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This study aimed to explore the psychological mechanisms through which psychological safety and self-efficacy mediate the relationship between leader-expressed humility and employee voice. Moreover, attribution theory was applied to examine the possible detrimental effects of leader-expressed humility when employees perceive manipulative intentions in their humble leader. The current study proposed the leader’s manipulative intention as a moderator to weaken the indirect relationships between leader-expressed humility and employee voice through psychological safety and self-efficacy. Time-lagged supervisor–subordinate matched data were used to test the model. Our findings reveal leader’s manipulative intention weakens the positive effect that leader-expressed humility impacts on employee voice through psychological safety and self-efficacy. The implications of the findings were discussed from both theoretical and practical perspectives.

Shu-Chen Chen,1 Yu-Zhu Diao,1 Zi-Han Zhao,2 Xiao-Ling Li1 1Medical Oncology Department of Thoracic Cancer 1, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, Liaoning 110042, People’s Republic of China; 2The Second Clinical College of Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of ChinaCorrespondence: Xiao-Ling LiMedical Oncology Department of Thoracic Cancer 1, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, No. 44, Xiaoheyan Road, Dadong District, Shenyang, Liaoning 110042, People’s Republic of ChinaTel/Fax +86-24-31916361Email lixiaoling_med@163.comBackground: Lung cancer has the highest incidence among solid tumors in men and is the third most common cancer in women. Despite improved understanding of genomic and mutational landscape in non-small cell lung cancer (NSCLC), the five-year survival in these patients has remained stagnant at a dismal 15%. The first line of treatment commonly adapted for NSCLC patients with somatic mutation in EGFR is tyrosine kinase inhibitor gefitinib or erlotinib. EGFR mutant cells seem to be intrinsically sensitive to tyrosine kinase inhibitors; however, the remaining 20– 30% patients are resistant to tyrosine kinase inhibitor.Materials and Methods: Here we show, using in vitro normal and NSCLS cell lines, that the lncRNA Prostate androgen-regulated transcript 1 (PART1) is expressed at higher levels in NSCLC cells compared to normal lung epithelial cell line, corroborating two earlier studies.Results: We additionally show that these cells are resistant to erlotinib which is reversed in some, but not all, cell lines following suppression of PART1 expression. The differential response to erlotinib following siRNA-mediated knockdown of PART1 was found to be related to the mutational status of KRAS. Only in cells with wild-type KRAS suppression of PART1 sensitized them to erlotinib. Knockdown of mutant KRAS did not sensitize those cell lines to erlotinib. But knockdown of mutant KRAS along with suppression of PART1 sensitized the cells to treatment with erlotinib. The results from the study reveal a yet undefined and important role of lncRNA PART1 in defining sensitivity to erlotinib. This action is mediated by mutation status of KRAS.Conclusion: Even though preliminary, our results indicate PART1 might be a potential candidate for targeted therapy or used as a predictor of chemosensitivity in patients with NSCLC.Keywords: lncRNA, PART1, KRAS, non-small cell lung cancer, chemosensitivity, erlotinib

Medial calcific sclerosis (MCS) of Monckeberg a nonocclusive calcification of the media of small to medium-sized muscular arteries, may frequently occur in the prolapsed uteri. The etiology and pathogenesis of MCS is still obscure. In the present investigation, we use routine hysterectomy specimen of prolapsed uteri to investigate age distribution, and localized vasotonic effect of parity. Systemic risk factors of hypertension and diabetes mellitus on atherosclerosis as well as on arteriolosclerosis are also investigated to see if there is any association with these and MCS in the prolapsed uterus. One hundred and fifteen cases of uterine prolapse are analyzed. The occurrence rate of MCS was 53.04􏰀(61 of 115 cases). The mean age of MCS cases is 69.8 (SD=6.4), and cases without MCS, 54.5 (n=54, SD=7.6). [T-test􏰁t=11.72, p=0.000, 95􏰀CI=12.71-17.89]. The percentage of MCS increases positively with each 10-year age interval starting from age 50. No MCS is found in the 23 cases aged less than 50. [Extended Mantel-Haenszel test for trend:χ2= 44.766 (DF=1), P=0.000]. Thus, we note that there is significant correlation of MCS and patient age, with an increasing trend of MCS as aging process continued past the age of 50. Significant difference was noted with MCS and parity between the two groups (5.01 vs. 3.28) evidenced by Chi-square test for relationship of the parity and MCS between parity of 3 or less and more than 3 [χ2= 22.924, P=0.000]. No significant relationship was found for either hypertension or DM with MCS in the prolapsed uterus. Significant uterine weight loss was detected in those with MCS, when compared with non-MCS group [T-test: t=7.048, P=0.000, 95% CI (42.29-75.37)]. Lesion of MCS is a progressive degenerative change leading to smooth muscle necrosis of the media of small to medium-sized muscular arteries and superimposed calcium deposition. Smooth muscle cell necrosis or apoptosis with evident apoptotic bodies are diffusely present in media and may also be in intima. The investigation adds support to the prevailing concept that MCS in the prolapsed uterus is correlated to prolonged localized vasotonic influence as well as the aging process.