Health want? Despite its touted interdisciplinarity, to date there has been limited engagement with the social sciences and humanities – in particular with streams of critical social theory that enable a response to this question. In this paper we draw on the critical social sciences to consider how One Health is defined, conceptualized, and positioned, and discuss what we see as vital challenges within One Health that both limit its potential for meaningful change and contribute to a potential for ongoing harm – namely, medicalization, anthropocentrism, and colonial-capitalism. We then advance three areas in the critical social sciences that hold potential for addressing these challenges – feminist, posthuman, and anti-colonial approaches. By doing so we seek to encourage a deeper transdisciplinarity within One Health – one that is open to a genuine engagement with insights from critical social theory and a re-orientation towards more creative and radical re-imaginings in the service of wellbeing for diverse peoples, animals, other beings, and the land.
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- 2023
42. A 50-year-old refugee woman with a lithopedion and a lifetime of trauma: a case report
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Waseem Sous, Michaela Sous, Ayorinde Soipe, Amy E. Caruso Brown, and Andrea V. Shaw
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Reproductive Medicine ,Obstetrics and Gynecology ,General Medicine - Abstract
Background Lithopedion is a term that refers to a fetus that has calcified or changed to bone. The calcification may involve the fetus, membranes, placenta, or any combination of these structures. It is an extremely rare complication of pregnancy and can remain asymptomatic or present with gastrointestinal and/or genitourinary symptoms. Case presentation A 50-year-old Congolese refugee with a nine-year history of retained fetus after a fetal demise was resettled to the United States (U.S.). She had chronic symptoms of abdominal pain and discomfort, dyspepsia, and gurgling sensation after eating. She experienced stigmatization from healthcare professionals in Tanzania at the time of the fetal demise and subsequently avoided healthcare interaction whenever possible. Upon arrival to the U.S., evaluation of her abdominal mass included abdominopelvic imaging which confirmed the diagnosis of lithopedion. She was referred to gynecologic oncology for surgical consultation given intermittent bowel obstruction from underlying abdominal mass. However, she declined intervention due to fear of surgery and elected for symptom monitoring. Unfortunately, she passed away due to severe malnutrition in the context of recurrent bowel obstruction due to the lithopedion and continued fear of seeking medical care. Conclusion This case demonstrated a rare medical phenomenon and the impact of medical distrust, poor health awareness, and limited access to healthcare among populations most likely to be affected by a lithopedion. This case highlighted the need for a community care model to bridge the gap between the healthcare team and newly resettled refugees.
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- 2023
43. Search for New Physics in Electronic Recoil Data from XENONnT
