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Additional file 1: Table S1. Characteristics of Study Participants by Gender According to Age Group.

Supplemental material, sj-docx-1-aop-10.1177_10600280231183510 for Association of Argatroban Dose With Coagulation Laboratory Test in Patients on Extracorporeal Membrane Oxygenation: Activated Clotting Time vs Activated Partial Thromboplastin Time by Hyun-Young Ahn, Yuju Jung, Tae Wan Kim, Yang Hyun Cho, Jeong Hoon Yang, Chi Ryang Chung, Myung-Sook Min and Ryoung-Eun Ko in Annals of Pharmacotherapy

BackgroundNo data is available on delirium prediction models in the cardiac intensive care unit (CICU), although preexisting delirium prediction models [PREdiction of DELIRium in ICu patients (PRE-DELIRIC) and Early PREdiction of DELIRium in ICu patients (E-PRE-DELIRIC)] were developed and validated based on a population admitted to the general intensive care unit (ICU). Therefore, we externally validated the usefulness of the PRE-DELIRIC and E-PRE-DELIRIC models and compared their predictive performance in patients admitted to the CICU.MethodsA total of 2,724 patients admitted to the CICU were enrolled between September 2012 and December 2018. Delirium was defined as at least one positive Confusion Assessment Method for the ICU (CAM-ICU) which was screened at least once every 8 h. The PRE-DELIRIC value was calculated within 24 h of CICU admission, and the E-PRE-DELIRIC value was calculated at CICU admission. The predictive performance of the models was evaluated by using the area under the receiver operating characteristic (AUROC) curve, and the calibration slope was assessed graphically by plotting.ResultsDelirium occurred in 677 patients (24.8%) when the patients were assessed thrice daily until 7 days of the CICU stay. The AUROC curve for the prediction of delirium was significantly greater for PRE-DELIRIC values [0.84, 95% confidence interval (CI): 0.82–0.86] than for E-PRE-DELIRIC values (0.79, 95% CI: 0.77–0.80) [z score of −6.24 (p < 0.001)]. Net reclassification improvement for the prediction of delirium increased by 0.27 (95% CI: 0.21–0.32, p < 0.001). Calibration was acceptable in the PRE-DELIRIC model (Hosmer-Lemeshow p = 0.170) but not in the E-PRE-DELIRIC model (Hosmer-Lemeshow p < 0.001).ConclusionAlthough both models have good predictive performance for the development of delirium, even in critically ill cardiac patients, the performance of the PRE-DELIRIC model might be superior to that of the E-PRE-DELIRIC model. Further studies are required to confirm our results and design a specific delirium prediction model for CICU patients.

Additional file 1: Table S1. Cause of admission. Table S2. Hazard ratio (95% CI) for cognitive impairment or psychiatric problems within 2 years of discharge in patients with delirium versus patients without delirium using a conservative definition of delirium. Table S3. Hazard ratio (95% CI) for psychiatric problems within 2 years of discharge in patients with delirium versus patients without delirium

Additional file 2: Table S1. Characteristics of pediatric patients in intensive care units according to poverty status by age groups.

The Functional Status Score for the Intensive Care Unit (FSS-ICU) evaluates the physical function of ICU patients. The objective of the study was to translate and cross-culturally adapt the FSS-ICU into Korean and assess its reliability and validity. An expert committee supervised the forward and backward translation process and the final translated version. Experienced physiotherapists assessed patients (n= 31) from a medical ICU using the Korean version of FSS-ICU. Intra-class correlation coefficients (ICCs) and Bland–Altman’s plots were used to evaluate reliability, and Cronbach’s alpha for internal consistency. Construct validity was evaluated using Spearman’s correlation coefficients. Two physiotherapists in each of the two university hospitals independently assessed 31 medical ICU patients, with a mean FSS-ICU total score of 23 (range: 4–35). The FSS-ICU Korean version demonstrated excellent internal consistency, with Cronbach’s alpha of 0.897 for the total FSS-ICU score, and a range of 0.844–0.892 with deletion of each individual activity within the FSS-ICU. Intra-rater and inter-rater reliability were excellent for all of five FSS-ICU activities and the total score, with an ICC range of 0.930–0.993. Bland–Altman’s plots revealed a mean difference in FSS-ICU total score of 0.2 (95% limits of agreement: −1.9 to 2.3) between two physiotherapists. The Korean version of FSS-ICU had good convergent and divergent validity with moderate to strong correlation with mobility and muscle strength measures, and poor correlation with unrelated measures. The Korean version of the FSS-ICU showed excellent intra-rater and inter-rater reliability, internal consistency, and construct validity for medical ICU patients. The results of this study, along with prior publications, support that the FSS-ICU Korean version is a valid and reliable assessment tool for the ICU environment.Implications for rehabilitationIntensive care unit patients usually experience decreased muscle strength and physical function.The Korean version of the Functional Status Score for the Intensive Care Unit (FSS-ICU) is suitable for use with Korean speakers and has a valid, reliable measurement tool for physical function of intensive care unit patients.A well-standardized training with videos and written materials is important to ensure correct implementation of the Korean version of the FSS-ICU. Intensive care unit patients usually experience decreased muscle strength and physical function. The Korean version of the Functional Status Score for the Intensive Care Unit (FSS-ICU) is suitable for use with Korean speakers and has a valid, reliable measurement tool for physical function of intensive care unit patients. A well-standardized training with videos and written materials is important to ensure correct implementation of the Korean version of the FSS-ICU.

