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Ersin Sar&inodot;çam,1,2 Ali Do&gbreve;an Dursun,3,4 Gülçin Türkmen Sar&inodot;y&inodot;ld&inodot;z,5,6 Nalan Can,7 Engin Bozkurt,1 U&gbreve;ur Gönüllü,8 Nihal Basay,9 Meral Türkmen,10 Abdülaziz Denli,11 Mustafa Ünlü12 1Department of Cardiology, Medicana International Ankara Hospital, Ankara, Turkey; 2Department of Cardiology, At&inodot;l&inodot;m University Medical School, Ankara, Turkey; 3Department of Physiology, At&inodot;l&inodot;m University Medical School, Ankara, Turkey; 4Check-up Center, Home Care Services, Medicana International Ankara Hospital, Ankara, Turkey; 5Department of General Surgery, Medicana International Ankara Hospital, Ankara, Turkey; 6Operating Room Services, Vocational School of Health Services, At&inodot;l&inodot;m University, Ankara, Turkey; 7Department of Nuclear Medicine, Medicana International Ankara Hospital, Ankara, Turkey; 8Department of Pulmonary Medicine, At&inodot;l&inodot;m University Medical School, Ankara, Turkey; 9Department of Pulmonary Medicine, Medicana International Ankara Hospital, Ankara, Turkey; 10Department of Internal Medicine, Medicana International Ankara Hospital, Ankara, Turkey; 11Department of Physical Medicine and Rehabilitation, Medicana International Ankara Hospital, Ankara, Turkey; 12Department of Nuclear Medicine, Gazi University Medical School, Ankara, TurkeyCorrespondence: Ersin Sar&inodot;çamDepartment of Cardiology, Medicana International Ankara Hospital, Sö&gbreve;ütözü Cd. 2165. Sokak No: 6, Sö&gbreve;ütözü, Ankara, 06520, TurkeyTel +90 5324066440Fax +90 3122203170Email saricamersin@yahoo.comBackground: In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acute COVID-19 by using biomarkers such as NT-proBNP and nitric oxide (NO) and cardiac imaging modalities.Methods: In this cross-sectional study, a total of 105 participants were included according to the existence of symptoms, and 40 of these participants were asymptomatic patients. The ages of the participants ranged from 20 to 50 years. All patients were healthy before COVID-19. The symptoms were defined as palpitations and/or fatigue association with exercise in post-acute COVID-19 term. The comparison of the two groups was made by using biochemical parameters (NT-proBNP, Troponin I, NO) and imaging techniques (echocardiography, cardiovascular magnetic resonance (CMR) and cardiac positron emission tomography (PET)).Results: The symptomatic patients had higher NT-proBNP levels compared with asymptomatic patients (132.30± 35.15; 76.86± 16.79, respectively; p < 0.001). Interestingly, the symptomatic patients had lower NO levels than asymptomatic patients (9.20± 3.08; 16.15± 6.02, respectively; p < 0.001). Echocardiography and CMR were normal. However, we found regional increased 18F-FDG uptake on cardiac PET to be compatible with myocardial fatigue.Conclusion: We found elevated NT-proNBP levels, low serum NO levels, and increased 18F-FDG uptake on cardiac PET in post-acute COVID syndrome. Cardiac PET could replace or be added to CMR for detecting subtle subacute/chronic myocarditis. The follow-up of patients with post-acute COVID-19 could target the possibility of risk of heart failure.Keywords: post-acute COVID-19, cardiac involvement, laboratory tests, imaging