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XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Gardner, R., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Paschos, P., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Stephen, J., Takeda, A., Tan, P.-L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., Zhu, T., IoP (FNWI), XENON (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Aprile, E, Abe, K, Agostini, F, Ahmed Maouloud, S, Althueser, L, Andrieu, B, Angelino, E, Angevaare, J R, Antochi, V C, Antón Martin, D, Arneodo, F, Baudis, L, Baxter, A L, Bellagamba, L, Biondi, R, Bismark, A, Brown, A, Bruenner, S, Bruno, G, Budnik, R, Bui, T K, Cai, C, Capelli, C, Cardoso, J M R, Cichon, D, Clark, M, Colijn, A P, Conrad, J, Cuenca-García, J J, Cussonneau, J P, D'Andrea, V, Decowski, M P, Di Gangi, P, Di Pede, S, Di Giovanni, A, Di Stefano, R, Diglio, S, Eitel, K, Elykov, A, Farrell, S, Ferella, A D, Ferrari, C, Fischer, H, Fulgione, W, Gaemers, P, Gaior, R, Gallo Rosso, A, Galloway, M, Gao, F, Gardner, R, Glade-Beucke, R, Grandi, L, Grigat, J, Guida, M, Hammann, R, Higuera, A, Hils, C, Hoetzsch, L, Howlett, J, Iacovacci, M, Itow, Y, Jakob, J, Joerg, F, Joy, A, Kato, N, Kara, M, Kavrigin, P, Kazama, S, Kobayashi, M, Koltman, G, Kopec, A, Kuger, F, Landsman, H, Lang, R F, Levinson, L, Li, I, Li, S, Liang, S, Lindemann, S, Lindner, M, Liu, K, Loizeau, J, Lombardi, F, Long, J, Lopes, J A M, Ma, Y, Macolino, C, Mahlstedt, J, Mancuso, A, Manenti, L, Marignetti, F, Marrodán Undagoitia, T, Martens, K, Masbou, J, Masson, D, Masson, E, Mastroianni, S, Messina, M, Miuchi, K, Mizukoshi, K, Molinario, A, Moriyama, S, Morå, K, Mosbacher, Y, Murra, M, Müller, J, Ni, K, Oberlack, U, Paetsch, B, Palacio, J, Paschos, P, Peres, R, Peters, C, Pienaar, J, Pierre, M, Pizzella, V, Plante, G, Qi, J, Qin, J, Ramírez García, D, Reichard, S, Rocchetti, A, Rupp, N, Sanchez, L, Dos Santos, J M F, Sarnoff, I, Sartorelli, G, Schreiner, J, Schulte, D, Schulte, P, Schulze Eißing, H, Schumann, M, Scotto Lavina, L, Selvi, M, Semeria, F, Shagin, P, Shi, S, Shockley, E, Silva, M, Simgen, H, Stephen, J, Takeda, A, Tan, P-L, Terliuk, A, Thers, D, Toschi, F, Trinchero, G, Tunnell, C, Tönnies, F, Valerius, K, Volta, G, Wei, Y, Weinheimer, C, Weiss, M, Wenz, D, Wittweg, C, Wolf, T, Xu, D, Xu, Z, Yamashita, M, Yang, L, Ye, J, Yuan, L, Zavattini, G, Zhong, M, Zhu, T, and HEP, INSPIRE
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xenon: target ,neutrino: solar ,[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex] ,WIMP ,electronic recoil ,General Physics and Astronomy ,FOS: Physical sciences ,coupling constant: upper limit ,dark matter: direct detection ,WIMP: dark matter ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,recoil ,Dark Matter ,ddc:530 ,coupling: (axion 2electron) ,Xenon nT ,xenon: liquid ,photon: hidden sector ,boson: dark matter ,axion: dark matter ,background ,new physics: search for ,Physics ,dark matter: detector ,neutrino: magnetic moment ,Xenon nT, Dark Matter, WIMP, electronic recoil ,coupling: (axion 2photon) ,axion: solar ,experimental results - Abstract
We report on a blinded analysis of low-energy electronic-recoil data from the first science run of the XENONnT dark matter experiment. Novel subsystems and the increased 5.9 tonne liquid xenon target reduced the background in the (1, 30) keV search region to $(15.8 \pm 1.3)$ events/(tonne$\times$year$\times$keV), the lowest ever achieved in a dark matter detector and $\sim$5 times lower than in XENON1T. With an exposure of 1.16 tonne-years, we observe no excess above background and set stringent new limits on solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter., Comment: 10 pages, 6 figures. Data points are available in https://zenodo.org/record/7311940
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- 2022
44. Crystal structure of undecacalcium decaarsenide, Ca11As10
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Andrea V. Hoffmann, Viktor Hlukhyy, and Thomas F. Fässler
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Inorganic Chemistry ,General Materials Science ,Condensed Matter Physics - Abstract
Ca11As10, tetragonal, I4/mmm (no. 139), a = 11.2532(1) Å, c = 16.2351(4) Å, and V = 2055.92(6) Å3, Z = 4, R gt (F) = 0.0347, wR ref (F 2) = 0.0931, T = 150 K.
