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The literary works of Chinese women writers became an important component of literature in the 1980s and 1990s, developing new trends, techniques and perspectives, and revealing the multiplicity of women’s experiences and private lives. The thesis seeks to fill a gap in studies of Chinese literature by examining post-Mao fiction published from 1986 to 2000 by Wang Anyi, Tie Ning and Chi Li from a poststructuralist feminist perspective, and offering fresh insights into their treatment of sexuality, subjectivity and femininity. In doing so, it contributes to the feminist study of Chinese women’s writing and to a better understanding of contemporary Chinese culture in relation to patriarchy, misogyny, feminism and transgression. Specifically, this thesis investigates how these three prominent authors positively assert the notion of sexual difference and form an alternative subjectivity that destabilises traditional humanistic beliefs in the patriarchal system. It analyses their creations of different representations of female subjectivity. It analyses how they negotiate women’s identities and spaces among diverse historical forces in their writing, challenging dominant gender narratives. While all the textual analyses in this thesis are commonly informed by poststructuralist feminist notions of female subjectivity, differences, transgression and spatiality, they demonstrate the writers’ different treatment of feminist themes in social, political and economic aspects. Wang Anyi highlights sexual awakening, the tension between sexual desire and social morality, and women’s self-preservation. Tie Ning discloses the negative effects of political forces on women, including female victimisation and male violence, and valorises women’s self-realisation and self-transformation. With a particular focus on economic aspects, Chi Li pays attention to women’s self-sufficiency and self-affirmation, internationally inspired ideals of femininity, urban consumer culture and sisterhood.

l'A. analizza una ipotesi di abbandono di animale, alla luce di una decisione significativa potendosi prestare a fungere da precedente anche per la incriminazione di tutte quelle pratiche, che talora assurgono addirittura alla dignità di discipline “sportive”, in cui gli animali vengono sistematicamente stipati in gabbie e trasportati per lunghi tragitti privi di luce e di cibo.

In my review-essay I focus on some questions left open in Ferraris’ book Documentalità. Its limits are the same as those of a descriptive metaphysics of the social world that does not investigate, but rather assumes as its starting points, problematic basic relations such as those between individual and intelligibility, the givenness of essences and our access to them, the difference between objects and objectification. Finally, Ferraris’ conflation of production and practice brings me eventually to the link conspicuously missing in Ferraris’ analysis: the subjects who produce and hand down the documents we decided to turn our exclusive attention to.

The purpose of this study was to prepare and evaluate the feasibility and biocompatibility of a new composite as a bone substitute. The new composite (GTGC) was mainly composed of tricalcium phosphate ceramics and gelatin to which Chi-Li-Saan, a Chinese medicinal remedy was added. The GTGC composite was manually packed into cylindrical Teflon molds, dried overnight in an oven and sterilized by γ-ray prior to use. Mature New Zealand rabbits, weighting 3–3.5 kg, underwent full-thickness excision of the parietal bone. In the experimental group, bone defects of 12 animals were filled with the GTGC composites and another 12 unreconstructed rabbits were considered as controls. Three rabbits were examined for each group in every time period at 2, 4, 8 and 12 weeks after operation. There was no evidence of adverse tissue reaction to the GTGC composite. In addition, examination with light and fluorescent microscopy revealed a significantly greater amount of new bone ingrowth in the GTGC group at the same implantion time as compared with the controls. Therefore, the GTGC composite could serve as a useful substitute when repairing bone defects.

International audience

International audience

International audience

L'autore presenta i stećci - monumenti funerari monolitici tardomedievali - dedicando una particolare attenzione alla loro appartenenza culturale e al periodo della loro creazione. Il punto di partenza della sua tesi sono i risultati dello studio di questi monumenti concentrati nella regione di Zettina (Cetina) in Dalmazia.

The paper studied by Yong-chi Li and R.F. Shen (2007) includes some problems regarding the application of the proposed Neural Network (NN) approach. A very limited number of data has been used as testing set (only 3 among 52 data sets) which should be 20–30% of the database. The NN application in the study is not a function approximation problem where same input must always lead to the same output. NNs cannot be used for such an application. Moreover the generalization capability of the NN model has not been investigated. This discussion, aims to points out controversial points of the paper.

Entre blandices exotico-commerciales et une réalité plus prosaïque, entre séductions identitaires et mirages culturels, la Chine réserve quelques surprises. Et autant de déconvenues. Stéphane Fière, guide-interprète depuis près de trente ans en Chine, met en scène ce jeu de miroirs déformants sur fond de bouleversements sociaux et culturels. “Dans la société nouvelle, entre les injonctions contradictoires, entre l’amour et les convenances, entre l’argent et les cinq vertus, comment choisir ?...

