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Supplemental material, sj-docx-3-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Supplemental material, sj-pdf-1-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Supplemental material, sj-docx-4-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Supplemental material, sj-docx-1-dhj-10.1177_20552076231176652 for Real-world integration of the protocol for responding to and assessing patients’ assets, risks, and experiences tool to assess social determinants of health in the electronic medical record at an academic medical center by Carrie R Howell, Heather Bradley, Li Zhang, John D Cleveland, Dustin Long, Trudi Horton, Olivia Krantz, Michael J Mugavero and Winter L Williams, Alesha Amerson, Andrea L Cherrington in DIGITAL HEALTH

Supplemental material, sj-docx-5-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Supplemental material, sj-docx-4-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Supplemental material, sj-docx-5-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Supplemental material, sj-docx-3-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Supplemental material, sj-pdf-2-ctj-10.1177_17407745231175919 for Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial by Andrea L Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B Buse, Basma Fattaleh, Stephen P Fortmann, Stephanie Hall, Sophia H Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S Phillips, Analyn Uy Jackson, Andrea Waltje, M Diane McKee and the GRADE Research Group in Clinical Trials

Objective: We investigated sex and racial differences in insulin sensitivity, β-cell function and HbA1c, and the associations with selected phenotypic characteristics. Research Design and Methods: This is a cross-sectional analysis of baseline data from 3,108 GRADE participants. All had type 2 diabetes diagnosed Results: The cohort was 56.6±10 years of age (mean±SD), 63.8% male, with BMI 34.2±6.7 kg/m2, HbA1c 7.5±0.5% and type 2 diabetes duration 4.0±2.8 years. Women had higher DI than men but similar insulin sensitivity. DI was the highest in Black/African Americans, followed by American Indians/Alaska Natives, Asians and Whites in descending order. Compared to white, American Indian/Alaska Native had significantly higher HbA1c but Black/African Americans and Asians had lower HbA1c. However, when adjusted for glucose levels, Black/African Americans had higher HbA1c than whites. Insulin sensitivity correlated inversely with BMI, waist to hip ratio, triglyceride to HDL cholesterol ratio (TG/HDL- C) and the presence of metabolic syndrome; whereas DI was associated directly with age and inversely with BMI, HbA1c and TG/HDL-C. Conclusion: In the GRADE cohort, β-cell function differed by sex and race and was associated with the concurrent level of HbA1c. HbA1c also differed among the races, but not sex. Age, BMI and TG/HDL-C were associated with multiple measures of β-cell function and insulin sensitivity.

Supplemental material, Supplement_I_ for Development and validation of the Capacity to Treat Chronic Pain and Opioid Use Disorder (CAP-POD) questionnaire by Allyson L Varley, Burel R Goodin, Heith Copes, Stefan G Kertesz, Kevin Fontaine, Andrea L Cherrington and Peter S Hendricks in Implementation Research and Practice

Additional file 1. Topic guide for lipid lowering therapy focus groups.