1. Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
- Author
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Cook, Michael B. Guenel, Pascal Gapstur, Susan M. van den Brandt, Piet A. Michels, Karin B. Casagrande, John T. Cooke, Rosie Van Den Eeden, Stephen K. Ewertz, Marianne Falk, Roni T. Gaudet, Mia M. Gkiokas, George Habel, Laurel A. and Hsing, Ann W. Johnson, Kenneth Kolonel, Laurence N. La Vecchia, Carlo Lynge, Elsebeth Lubin, Jay H. McCormack, Valerie A. Negri, Eva Olsson, Hakan Parisi, Dominick and Petridou, Eleni Th. Riboli, Elio Sesso, Howard D. Swerdlow, Anthony Thomas, David B. Willett, Walter C. Brinton, Louise A. more...
- Abstract
Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (> 60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97-1.71; OR>0 more...
- Published
- 2015