CONTEXT: Papillary thyroid carcinoma(PTC)s are the indolent progressive tumours. Survivin is a unique bifunctional protein with cell cycle regulation and apoptosis inhibition. The expression of this protein has been shown to be increased in thyroid tumours correlated with aggressive behavior from well differentiated to anaplastic. OBJECTIVE: In this study, we aimed to investigate the relationship between immunohistochemically survivin expression and tumour-associated prognostic factors in papillary thyroid carcinomas. DESIGN: In patients with thyroidectomy, we compared the clinicopathological findings and immunohistochemical positivity for survivin. SUBJECTS AND METHODS: In 109 patients, sex, age, tumour size, histological tumour variant, tumour focality, tumour border pattern, tumour peripheral/intratumoural lymphocytic and stromal response, intraglandular spread, extrathyroideal spread, lymph node metastases, lymphocytic tiroiditis and relationships of these findings with survivin positivity were investigated. RESULTS: When we indicated the tumour size and compared it with survivin expression, tumour size correlates with, survivin expression (p = 0.016). Survivin expression was correlated statistically significant with lymphovascular invasion, without stromal response and with intraglandular extension respectively (p

ObjectiveThe objective of this study is to understand the role of altered in vivo mechanical environments in knee joints post anterior cruciate ligament (ACL)-injury in chondrocyte vulnerability against mechanical stimuli and in the progression of post-traumatic osteoarthritis (PT-OA).MethodsDifferential in vivo mechanical environments were induced by unilateral ACL-injury (uni-ACL-I) and bilateral ACL-injury (bi-ACL-I) in 8-week-old female C57BL/6 mice. The gait parameters, the mechano-vulnerability of in situ chondrocytes, Young’s moduli of cartilage extracellular matrix (ECM), and the histological assessment of OA severity (OARSI score) were compared between control and experimental groups at 0∼8-weeks post-ACL-injury.ResultsWe found that bi-ACL-I mice experience higher joint-loading on their both injured limbs, but uni-ACL-I mice balance their joint-loading between injured and uninjured hind limbs resulting in a reduced joint-loading during gait. We also found that at 4- and 8-week post-injury the higher weight-bearing hind limbs (i.e., bi-ACL-I) had the increased area of chondrocyte death induced by impact loading and higher OARSI score than the lower weight-bearing limbs (uni-ACL-I). Additionally, we found that at 8-weeks post-injury the ECM became stiffer in bi-ACL-I joints and softer in uni-ACL-I joints.ConclusionsOur results show that ACL-injured limbs with lower in vivo joint-loading develops PT-OA significantly slower than injured limbs with higher joint-loading during gait. Our data also indicate that articular chondrocytes in severe PT-OA are more fragile from mechanical impacts than chondrocytes in healthy or mild PT-OA. Thus, preserving physiologic joint-loads on injured joints will reduce chondrocyte death post-injury and may delay PT-OA progression.

Physicochemical Problems of Mineral Processing; ISSN 2084-4735

Nagehan Can,1 Onur Catak,2 Burak Turgut,2 Tamer Demir,2 Nevin Ilhan,3 Tuncay Kuloglu,4 Ibrahim Hanifi Ozercan5 1Department of Ophthalmology, Elaziğ Training and Research Hospital, 2Department of Ophthalmology, 3Department of Biochemistry, 4Department of Histology and Embryology, 5Department of Pathology, School of Medicine, Firat University, Elaziğ, Turkey Abstract: Damage to retinal ganglion cells due to elevation of intraocular pressure (IOP) is responsible for vision loss in glaucoma. Given that loss of these cells is irreversible, neuroprotection is crucial in the treatment of glaucoma. In this study, we investigated the possible antioxidant and neuroprotective effects of ghrelin on the retina in an experimental glaucoma model. Twenty-one Sprague–Dawley rats were randomly assigned to three groups comprising seven rats each. The rats in the control group were not operated on and did not receive any treatment. In all rats in the other groups, IOP was increased by cauterizationof thelimbal veins. After creation of the IOP increase, saline 1 mL/kg orghrelin 40 µg/kg was administered intraperitoneally every day for 14 days in the vehicle control group and ghrelin groups, respectively. On day 14 of the study, the eyes were enucleated. Levels of malondialdehyde (MDA), nitric oxide (NO), and nitric oxide synthase-2 (NOS2) in anterior chamber fluid were measured. The retinas were subjected to immunohistochemistry staining for glial fibrillary acidic protein (GFAP), S-100, andvimentin expression. Mean levels of MDA, NO, and NOS2 in the aqueous humor were higher in the vehicle control group than in the control group (P0.05). Retinal TUNEL and immunohistochemistry staining in the vehicle control group showed an increase in apoptosis and expression of GFAP, S-100, and vimentin compared with the control group (P

