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Background: Genetic variability in LRRK2 has been unequivocally established as a major risk factor for familial and sporadic forms of PD in ethnically diverse populations. Objectives: To resolve the role of LRRK2 in the Indian population. Methods: We performed targeted resequencing of the LRRK2 locus in 288 cases and 298 controls and resolved the haplotypic structure of LRRK2 in a combined cohort of 800 cases and 402 controls in the Indian population. We assessed the frequency of novel missense variants in the white and East Asian population by leveraging exome sequencing and densely genotype data, respectively. We did computational modeling and biochemical approach to infer the potential role of novel variants impacting the LRRK2 protein function. Finally, we assessed the phosphorylation activity of identified novel coding variants in the LRRK2 gene. Results: We identified four novel missense variants with frequency ranging from 0.0008% to 0.002% specific for the Indian population, encompassing armadillo and kinase domains of the LRRK2 protein. A common genetic variability within LRRK2 may contribute to increased risk, but it was nonsignificant after correcting for multiple testing, because of small cohort size. The computational modeling showed destabilizing effect on the LRRK2 function. In comparison to the wild-type, the kinase domain variant showed 4-fold increase in the kinase activity. Conclusions: Our study, for the first time, identified novel missense variants for LRRK2, specific for the Indian population, and showed that a novel missense variant in the kinase domain modifies kinase activity in vitro. © 2018 International Parkinson and Movement Disorder Society.

This paper presents competitive algorithms for a novel class of online optimization problems with memory. We consider a setting where the learner seeks to minimize the sum of a hitting cost and a switching cost that depends on the previous $p$ decisions. This setting generalizes Smoothed Online Convex Optimization. The proposed approach, Optimistic Regularized Online Balanced Descent, achieves a constant, dimension-free competitive ratio. Further, we show a connection between online optimization with memory and online control with adversarial disturbances. This connection, in turn, leads to a new constant-competitive policy for a rich class of online control problems., Neural Information Processing Systems (NeurIPS 2020)

We report the discovery and analysis of the planetary microlensing event OGLE-2017-BLG-0406, which was observed both from the ground and by the ${\it Spitzer}$ satellite in a solar orbit. At high magnification, the anomaly in the light curve was densely observed by ground-based-survey and follow-up groups, and it was found to be explained by a planetary lens with a planet/host mass ratio of $q=7.0 \times 10^{-4}$ from the light-curve modeling. The ground-only and ${\it Spitzer}$-"only" data each provide very strong one-dimensional (1-D) constraints on the 2-D microlens parallax vector $\bf{\pi_{\rm E}}$. When combined, these yield a precise measurement of $\bf{\pi_{\rm E}}$, and so of the masses of the host $M_{\rm host}=0.56\pm0.07\,M_\odot$ and planet $M_{\rm planet} = 0.41 \pm 0.05\,M_{\rm Jup}$. The system lies at a distance $D_{\rm L}=5.2 \pm 0.5 \ {\rm kpc}$ from the Sun toward the Galactic bulge, and the host is more likely to be a disk population star according to the kinematics of the lens. The projected separation of the planet from the host is $a_{\perp} = 3.5 \pm 0.3 \ {\rm au}$, i.e., just over twice the snow line. The Galactic-disk kinematics are established in part from a precise measurement of the source proper motion based on OGLE-IV data. By contrast, the ${\it Gaia}$ proper-motion measurement of the source suffers from a catastrophic $10\,\sigma$ error., Comment: 40 pages, 12 figures, 10 tables, accepted for publication in The Astronomical Journal

