1. Neuroprotective effect of Spirulina (Arthrospira) maxima against kainic acid-induced neurotoxicity
- Author
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Chamorro-Cevallos German, Alva-Sanchez Claudia, Perez-Juarez Angelica, Pacheco-Rosado Jorge, and Paniagua-Castro Norma
- Subjects
Pharmacology ,Kainic acid ,Antioxidant ,biology ,medicine.medical_treatment ,Neurotoxicity ,Pharmaceutical Science ,Plant Science ,medicine.disease ,biology.organism_classification ,medicine.disease_cause ,Neuroprotection ,Lipid peroxidation ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Biochemistry ,Drug Discovery ,medicine ,Spirulina (dietary supplement) ,Arthrospira ,Oxidative stress - Abstract
Oxidative stress has been implicated in the pathophysiology of neurologic disorders and brain dysfunctions. Spirulina (Arthrospira) maxima (SP) is a cyanobacteria with nutritional, pharmacological and important antioxidant activity. This study aims to evaluate the neuroprotective role of SP against kainic acid (KA) neurotoxicity. Male SW mice were treated with SP for 24 days (200, 400 and 800 mg/kg, (o.v.) and KA (35 mg/kg) was intraperitoneally administered as a single dose on day 14. After the treatment, neurobehavioral changes were monitored and lipid peroxidation in hippocampus was studied as an index of oxidative stress. These studies indicate that SP treatment reduced oxidative stress and protected against the damaging neurobehavioral effects of KA, suggesting it could be a possible alternative in treating neurodegenerative diseases. Key words: Hippocampus, kainic acid, neurobehavioral effects, neuroprotection, Spirulina.
- Published
- 2012