In this study, the thermoluminescence (TL) characteristics of Ag-doped and undoped lithium tetraborate (Li2B4O7, LTB) materials, grown using the Czochralski method, were reported. The TL properties of LTB:Ag, such as glow curve structure, dose response, fading and reproducibility, were investigated. The glow curve of the Li2B4O7:Ag single crystal consists of four peaks located at approximately 75, 130, 190 and 275 degrees C; in undoped LTB, the single crystal shows a broad glow curve with peaks at 65, 90, 125, 160 and 190 degrees C using a heating rate of 5 degrees C/s in the 50-350 degrees C temperature region. The high temperature peak of Ag-doped sample at 275 degrees C has a nonlinear dose response within the range from 33mGy to 9Gy. There is a linear response in the range of 33-800mGy; after which, a sublinear region appears up to 9Gy for Ag-doped LTB single crystal. For undoped single crystal, the dose response is supralinear for low doses and linear for the region between 1 and 9Gy. The thermal fading ratio of the undoped material is almost 60% for the high temperature peak after 7days. Ag-doped LTB single crystal exhibits different behaviour over a period of 7days.

In this study, the thermoluminescence (TL) characteristics of Ag-doped and undoped lithium tetraborate (Li2B4O7, LTB) materials, grown using the Czochralski method, were reported. The TL properties of LTB:Ag, such as glow curve structure, dose response, fading and reproducibility, were investigated. The glow curve of the Li2B4O7:Ag single crystal consists of four peaks located at approximately 75, 130, 190 and 275°C; in undoped LTB, the single crystal shows a broad glow curve with peaks at 65, 90, 125, 160 and 190°C using a heating rate of 5°C/s in the 50–350°C temperature region. The high temperature peak of Ag-doped sample at 275°C has a nonlinear dose response within the range from 33 mGy to 9 Gy. There is a linear response in the range of 33–800 mGy; after which, a sublinear region appears up to 9 Gy for Ag-doped LTB single crystal. For undoped single crystal, the dose response is supralinear for low doses and linear for the region between 1 and 9 Gy. The thermal fading ratio of the undoped material is almost 60% for the high temperature peak after 7 days. Ag-doped LTB single crystal exhibits different behaviour over a period of 7 days. Copyright © 2016 John Wiley & Sons, Ltd.

The influence of microwave radiation on sulphide minerals in inert atmosphere has been investigated with respect to their processing characteristics such as magnetic susceptibility and floatability. Pure sulphide mineral samples were prepared in different size fractions. Microflotation tests were performed and magnetic susceptibilities of samples were measured after treating with microwave energy in inert atmosphere at three power levels for six time intervals. Possible modifications on the mineral surfaces due to microwave energy and exposure time were evaluated by XRD and optical microscopy. The results showed that selective separation of sulphide minerals in terms of floatability and magnetic separation could be possible.

The kinetics and mechanism of the chemical interaction between silicon nitride and titanium carbide were investigated using thermogravimetric analysis (TGA). The samples were reacted isothermally at temperatures between 1600°C and 1700°C under nitrogen and argon atmospheres. The extent and rate of reaction increased with increasing temperature under both atmospheres; however, both the extent and rate were higher under argon. Silicon nitride, in the presence of titanium carbide, was thermally stable under nitrogen and the reactions were confined to Si3N4/TiC and TiC/N2 interfaces. Under argon atmosphere silicon nitride dissociated completely to liquid silicon and nitrogen gas within about four hours of reaction time, depending on temperature, and a different reaction mechanism prevailed. The kinetics of interaction between silicon nitride and titanium carbide under nitrogen atmosphere was found to be controlled by the rate of diffusion of nitrogen into the titanium carbide/carbonitride phase. Under argon atmosphere the rate was found to be controlled by the rate of dissociation of silicon nitride. For both cases the mechanisms of reactions were determined in detail and then modelled.

