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In this paper, we consider the chemotaxis-Navier-Stokes model with realistic boundary conditions matching the experiments of Hillesdon, Kessler et al. in a two-dimensional periodic strip domain. For the lower boundary, we impose the usual homogeneous Neumann-Neumann-Dirichlet boundary condition. While, for the upper boundary, since it is open to the atmosphere, we consider three kinds of different mixed non-homogeneous boundary conditions, that is, (i) Neumann-Dirichlet-Navier slip boundary condition; (ii) Zero flux-Dirichlet-Navier slip boundary condition; (iii) Zero flux-Robin-Navier slip boundary condition. For boundary conditions (i) and (iii), the existence and uniqueness of global classical solutions for any initial data and any large chemotactic sensitivity coefficient is established, and for boundary condition (ii), the existence and uniqueness of global classical solutions for any initial data and small chemotactic sensitivity coefficient is proved.

Purpose The purpose of this paper is to reveal the inner mechanisms of the role of industrial internet platforms in empowering the digital transformation of SMEs. This ROOTCLOUD-based case study shows that knowledge integration and knowledge sharing and driving play essential empowering roles in the impact of industrial internet platforms on the digital transformation of SMEs. The industrial internet platform promotes knowledge integration on the supply side, empowers cross-domain knowledge sharing and shapes the knowledge-driven digital supply chain system in the digital transformation processes of SMEs. Design/methodology/approach This paper presents a qualitative analysis of the knowledge empowerment role played by industrial internet platforms in the digital transformation process of SMEs. Based on theoretical sampling, this paper selects ROOTCLOUD as a typical case to analyse the implementation mechanism of the industrial internet platform in solving the digital transformation problems and challenges faced by SMEs. Findings Knowledge management (knowledge integration, sharing and driving) plays an important intermediary role between the empowerment of industrial internet platform and the digital transformation of SMEs. Specifically, the industrial internet platform empowers SMEs with knowledge, empowers supply-side knowledge integration, empowers cross-domain knowledge sharing and facilitates the formation of knowledge-driven supply chain systems. Research limitations/implications This study clarifies the mechanism underlying the digital transformation of SMEs empowered by industrial internet platforms, that is, the empowerment of industrial internet platform enhances the level of knowledge integration and sharing of SMEs, thus improving the effectiveness of SMEs in achieving digital transformation. Further empirical studies should be conducted on the above mechanism. Originality/value Based on the theoretical perspective of knowledge management, this paper discusses the problems and challenges faced in the digital transformation of SMEs through knowledge empowerment by the industrial internet platform ROOTCLOUD and proposes that knowledge empowerment in the industrial internet platform helps supply-side knowledge integration, promotes cross-domain knowledge sharing and contributes to forming a knowledge-driven supply chain system, thereby promoting the digital transformation of SMEs. System architects and relevant policy departments should pay attention to data-centred system construction, improve the construction of data-based collaborative application ecology and encourage industrial internet platforms to provide more targeted knowledge empowerment solutions for SMEs.

Dan Long,1 Ting Yang,1 Jie Chen,1 Ying Dai,1 Li Chen,1 Feiyong Jia,2 Lijie Wu,3 Yan Hao,4 Ling Li,5 Jie Zhang,6 Xiaoyan Ke,7 Mingji Yi,8 Qi Hong,9 Jinjin Chen,10 Shuanfeng Fang,11 Yichao Wang,12 Qi Wang,13 Chunhua Jin,14 Tingyu Li1 1Chongqing Key Laboratory of Child Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center of Child Health and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, People’s Republic of China; 3Research Center for Child Development and Behavior, Harbin Medical University, Harbin, People’s Republic of China; 4Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 5Department of Children Rehabilitation, Hainan Women and Children’s Medical Center, Haikou, People’s Republic of China; 6Children Health Care Center, Xi’an Children’s Hospital, Xi’an, People’s Republic of China; 7The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 8Department of Child Health Care, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 9Maternal and Child Health Hospital of Baoan, Shenzhen, People’s Republic of China; 10Department of Child Health Care, Shanghai Children’s Hospital, Shanghai, People’s Republic of China; 11Department of Child Health Care, Children’s Hospital Affiliated of Zhengzhou University, Zhengzhou, People’s Republic of China; 12National Health Commission Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Hospital, Changsha, People’s Republic of China; 13Deyang Maternal and Child Health Hospital, Deyang, People’s Republic of China; 14Department of Children Health Care, Capital Institute of Pediatrics, Beijing, People’s Republic of ChinaCorrespondence: Tingyu Li, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, People’s Republic of China, Tel +86 23 63630913, Fax +86 23 63622754, Email tyli@vip.sina.comPurpose: The present study investigated the age of diagnosis, treatment and demographic factors of Chinese children with autism spectrum disorders (ASD), to provide a scientific basis for the early detection, diagnosis, and intervention of ASD.Patients and Methods: A total of 1500 ASD children aged 2– 7 years old from 13 cities in China were administered questionnaires to examine their diagnosis, treatment, and basic family information. The Childhood Autism Rating Scale (CARS) was used to measure the symptoms and severity of ASD children, and the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016) was utilized to measure neurodevelopmental levels of ASD children.Results: We found that for children with ASD, the median (p25, p75) age for the initial detection of social behavioral developmental delay was 24 (18, 30) months, while the age for the initial diagnosis was 29 (24, 36) months and the age for the beginning of intervention was 33 (27, 42) months. Multiple linear regression (MLR) analysis suggested that in children with ASD whose parents were divorced, separated, or widowed, or whose mothers were engaged in physical work, the initial detection of social behavioral developmental delay happened later. For the children with ASD who lived in urban areas, had higher levels of ASD symptom severity or whose parents were not divorced or separated, the age for the initial diagnosis was earlier. For the children with ASD who lived in urban areas or whose mothers had received higher level of education, the earlier age for the beginning of intervention was observed, while for those with ASD whose mothers were engaged in physical work, the age for the beginning of training was later.Conclusion: It is recommended to actively carry out health education of ASD and strengthen the support for ASD families to enhance their rehabilitation level.Keywords: autism spectrum disorders, children, age, influencing factors, multicenter