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- 2022
45. The Effect of Age on Outcomes After Neoadjuvant Chemotherapy for Breast Cancer
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Francys C. Verdial, Anita Mamtani, Kate R. Pawloski, Varadan Sevilimedu, Timothy M. D’Alfonso, Hong Zhang, Mary L. Gemignani, Andrea V. Barrio, Monica Morrow, and Audree B. Tadros
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Oncology ,Surgery - Published
- 2022
46. Emission of single and few electrons in XENON1T and limits on light dark matter
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Aprile, E, Abe, K, Agostini, F, Maouloud, Sa, Alfonsi, M, Althueser, L, Angelino, E, Angevaare, Jr, Antochi, Vc, Martin, Da, Arneodo, F, Baudis, L, Baxter, Al, Bellagamba, L, Bernard, A, Biondi, R, Bismark, A, Brown, A, Bruenner, S, Bruno, G, Budnik, R, Capelli, C, Cardoso, Jmr, Cichon, D, Cimmino, B, Clark, M, Colijn, Ap, Conrad, J, Cuenca-Garcia, Jj, Cussonneau, Jp, D'Andrea, V, Decowski, Mp, Di Gangi, P, Di Pede, S, Di Giovanni, A, Di Stefano, R, Diglio, S, Elykov, A, Farrell, S, Ferella, Ad, Fischer, H, Fulgione, W, Gaemers, P, Gaior, R, Galloway, M, Gao, F, Glade-Beucke, R, Grandi, L, Grigat, J, Higuera, A, Hils, C, Hoetzsch, L, Howlett, J, Iacovacci, M, Itow, Y, Jakob, J, Joerg, F, Joy, A, Kato, N, Kavrigin, P, Kazama, S, Kobayashi, M, Koltman, G, Kopec, A, Landsman, H, Lang, Rf, Levinson, L, Li, I, Li, S, Liang, S, Lindemann, S, Lindner, M, Liu, K, Lombardi, F, Long, J, Lopes, Jam, Ma, Y, Macolino, C, Mahlstedt, J, Mancuso, A, Manenti, L, Manfredini, A, Marignetti, F, Undagoitia, Tm, Martens, K, Masbou, J, Masson, D, Masson, E, Mastroianni, S, Messina, M, Miuchi, K, Mizukoshi, K, Molinario, A, Moriyama, S, Mora, K, Mosbacher, Y, Murra, M, Muller, J, Ni, K, Oberlack, U, Paetsch, B, Palacio, J, Peres, R, Pienaar, J, Pierre, M, Pizzella, V, Plante, G, Qi, J, Qin, J, Garcia, Dr, Reichard, S, Rocchetti, A, Rupp, N, Sanchez, L, dos Santos, Jmf, Sarnoff, I, Sartorelli, G, Schreiner, J, Schulte, D, Eissing, Hs, Schumann, M, Lavina, Ls, Selvi, M, Semeria, F, Shagin, P, Shi, S, Shockley, E, Silva, M, Simgen, H, Takeda, A, Tan, Pl, Terliuk, A, Thers, D, Toschi, F, Trinchero, G, Tunnell, C, Tonnies, E, Valerius, K, Volta, G, Wei, Y, Weinheimer, C, Weiss, M, Wenz, D, Wittweg, C, Wolf, T, Xu, Z, Yamashita, M, Yang, L, Ye, J, Yuan, L, Zavattini, G, Zhang, Y, Zhong, M, Zhu, T, Zopounidis, Jp, IoP (FNWI), XENON (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, V. C., Anton Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-Garcia, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodan Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Mora, K., Mosbacher, Y., Murra, M., Muller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramirez Garcia, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulze Eissing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tonnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., and Zopounidis, J. P.
