1. Targeting antibiotic resistance
- Author
-
Chellat, Mathieu F., Raguž, Luka, and Riedl, Rainer
- Subjects
0301 basic medicine ,medicine.medical_specialty ,medicine.drug_class ,Antibiotic resistance ,030106 microbiology ,Antibiotics ,Reviews ,Medicinal chemistry ,Review ,Drug resistance ,Molecular Dynamics Simulation ,Pharmacology ,antibiotics ,Catalysis ,World health ,Drug design ,Structure-Activity Relationship ,03 medical and health sciences ,615: Pharmakologie und Therapeutik ,Bacterial Proteins ,Drug Resistance, Multiple, Bacterial ,medicine ,Intensive care medicine ,Oxazoles ,Oxazolidinones ,Bacteria ,business.industry ,Public health ,Conventional treatment ,Treatment options ,General Chemistry ,Organophosphates ,Anti-Bacterial Agents ,540: Chemie ,structure–activity relationships ,Macrolides ,business - Abstract
Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human‐pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last‐resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled “Combat drug resistance: no action today means no cure tomorrow” triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.
- Published
- 2016
- Full Text
- View/download PDF