Acute bronchiolitis is predominantly a viral disease. Respiratory syncytial virus is the most common agent, but other newly identified viruses have also been considered as causes. The aim of the present study is to determine the respiratory viruses causing acute bronchiolitis in hospitalized infants. Infants younger than 2 years of age who were hospitalized for acute viral bronchiolitis in a children's hospital between November 2011 and May 2012 were evaluated for the presence of viruses as etiologic agents using a realtime polymerase chain reaction method.A total of 55 infants were included in this study. The mean age of the children was 6.98±5.53 months, and 63.6% were male. In the 55 children, 63 viruses were detected. A single viral pathogen was detected in 47 (85.5%) patients, and two viruses were co-detected in 8 (14.6%) patients. Respiratory syncytial virus was the most common virus identified, accounting for 25 (45.5%) cases, followed by rhinovirus (n=9, 16.4%), and human metapneumovirus (n = 8, 14.5%).Although respiratory syncytial virus remains the major viral pathogen in infants hospitalized for acute broncholitis, more than half of bronchiolitis cases are associated with other respiratory viruses.

A case of angiomyxolipoma in the posterior neck region of a 36-year-old man is presented. Although lipomatous tumors are very frequent among benign soft tissue neoplasms, angiomyxolipoma has been reported only in seven case studies before. We present a new case of a typical angomyxolipoma. Histopathologically, admixture of mature adipocytes, poorly cellular myxoid spindle cell areas and abundant vascular structures are the striking components of this tumor. Myxoid spindle cell lipoma, vascular spindle cell lipoma, myxoid liposarcoma, myxolipoma, angiolipoma and pseudoangiomatous spindle cell lipoma can be considered in the differential diagnosis of angiomyxolipoma. Immunohistochemistry is usually helpful in the diagnosis of this extremely rare entity. In our case, positive staining for vimentin and sparse positivity for CD34, in the absence of reactivity for SMA, desmin, S-100 protein and HMB45 in the spindle cells, are the most important immunohistochemical features that help in the differential diagnosis. Otuz altı yaşındaki bir erkek hastanın ensesinde ortaya çıkan bir anjiyomiksolipoma olgusu sunulmaktadır. Lipomatöz tümörlere benign yumuşak doku neoplazileri arasında oldukça sık rastlansa da, anjiyomiksolipom tanısı ile sadece yedi olgu sunumu vardır. Burada tipik anjiyomiksolipom olan yeni bir olguyu sunmaktayız. Histopatolojik olarak bu tümörün en çarpıcı özelliği birbiri içine giren matür yağ dokusu ve hücreden fakir miksoid iğsi hücreli alanlar ve eşlik eden çok sayıda damar yapısıdır. Miksoid iğsi hücreli lipom, vasküler iğsi hücreli lipom, miksoid liposarkom, miksolipom, anjiyolipom ve psödoanjiyomatöz iğsi hücreli lipom anjiyomiksolipom ayırıcı tanıya girebilecek olan lezyonlardır. Bu son derece nadir lezyonun ayırıcı tanısında immunohistokimya oldukça destekleyicidir. Bizim olgumuzda iğsi hücrelerdeki SMA, desmin, S-100 protein ve HMB45 negatifliği ve bunun beraberinde vimentin pozitifliği ve CD34 zayıf pozitifliği tanıya yardımcı olan immunohistokimyasal bulgular olmuştur., Otuz altı yaşındaki bir erkek hastanın ensesinde ortaya çıkan bir anjiyomiksolipoma olgusu sunulmaktadır. Lipomatöz tümörlere benign yumuşak doku neoplazileri arasında oldukça sık rastlansa da, anjiyomiksolipom tanısı ile sadece yedi olgu sunumu vardır. Burada tipik anjiyomiksolipom olan yeni bir olguyu sunmaktayız. Histopatolojik olarak bu tümörün en çarpıcı özelliği birbiri içine giren matür yağ dokusu ve hücreden fakir miksoid iğsi hücreli alanlar ve eşlik eden çok sayıda damar yapısıdır. Miksoid iğsi hücreli lipom, vasküler iğsi hücreli lipom, miksoid liposarkom, miksolipom, anjiyolipom ve psödoanjiyomatöz iğsi hücreli lipom anjiyomiksolipom ayırıcı tanıya girebilecek olan lezyonlardır. Bu son derece nadir lezyonun ayırıcı tanısında immunohistokimya oldukça destekleyicidir. Bizim olgumuzda iğsi hücrelerdeki SMA, desmin, S-100 protein ve HMB45 negatifliği ve bunun beraberinde vimentin pozitifliği ve CD34 zayıf pozitifliği tanıya yardımcı olan immunohistokimyasal bulgular olmuştur.