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High Energy Physics - Experiment (hep-ex) ,Physics - Instrumentation and Detectors ,XENON1T, Light dark matter, WIMP ,Light dark matter ,WIMP ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,XENON1T ,High Energy Physics - Experiment - Abstract
Delayed single- and few-electron emissions plague dual-phase time projection chambers, limiting their potential to search for light-mass dark matter. This paper examines the origins of these events in the XENON1T experiment. Characterization of the intensity of delayed electron backgrounds shows that the resulting emissions are correlated, in time and position, with high-energy events and can effectively be vetoed. In this work we extend previous S2-only analyses down to a single electron. From this analysis, after removing the correlated backgrounds, we observe rates < 30 events/(electron*kg*day) in the region of interest spanning 1 to 5 electrons. We derive 90% confidence upper limits for dark matter-electron scattering, first direct limits on the electric dipole, magnetic dipole, and anapole interactions, and bosonic dark matter models, where we exclude new parameter space for dark photons and solar dark photons., 20 pages, 17 figures
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- 2022
47. Abstract P2-13-06: Clinical implication of HER2 status change after neoadjuvant chemotherapy with Trastuzumab and Pertuzumab (HP) in patients with HER2-positive breast cancer
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Emanuela Ferraro, Anton Safonov, Hanna Y Wen, Edi Brogi, Mithat Gonan, Andrea V. Barrio, Pedram Razavi, Sarat Chandarlapaty, Shanu Modi, Andrew D. Seidman, Larry Norton, Mark E. Robson, and Chau T. Dang
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Cancer Research ,Oncology ,skin and connective tissue diseases ,neoplasms - Abstract
Background: Patients with early HER2-positive breast cancer (BC) and residual disease after HER2-targeted neoadjuvant chemotherapy (NAC) are at high risk of recurrence. It is estimated that 10-30% of HER2-positive breast cancers change HER2 status after trastuzumab alone, but the effects of adding pertuzumab on this phenomenon and clinical outcomes remain unclear. We previously reported a high rate (~50%) of HER2 status change after HP in a small subset of patients. Herein, we present an updated analysis incorporating pathological review of additional cases.Methods: We identified patients with HER2-positive BC who received NAC with pertuzumab and trastuzumab (NAC-HP) followed by surgery at our institution between September 1, 2013 to November 1, 2019. Patients with HER2 status performed either at MSKCC or outside institutions were included. Change in HER2 status on residual disease from baseline was evaluated. We defined HER2 positivity as immunohistochemistry (IHC) IHC3+ or IHC0-2+ FISH amplified (ratio ≥ 2 or ratio < 2 and HER2 copy number ≥ 6 signals/cell). HER2-low was defined as IHC 1+ or 2+, FISH non-amplified. Disease free survival (DFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Differences between patients with concordant and discordance HER2 status were assessed using the log-rank test.Results: Of 525 patients receiving NAC with HP, 229 (44%) patients had residual disease post NAC-HP. Among these 229 patients, 141 had both pre and post NAC-HP HER2 status available and were included in this analysis. HER2 status on biopsy specimens was determined at MSKCC in 35/141 (25%) and at external institution in 106/141 (75%). The majority of patients (84%) received dose-dense AC-THP; the remainder received TCHP or other HP-based regimens. Most (96%) of patients continued HP after surgery, and 2 patients received T-DM1. Of the 141 patients, 84/141(60%) were found to be HER2 concordant, while 57 (40%) were found to be HER2 discordant. In 13/57 (23%) patients, HER2 expression was lost (IHC 0), while in 44/57 (77%) patients, HER2-low profile was detected (IHC 1+ in 31, and IHC 2+, FISH non-amplified in 13). Further details are reported in the table. Patients with HER2 discordance after NAC-HP had similar survival outcome compared with patients who remained HER2 concordant (5-years DFS: 92.3% versus 88.7%, p=0.49 