Background:Emerging evidence over the past several years suggests that diurnal control of sodium excretion is sex dependent and involves the renal endothelin system. Given recent awareness of disruptions of circadian function in obesity, we determined whether diet-induced obesity impairs renal handling of an acute salt load at different times of day and whether this varies by sex and is associated with renal endothelin dysfunction.Methods:Male and female Sprague-Dawley rats were placed on a high-fat diet for 8 weeks before assessing renal sodium handling and blood pressure.Results:Male, but not female, rats on high fat had a significantly reduced natriuretic response to acute NaCl injection at the beginning of their active period that was associated with lower endothelin 1 (ET-1) excretion, lower ET-1 mRNA expression in the cortex and outer medulla as well as lower ETBreceptor expression in the outer medulla of the high-fat rats. Obese males also had significantly higher blood pressure (telemetry) that was exacerbated by adding high salt to the diet during the last 2 weeks. While female rats developed hypertension with a high-fat diet, they were not salt sensitive and ET-1 excretion was unchanged.Conclusions:These data identify diet-induced obesity as a sex-specific disruptive factor for maintaining proper sodium handling. Although high-fat diets induce hypertension in both sexes, these data reveal that males are at greater risk of salt-dependent hypertension and further suggest that females have more redundant systems that can be productive against salt-sensitive hypertension in at least some circumstances.

Background We aimed to compare differences in infant feeding patterns (breastfeeding and complementary food supplementation) between children with the autism spectrum disorder (ASD) and typically developing (TD) children through a multicentre study. The relationship between these patterns and later core symptoms and neurodevelopment in children with ASD was also investigated. Methods We analysed breastfeeding and complementary feeding patterns in 1389 children with ASD and 1190 TD children. The Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016) was used to assess neurodevelopmental levels. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), Childhood Autism Rating Scale (CARS), and ASD Warning Behavior Subscale of the CNBS-R2016 were used to assess ASD symptoms. Results Children with ASD had a shorter breastfeeding duration in infancy (8 (3–12) months vs. 10 (6–14) months, P P P Conclusions Children with ASD have a shorter duration of breastfeeding, a later introduction of complementary foods, and poorer acceptance of complementary foods than TD children. These feeding patterns may be related to the symptoms and growth of children with ASD. The research suggests that continued breastfeeding for longer than 12 months may be beneficial in reducing ASD symptoms and that infants who have difficulty introducing complementary foods should be followed up for neurodevelopment. Trial registration The ethics committee of the Children’s Hospital of Chongqing Medical University approved the study. Approval Number: (2018) IRB (STUDY) NO. 121, and registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR2000031194, registered on 23/03/2020).

Night shift work increases risk of cardiovascular disease associated with an irregular eating schedule. Elevating this risk is the high level of salt intake observed in the typical Western diet. Renal Na(+) excretion has a distinct diurnal pattern, independent of time of intake, yet the interactions between the time of intake and the amount of salt ingested are not clear. The hypothesis of the present study was that limiting food intake to the typically inactive period in addition to high-salt (HS) feeding will disrupt the diurnal rhythm of renal Na(+) excretion. Male Sprague-Dawley rats were placed on either normal-salt (NS; 0.49% NaCl) or HS (4% NaCl) diets. Rats were housed in metabolic cages and allowed food ad libitum and then subjected to inactive period time-restricted feeding (iTRF) for 5 days. As expected, rats fed NS and allowed food ad libitum had a diurnal pattern of Na(+) excretion. The diurnal pattern of Na(+) excretion was not significantly different after 5 days of iTRF compared with ad libitum rats. In response to HS, the diurnal pattern of Na(+) excretion was similar to NS-fed rats. However, this pattern was attenuated after 5 days of HS iTRF. The diurnal excretion pattern of urinary aldosterone was abolished in both NS iTRF and HS iTRF rats. These data support the hypothesis that HS intake combined with iTRF impairs circadian mechanisms associated with renal Na(+) excretion. NEW & NOTEWORTHY Timing of food intake normally has little effect on the diurnal pattern of Na(+) and water excretion. However, rats on a high-salt diet were unable to maintain this pattern, yet K(+) excretion was more readily adjusted to match timing of intake. These data support the hypothesis that Na(+) and water homeostasis are impacted by timing of high-salt diets.

