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19 results on '"Churnosov M"'

1. LOXL1 gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia

Author

Eliseeva, N., Ponomarenko, I., Evgeny Reshetnikov, Dvornyk, V., and Churnosov, M.

Subjects
eye diseases, Research Article
Abstract

Purpose This study was aimed to replicate the previously reported associations of the three LOXL1 gene polymorphisms with exfoliation glaucoma (XFG) and to analyze these genetic variants for their possible contribution to primary open-angle glaucoma (POAG) in Caucasians from central Russia. Methods In total, 932 participants were recruited for the study, including 328 patients with XFG, 208 patients with POAG, and 396 controls. The participants were of Russian ethnicity (self-reported) and born in Central Russia. They were genotyped at three single nucleotide polymorphisms (SNPs) of the LOXL1 gene (rs2165241, rs4886776, and rs893818). The association was analyzed using logistic regression. Results Allele C of rs2165241 was associated with a decreased risk of XFG (odds ratio [OR] =0.27–0.45, pperm ≤5*10−6) and POAG (OR=0.35–0.47, рperm≤0.001), and allele A of rs4886776 and rs893818 were associated with a lower risk of XFG (OR=0.53–0.57, рperm≤0.001). Haplotype TGG of loci rs2165241-rs4886776-rs893818 was associated with an elevated risk of XFG (OR=2.23, рperm=0.001) and POAG (OR=2.01, рperm=0.001), haplotype CGG was also associated with a decreased risk of XFG (OR=0.45, рperm=0.001) and POAG (OR=0.35, рperm=0.001). Haplotype CAA was associated with a decreased risk of XFG only (OR=0.50, рperm=0.001). Conclusions Polymorphisms rs2165241, rs4886776, and rs893818 of the LOXL1 gene showed association with XFG and POAG in a Caucasian sample from central Russia.

Published
2021

3. Characterizing the genetic history of admixture across inner Eurasia

Author

Jeong, C., Balanovsky, O., Lukianova, E., Kahbatkyzy, N., Flegontov, P., Zaporozhchenko, V., Immel, A., Wang, C., Ixan, O., Khussainova, E., Bekmanov, B., Zaibert, V., Lavryashina, M., Pocheshkhova, E., Yusupov, Y., Agdzhoyan, A., Sergey, K., Bukin, A., Nymadawa, P., Churnosov, M., Skhalyakho, R., Daragan, D., Bogunov, Y., Bogunova, A., Shtrunov, A., Dubova, N., Zhabagin, M., Yepiskoposyan, L., Churakov, V., Pislegin, N., Damba, L., Saroyants, L., Dibirova, K., Artamentova, L., Utevska, O., Idrisov, E., Kamenshchikova, E., Evseeva, I., Metspalu, M., Robbeets, M., Djansugurova, L., Balanovska, E., Schiffels, S., Haak, W., Reich, D., and Krause, J.

Abstract

The indigenous populations of inner Eurasia, a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra, harbor tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine, and Uzbekistan. We furthermore report genome-wide data of two Eneolithic individuals (~5,400 years before present) associated with the Botai culture in northern Kazakhstan. We find that inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries. This genetic separation is well mirrored by geography. The ancient Botai genomes suggest yet another layer of admixture in inner Eurasia that involves Mesolithic hunter-gatherers in Europe, the Upper Paleolithic southern Siberians and East Asians. Admixture modeling of ancient and modern populations suggests an overwriting of this ancient structure in the Altai-Sayan region by migrations of western steppe herders, but partial retaining of this ancient North Eurasian-related cline further to the North. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North Caucasus populations from the steppe.