and 5-yr OS 93.6% versus 88.4%, p=0.70).Conclusions: In a single center cohort, discordant HER2 status after NAC-HP appeared frequently without statistically significant impact on survival outcome, although this finding may be due to the small size and hence low statistical power. Of these, HER2-low profile is the most frequent post treatment HER2 status change. This raises the possibility that patients with change in HER2 status may have heterogenous expression of HER2 at baseline, and HER2-loss or low sub-clones survive as residual disease due to the selection pressure of HP. Alternatively, anti-HER2 therapy may suppress HER2 expression in surviving cells. These findings could inform studies of tailored approaches in the post-neoadjuvant setting based on the biological profile of residual disease. Pre NAC-HP HER2 statusNPost NAC-HP HER2 statusNDiscordantN=57IHC 3+: 19IHC0: 4IHC1+: 9IHC2+ FISH not ampl: 6IHC 0-2+ FISH ampl: 38IHC0: 9IHC1+: 22IHC2+ FISH not ampl: 7Concordant N= 84IHC 3+: 59IHC 3+: 47IHC 0- 2+ FISH ampl: 12IHC 0-2+ FISH ampl: 25IHC 3+: 4IHC 0- 2+ FISH ampl: 21 Citation Format: Emanuela Ferraro, Anton Safonov, Hanna Y Wen, Edi Brogi, Mithat Gonan, Andrea V. Barrio, Pedram Razavi, Sarat Chandarlapaty, Shanu Modi, Andrew D. Seidman, Larry Norton, Mark E. Robson, Chau T. Dang. Clinical implication of HER2 status change after neoadjuvant chemotherapy with Trastuzumab and Pertuzumab (HP) in patients with HER2-positive breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-13-06.
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- 2022
48. Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile Toxins A and B
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Deiziane V. S. Costa, Jae H. Shin, Sophia M. Goldbeck, David T. Bolick, Flavio S. Mesquita, Andrea V. Loureiro, Mônica J. Rodrigues-Jesus, Gerly A. C. Brito, and Cirle A. Warren
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Immunology ,Immunology and Allergy - Abstract
Increased risk of intestinal dysfunction has been reported in patients after Clostridioides difficile infection (CDI). Enteric glial cells (EGCs), a component of the enteric nervous system (ENS), contribute to gut homeostasis. Previous studies showed that adenosine receptors, A2A and A2B, modulate inflammation during CDI. However, it is unknown how these receptors can modulate the EGC response to the C. difficile toxins (TcdA and TcdB). We investigated the effects of these toxins on the expression of adenosine receptors in EGCs and the role of these receptors on toxin-induced EGC death. Rat EGCs line were incubated with TcdA or TcdB alone or in combination with adenosine analogues 1h prior to toxins challenge. After incubation, EGCs were collected to evaluate gene expression (adenosine receptors and proinflammatory markers) and cell death. In vivo, WT, A2A, and A2B KO mice were infected with C. difficile, euthanized on day 3 post-infection, and cecum tissue was processed. TcdA and TcdB increased A2A and A3 transcripts, as well as decreased A2B. A2A agonist, but not A2A antagonist, decreased apoptosis induced by TcdA and TcdB in EGCs. A2B blocker, but not A2B agonist, diminished apoptosis in EGCs challenged with both toxins. A3 agonist, but not A3 blocker, reduced apoptosis in EGCs challenged with TcdA and TcdB. Inhibition of protein kinase A (PKA) and CREB, both involved in the main signaling pathway driven by activation of adenosine receptors, decreased EGC apoptosis induced by both toxins. A2A agonist and A2B antagonist decreased S100B upregulation induced by C. difficile toxins in EGCs. In vivo, infected A2B KO mice, but not A2A, exhibited a decrease in cell death, including EGCs and enteric neuron loss, compared to infected WT mice, reduced intestinal damage and decreased IL-6 and S100B levels in cecum. Our findings indicate that upregulation of A2A and A3 and downregulation of A2B in EGCs and downregulation of A2B in intestinal tissues elicit a protective response against C. difficile toxins. Adenosine receptors appear to play a regulatory role in EGCs death and proinflammatory response induced by TcdA and TcdB, and thus may be potential targets of intervention to prevent post-CDI intestinal dysmotility.