Economics and management believe that income and price play decisive roles in consumer demand for commodities. However, there is no analysis of the order-preserving or order-reversing mapping between consumer demand and utility when income and price are not constrained. Customer utility is always determined by the amount of commodities in real life. This research analyzes the mapping relationship between the amount of commodities and utility. The set which consists of consumption bundles with a binary relation is a poset. The set of utility values with the binary relation is a chain. Furthermore, the relationship between consumption bundles and utilities is illustrated by figures. If the increasing directions of utility and the amount of commodities are consistent, the utility function is order-preserving. If they are opposite, the utility function is order-reversing. Finally, examples are included to illustrate the mapping relationship between consumption bundles and utilities.

After the boom in luxury brands’ consumption, the consumers’ motivation to buy these brands has gained the interest of researchers in the marketing field. We organized the present study using the grounded theory approach to obtain insight into the motivations behind luxury consumption through interviews with 12 individuals. We used these data to propose a model of motivations behind luxury consumption, which constitutes three categories, i.e., relatedness (conformity of evolutionary psychology and the influence on formal social activities), competence (social status and confidence), and autonomy (others’ attitudes and opinions and uniqueness). Our findings could contribute to better understanding of the motivations behind luxury consumption and proposed the possible theoretical and managerial implications in the future.

Background In recent years, some researchers have engaged in scientific misconduct such as fabrication, falsification, and plagiarism to achieve higher research performance. Considering their detrimental effects on individuals’ health status (e.g., patients, etc.) and extensive financial costs levied upon healthcare systems, such wrongdoings have even more salience in medical sciences. However, there has been little discussion on the possible influence of medical researchers’ existing creative performance on scientific misconduct, and the moral psychological mechanisms underlying those effects are still poorly understood. Methods We build a moderated mediation model to test how medical researchers’ creative performance affects their scientific misconduct and explore the role of moral licensing and moral identity in this process. Based on situational experiments and projection techniques, 287 medical researchers in China participated in a survey. Results Medical researchers’ creative performance positively relates to scientific misconduct, and moral licensing plays a mediating role in the relationship between them. In addition, moral identity has a negative moderating effect on the mediating effect of moral licensing on creative performance and scientific misconduct. Conclusion Moral licensing plays a fully mediating role in the relationship between creative performance and scientific misconduct. And moral identity negatively moderates the indirect effect of creative performance on scientific misconduct through moral licensing. The findings provide theoretical and practical implications for the prevention of medical researchers’ scientific misconduct.

In this paper, we deal with the following chemotaxis-Stokes model with non-Newtonian filtration slow diffusion (namely, p > 2 ) { n t + u ⋅ ∇ n = ∇ ⋅ ( | ∇ n | p − 2 ∇ n ) − χ ∇ ⋅ ( n ∇ c ) , c t + u ⋅ ∇ c − Δ c = − c n , u t + ∇ π = Δ u + n ∇ φ , div u = 0 in a bounded domain Ω of R 3 with zero-flux boundary conditions and no-slip boundary condition. Similar to the study for the chemotaxis-Stokes system with porous medium diffusion, it is also a challenging problem to find an optimal p-value ( p ≥ 2 ) which ensures that the solution is global bounded. In particular, the closer the value of p is to 2, the more difficult the study becomes. In the present paper, we prove that global bounded weak solutions exist whenever p > p ⁎ ( ≈ 2.012 ) . It improved the result of [21] , [22] , in which, the authors established the global bounded solutions for p > 23 11 . Moreover, we also consider the large time behavior of solutions, and show that the weak solutions will converge to the spatially homogeneous steady state ( n ‾ 0 , 0 , 0 ) . Comparing with the chemotaxis-fluid system with porous medium diffusion, the present convergence of n is proved in the sense of L ∞ -norm, not only in L p -norm or weak-* topology.

Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders with unclear etiologies. Our recent work indicated that maternal exposure to triclosan (TCS) significantly increased the autistic-like behavior in rats, possibly through disrupting neuronal retinoic acid signaling. Although environmental endocrine disruptors (EEDs) have been associated with autism in humans, the relationship between TCS, one of the EEDs found in antibacterial daily necessities, and autism has received little attention.The aims of this multicenter study were to evaluate TCS concentrations in typically developing (TD) children and ASD children, and to determine the relationship between TCS levels and the core symptoms of ASD children.A total of 1345 children with ASD and 1183 TD children were enrolled from 13 cities in China. Ages ranged between 2 and 7 years. A questionnaire was used to investigate the maternal use of antibacterial daily necessities (UADN) during pregnancy. The core symptoms of ASD were evaluated using the Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), Social Response Scale (SRS), and the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). The TCS concentration was measured using LC-MS/MS.Maternal UADN during pregnancy may be an unrecognized potential environmental risk factor for ASD (OR=1.267, P = 0.023). Maternal UADN during pregnancy strongly correlated with TCS levels in the offspring (Adjusted β = 0.277, P 0.001). TCS concentration was higher in ASD children (P = 0.005), and positively correlated with ABC (Sensory subscales: P = 0.03; Social self-help subscales: P = 0.011) and SRS scale scores (Social awareness subscales: P = 0.045; Social communication subscales: P = 0.001; Autism behavior mannerisms subscales: P = 0.006; SRS total score: P = 0.003) in ASD children. This association was more pronounced in boys than in girls.To our knowledge, this is the first case-control study to examine the correlation between TCS and ASD. Our results suggest that maternal UADN during pregnancy may be a potential risk of ASD in offspring. Further detection of TCS levels showed that maternal UADN during pregnancy may be associated with excessive TCS exposure. In addition, the level of TCS in children with ASD is higher than TD children. The higher levels of TCS in children with ASD may be significantly associated with more pronounced core symptoms, and this association was more significant in male children with ASD.

Objective: Early lactate clearance was associated with mortality in sepsis patients, but needs further clarification whether it should be adjusted according to the age. Our study aimed to investigate the predictive value of early 6-hour lactate clearance rate with the mortality rate of septic shock patients according to age stratification.Methods and Results: This was a prospective, single center and observational study. A total of 261 patients with mean age of 69.5 years were enrolled. Male patients accounted for 61.6%, with a total mortality rate of 47.5%. The blood lactate levels (LAC1) of patients showed no significnat differences between Survival Group and Death Group (P=0.767) during ICU admission. However, after 6-hour treatment, the blood lactate levels of patients in Survival Group were significantly lower compared to Death Group (P65 years and ≤65 years was 0.778 and 0.845. AUC value of ROC curve for patients >80 years and ≤80 year old was 0.751 and 0.818. However, the lactate clearance rate showed no significant differences between Survival Group patients of different age (P= 0.5413 and P=0.338), respectively.Conclusion: In clinical practice, The blood lactate levels (LAC1) of patients showed no significnat differences between Survival Group and Death Group,but early 6-hour lactate clearance rate could be used to predict the mortality rate of patients with age stratification, with optimal accuracy.

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA which has been identified to be involved in alternative non-homologous end joining (A-NHEJ) pathways by binding with PARP1 and LIG3 in myeloma cells. This study aims to explore the roles of MALAT1 in DNA repair processes in non-small cell lung cancer (NSCLC). The interactions between MALAT1 and proteins were identified by co-immunoprecipitation and RNA pulldown. The interactions between MALAT1 and microRNAs (miRNA) were predicted by bioinformatics tools and confirmed by luciferase assay and RNA pulldown. The DNA damages were quantified by comet assay. The cell viability was examined by MTT assay and the cell apoptosis was determined by flow cytometry. MALAT1 is identified to be involved in A-NHEJ pathway in NSCLC cells. However, in LIG3-null cells where A-NHEJ pathway is inactivated, targeting MALAT1 still increases DNA damages, suggesting that MALAT1 participates in other DNA repair pathways. Subsequently, MALAT1 is identified to bind with miR-146a and miR-216b, which directly target the 3′UTR of BRCA1. MALAT1 is confirmed to functions as a competing endogenous RNA (ceRNA) absorbing miR-146a and miR-216b, upregulating BRCA1 expression and protecting Homologous Recombination (HR) pathway in NSCLC cells. Finally, overexpression MALAT1 protects NSCLC cells from the cytotoxic effect of cisplatin. While, targeting MALAT1 in NSCLC cells induces DNA damages by repressing HR pathway and sensitizes NSCLC cells to cisplatin which had the potential for NSCLC treatment. MALAT1 is involved in HR pathway by protecting BRCA1 and targeting MALAT1 induces DNA damages in NSCLC.

In this paper, we consider the following system { u t = Δ u − χ ∇ ⋅ ( u ∇ ω ) , v t = d v Δ v − ξ ∇ ⋅ ( v ∇ ω ) , m t = d m Δ m + u − m , ω t = − ( γ 1 u + m ) ω , in two dimensional space with zero-flux boundary conditions. This model was proposed by Franssen et al. [7] to characterize the invasion and metastatic spread of cancer cells. We first establish the global existence of uniformly bounded global strong solutions. Then using the decay of ECM and the positivity of MDE, we further improve the regularity of obtained solutions, and achieve the uniform boundedness of solutions in the classical sense. Subsequently, we also prove the uniqueness of solutions. After that, we turn our attention to the large time behavior of solutions, and show that the global classical solution strongly converges to a semi-trivial steady state in the large time limit.

