1. Volume Progression and Imaging Classification of Polycystic Liver in Early Autosomal Dominant Polycystic Kidney Disease
- Author
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Bae, Kyongtae T., Tao, Cheng, Feldman, Robert, Yu, Alan S.L., Torres, Vicente E., Perrone, Ronald D., Chapman, Arlene B., Brosnahan, Godela, Steinman, Theodore I., Braun, William E., Mrug, Michal, Bennett, William M., Harris, Peter C., Srivastava, Avantika, Landsittel, Douglas P., and Abebe, Kaleab Z.
- Subjects
Male ,Transplantation ,Epidemiology ,Cysts ,Liver Diseases ,Critical Care and Intensive Care Medicine ,Kidney ,Polycystic Kidney, Autosomal Dominant ,Magnetic Resonance Imaging ,Liver ,Nephrology ,Disease Progression ,Humans ,Original Article ,Female ,Prospective Studies ,Glomerular Filtration Rate - Abstract
BACKGROUND AND OBJECTIVES: The progression of polycystic liver disease is not well understood. The purpose of the study is to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective longitudinal magnetic resonance images from 670 patients with early autosomal dominant polycystic kidney disease for up to 14 years of follow-up were evaluated to measure height-adjusted liver cystic volume and height-adjusted liver volume. Among them, 245 patients with liver cyst volume >50 ml at baseline were included in the longitudinal analysis. Linear mixed models on log-transformed height-adjusted liver cystic volume and height-adjusted liver volume were fitted to approximate mean annual rate of change for each outcome. The association of sex, body mass index, genotype, baseline height-adjusted total kidney volume, and Mayo imaging class was assessed. We calculated height-adjusted liver cystic volume ranges for each specific age and divided them into five classes on the basis of annual percentage increase in height-adjusted liver cystic volume. RESULTS: The mean annual growth rate of height-adjusted liver cystic volume was 12% (95% confidence interval, 11.1% to 13.1%; P
- Published
- 2022