WOS: 000330579600065, In this paper, we report on structural and optical properties of terbium and europium doped barium stannate phosphors (BaSnO3) synthesised by conventional solid state reaction method. We have studied those materials by using X-ray diffraction (XRD), radioluminescence (RL) and photoluminescence (PL) techniques. XRD patterns confirm that the BaSnO3 sintered at 1400 degrees C exhibit orthorhombic structure and that the Tb3+ and Eu3+ substitution of Ba2+ does not change the structure of the BaSnO3 host. The optical emission spectrum is characterized a broad band centered at 897 nm (1.38 eV), with a high-energy tail approximately 750 nm from the host lattice. Other emission signals that are characteristic of the 3 + oxidation state of rare earth elements were generated by Eu and Tb doping. Luminescence measurements show that the series of emission states D-5(4) -> F-7(6), D-5(4) -> F-7(5), D-5(4) -> F-7(4) and D-5(4) -> F-7(3) corresponding to the typical (4)f -> (4)f infra-configuration forbidden transitions of Tb3+ are appeared and the major emission peak at 540 nm is due to D-5(4) -> F-7(5) transitions of Tb3+. On the other hand, the emission spectrum of Eu doped BaSnO3 phosphor exhibits a series of emission bands, which are attributed to the D-5(0) -> F-7(j) (j = 0-4) transitions of Eu3+ ions. The dominant emission of Eu3+ corresponding to the electric dipole transition D-5(0) -> F-7(2) is located at 613 nm. The sharp emission properties exhibited demonstrate that the BaSnO3 is a suitable host for rare-earth ion doped phosphor material. This work clearly confirms the unusual near infrared (NIR) PL discovered by H. Mizoguchi et al. in BaSnO3 at room temperature. (C) 2013 Elsevier B.V. All rights reserved.

Idiopathic anaphylaxis remains a perplexing disorder in which existing prophylactic therapy is inadequate. In this prospective study, we sought to determine whether patients with idiopathic anaphylaxis might have evidence for a clonal disorder of mast cells related to mastocytosis and for which novel targeted therapies might be considered. We report 12 patients with “idiopathic” anaphylaxis who did not exhibit either urticaria pigmentosa or the characteristic bone marrow biopsy finding of multifocal mast-cell aggregates observed in systemic mastocytosis. Of these 12 patients, 5 had evidence of 1 or more minor criteria for mastocytosis. C-KIT mutational analysis was positive for the 816D>V activating mutation in 3 of 3 patients in CD25+ bone marrow cells where the analysis was performed. These results demonstrate the presence of an aberrant mast-cell population carrying clonal markers in a subset of patients diagnosed with “idiopathic” anaphylaxis, who may respond to inhibitors targeting mutated C-KIT. This intramural clinical trial was conducted in 2003 and 2004 and was registered at http://clinicalcenter.nih.gov with a study number 03-I-0010. Since the study is now closed, it is no longer available online.