Kidney function follows a 24-h rhythm subject to regulation by circadian genes including the transcription factor Bmal1. A high-salt diet induces a phase shift in Bmal1 expression in the renal inner medulla that is dependent on endothelin type B (ETB) receptors. Furthermore, ETB receptor-mediated natriuresis is sex dependent. Therefore, experiments tested the hypothesis that collecting duct Bmal1 regulates blood pressure in a sex-dependent manner. We generated a mouse model that lacks Bmal1 expression in the collecting duct, where ETB receptor abundance is highest. Male, but not female, collecting duct Bmal1 knockout (CDBmal1KO) mice had significantly lower 24-h mean arterial pressure (MAP) than flox controls (105 ± 2 vs. 112 ± 3 mmHg for male mice and 106 ± 1 vs. 108 ± 1 mmHg for female mice, by telemetry). After 6 days on a high-salt (4% NaCl) diet, MAP remained significantly lower in male CDBmal1KO mice than in male flox control mice (107 ± 2 vs. 113 ± 1 mmHg), with no significant differences between genotypes in female mice (108 ± 2 vs. 109 ± 1 mmHg). ETB receptor blockade for another 6 days increased MAP similarly in both male and female CDBmal1KO and flox control mice. However, MAP remained lower in male CDBmal1KO mice than in male flox control mice (124 ± 2 vs. 130 ± 2 mmHg). No significant differences were observed between female CDBmal1KO and flox mice during ETB blockade (130 ± 2 vs. 127 ± 2 mmHg). There were no significant genotype differences in amplitude or phase of MAP in either sex. These data suggest that collecting duct Bmal1 has no role in circadian MAP but plays an important role in overall blood pressure in male, but not female, mice.

Variants in NAA15 are closely related to neurodevelopmental disorders (NDDs). In this study, we investigated the spectrum and clinical features of NAA15 variants in a Chinese NDD cohort of 769 children. Four novel NAA15 pathogenic variants were detected by whole-exome sequencing, including three de novo variants and one maternal variant. The in vitro minigene splicing assay confirmed one noncanonical splicing variant (c.1410+5G>C), which resulted in abnormal mRNA splicing. All affected children presented mild developmental delay, and catch-up trajectories were noted in three patients based on their developmental scores at different ages. Meanwhile, the literature review also showed that half of the reported patients with NAA15 variants presented mild/moderate developmental delay or intellectual disability, and possible catch-up sign was indicated for three affected patients. Taken together, our study expanded the spectrum of NAA15 variants in NDD patients. The affected patients presented mild developmental delay, and possible catch-up developmental trajectories were suggested. Studying the natural neurodevelopmental trajectories of NDD patients with pathogenic variants and their benefits from physical rehabilitations are needed in the future for precise genetic counseling and clinical management.

Background Premenopausal women are less likely to develop hypertension and salt‐related complications than are men, yet the impact of sex on mechanisms regulating Na + homeostasis during dietary salt challenges is poorly defined. Here, we determined whether female rats have a more efficient capacity to acclimate to increased dietary salt intake challenge. Methods and Results Age‐matched male and female Sprague Dawley rats maintained on a normal‐salt (NS) diet (0.49% NaCl) were challenged with a 5‐day high‐salt diet (4.0% NaCl). We assessed serum, urinary, skin, and muscle electrolytes; total body water; and kidney Na + transporters during the NS and high‐salt diet phases. During the 5‐day high‐salt challenge, natriuresis increased more rapidly in females, whereas serum Na + and body water concentration increased only in males. To determine if females are primed to handle changes in dietary salt, we asked the question whether the renal endothelin‐1 natriuretic system is more active in female rats, compared with males. During the NS diet, female rats had a higher urinary endothelin‐1 excretion rate than males. Moreover, Ingenuity Pathway Analysis of RNA sequencing data identified the enrichment of endothelin signaling pathway transcripts in the inner medulla of kidneys from NS‐fed female rats compared with male counterparts. Notably, in human subjects who consumed an Na + ‐controlled diet (3314–3668 mg/day) for 3 days, women had a higher urinary endothelin‐1 excretion rate than men, consistent with our findings in NS‐fed rats. Conclusions These results suggest that female sex confers a greater ability to maintain Na + homeostasis during acclimation to dietary Na + challenges and indicate that the intrarenal endothelin‐1 natriuretic pathway is enhanced in women.

Network environments have recently emerged as a considerable research area. In addition to government supervision, platform supervision is also critical to improve network environments. So, we should improve the social network platform’s single regulatory model. Against this background, we described public opinion supervision as a game between marketing accounts, netizens, and the platform. Unlike previous studies, we considered the influence of marketing accounts on online public opinion. Because of the players’ bounded rationality, we built an evolutionary game model, and by solving it, we obtained the evolutionarily stable strategy (ESS). Then, we analyzed the influence of relevant parameters on the evolutionary stable state. Our research results show that if the authenticity of the information is not high, to not publish is the best choice for the marketing account, and to not participate is the best choice for the netizen. The platform penalty for the marketing account is also directly related to the marketing account’s decision making. The platform penalty for the government, as well as the increase in the penalty risk coefficient, considerably affected the choice of platform. Finally, we put forward the “pre-event–in-the-event–post-event” three-stage supervision model, which provides countermeasures and suggestions for all parties to jointly maintain the network environment.