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- 2023
49. Fertility decline in female mosquitoes is regulated by theorcoolfactory co-receptor
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Olayinka G. David, Kevin M. Sanchez, Andrea V. Arce, Andre Luis Costa-da-Silva, Anthony J. Bellantuono, and Matthew DeGennaro
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SUMMARYFemaleAedes aegyptimosquitoes undergo multiple rounds of reproduction, known as gonotrophic cycles. These cycles span the period from blood meal intake to oviposition. Understanding how reproductive success is maintained across gonotrophic cycles allows for the identification of molecular targets to reduce mosquito population growth. Odorant receptor co-receptor (orco) encodes a conserved insect-specific transmembrane ion channel that complexes with tuning odorant receptors (ORs) to form a functional olfactory receptor.orcoexpression has been identified in the male and female mosquito germline, but its role is unclear. We report anorco-dependent, maternal effect reduction in fertility after the first gonotrophic cycle. This decline was rescued by repairing theorcomutant locus. Eggs deposited byorcomutant females are fertilized but the embryos reveal developmental defects, reduced hatching, and changes in ion channel signaling gene transcription. We present an unexpected role for an olfactory receptor pathway in mosquito reproduction.HIGHLIGHTSLoss of theorcoolfactory co-receptor promotes female mosquito fertility decline.After their first reproductive cycle completes,Ae. aegypti orcomutant females produce embryos with disrupted development and reduced hatching.CRISPR/Cas9-mediated repair of theorcomutation rescues the fertility defect.Gene expression profiling of embryos fromorcomutant females supports a role for ion channel signaling in mosquito development.
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- 2023
50. Neutrinoless Double Beta Decay
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Adams, C., Alfonso, K., Andreoiu, C., Angelico, E., Arnquist, I. J., Asaadi, J. A. A., Avignone, F. T., Axani, S. N., Barabash, A. S., Barbeau, P. S., Baudis, L., Bellini, F., Beretta, M., Bhatta, T., Biancacci, V., Biassoni, M., Bossio, E., Breur, P. A., Brodsky, J. P., Brofferio, C., Brown, E., Brugnera, R., Brunner, T., Burlac, N., Caden, E., Calgaro, S., Cao, G. F., Cao, L., Capelli, C., Cardani, L., Castillo Fernández, R., Cattadori, C. M., Chana, B., Chernyak, D., Christofferson, C. D., Chu, P. -H, Church, E., Cirigliano, V., Collister, R., Comellato, T., Dalmasson, J., D Andrea, V., Daniels, T., Darroch, L., Decowski, M. P., Demarteau, M., Meireles Peixoto, S., Detwiler, J. A., Devoe, R. G., Di Domizio, S., Di Marco, N., Di Vacri, M. L., Dolinski, M. J., Efremenko, Yu, Elbeltagi, M., Elliott, S. R., Engel, J., Fabris, L., Fairbank, W. M., Farine, J., Febbraro, M., Figueroa-Feliciano, E., Fields, D. E., Formaggio, J. A., Foust, B. T., Franke, B., Fu, Y., Fujikawa, B. K., Gallacher, D., Gallina, G., Garfagnini, A., Gingras, C., Gironi, L., Giuliani, A., Gold, M., Gornea, R., Grant, C., Gratta, G., Green, M. P., Grinyer, G. F., Julieta