International Conference on Luminescence and Optical Spectroscopy of Condensed Matter (ICL'08) -- JUL 07-11, 2008 -- Univ Lumiere Lyon 2, Lyon, FRANCE, WOS: 000281959600026, Rare earths, especially Dy or Tm doped CaSO4 phosphors are actively studied. They have high sensitivity, a large dynamic range, thermal stability and ease of preparation. Nevertheless, they can be enhanced by inclusion of lithium and this study reports some effects of lithium co-dopant on the TL and radioluminescence (RL) emissions of two TL phosphors. Addition of Li as a co-dopant ion was made either during chemical preparation of the phosphors, or as a binder component mixed with the basic phosphors matrix during the process of pressing and sintering the TLD pellets., Lyon 1, CNRS, LPCM, Univ Lyon, Claude Bernard, Ministry of Higher Educ, Region Rhone Alpes, Conseil Gen Rhone, City of Lyon, DGA, Saint-Gobain & Philips

Diabetin lens antioksidan sisteminde hasara neden olarak, lensin opaklaşmasına yol açtığı bilinmektedir. Bu çalışmada, tip il diabette olumlu etkisi gösterilmiş olan Aloe yaprak ekstresinİn, sıçanların lenslerinde diabetin neden olduğu oksidatif hasara etkisi incelenmiştir .Tip II diabet, 2 günlük Wistar sıçan yavrularına 100 mg/kg dozda streptozotosin injeksiyonu ile oluşturuldu (nOSTZ-diabetik sıçanlar). 2 ay sonra, diabetik olan sıçanlar 4 gruba ayrıldı ve bu gruplara, 15 gün süreyle, günde bir kez, ağızdan, aşağıdaki ekstreler verildi: 1. Kontrol: fosfatla tampon lanmış % 0.9 NaCl (PBS; 6 ml/kg). 2. Aloe yaprak pulpası ekstresi (500 mg/kg). 3. Aloe yaprak jeli ekstresi (10 ml/kg), 4. Glibenklamid (1 mg/kg). 15. gün, eter anestezisi altında kesilen sıçanların lensleri ayrılarak izotonik tuzlu suda homojenize edildi. Oksidatif stres parametreleri olarak seçilen glutatyon (GSH) ve lipid peroksidasyonu (LPO) düzeyleri, lens dokusunda spektrofo to metrik yöntemlerle tayin edildi. Aloe ekstrelerinin ve glibenklamidin tip-II diabetik sıçanların lens GSH düzeylerini arttırması, A/oe'nin olumlu etkisini göstermektedir. Aloe pulpa ekstresi ve glibenklamidin LPO düzeyine anlamlı bir etkisi olmadığı, Aloe jel ekstresi verilen grupta ise LPO düzeyinde hafif bir artış olduğu gözlemlendi.Aloe yaprak pulpası ve jeli ekstrelerinin ve glibenklamidin, hipoglisemik ilaç olarak kullanıldıkları takdirde, diabetin lenslerde oluşturduğu hasarı bir ölçüde önlediği sonucuna varıldı.

Yttrium gadolinium aluminate ((Y1-xGdx)(3) Al5O12:Ce) doped cerium phosphors with the different yttrium and gadolinium concentration were prepared by a wet-chemical route via the reagent simultaneous addition technique (WCS-SimAdd). The phosphors were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and photoluminescence (PL), radioluminescence (RL) of cerium doped yttrium gadolinium aluminate phosphors. With increasing Gd dopant concentration, the PL intensity was shifted to the red region. Preliminary RI measurements were performed to further evaluate these newly prepared materials. Intense RL was observed that is typical of Ce3+ doped structure. (C) 2012 Elsevier B.V. All rights reserved.