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BackgroundSeveral studies have reported the use of anterior, posterior and lateral quadratus lumborum block (QLB) for pain control in hip surgeries. However, high-quality evidence is lacking. The current review aimed to summarize data on the efficacy of QLB for pain control in patients undergoing hip surgeries.MethodsPubMed, Embase, and Google Scholar databases were searched up to August 5, 2021 for randomized controlled trials (RCTs) or non-RCTs assessing the efficacy of QLB for any type of hip surgery.ResultsThirteen studies were included (nine RCTs and four non-RCTs). On pooled analysis, there was a statistically significant reduction of 24-h total opioid consumption in patients receiving QLB as compared to the control group (MD: −9.92, 95% CI: −16.35, −3.48 I2 = 99% p = 0.003). We noted a statistically significant reduction of pain scores in the QLB group as compared to control group at 2–4 h (MD: −0.57, 95% CI: −0.98, −0.17 I2 = 61% p = 0.005), 6–8 h (MD: −1.45, 95% CI: −2.09, −0.81 I2 = 86% p < 0.00001), 12 h (MD: −1.12, 95% CI: −1.89, −0.34 I2 = 93% p = 0.005), 24 h (MD: −0.71, 95% CI: −1.27, −0.15 I2 = 89% p = 0.01) and 48 h (MD: −0.76, 95% CI: −1.37, −0.16 I2 = 85% p = 0.01) after the procedure. There was a statistically significant reduction in the risk of nausea/vomiting (RR: 0.40, 95% CI: 0.18, 0.88 I2 = 62% p = 0.02) in patients receiving QLB but no difference in the risk of pruritis (RR: 0.46, 95% CI: 0.17, 1.24 I2 = 16% p = 0.13) and urinary retention (RR: 0.44, 95% CI: 0.19, 1.02 I2 = 0% p = 0.06).ConclusionQLB as a part of a multimodal analgesic regimen reduces opioid consumption and pain scores in patients undergoing hip surgeries. The certainty of evidence based on GRADE was moderate. Despite the statistically significant results, the clinical relevance of the analgesic efficacy of QLB is debatable due to the small effect size.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42021267861.

Background Autism spectrum disorder (ASD) is a group of clinically heterogenic neurodevelopmental disorders, with intellectual disability being one of its common comorbidities. No large-sample, multicenter study has focused on the neurodevelopmental aspect of preschoolers with ASD. This study investigated the neurodevelopmental characteristics of preschoolers with ASD in China and explored the association between them and the core symptoms. Methods We enrolled 1019 ASD preschoolers aged 2–7 years old from 13 cities around China between May 2018 and December 2019, and used the revised Children Neuropsychological and Behavior Scale (CNBS-R2016) to assess their neurodevelopment. Their autistic core behaviors were evaluated based on their Social Responsiveness Scale (SRS), Autism Behavior Checklist (ABC), Child Autism Rating Scale (CARS), and communication warning behavior (CWB) scores in the CNBS-R2016. Results Based on general developmental quotient (GQ) 70%) was found in language and personal-social skills, followed by fine motor skills (68.9%). Gross motor skills had the lowest DD rate (34.0%). We found that fine motor, language, and personal-social developmental quotients (DQs) were significantly lower than gross motor skills in no DD (GQ > 70), mild DD (GQ 55–69), and moderate and below DD groups (GQ ≤ 54). Furthermore, the DQs for language and personal-social skills were significantly lower than for gross and fine motor skills in both DD groups. The ABC, SRS, CARS, and CWB scores in the no DD group were the lowest, moderate in the mild DD group, and highest in the moderate and below DD group. Besides, negative correlations were found between the DQs of the four domains and the ABC, SRS, CARS, and CWB scores, of which the language and personal-social skills DQs had the strongest correlations. Conclusions Preschoolers with ASD had unbalanced neurodevelopment domain patterns and their neurodevelopmental levels were negatively correlated with the autism core symptoms. Hence, pediatricians should actively evaluate the neurodevelopment of children with ASD and conduct long-term follow-up during their early childhood to promote early diagnosis and develop personalized intervention plans. Trial registration ChiCTR2000031194, registered on 03/23/2020.

BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder, and show a striking male bias in prevalence. Vitamin A (VA) is essential for brain development, and abnormalities in its metabolite retinoic acid are associated with the pathophysiology of ASD. This national multicenter study was conducted to investigate the relationship between serum VA level and core symptoms in ASD children and whether there are still sex differences.MethodA total of 1,300 children with ASD and 1,252 typically-developing (TD) controls aged 2–7 years old from 13 cities in China were enrolled in this study. The symptoms of children with ASD were evaluated by the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood autism rating scale (CARS). The neurodevelopmental level of the children was evaluated with the revised Children Neuropsychological and Behavior Scale (CNBS-R2016). The serum level of VA was measured by high-performance liquid chromatography (HPLC).ResultsThe serum VA level in children with ASD was significantly lower than that in TD children, especially in boys with ASD. Furthermore, VA levels in male children with ASD were lower than those in female children with ASD. In addition, we found that serum VA level was negatively correlated the SRS, CARS and communication warming behavior of CBNS-R2016 scores in boys with ASD. In terms of developmental quotients, serum VA level was positively associated with the general quotient, language quotient, gross motor quotient and personal-social quotient of boys with ASD, but no difference was found in girls with ASD.ConclusionsASD children, especially boys, have lower serum VA levels than TD children. Moreover, serum VA status is more commonly associated with clinical symptoms and neurodevelopment in boys with ASD.

