Search

Background Cardiac paragangliomas (PGLs) are clinically rare, with hypertension and metabolic changes as the main symptoms. The tumor is highly related to gene mutation, and surgery is presently the effective treatment. Medical history and clinical manifestations of the patient, routine laboratory examinations and imaging examinations, and pathological examination can help the final diagnosis. Case presentation The present study presents a 31-year-old male patient with a left atrial mass. The initial symptom was cough. Cardiac enlargement was found during the chest X-ray. The follow-up imaging examination revealed a left atrial occupying lesion, and the possibility of malignant occupying lesions was not ruled out. The patient underwent surgical resection of the mass. The final pathological result revealed paraganglioma. The thoracic computed tomography review two months after the operation revealed that the original occupying lesion disappeared, and no new lesion was found. Conclusions Pheochromocytomas and paragangliomas (PPGLs) are a kind of neuroendocrine tumors. PPGLs can cause secondary hypertension, and lead to a series of clinical syndromes, including myocardial injury, metabolic changes, and so on. The occurrence of PPGIs is related to gene mutation. Biochemical detection, imaging examination, and genetic testing can help diagnose. The tumor should be surgically removed as soon as possible after the diagnosis. As a functional tumor, PPGLs should be fully prepared before surgery to avoid anesthesia and huge fluctuations in blood pressure during and after surgery, or the occurrence of fatal hypertensive crisis and intractable hypotension after tumor resection. Adequate preoperative preparation directly affects the prognosis of patients after surgery. Therefore, multidisciplinary cooperation before, during, and after the operation is extremely important.

In the attack simulation technology, testers simulate hackers to attack the industrial control system, and judge whether the system contains specific security vulnerabilities according to the returned results. This technology has become an important security test method. Firstly, based on the vulnerability mechanism of electric power industry control protocol, this paper puts forward the model of attack data package assembly, confusion and encapsulation. By using multiple types of attack modules to achieve attack data package assembly, mutation and confusion, to ensure that attack data package can bypass the system protection mechanism and have the ability to avoid checking and killing, and then realize the protocol data package encapsulation according to the electric power industry control protocol specification. Secondly, this paper focuses on the test case that malicious message is expanded with the model of counter neural network to generate new effective attack data package, which effectively improves the vulnerability detection rate and reduces the security risk of the system.

We propose a new design of a binder/carbon-free air electrode with tips-bundled Pt/Co3O4 nanowires grown directly on Ni foam substrate. In this design, the side reactions related to binder/carbon are excluded. The presence of Pt not only promotes the formation of the tips-bundled structure of Co3O4 nanowires but also directs the uniform deposition of a fluffy, thin Li2O2 layer only on the periphery of Pt/Co3O4 nanowires. This crystallization habit of Li2O2 makes it easy to decompose upon recharge with reduced side reactions. As a result, Li–O2 batteries with this cathode show low polarization.

Tubular 0.5Li 2 MnO 3 ·0.5Li 4 Mn 5 O 12 has been synthesized by a facile self-templating method starting from tubular β-MnO 2 . The wall thickness and diameter of 0.5Li 2 MnO 3 ·0.5Li 4 Mn 5 O 12 nanotubes are around 200 and 500 nm, respectively. X-ray diffraction and transmission electron microscopy observations confirm the composite character, where the Li 4 Mn 5 O 12 nano-domains are integrated with the Li 2 MnO 3 nano-domains. The tubular composite synthesized at 600 °C exhibits better electrochemical properties than that synthesized at 700 °C due to the higher ratio of LiMn 2 O 4 decomposed from Li 4 Mn 5 O 12 . The tubular composite also exhibits better electrochemical properties than the microsized aggregated particles due to the unique tubular nanostructure with large specific surface, short Li-ion diffusion pathway, and loose stacking of the tubes.

Despite increasing pressure to make more efficient use of water resources, the widespread use of reclaimed water still remains a contentious issue, primarily because of risks to human health arising from water pollution by organic compounds. Therefore, safety evaluation of reclaimed water is an urgent need. The aim of this study was to determine the genotoxic potential of reclaimed water during low and high water periods. Reverse phase C-18 solid-phase extraction (RP-C18SPE) was used for the extraction of organic compounds from water samples. The tests, namely, Ames, micronucleus and chromosome aberrations were used to determine the damage caused by water samples on genetic material. Ames tests showed that both influent and effluent reclaimed water, except influent after metabolism by S9 in high water period, induced mutation of TA98 and TA100 strains of Salmonella typhimurium in a concentration-response manner. There were no significant differences in micronucleus and chromosome aberration tests. Even af...

Meta-analysis Polymorphism Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive. To drive a more precise estimation, we performed a meta-analysis based on 1,060 cases and 1,225 controls from 7 published case-control studies. PubMed and CNKI literature search were conducted to identify all eligible studies investigating such a relationship. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, recessive model, and allele-frequency genetic model. In the overall analysis, the frequency of CYP1A1*2A genotype was significantly associated with susceptibility to idiopathic male infertility. Further stratified analysis by ethnicity showed notable association between the polymorphism and risk of idiopathic male infertility in Asians. In conclusion, these results support that the CYP1A1*2A genotype polymorphism mainly contributes to idiopathic male infertility susceptibility in Asians but not in Caucasians.

To clarify the possible mechanisms of α-anordin and probimane on calmodulin Ca++-Mg++ ATPase system, enzyme dynamic study was carried out by determining three dynamic parameters [the substrate concentration (ATP)-response curve, dose (inhibitors)-response curve and time-response curve]. Our data have shown that the inhibitory rates of α-anordrin and probimane are unrelated to substrate (APT) concentrations, but related to calmodulin concentrations. The inhibition of α-anordrin and probimane is very quick that is completed within 1 to 5 min and can maintain more than 1 hr in the same inhibitory rates. So it is possible that α-anordrin and probimane are calmodulin competitors with calmodulin-like binding whose actions can occur by affecting the reaction balance of substrate and product on target enzymes of calmodulin (Ca++-Mg++-ATPase).

To investigate the influence of probimane on the lipoperoxidation of human red cells in vitro. Malondialdehyde (MDA) of human red cells induced by hydrogen peroxide was assayed by means of colorimetry. It was shown that probimane (> 2 µM) could inhibit the lipoperoxidation without adriamycin. The inhibitory rates of probimane were 9.3% (2 µM) and 35.3% (10 µM) respectively (P