1. Fully automated deep learning powered calcium scoring in patients undergoing myocardial perfusion imaging
- Author
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Sartoretti, Thomas, Gennari, Antonio G, Sartoretti, Elisabeth, Skawran, Stephan, Maurer, Alexander, Buechel, Ronny R, Messerli, Michael, Beeldvorming, RS: Carim - B06 Imaging, RS: Carim - H02 Cardiomyopathy, Cardiologie, University of Zurich, and Messerli, Michael
- Subjects
STRESS ,IMPACT ,610 Medicine & health ,10181 Clinic for Nuclear Medicine ,Diagnostic and prognostic application ,Atherosclerosis ,2705 Cardiology and Cardiovascular Medicine ,DISEASE ,ITERATIVE RECONSTRUCTION ,10036 Medical Clinic ,SPECT ,2741 Radiology, Nuclear Medicine and Imaging ,Radiology, Nuclear Medicine and imaging ,CAD ,CORONARY ,Cardiology and Cardiovascular Medicine ,CARDIAC CT ,CT - Abstract
Background To assess the accuracy of fully automated deep learning (DL) based coronary artery calcium scoring (CACS) from non-contrast computed tomography (CT) as acquired for attenuation correction (AC) of cardiac single-photon-emission computed tomography myocardial perfusion imaging (SPECT-MPI). Methods and Results Patients were enrolled in this study as part of a larger prospective study (NCT03637231). In this study, 56 Patients who underwent cardiac SPECT-MPI due to suspected coronary artery disease (CAD) were prospectively enrolled. All patients underwent non-contrast CT for AC of SPECT-MPI twice. CACS was manually assessed (serving as standard of reference) on both CT datasets (n = 112) and by a cloud-based DL tool. The agreement in CAC scores and CAC score risk categories was quantified. For the 112 scans included in the analysis, interscore agreement between the CAC scores of the standard of reference and the DL tool was 0.986. The agreement in risk categories was 0.977 with a reclassification rate of 3.6%. Heart rate, image noise, body mass index (BMI), and scan did not significantly impact (p=0.09 - p=0.76) absolute percentage difference in CAC scores. Conclusion A DL tool enables a fully automated and accurate estimation of CAC scores in patients undergoing non-contrast CT for AC of SPECT-MPI.
- Published
- 2023