Various routing protocols have been proposed for ad hoc networks such as the Internet of Things (IoT). Most of the routing protocols introduced for IoT are specific to applications and networks. In the current literature, it is essential to configure all the network nodes with a single proposed protocol. Moreover, it is also possible for a single IoT network to consist of different kinds of nodes. Two or more IoT networks can also be connected to create a bigger heterogeneous network. Such networks may need various routing protocols with some gateway nodes installed. The role of gateway nodes should not be limited to the interconnection of different nodes. In this paper, a multi-mode hybrid routing mechanism is proposed that can be installed on all or a limited number of nodes in a heterogenous IoT network. The nodes configured with the proposed protocols are termed smart nodes. These nodes can be used to connect multiple IoT networks into one. Furthermore, a game-theory-based model is proposed that is used for intercommunication among the smart nodes to gain optimal efficiency. Various performance matrices are assessed under different network scenarios. The simulation results show that the proposed mechanism outperforms in broader heterogeneous IoT networks with diverse nodes.

IntroductionThis study aimed to investigate the prevalence of developmental regression in children with Autism Spectrum Disorder (ASD) and to explore its relationship with disease severity.MethodsWe finally included 1,027 ASD children aged 2–5 years from 13 cities in China: 138 with regressive ASD and 889 with non-regressive ASD. The Social Responsiveness Scale (SRS), Autism Behavior Checklist (ABC), Child Autism Rating Scale (CARS), and Children Neuropsychological and Behavioral Scale-Revision 2016 (CNBS-R2016) were used to evaluate the core symptoms and developmental status of children in the two groups.ResultsAmong the 1,027 ASD children eventually included, 138 (13.44%) cases showed regressive behavior and the average regression occurring age was 24.00 (18.00–27.00) months. Among the regressive children, 105 cases (76.09%) had language regression, 79 cases (57.25%) had social regression, and 4 cases (2.90%) had motor regression. The total scores of ABC and the sub-score of sensory and stereotypic behavior (β = 5.122, 95% CI: 0.818, 9.426, P < 0.05; β = 1.104, 95% CI: 0.120, 2.089, P < 0.05; β = 1.388, 95% CI: 0.038, 2.737, P < 0.05), the SRS total scores and the sub-score of autistic mannerisms (β = 4.991, 95% CI: 0.494, 9.487, P < 0.05; β = 1.297, 95% CI: 0.140, 2.453, P < 0.05) of children in the regressive group were all higher than the non-regressive group. The total developmental quotient (DQ) of CNBS-R2016 and the DQ of gross motor, fine motor, adaptive behavior, language (β = −5.827, 95% CI: −11.529, −0.125, P < 0.05) and personal society in the regressive group were lower than the non-regressive group and the proportion of children with intelligent developmental impairment was higher the non-regressive group.ConclusionRegressive autism is mainly manifested as language and social regression. Children with regressive ASD have more severe core symptoms, lower neurodevelopmental level DQ, and more serious disease degree than children with non-regressive ASD, which requires further etiological examinations and more clinical attention.

Periodical road manhole cover measurement is extremely important to ensure road safety and reduce traffic disasters. This letter proposes an effective method for delineating road manhole covers from mobile laser scanning point cloud data. To improve processing efficiency, first, road surface points are segmented and rasterized into georeferenced intensity images. Then, object-oriented patches are generated through superpixel segmentation and further fed to a convolutional capsule network classifier for manhole cover detection. Finally, manhole covers are accurately delineated through a marked point process of disks. Quantitative evaluations on three data sets show that an average completeness, correctness, quality, and ${F} _{1}$ -measure of 0.965, 0.961, 0.929, and 0.963, respectively, are obtained. Comparative studies with three existing methods confirm that the proposed method performs superiorly in delineating manhole covers of varying conditions and on complex road surface environments.

This paper is concerned with the time periodic problem to a coupled chemotaxis-fluid model with porous medium diffusion \begin{document}$ \Delta n^m $\end{document} . The global existence of solutios for the initial and boundary value problem of this model have been studied by many authors, and in particular, the global solvability is established for \begin{document}$ m>\frac65 $\end{document} in dimension 3. Here, taking advantage of a double-level approximation scheme, we establish the existence of uniformly bounded time periodic solution for any \begin{document}$ m\ge \frac 65 $\end{document} and any large periodic source \begin{document}$ g(x, t) $\end{document} . In particular, the energy estimates techniques we used also applicable to the proof of global existence of the initial-boundary value problem, and one can supply the existence of global solutions for \begin{document}$ m = \frac65 $\end{document} by this method.