We report the discovery of a cold Super-Earth planet (m(p) = 4.4 +/- 0.5 M-circle plus) orbiting a low-mass (M = 0.23 +/- 0.03 M-circle dot) M dwarf at projected separation a(perpendicular to) l = 1.18 +/- 0.10 a.u., i.e., about 1.9 times the distance the snow line. The system is quite nearby for a microlensing planet, D-L = 0.86 +/- 0.09 kpc. Indeed, it was the large lens-source relative parallax pi(rel) = 1.0 mas (combined with the low mass M) that gave rise to the large, and thus well-measured, "microlens parallax" pi(E) proportional to (pi(rel)/M)(1)(/2) that enabled these precise measurements. OGLE-2017-BLG-1434Lb is the eighth microlensing planet with planet-host mass ratio q < 1 x 10(-4).\ud \ud We apply a new planet-detection sensitivity method, which is a variant of "V/V-max", to seven of these eight planets to derive the mass-ratio function in this regime. We find dN/ d lnq proportional to q(P) , with p =1.05(-0.68)(+0.78), which confirms the "turnover" in the mass function found by Suzuki et al. relative to the power law of opposite sign n = -0.93 +/- 0.13 at higher mass ratios q greater than or similar to 2 x 10(-4). We combine our result with that of Suzuki et al. to obtain p = 0.73(-0.34)(+0.42.)

We report the discovery of a cold Super-Earth planet (m_p=4.4 +/- 0.5 M_Earth) orbiting a low-mass (M=0.23 +/- 0.03 M_Sun) M dwarf at projected separation a_perp = 1.18 +/- 0.10 AU, i.e., about 1.9 times the snow line. The system is quite nearby for a microlensing planet, D_Lens = 0.86 +/- 0.09 kpc. Indeed, it was the large lens-source relative parallax pi_rel=1.0 mas (combined with the low mass M) that gave rise to the large, and thus well-measured, "microlens parallax" that enabled these precise measurements. OGLE-2017-BLG-1434Lb is the eighth microlensing planet with planet-host mass ratio q < 1 * 10^-4. We apply a new planet-detection sensitivity method, which is a variant of "V/V_max", to seven of these eight planets to derive the mass-ratio function in this regime. We find dN/d(ln q) ~ q^p, with p = 1.05 (+0.78,-0.68), which confirms the "turnover" in the mass function found by Suzuki et al. relative to the power law of opposite sign n = -0.93 +/- 0.13 at higher mass ratios q >~ 2 * 10^-4. We combine our result with that of Suzuki et al. to obtain p = 0.73 (+0.42,-0.34)., Comment: 53 pages, 16 figures

We present Korea Microlensing Telescope Network (KMTNet) light curves for microlensing-event candidates for the 2016 season, which covers an area of 97 sq.deg observed at cadences ranging from Gamma=0.2/hr to Gamma=8/hr from three southern sites in Chile, South Africa, and Australia. These 2163 light curves are comprised of 1856 "clear microlensing" and 307 "possible microlensing" events (including 265 previously released from the K2 C9 field). The data policy is very similar to the one governing the 2015 release. The changes relative to 2015 in the algorithms to find and vet microlensing events are comprehensively described., Comment: 14 pages, 2 Figures, submitted to AAS Journals

著者人数: 61名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 鈴木, 大介), Accepted: 2018-09-27, 資料番号: SA1180205000

We report the discovery of a cold Super-Earth planet (m_p=4.4 +/- 0.5 M_Earth) orbiting a low-mass (M=0.23 +/- 0.03 M_Sun) M dwarf at projected separation a_perp = 1.18 +/- 0.10 AU, i.e., about 1.9 times the snow line. The system is quite nearby for a microlensing planet, D_Lens = 0.86 +/- 0.09 kpc. Indeed, it was the large lens-source relative parallax pi_rel=1.0 mas (combined with the low mass M) that gave rise to the large, and thus well-measured, "microlens parallax" that enabled these precise measurements. OGLE-2017-BLG-1434Lb is the eighth microlensing planet with planet-host mass ratio q < 1 * 10^-4. We apply a new planet-detection sensitivity method, which is a variant of "V/V_max", to seven of these eight planets to derive the mass-ratio function in this regime. We find dN/d(ln q) ~ q^p, with p = 1.05 (+0.78,-0.68), which confirms the "turnover" in the mass function found by Suzuki et al. relative to the power law of opposite sign n = -0.93 +/- 0.13 at higher mass ratios q >~ 2 * 10^-4. We combine our result with that of Suzuki et al. to obtain p = 0.73 (+0.42,-0.34)., 53 pages, 16 figures

