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Antidiabetic drugs are among the most prescribed and consumed pharmaceuticals worldwide. Their occurrence in environment was little investigated due of lack of analytcial methods for their detection in waters. In this work has been developed a selective SPE-UHPLC/MS/MS method for isolation, identification and quantification of some antidiabetic compounds. The 3 selected analytes (glyburide, glimepiride and repaglinide) were separated on Eclipse C18 LC column at 300C using isocrat elution with mobile phase of acetonitrile: 0.04% acetic acid (60/40, v/v %). The optimal flow rate was 0.2 mL/min and the injected volum was 10 µL. The contaminants were detected in negative electropray ionization mode (ESI-) by Multiple Reaction Monitoring (MRM). Collision energy, fragmentor voltages were optimized to obtain high sensitivity. Optimization of SPE-LC-MS/MS parameters gave low quantification limit values between 0.27 and 11.1 ng/L. The organic pollutants were isolated from waste water samples on Strata C18 cartridges. The linear regressions were drawn in the interval of 1-100ng/L with good determination coefficients. Spike recovery rates were between 74.5 and 88.2% for waste water, with satisfactory precisions (RSD

Photocatalytic degradation of carbamazepine (CBZ) from spiked aqueous solutions, via a UV/TiO2 system, was investigated, and the optimum photocatalyst type (P25 Degussa) and dose (500 mg/L), as well as irradiation time (45 min), were established. The degradation process kinetics was studied, and a degradation rate constant of 3.14 × 10−5 M min−1 was calculated for CBZ, using the Langmuir–Hinshelwood equation. Experiments performed in the presence of scavengers showed that the main reactive species involved in the degradation process are holes and free hydroxyl radicals; superoxide radicals also play a role in CBZ degradation. Eight transformation products of CBZ were identified, and a possible degradation pathway, consisting of four routes, was proposed. Toxicity and genotoxicity tests were also performed for both untreated and treated CBZ solutions, proving that the use of a UV/TiO2 system represents a suitable treatment approach for aqueous systems with CBZ content.