Published
2018

19. Ancient human genomes suggest three ancestral populations for present-day Europeans

Author

Joanna L. Mountain, Michael F. Hammer, Ruslan Ruizbakiev, Cesare de Filippo, Kumarasamy Thangaraj, David E. C. Cole, Haim Ben-Ami, Leila Laredj, Mark Lipson, Jüri Parik, Valentino Romano, Andres Ruiz-Linares, Fouad Berrada, Dominique Delsate, Ugur Hodoglugil, Antti Sajantila, Olga Utevska, Shahlo Turdikulova, Tor Hervig, Ludmila P. Osipova, Hovhannes Sahakyan, Robert W. Mahley, Ramiro Barrantes, Kirsten I. Bos, Stanislav Dryomov, Peter H. Sudmant, Nadin Rohland, Heng Li, Gabriel Renaud, Mikhail Voevoda, Claudio M. Bravi, Jean-Michel Guinet, Rem I. Sukernik, Joachim Wahl, Matthias Meyer, Christos Economou, Kay Prüfer, Graciela Bailliet, Mait Metspalu, Mikhail Churnosov, Iosif Lazaridis, Johannes Krause, Bonnie Berger, Levon Yepiskoposyan, Francesca Brisighelli, Francesco Calì, Irene Gallego Romero, Oleg Balanovsky, George Ayodo, Alan Cooper, Alissa Mittnik, Julio Molina, George van Driem, Jean-Michel Dugoujon, Larissa Damba, Fedor Platonov, Nick Patterson, David Reich, Thomas B. Nyambo, David Comas, Olga L. Posukh, Béla Melegh, Draga Toncheva, Alena Kushniarevich, Brenna M. Henn, Montgomery Slatkin, René Vasquez, Elena B. Starikovskaya, Joachim Burger, Ayele Tarekegn, Tatijana Zemunik, Ene Metspalu, Sena Karachanak-Yankova, Lalji Singh, Wolfgang Haak, Susanna Sawyer, Rick A. Kittles, Cheryl A. Winkler, Svante Pääbo, Francisco Rothhammer, Marina Gubina, Pierre Zalloua, Aashish R. Jha, Swapan Mallick, Sergi Castellano, Qiaomei Fu, Desislava Nesheva, Sergey Litvinov, Ingrida Uktveryte, Michael Francken, Cosimo Posth, Theologos Loukidis, Cristian Capelli, Janet Kelso, Sarah A. Tishkoff, Toomas Kivisild, Mark G. Thomas, Elin Fornander, Mercedes Villena, Fredrik Hallgren, Vaidutis Kučinskas, Daniel Corach, George B.J. Busby, Judit Bene, William Klitz, Hamza A. Babiker, Karola Kirsanow, Ruth Bollongino, Rita Khusainova, Evan E. Eichler, Sardana A. Fedorova, Klemetti Näkkäläjärvi, Igor Rudan, Susanne Nordenfelt, Joshua G. Schraiber, Elena Balanovska, Antonio Salas, Richard Villems, Gabriel Bedoya, Elza Khusnutdinova, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Mathematics, Lipson, Mark, Berger Leighton, Bonnie, Lazaridis,I, Patterson,P, Mittnik,A, Renaud,G, Mallick,S, Kirsanow,K, Sudmant,PH, Schraiber,JG, Castellano,S, Lipson,M, Berger,B, Economou,C, Bollongino,R, Fu,Q, Bos,KI, Nordenfelt,S, Li,H, De Filippo,C, Pruefer,K, Sawyer, Posth,C, Haak1,H, Hallgren,F, Fornander,E, Rohland,N, Delsate,D, Francken,M, Guinet,JM, Wah,J, Ayodo,G, Babiker,HA, Bailliet,G, Balanovska,E, Balanovsky,O, Barrantes,R, Bedoya,G, Ben-Ami,H, Bene,J, Berrada,F, Bravi,CM, Brisighelli,F, Busby,GBJ, Cali,F, Churnosov,M, Cole,DEC, Corach,D, Damba,L, van Driem,G, Dryomov,S, Dugoujon,JM, Fedorova,SA, Gallego Romero,I, Gubina,M, Hammer,M, Henn,BM, Hervig,T, Hodoglugi,U, Jha,AR, Karachanak-Yankova,S, Khusainova,R, Khusnutdinova,E, Kittles,R:Kivisild,T, Klitz,W, Kucˇinskas,V, Kushniarevich,A, Laredj,L, Litvinov,S, Loukidis,T, Mahley,RW, Melegh,B, Metspalu,E, Molina,J, Mountain,J, Na¨kka¨la¨ja¨rvi,K, Nesheva,D, Nyambo,T, Osipova,L, Parik,J, Platonov,F, Posukh,O, Romano,V, Rothhammer,F, Rudan,I, Ruizbakiev,R, Sahakyan,H, Sajantila,A, Salas,A, Starikovskaya,EB, Tarekegn,A, Toncheva,D, Turdikulova,S, Uktveryte,I, Utevska,O, Vasquez,R, Villena,M, Voevoda,M, Winkler,CA, Yepiskoposyan,L, Zalloua,P, Zemunik,T, Cooper, Capelli,C, Thomas,MG, Ruiz-inares,A, Tishkoff,SA, Singh,L, Thangaraj,K, Villems,R, Comas,D, Sukernik,R, Metspalu,M, Meyer,M, Eichler,EE, Burger,J, Slatkin,M, Pa¨a¨bo,S, Kelso,J, Reich,D, and Krause,J

Subjects
History, Neanderthal, Biología, Population Dynamics, Present day, Genoma humà, Genome, purl.org/becyt/ford/1 [https], Basal (phylogenetics), Settore BIO/13 - Biologia Applicata, History, Ancient, Genetics, Principal Component Analysis, education.field_of_study, 0303 health sciences, Multidisciplinary, Ancient DNA, 030305 genetics & heredity, food and beverages, Agriculture, Genomics, 3. Good health, Europe, Workforce, CIENCIAS NATURALES Y EXACTAS, Human, Archaeogenetics, Asia, Lineage (genetic), EUROPE, Otras Ciencias Biológicas, European Continental Ancestry Group, Population, Settore BIO/08 - ANTROPOLOGIA, evolution, Europeans, Biology, Article, White People, Ancient, Genètica de poblacions humanes, Human origins, Ciencias Biológicas, 03 medical and health sciences, HUMAN ORIGINS, biology.animal, Humans, ANCIENT DNA, purl.org/becyt/ford/1.6 [https], education, Quantitative Biology - Populations and Evolution, Denisovan, 030304 developmental biology, Genetic diversity, ancient DNA, modern DNA, Europeans, prehistory, Genome, Human, Populations and Evolution (q-bio.PE), biology.organism_classification, Evolutionary biology, FOS: Biological sciences, Upper Paleolithic, Human genome, GENOMICS
Abstract

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes1,2,3,4 with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians3, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations’ deep relationships and show that early European farmers had ∼44% ancestry from a ‘basal Eurasian’ population that split before the diversification of other non-African lineages., Instituto Multidisciplinario de Biología Celular

Published
2014

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