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Network Function Virtualization (NFV) and Software Defined Networking (SDN) changed radically the way 5G networks will be deployed and services will be delivered to vertical applications (i.e., through dynamic chaining of virtualized functions deployed in distributed clouds to best address latency requirements). In this work, we present a service chaining orchestration system, namely LASH-5G, running on top of an experimental set-up that reproduces a typical 5G network deployment with virtualized functions in geographically distributed edge clouds. LASH-5G is built upon a joint integration effort among different orchestration solutions and cloud deployments and aims at providing latency-aware, adaptive and reliable service chaining orchestration across clouds and network resource domains interconnected through SDN. In this paper, we provide details on how this orchestration system has been deployed and it is operated on top of the experimentation infrastructure provided within the Fed4FIRE+ facility and we present performance results assessing the effectiveness of the proposed orchestration approach.

Background The aim of this study was to define different characteristics of infants with esophageal atresia and correlations with neonatal level of care, morbidity and mortality occurring during hospital stay. Methods Charts of all newborns with esophageal atresia (EA) admitted to our University NICU between January 2003 and November 2016 were reviewed and subdivided in four groups related to different clinical presentations; EA as an isolated form (A), with a concomitant single malformation (B), as VACTERL association (C), and in the context of a syndrome or an entity of multiple congenital anomalies (D). Results We recruited 67 infants with EA (with or without tracheoesophageal fistula), distributed in groups as follows: A 31.3%, B 16.4%, C 26.8% and D 25.3%. Type of atresia was not statistically different among different groups. Mortality was higher in groups C and D, especially if associated with congenital heart defects. In survivors, we found different auxological evolution and prognostic profiles considering duration in days of invasive mechanical ventilation and total parenteral nutrition, as well as length of stay and corrected gestational age at discharge. Conclusions In the context of genetic and syndromic entities, subjects with VACTERL association showed a lower mortality rate although a higher and more complex level of intensive care was noted in comparison to infants without VACTERL genetic and syndromic entities.

Il contributo esamina la tematica delle direttive anticipate di trattamento, valutando se, ed entro quali limiti, sia possibile conferire efficacia alle determinazioni espresse dal paziente in vista o nell'eventualità di un sopravvenuto stato di incapacità di intendere e di volere.