We analyze an ensemble of microlensing events from the 2015 Spitzer microlensing campaign, all of which were densely monitored by ground-based high-cadence survey teams. The simultaneous observations from Spitzer and the ground yield measurements of the microlensing parallax vector $\pi_{\rm E}$, from which compact constraints on the microlens properties are derived, including $\lesssim$25\% uncertainties on the lens mass and distance. With the current sample, we demonstrate that the majority of microlenses are indeed in the mass range of M dwarfs. The planet sensitivities of all 41 events in the sample are calculated, from which we provide constraints on the planet distribution function. In particular, assuming a planet distribution function that is uniform in $\log{q}$, where $q$ is the planet-to-star mass ratio, we find a $95\%$ upper limit on the fraction of stars that host typical microlensing planets of 49\%, which is consistent with previous studies. Based on this planet-free sample, we develop the methodology to statistically study the Galactic distribution of planets using microlensing parallax measurements. Under the assumption that the planet distributions are the same in the bulge as in the disk, we predict that $\sim$1/3 of all planet detections from the microlensing campaigns with Spitzer should be in the bulge. This prediction will be tested with a much larger sample, and deviations from it can be used to constrain the abundance of planets in the bulge relative to the disk., Comment: published on Astronomical Journal

e present the analysis of the binary gravitational microlensing event MOA-2015-BLG-020. The event has a fairly long timescale (˜63 days) and thus the light curve deviates significantly from the lensing model that is based on the rectilinear lens-source relative motion. This enables us to measure the microlensing parallax through the annual parallax effect. The microlensing parallax parameters constrained by the ground-based data are confirmed by the Spitzer observations through the satellite parallax method. By additionally measuring the angular Einstein radius from the analysis of the resolved caustic crossing, the physical parameters of the lens are determined. It is found that the binary lens is composed of two dwarf stars with masses {M}1=0.606+/- 0.028 {M}⊙ and {M}2=0.125 +/- 0.006 {M}⊙ in the Galactic disk. Assuming that the source star is at the same distance as the bulge red clump stars, we find the lens is at a distance {D}L=2.44+/- 0.10 {kpc}. We also provide a summary and short discussion of all of the published microlensing events in which the annual parallax effect is confirmed by other independent observations.

We present microlensing events in the 2015 Korea Microlensing Telescope Network (KMTNet) data and our procedure for identifying these events. In particular, candidates were detected with a novel "completed event" microlensing event-finder algorithm. The algorithm works by making linear fits to a (t0,teff,u0) grid of point-lens microlensing models. This approach is rendered computationally efficient by restricting u0 to just two values (0 and 1), which we show is quite adequate. The implementation presented here is specifically tailored to the commission-year character of the 2015 data, but the algorithm is quite general and has already been applied to a completely different (non-KMTNet) data set. We outline expected improvements for 2016 and future KMTNet data. The light curves of the 660 "clear microlensing" and 182 "possible microlensing" events that were found in 2015 are presented along with our policy for their public release., Comment: AJ, in press, 39 pages, 12 figures. Lightcurves at http://kmtnet.kasi.re.kr/~ulens/event/2015/ . See Section 5 for data policy

We analyze an ensemble of microlensing events from the 2015 Spitzer microlensing campaign, all of which were densely monitored by ground-based high-cadence survey teams. The simultaneous observations from Spitzer and the ground yield measurements of the microlensing parallax vector $��_{\rm E}$, from which compact constraints on the microlens properties are derived, including $\lesssim$25\% uncertainties on the lens mass and distance. With the current sample, we demonstrate that the majority of microlenses are indeed in the mass range of M dwarfs. The planet sensitivities of all 41 events in the sample are calculated, from which we provide constraints on the planet distribution function. In particular, assuming a planet distribution function that is uniform in $\log{q}$, where $q$ is the planet-to-star mass ratio, we find a $95\%$ upper limit on the fraction of stars that host typical microlensing planets of 49\%, which is consistent with previous studies. Based on this planet-free sample, we develop the methodology to statistically study the Galactic distribution of planets using microlensing parallax measurements. Under the assumption that the planet distributions are the same in the bulge as in the disk, we predict that $\sim$1/3 of all planet detections from the microlensing campaigns with Spitzer should be in the bulge. This prediction will be tested with a much larger sample, and deviations from it can be used to constrain the abundance of planets in the bulge relative to the disk., published on Astronomical Journal

Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a fast and efficient genotyping platform designed for the investigation of genetic variation in neurodegenerative diseases. Here, we present its updated version, named NeuroChip. The NeuroChip is a low-cost, custom-designed array containing a tagging variant backbone of about 306,670 variants complemented with a manually curated custom content comprised of 179,467 variants implicated in diverse neurological diseases, including Alzheimer's disease, Parkinson's disease, Lewy body dementia, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy. The tagging backbone was chosen because of the low cost and good genome-wide resolution; the custom content can be combined with other backbones, like population or drug development arrays. Using the NeuroChip, we can accurately identify rare variants and impute over 5.3 million common SNPs from the latest release of the Haplotype Reference Consortium. In summary, we describe the design and usage of the NeuroChip array and show its capability for detecting rare pathogenic variants in numerous neurodegenerative diseases. The NeuroChip has a more comprehensive and improved content, which makes it a reliable, high-throughput, cost-effective screening tool for genetic research and molecular diagnostics in neurodegenerative diseases.

The microlens parallax is a crucial observable for conclusively identifying the nature of lens systems in microlensing events containing or composed of faint (even dark) astronomical objects such as planets, neutron stars, brown dwarfs, and black holes. With the commencement of a new era of microlensing in collaboration with space-based observations, the microlens parallax can be routinely measured. In addition, space-based observations can provide opportunities to verify the microlens parallax measured from ground-only observations and to find a unique solution of the lensing lightcurve analysis. However, since most space-based observations cannot cover the full lightcurves of lensing events, it is also necessary to verify the reliability of the information extracted from fragmentary space-based lightcurves. We conduct a test based on the microlensing event OGLE-2016-BLG-0168 created by a binary lens system consisting of almost equal mass M-dwarf stars to demonstrate that it is possible to verify the microlens parallax and to resolve degeneracies by using the space-based lightcurve even though the observations are fragmentary. Since space-based observatories will frequently produce fragmentary lightcurves due to their short observing windows, the methodology of this test will be useful for next-generation microlensing experiments that combine space-based and ground-based collaboration., 9 pages, 5 figures, 3 tables, submitted in ApJ

We present the analysis of the gravitational microlensing event OGLE-2011-BLG-0251. This anomalous event was observed by several survey and follow-up collaborations conducting microlensing observations towards the Galactic Bulge. Based on detailed modelling of the observed light curve, we find that the lens is composed of two masses with a mass ratio q=1.9 x 10^-3. Thanks to our detection of higher-order effects on the light curve due to the Earth's orbital motion and the finite size of source, we are able to measure the mass and distance to the lens unambiguously. We find that the lens is made up of a planet of mass 0.53 +- 0.21,M_Jup orbiting an M dwarf host star with a mass of 0.26 +- 0.11 M_Sun. The planetary system is located at a distance of 2.57 +- 0.61 kpc towards the Galactic Centre. The projected separation of the planet from its host star is d=1.408 +- 0.019, in units of the Einstein radius, which corresponds to 2.72 +- 0.75 AU in physical units. We also identified a competitive model with similar planet and host star masses, but with a smaller orbital radius of 1.50 +- 0.50 AU. The planet is therefore located beyond the snow line of its host star, which we estimate to be around 1-1.5 AU., 12 pages, 7 figures, 3 tables; A&A in press

We use neutron reflectometry to investigate the interlayer exchange coupling between Ga$_{0.97}$Mn$_{0.03}$As ferromagnetic semiconductor layers separated by non-magnetic Be-doped GaAs spacers. Polarized neutron reflectivity measured below the Curie temperature of Ga$_{0.97}$Mn$_{0.03}$As reveals a characteristic splitting at the wave vector corresponding to twice the multilayer period, indicating that the coupling between the ferromagnetic layers are antiferromagnetic (AFM). When the applied field is increased to above the saturation field, this AFM coupling is suppressed. This behavior is not observed when the spacers are undoped, suggesting that the observed AFM coupling is mediated by charge carriers introduced via Be doping. The behavior of magnetization of the multilayers measured by DC magnetometry is consistent with the neutron reflectometry results., 4 pages, 4 figures

We report time resolved measurements of spin relaxation in doped and undoped InSb quantum wells using degenerate and two-color magneto-optical Kerr effect techniques. We observed that the photo-excited spin dynamics are strongly influenced by laser excitation fluence and the doping profile of the samples. In the low fluence regime, an oscillatory pattern was observed at low temperatures ($\leq$ 77 K) in the samples with an asymmetric doping profile which might be attributed to the quasi-collision-free spin relaxation regime. Our measurements also suggest the influence of the barrier materials (Al$_{x}$In$_{1-x}$Sb) on the spin relaxation in these material systems.

