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Supplementary Material 1. Figure S1. Flowchart of study participants. Table S1. Association of baseline lipid values with incident myocardial infarction and stroke in patients with type 2 diabetes mellitus. Table S2. Hazard ratios and 95% confidence intervals of myocardial infarction (A) and ischemic stroke (B) according to the quartiles of the remnant cholesterol in subgroups.

Additional file 1: Table S1.Hazardratios for (A) MACEs, (B) CV events, and (C) CVmortality according to TG quartiles.Table S2.Hazardratios for (A) MACEs, (B) CV events, and (C) CV mortality according to HDLquartiles (reversed). Table S3.Characteristics of study participants who were included in the analyses versusthose who were excluded from the analyses.Figure S1. Cubic spline curves of hazard ratios forMACEs, CV events, and CV mortality according to AIP levels. Figure S2. Subgroupanalyses for the risk of (A) MACEs, (B) CV events, and (C) CV mortality.

Jiwoo Lee, Yun Kyung Cho, Hwi Seung Kim, Chang Hee Jung, Joong-Yeol Park, Woo Je Lee Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of KoreaCorrespondence: Woo Je LeeDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, Republic of KoreaTel +82-2-3010-5882Fax +82-2-2045-4034Email lwjatlas@gmail.comPurpose: For patients with type 2 diabetes (T2DM) who remain above their glycemic target on insulin therapy, a combination of insulin and a glucagon-like peptide 1 receptor agonist has been recommended. However, few studies have been conducted to determine the clinical efficacy and parameters affecting the response to this combination in a real-world setting. This study aimed to investigate the clinical efficacy and parameters affecting the glycemic response to dulaglutide as an add-on to insulin therapy for T2DM in a real-world clinical setting.Patients and methods: A retrospective study was performed in 120 patients with T2DM who had initiated dulaglutide as an add-on to insulin therapy between January 2017 and December 2018. After 6 months of treatment, the change in glycated hemoglobin (HbA1c) was evaluated. Multiple linear regression analysis was used to determine the parameters affecting the therapeutic response to dulaglutide.Results: The mean age of the patients was 55.1 years and 57.5% were male. The mean baseline HbA1c, body mass index, and duration of diabetes were 9.1%, 27.5 kg/m2, and 17.2 years, respectively. The change in HbA1c between baseline and 6 months was −0.97% (95% confidence interval [CI]: −1.28 to −0.66%, P