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Objectives: The sense of smell plays an important role in daily life. Olfactory impairment can significantly affect an individual’s quality of life. Topical carbonic anhydrase inhibitors are commonly used to treat elevated intraocular pressure (IOP). One potential side effect of these drugs is a loss of the sense of smell. This study is an examination of changes in olfactory function in patients who used dorzolamide and brinzolamide to control IOP after a laser capsulotomy. Methods: A total of 60 patients with posterior capsule opacification were included in the study. Sniffin’ Sticks (Burghart Messtechnik GmbH, Wedel, Germany) were used to evaluate patient olfactory sensitivity before starting the topical treatment and after 1 week of treatment. Results: No statistically significant decrease in olfactory performance was observed in users of either brinzolamide or dorzolamide (p=0.705, p=0.405 respectively). Conclusion: No negative effect on the sense of smell was determined after 7 days of topical application of a carbonic anhydrase enzyme inhibitor to the eye in patients with no previous anosmia.

WOS: 000455896800006, The bioaccumulation of UO22+ (uranyl ion) was investigated by using dry biomass of Botryococcus braunii. Experiments were conducted based on a rotatable central composite design (CCD) and analyzed using response surface methodology (RSM), which was used to optimize the bioaccumulation process. In this goal, the effects of parameters such as initial uranium (VI) concentration, pH, temperature and contact time were studied. The optimum conditions for maximum removal (87%) of UO22+ from an aqueous solution were as follows: initial uranium (VI) concentration (55 mg/l), pH (3.6), temperature (46 degrees C) and contact time (74 min). Langmuir and Freundlich isotherms and also thermodynamic parameters like Enthalpy (Delta H degrees), Entropy (Delta S degrees), standard Gibbs free energy (Delta G degrees) were investigated, as well.

Gold nanoparticles are exciting materials because of their potential applications in optics, electronics, biomedical, and pharmaceutical fields. In recent years, environmentally friendly, low-cost biosynthesis methods with bio-applicable features have continued to be developed for the synthesis of gold nanoparticles. In the present study, an actinobacterial strain was isolated from the Petrosia ficiformis (Poiret 1798) sponge, which was collected from a marine environment, and the gold nanoparticle synthesis was performed for the first time from the bacteria type belonging to the Citricoccus genus. The synthesis conditions were optimized using the Box-Behnken experimental design, with a statistical method that included three independent variables (temperature, time, and mixture ratio) to affect the synthesis at three levels (+1, 0, and -1). Accordingly, the conditions proposed for the biosynthesis of gold nanoparticles at the maximum optical density values that are specific for the Citricoccus sp. K1D109 strain were estimated as 35 degrees C temperature, 24 h, and 1/5 mixture ratio (cell-free extract/HAuCl4 center dot 3H(2)O). When recommended conditions were applied, it was determined that the maximum absorbance of the synthesized gold nanoparticles is 1.258 at 545 nm, and their sizes are in the range of 25-65 nm, according to transmission electron microscopy (TEM) data.

WOS: 000369975800062, PubMed: 26029401, The asymmetric unit of the title polymeric compound, [Zn(C8H5O3)(2)(C4H4N2)(H2O)](n), contains two molecular units. Each unit comprises two 4-formylbenzoate (FB) anions, one pyrazine molecule and one coordinating water molecule; the FB anions act either as bidentate or as monodentate ligands. The O atoms of the bidentately coordinating FB anions are disordered over two positions, and they were refined with fixed occupancy ratios of 0.75:0.25 and 0.70:0.30, respectively. In the ordered monodentately coordinating FB anions, the carboxylate groups are twisted away from the attached benzene rings (B and E) by 12.1 (2) and 9.2 (2)degrees, respectively. In the disordered FB anions, the corresponding angles are 14.1 (1) and 4.0 (2)degrees for benzene rings A and D, respectively. Benzene rings A and B are oriented at a dihedral angle of 45.7 (1)degrees, D and E at 23.2 (1)degrees. Pyrazine ring C makes dihedral angles of 85.6 (1) and 72.7 (1)degrees, respectively, with benzene rings A and B, and pyrazine ring F makes dihedral angles of 87.0 (1) and 81.3 (1)degrees with benzene rings D and E, respectively. The pyrazine ligands bridge the Zn-II cations, forming polymeric chains running parallel to the b-axis direction. Mediumstrength intramolecular O-H center dot center dot center dot O hydrogen bonds link the water molecules to the carboxylate O atoms. In the crystal, water-carboxylate O-H center dot center dot center dot O hydrogen bonds link adjacent chains into layers parallel to the bc plane. The layers are linked via weak pyrazine-formyl C-H center dot center dot center dot O and formyl-carboxylate C-H center dot center dot center dot O hydrogen bonds. pi-pi contacts between the benzene rings, with centroid-to-centroid distances of 3.7765 (16), 3.7905 (15) and 3.8231 (16) angstrom, may further stabilize the structure. There are also weak C-H center dot center dot center dot pi interactions present., State of Planning Organization [2010K120480]; Kafkas University [2012-FEF-12], The authors acknowledge the Aksaray University Science and Technology Application and Research Center, Aksaray, Turkey, for the use of the Bruker SMART BREEZE CCD diffractometer (purchased under grant No. 2010K120480 of the State of Planning Organization). This work was supported financially by Kafkas University Research Fund (grant No. 2012-FEF-12).

WOS: 000369975800045, PubMed: 26029384, In the title polymeric compound, [Co(C8H5O3)(2)(C4H4N2)(H2O)(2)](n), the Co-II atom is located on a twofold rotation axis and has a slightly distorted octahedral coordination sphere. In the equatorial plane, it is coordinated by two carboxylate O atoms of two symmetry-related monodentate formylbenzoate anions and by two N atoms of two bridging pyrazine ligands. The latter are bisected by the twofold rotation axis. The axial positions are occupied by two O atoms of the coordinating water molecules. In the formylbenzoate anion, the carboxylate group is twisted away from the attached benzene ring by 7.50 (8)degrees, while the benzene and pyrazine rings are oriented at a dihedral angle of 64.90 (4)degrees. The pyrazine ligands bridge the Co-II cations, forming linear chains running along the b-axis direction. Strong intramolecular O-H center dot center dot center dot O hydrogen bonds link the water molecules to the carboxylate O atoms. In the crystal, weak O-H-water center dot center dot center dot O-water hydrogen bonds link adjacent chains into layers parallel to the bc plane. The layers are linked via C-H-pyrazine center dot center dot center dot O-formyl hydrogen bonds, forming a three-dimensional network. There are also weak C-H center dot center dot center dot pi interactions present., Aksaray University Science and Technology Application and Research Center, Aksaray, Turkey [2010K120480]; Kafkas University Research Fund [2012-FEF-12], The authors acknowledge the Aksaray University Science and Technology Application and Research Center, Aksaray, Turkey, for the use of the Bruker SMART BREEZE CCD diffractometer (purchased under grant No. 2010K120480 of the State of Planning Organization). This work was supported financially by the Kafkas University Research Fund (grant No. 2012-FEF-12).