Background The benefits of low-dose ketamine for patients with treatment-resistant depression (TRD) and prominent suicidal ideation require further investigation. The effects of treatment refractoriness, the duration of the current depressive episode, and the number of prior antidepressant failures on ketamine efficacy also require clarification. Methods We recruited 84 outpatients with TRD and prominent suicidal ideation—defined as a score ≥4 on item 10 of the Montgomery–Åsberg Depression Rating Scale (MADRS)—and randomized them into 2 groups to receive 0.5 mg/kg ketamine or 0.045 mg/kg midazolam. We assessed depressive and suicidal symptoms prior to infusion; 240 minutes post infusion; and 2, 3, 5, 7, and 14 days post infusion. Results According to the MADRS scores, the antidepressant effect (P = .035) was significantly noted in the ketamine group up to 14 days than in the midazolam group. However, the antisuicidal effect of ketamine, as measured by the Columbia-Suicide Severity Rating Scale Ideation Severity Subscale (P = .040) and MADRS item 10 (P = .023), persisted only 5 days post infusion. Furthermore, the antidepressant and antisuicidal effects of ketamine infusion were noted particularly in patients whose current depressive episode lasted Conclusions Low-dose ketamine infusion is a safe, tolerable, and effective treatment for patients with TRD and prominent suicidal ideation. Our study highlights the importance of timing; specifically, ketamine is more likely to achieve therapeutic response when the current depressive episode lasted

Aims: This study aims to investigate the function of positive feedback loops involving noncoding RNA in diabetic wound healing. Methods: We developed a mouse diabetic wound model to confirm that hyperglycemia can impair wound healing. We also used an in vitro keratinocyte model in high-glucose conditions to investigate the mechanism of delayed wound healing. Results: MALAT1 was decreased in diabetic mouse wound tissue and can promote keratinocyte biological functions. MALAT1 could bind to miR-106a-5p to modulate the expression of ZNF148, a target gene of miR-106a-5p. Surprisingly, ZNF148 bound to a region in the MALAT1 promoter to stimulate gene expression. Conclusion: ZNF148-activated MALAT1 increases ZNF148 expression by competitively binding miR-106a-3p, generating a positive feedback loop that enhances keratinocyte function.

Postoperative ileus (POI) is a relatively common complication after spinal fusion surgery, which can lead to delayed recovery, prolonged length of stay and increased medical costs. However, little is known about the incidence and risk factors of POI after corrective surgery for patients with adolescent idiopathic scoliosis (AIS). This study was performed to report the incidence of POI and identify the independent risk factors for POI after postoperative corrective surgery.In this retrospective cohort study, A total of 318 patients with AIS who underwent corrective surgery from April 2015 to February 2021 were enrolled and divided into two groups: those with POI and those without POI. The Student's t test, Mann-Whitney U test, and Pearson's chi-square test were used to compare the two groups regarding patient demographics and preoperative characteristics (age, sex and the major curve type), intraoperative and postoperative parameters (lowest instrumented vertebra [LIV], number of screws, and length of stay), radiographic parameters (T5-12 thoracic kyphosis [TK], T10-L2 thoracolumbar kyphosis and height [TLK and T10-L2 height], L1-S1 lumbar lordosis [LL], and L1-5 height). Then, a multivariate logistic regression analysis was used to identify independent risk factors for POI, and a receiver operating characteristic (ROC) curve was performed to assess the predictive values of these risk factors.Forty-two (13.2%) of 318 patients who developed POI following corrective surgery were identified. The group with POI had a significantly longer length of stay, more lumbar screws, higher proportions of a major lumbar curve and lumbar anterior screw breech, and a lower LIV. Among radiographic parameters, the mean lumbar Cobb angle at baseline, the changes in the lumbar Cobb angle, and T10-L2 and L1-5 height from before to after surgery were significantly larger in the group with POI than in the group without POI. Multivariate logistic regression analysis showed that large changes in T10-L2 (odds ratio [OR] =2.846, P = 0.007) and L1-5 height (OR = 31.294, p = 0.000) and lumbar anterior screw breech (OR = 5.561, P = 0.006) were independent risk factors for POI. The cutoff values for the changes in T10-L2 and L1-5 height were 1.885 cm and 1.195 cm, respectively.In this study, we identified that large changes in T10-L2 and L1-5 height and lumbar anterior screw breech were independent risk factors for POI after corrective surgery. Improving the accuracy of pedicle screw placement might reduce the incidence of POI, and greater attention should be given to patients who are likely to have large changes in T10-L2 and L1-5 height after corrective surgery.

A simple and metal-free catalytic system composed of NaOtBu/DMF efficiently converted 5-HMF to FDCA with an 80.85% yield. 5-HMF analogues and various types of alcohols were also transformed to corresponding acids in satisfactory to excellent yield.

We reported the anchored carbon nanotube emitters shows enhanced field emission stability.