Additional file 3: Table S2. Pearson correlation coefficients among hospital variables. Odds ratio for in-hospital Mortality of patients with mechanical ventilation in volume-stratified subgroups.

Additional file 3: Table S1. Oxygenation and Ventilation profiles during ECMO (unmatched cohort). Table S2. ECMO parameters related to oxygenation (unmatched cohort). Table S3. Clinical outcomes according to configuration (unmatched cohort).

Additional file 2: Table S1. Odds ratio (95% CI) for in-hospital mortality according to ICU grade and combination of mechanical ventilator and vasopressor drugs, 2009 to 2014.

Supplemental material, Reviewer_1_v.1 for Duration of sweep gas off trial for weaning from venovenous extracorporeal membrane oxygenation by Soo Jin Na, Hee Jung Choi, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Jeong Hoon Yang, Gee Young Suh, Joong Hyun Ahn, Keumhee C. Carriere and Kyeongman Jeon in Therapeutic Advances in Respiratory Disease

Supplemental material, Author_Response_1 for Duration of sweep gas off trial for weaning from venovenous extracorporeal membrane oxygenation by Soo Jin Na, Hee Jung Choi, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Jeong Hoon Yang, Gee Young Suh, Joong Hyun Ahn, Keumhee C. Carriere and Kyeongman Jeon in Therapeutic Advances in Respiratory Disease

Supplemental material, Reviewer_1_v.2 for Duration of sweep gas off trial for weaning from venovenous extracorporeal membrane oxygenation by Soo Jin Na, Hee Jung Choi, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Jeong Hoon Yang, Gee Young Suh, Joong Hyun Ahn, Keumhee C. Carriere and Kyeongman Jeon in Therapeutic Advances in Respiratory Disease

Supplemental material, Reviewer_3_v.3 for Duration of sweep gas off trial for weaning from venovenous extracorporeal membrane oxygenation by Soo Jin Na, Hee Jung Choi, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Jeong Hoon Yang, Gee Young Suh, Joong Hyun Ahn, Keumhee C. Carriere and Kyeongman Jeon in Therapeutic Advances in Respiratory Disease

Supplemental material, Reviewer_3_v.2 for Duration of sweep gas off trial for weaning from venovenous extracorporeal membrane oxygenation by Soo Jin Na, Hee Jung Choi, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Jeong Hoon Yang, Gee Young Suh, Joong Hyun Ahn, Keumhee C. Carriere and Kyeongman Jeon in Therapeutic Advances in Respiratory Disease

Supplemental material, Author_Response_2 for Duration of sweep gas off trial for weaning from venovenous extracorporeal membrane oxygenation by Soo Jin Na, Hee Jung Choi, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Jeong Hoon Yang, Gee Young Suh, Joong Hyun Ahn, Keumhee C. Carriere and Kyeongman Jeon in Therapeutic Advances in Respiratory Disease

Supplemental material, Author_Response_3 for Duration of sweep gas off trial for weaning from venovenous extracorporeal membrane oxygenation by Soo Jin Na, Hee Jung Choi, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Jeong Hoon Yang, Gee Young Suh, Joong Hyun Ahn, Keumhee C. Carriere and Kyeongman Jeon in Therapeutic Advances in Respiratory Disease