The Angstrom Project is using a global network of 2m-class telescopes to conduct a high cadence pixel microlensing survey of the bulge of the Andromeda Galaxy (M31), with the primary aim of constraining its underlying bulge mass distribution and stellar mass function. Here we investigate the feasibility of using such a survey to detect planets in M31. We estimate the efficiency of detecting signals for events induced by planetary systems as a function of planet/star mass ratio and separation, source type and background M31 surface brightness. We find that for planets of a Jupiter-mass or above that are within the lensing zone (~1 -3 AU) detection is possible above 3 $\sigma$, with detection efficiencies ~3% for events associated with giant stars, which are the typical source stars of pixel-lensing surveys. A dramatic improvement in the efficiency of ~40 -- 60% is expected if follow-up observations on an 8m telescope are made possible by a real-time alert system., Comment: total 8 pages, including 8 figures, ApJ, submitted

We present a method to create spin-polarized beams of ballistic electrons in a two-dimensional electron system in the presence of spin-orbit interaction. Scattering of a spin-unpolarized injected beam from a lithographic barrier leads to the creation of two fully spin-polarized side beams, in addition to an unpolarized specularly reflected beam. Experimental magnetotransport data on InSb/InAlSb heterostructures demonstrate the spin-polarized reflection in a mesoscopic geometry, and confirm our theoretical predictions., 14 pages

We report the discovery of a cold Super-Earth planet (mp= 4.4±0.5 M⊕) orbiting a low-mass (M=0.23±0.03 M☉) dwarf at projected separation a⊥= 1.18±0.10 a.u., i.e., about 1.9 times the distance the snow line. The system is quite nearby for a microlensing planet, DL= 0.86±0.09 kpc. Indeed, it was the large lens-source relative parallax πrel=1.0 mas (combined with the low mass M) that gave rise to the large, and thus well- measured, "microlens parallax" πE∝(πrel/M)1/2 that enabled these precise measurements. OGLE-2017-BLG-1434Lb is the eighth microlensing planet with planet-host mass ratio q-4. We apply a new planet-detection sensitivity method, which is a variant of "V/Vmax", to seven of these eight planets to derive the mass- ratio function in this regime. We find dN/d lnq ∝ qp, with p=1.05+0.78-0.68, which confirms the "turnover" in the mass function found by Suzuki et al. relative to the power law of opposite sign n=-0.93±0.13 at higher mass ratios q≥2×10-4. We combine our result with that of Suzuki et al. to obtain p=0.73+0.42-0.34.

We report the discovery of microlensing planet OGLE-2017-BLG-0373Lb. We show that while the planet-host system has an unambiguous microlens topology, there are two geometries within this topology that fit the data equally well, which leads to a factor 2.5 difference in planet-host mass ratio, i.e., $q=1.5\times 10^{-3}$ vs. $q=0.6\times 10^{-3}$. We show that this is an "accidental degeneracy" in the sense that it is due to a gap in the data. We dub it "the caustic-chirality degeneracy". We trace the mathematical origins of this degeneracy, which should enable similar degenerate solutions to be easily located in the future. A Bayesian estimate, based on a Galactic model, yields a host mass $M=0.25^{+0.30}_{-0.15} M_\odot$ at a distance $D_L=5.9^{+1.3}_{-1.95}$ kpc. The lens-source relative proper motion is relatively fast, $\mu=9$ mas/yr, which implies that the host mass and distance can be determined by high-resolution imaging after about 10 years. The same observations could in principle resolve the discrete degeneracy in $q$, but this will be more challenging., Comment: 24 pages, 7 figures, 3 tables. Accepted for publication in Acta Astronomica. Light curves and callibration data are available on arXiv as Ancillary files and http://www.astrouw.edu.pl/~jskowron/ogle/ob170373/