In this study, the growth of fungi Trichoderma guizhouense NJAU4742 was significantly inhibited under acid stress, and the genes related to acid stress were identified based on transcriptome analysis. Four genes including tna1, adh2/4, and bna3 were significantly up-regulated. Meanwhile, intracellular hydrogen ions accumulated under acid stress, and ATP synthesis was induced to transport hydrogen ions to maintain hydrogen ion balance. The enhancement of glycolysis pathway was also detected, and a large amount of pyruvic acid from glycolysis was accumulated due to the activity limitation of PDH enzymes. Finally, acetaldehyde accumulated, resulting in the induction of adh2/4. In order to cope with stress caused by acetaldehyde, cells enhanced the synthesis of NAD

With the rapid development of infrastructure construction, some places have to face the problem of highway foundation disease, especially for the highway built on warm permafrost in cold region. In order to analyze the influence of confining pressure and vehicle load to the warm permafrost, the dynamic triaxial tests were conducted on the frozen soil extracted from highway in Yakeshi City. While the load frequency is 6 Hz and the test temperature is −1.5°C, we changed the confining pressure and axial stress amplitude, respectively, and then gained the deviator stress-strain curves. The test results show that the shape of deviator stress-strain curve is related to the deviator stress amplitude. When σ 3 = 25 kPa and σ 1 − σ 3 | max = 75 kPa, the hysteretic loops approximately appear rectangular and the dynamic modulus increases with loading time increasing for the compression effect. The specimen did not fail when the test stopped, and its hysteretic loop is stable. When σ 3 = 20 kPa and σ 1 − σ 3 | max = 100 kPa, the hysteretic loops become smoother and appear oval. The test stopped while the axial strain reached 5% after loading 1279 times, and the dynamic modulus decreases with loading time increasing. When σ 3 = 30 kPa and σ 1 − σ 3 | max = 115 kPa, the test stopped just after the 154th loop, and the hysteretic loop area linearly decreased with increasing loading time. The research conclusions in this article have numerous reference values for the highway design, construction, and operation built on the warm permafrost.

Background: Hemodialysis patients are at an increased risk of SARS-CoV-2 infection and are excluded from preauthorization COVID-19 vaccine trials; therefore, their immunogenicity is uncertain. Methods: To compare the antibody responses to homologous ChAdOx1 and mRNA-1273 SARS-CoV-2 vaccination in hemodialysis patients, 103 age- and sex-matched hemodialysis patients with two homologous prime-boost vaccinations were recruited to detect anti-receptor-binding domain (RBD) IgG levels and seroconversion rates (SCRs) 14 days after a prime dose (PD14), before and 28 days after a boost dose (pre-BD0 and BD28). Results: Both mRNA-1273 and ChAdOx1 vaccinations elicited immunogenicity in study subjects, and the former induced higher anti-RBD IgG levels than the latter. The SCRs of both groups increased over time and varied widely from 1.82% to 97.92%, and were significantly different at PD14 and pre-BD0 regardless of different thresholds. At BD28, the SCRs of the ChAdOx1 group and the mRNA-1273 group were comparable using a threshold ≥ 7.1 BAU/mL (93.96% vs. 97.92%) and a threshold ≥ 17 BAU/mL (92.73% vs. 97.92%), respectively, but they were significantly different using a threshold ≥ 20.2% of convalescent serum anti-RBD levels (52.73% vs. 95.83%). The seroconversion (≥20.2% of convalescent level) at BD28 was associated with mRNA-1273 vaccination after being adjusted for age, sex, body mass index, and the presence of solicited reactogenicity after a prime vaccination. Conclusion: Our prospective, observational cohort indicates that a full prime-boost mRNA-1273 vaccination is likely to provide higher immune protection in hemodialysis patients compared to ChAdOx1, and this population with a prime-boost ChAdOx1 vaccination should be prioritized for a third dose.

Non-small-cell lung cancer (NSCLC) is a typical inflammation-associated cancer, and lung adenocarcinoma (LUAD) is the most common pathological subtype. Epidermal growth factor (EGF) receptor (EGFR) mutations are the most common driver mutations of LUAD, and they have been identified as important therapeutic targets by EGFR-tyrosine kinase inhibitors (TKIs). The proinflammatory cytokine, interleukin (IL)-17A, and IL-17A-producing cells were reported to be elevated in the tumor microenvironment and peripheral blood of NSCLC patients and to be correlated with tumor progression and poor prognoses. However, the pathophysiological role of IL-17A in NSCLC remains unclear, although some studies suggested its involvement in cancer cell invasion and metastasis. Herein, we observed that expressions of IL-17A and its receptor, IL-17 receptor C (IL-17RC), were elevated in LUAD tissues and were correlated with poor survival in different lung cancer cohorts. In LUAD cells with mutant EGFR, the IL-17A/IL-17RC axis was shown to enhance phosphorylation of EGFR and Met, thereby promoting proliferation and resistance to EGFR-TKIs such as afatinib. In LUAD cells with wild-type (WT) EGFR, we found that the IL-17A/IL-17RC axis enhanced EGF-induced EGFR activation and cell proliferation through causing impairment of EGF-induced EGFR lysosomal degradation. Collectively, our results indicated diverse impacts of the IL-17A/IL-17RC axis on EGFR activation in LUAD cells with WT and mutant EGFR and suggested that developing therapeutic strategies against IL-17A/IL-17RC would be valuable for LUAD treatment.