Gruszko, Guan, Y., Guinn, I. S., Guiseppe, V. E., Gutierrez, T. D., Hansen, E. V., Hardy, C. A., Hauptman, J., Heffner, M., Heeger, K. M., Henning, R., Hergert, H., Aguilar, D. Hervas, Hodák, R., Holt, J. D., Hoppe, E. W., Horoi, M., Huang, H. Z., Inoue, K., Jamil, A., Jochum, J., Jones, B. J. P., Kaizer, J., Karapetrov, G., Kharusi, S. Al, Kidd, M. F., Kishimoto, Y., Klein, J. R., Kolomensky, Yu G., Kontul, I., Kornoukhov, V. N., Krause, P., Krücken, R., Kumar, K. S., Lang, K., Leach, K. G., Lenardo, B. G., Leonhardt, A., Li, A., Li, G., Li, Z., Licciardi, C., Lindsay, R., Lippi, I., Liu, J., Macko, M., Maclellan, R., Macolino, C., Majidi, S., Mamedov, F., Masbou, J., Massarczyk, R., Mastbaum, A. T., Mayer, D., Mazumdar, A., Mei, D. M., Mei, Y., Meijer, S. J., Mereghetti, E., Mertens, S., Mistry, K., Mitsui, T., Moore, D. C., Morella, M., Nattress, J. T., Neuberger, M., Ngwadla, X. E., Nones, C., Novosad, V., Nygren, D. R., Ondze, J. C. Nzobadila, O Donnell, T., Orebi Gann, G. D., Orrell, J. L., Ortega, G. S., Ouellet, J. L., Overman, C., Pagani, L., Palusova, V., Para, A., Pavan, M., Perna, A., Pertoldi, L., Pettus, W., Piepke, A., Piseri, P., Pocar, A., Povinec, P., Psihas, F., Pullia, A., Radford, D. C., Ramonnye, G. J., Rasiwala, H., Redchuk, M., Riboldi, S., Richardson, G., Rielage, K., Rogers, L., Rowson, P. C., Rukhadze, E., Saakyan, R., Sada, C., Salamanna, G., Salamida, F., Saldanha, R., Salvat, D. J., Sangiorgio, S., Schaper, D. C., Schönert, S., Schwarz, M., Schwartz, S. E., Shitov, Y., Simkovic, F., Singh, V., Slavickova, M., Sousa, A. C., Spadoni, F. L., Speller, D. H., Stekl, I., Sumathi, R. R., Surukuchi, P. T., Tayloe, R., Tornow, W., Torres, J. A., Totev, T. I., Triambak, S., Tyuka, O. A., Vasilyev, S. I., Velazquez, M., Viel, S., Vogl, C., Strum, K., Wang, Q., Waters, D., Watkins, S. L., Watts, M., Wei, W. -Z, Welliver, B., Wen, Liangjian, Wichoski, U., Wilde, S., Wilkerson, J. F., Winslow, L., Wiseman, C., Wu, X., Xu, W., Yang, H., Yang, L., Yu, C. H., Zeman, J., Zennamo, J., Zuzel, G., Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Science et Ingénierie des Matériaux et Procédés (SIMaP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and HEP, INSPIRE
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[PHYS.NUCL] Physics [physics]/Nuclear Theory [nucl-th] ,Nuclear Theory ,nucl-th ,[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th] ,[PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex] ,FOS: Physical sciences ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,nucl-ex ,Nuclear Theory (nucl-th) ,double-beta decay: (0neutrino) ,nuclear physics ,Nuclear Physics - Theory ,neutrino: Majorana ,Nuclear Physics - Experiment ,lepton number ,neutrino: mass ,Nuclear Experiment (nucl-ex) ,Nuclear Experiment ,activity report - Abstract
This White Paper, prepared for the Fundamental Symmetries, Neutrons, and Neutrinos Town Meeting related to the 2023 Nuclear Physics Long Range Plan, makes the case for double beta decay as a critical component of the future nuclear physics program. The major experimental collaborations and many theorists have endorsed this white paper., white paper submitted for the Fundamental Symmetries, Neutrons, and Neutrinos Town Meeting in support of the US Nuclear Physics Long Range Planning Process
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- 2023
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