Purpose Travel companies are increasingly hosting online communities to extend their initiatives of customer relationship management and gain additional insight into their business. While the benefits to companies from hosting online communities are clear, another closely related issue has not been given comparative attention: Why do customers engage voluntarily in online travel communities? The purpose of this paper is to answer the question by developing and testing a conceptual model that exploring the influence of socialization interactions on customer engagement with the community. Design/methodology/approach Hypotheses were tested by applying structural equation modeling based on survey data collected from an online travel community (n=665). Findings The results supported the research hypotheses and demonstrated that socialization interactions (i.e. information and social exchange) in the online travel community are important catalysts for customer engagement. Originality/value The contribution of this study is twofold. First, from a theoretical perspective, it offers new insights into the conceptualization of customer engagement and its antecedents in the context of the online travel community. Second, from a pragmatic perspective, the conceptual model derived from this research aids practitioners in stimulating customer engagement from the perspective of socialization interactions.

We consider the coupled chemotaxis-fluid model for periodic pattern formation on two- and three-dimensional domains with mixed nonhomogeneous boundary value conditions, and prove the existence of nontrivial time periodic solutions. It is worth noticing that this system admits more than one periodic solution. In fact, it is not difficult to verify that (0, c, 0, 0) is a time periodic solution. Our purpose is to obtain a time periodic solution with nonconstant bacterial density.

In this paper, we study the large time behavior of a chemotaxis model with nonlinear diffusion and consumption { u t = Δ u m − ∇ ⋅ ( u ∇ v ) + μ u ( 1 − u ) , v t − Δ v = − v u , where m > 1 . In a previous paper [5] , we have proved the existence and uniform boundedness of global weak solutions for any nonnegative initial data and any m > 1 . In this work, we show that the weak solutions strongly converge to ( 1 , 0 ) in the large time limit.

An electronic voting (e-voting) system allows voters to cast their votes secretly and securely over a public channel. Security is the critical issue that should be considered in such a system. In this paper, we propose a heterogeneous deniable authentication (HDA) protocol for e-voting systems. The proposed protocol allows a sender in a certificateless cryptography (CLC) environment to transmit a message to a receiver in a public key infrastructure (PKI)environment. Our protocol admits security proof in the random oracle model under the bilinear Diffie–Hellman (BDH) and computational Diffie–Hellman (CDH) assumptions. Additionally, our protocol provides batch verification, which can accelerate the verification of authenticators. Comprehensive analysis shows that our protocol is highly suitable for practical e-voting systems.

In this paper, we deal with the following coupled chemotaxis–haptotaxis system u t = Δ u m − χ ∇ ⋅ u ( 1 + u ) α ∇ v − ξ ∇ ⋅ u ( 1 + u ) β ∇ ω + μ u ( 1 − u − ω ) , v t = Δ v − v + u , ω t = − v ω in a bounded domain Ω of R 3 corresponding to zero-flux boundary conditions. We showed that for any m > 0 , the problem admits a global bounded weak solution. Subsequently, we also discussed the large time behavior of solutions for the fast diffusion case, and showed that when 0 m ≤ 1 , for appropriately large μ , for any initial datum, the solution ( u , v , ω ) goes to the steady state ( 1 , 1 , 0 ) as t → ∞ . The global existence result improved the work of Liu et al. (2016) in dimension 3, in which, the global existence is established for min { α , β } > 4 3 − m with m > 4 3 or m ≤ 1 .

In this paper, the existing quadrature element method (QEM) is extended to analyze the three-dimensional (3D) free vibration of multi-directional functionally graded material (FGM) parallelepipeds under general boundary conditions. The material properties vary continuously in multiple directions according to a power-law form. Formulations of the multi-directional FGM parallelepiped element are given. Since the element nodes do not coincide with the integration points, a different way is used to compute the strains at integration points to derive explicit element stiffness matrix. A number of case studies on multi-directional FGM square and rhombic thick plates with general boundary conditions and different power-law exponents have been conducted. The effect of power-law exponents and boundary conditions on the free vibration behavior of FGM plates is investigated. The natural frequencies are in excellent agreement with either existing results or data obtained by ABAQUS using fine meshes. It is demonstrated that the extended QEM is simple in formulations and capable of capturing the 3D vibration behavior of the multi-directional FGM plates with high precision. New results are presented and may be used as benchmark solutions for future researches.

We aimed to investigate the relationship between vitamin D status and core symptoms and neurodevelopmental levels in children with ASD with a multicenter survey.We enrolled 1321 ASD children and 1279 typically developing (TD) children aged 2-7 years from 13 cities in China. ASD symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016).Children with ASD had lower serum 25(OH)D levels than TD children. Serum 25(OH)D levels were negatively associated with CARS and communication warning behavior of CNBS-R2016 scores, and were not associated with the development quotients of ASD children. ASD Children were grouped based on the quartiles for 25(OH)D levels in the controls, and children in the first to third quartiles had higher SRS social communication and/or CARS and communication warning behavior of CNBS-R2016 scores than those in the fourth quartile.Serum 25(OH)D levels were primarily associated with core symptoms in children with ASD, and individuals with relatively lower 25(OH)D levels displayed worse autistic symptomatology. More research is needed to determine whether vitamin D supplements would be a useful treatment for ASD.