Reliable assessment of asthma control is essential for effective treatment. Although several methods are used to assess asthma control, it is still suboptimal all over the world. Childhood asthma control test (C-ACT) is a widely used complementary test in determining the level of asthma control in conjunction with GINA guidelines.To evaluate the consistency between the childhood asthma control test (C-ACT) and the Global Initiative for Asthma (GINA) guideline-based asthma control measure in children with asthma and, if present, to investigate the reasons for any discrepancy.Patients and their caregivers filled a C-ACT and a socioeconomic status survey before the physician visit. Asthma control level was also assessed according to GINA criteria by a pediatric allergist who was blinded to C-ACT scores.The mean age of the total 314 patients was 9.0 ± 1.9 yr, ranging between 4.3 and 11.8 yr, of whom 56.1% (n = 176) were men. Regarding the study group, 54.8% of patients were controlled according to GINA, and 51.0% of patients were controlled according to C-ACT (score ≥20). There was inconsistency between GINA and C-ACT in 26.7% (84/314) of the study group when the patients were evaluated individually (κ = 0.464). There was not any significant variable that could predict the consistency and inconsistency between these methods.Consistency between GINA and C-ACT is not as to be expected. Using only one method for determining the control level of asthma does not seem to be reliable and accurate.

We, herein, study the thermoluminescence (TL) and cathodoluminescence (CL-SEM) emissions of a cornmercial turquoise [CuAl6(P04)4(OH)8-4H20] to obtain its luminescent features. The widespread use of this material in jewellery makes it interesting to determine its possible use as an emergency dosimeter.CL spectrum of bulk sample displays an intense broad emission from ~260 to ~50 nm together with a weaker narrow band at ~710 nm. Through EDS and EMPA chemical analyses, an important amount of rare earth elements (REE) such as Ce, La, Y, Nd, Dy, Yb, Er, Pr, Sm, Gd, Ho, Tb, and Tm ha ve been identified in the phosphate phases. Apatite [Ca5[OH(PO4)3]], monazite [(Ce,La,Nd,Th)PO4] and xenotime [YP04] have been detected in the turquoise matrix, as well as very small amounts of quartz [Si021. Turquoise itself has a high content in Zn substituting for Cu, together with small amounts of Cr substituting for Al. The well defined peak observed at ~710 nm can be due to Cr3+ activation centers io the Turquoise lattice. The broad emission is probably associated with a big variety of REE activators. Regarding the blue TL, two emission bands (190° and 330°C) appear in the natural aJiquot whereas the irradiated sample displays 00 response at all. As observed in other natural materials, this glow emission could be due to (i) structural defects, (ii) consecutive breaking linking bonds (e.g. Al-O, Cr-O, etc.) from the lattice of the different phosphates induced during the TL readout and (iii) the losses of structural water molecules in the turquoise lattice., This work has been supported partly by a JAE-Doc CSIC post-PhD. Contract and by the CICYT (FIS2007-61823) project. We are very grateful to the helpful comments of anonymous reviewers

Background Translocations involving region 5q31-32 ( PDGFRB ) have been reported in a variety of myeloproliferative diseases and are often associated with significant peripheral eosinophilia. We report an unusual case of a patient presenting with peripheral basophilia and systemic mastocytosis in whom cytogenetic analysis revealed a t(4;5)(q21.1;q31.3). Design and Methods We used molecular analyses to determine the role of PDGFRB in this case. The patient was treated with imatinib. Results Fluorescence in situ hybridization (FISH) documented a breakpoint in PDGFRB . In agreement with this, the patient responded very well to imatinib with resolution of clinical symptoms, basophilia, and mast cell disease. Molecular analyses revealed that PDGFRB , encoding an imatinib-sensitive tyrosine kinase, was fused to PRKG2 . The fusion gene incorporates the first two exons of PRKG2 fused to the truncated exon 12 of PDGFRB , resulting in the disruption of its juxtamembrane domain. Functional studies confirmed that the activity and transforming properties of PRKG2-PDGFRβ were dependent on the disruption of the auto-inhibitory juxtamembrane domain. Conclusions Our results identify a second case of the PRKG2-PDGFRB fusion and confirm the unusual PDGFRB breakpoint associated with this fusion. This work also illustrates the use of imatinib for the treatment of specific cases of systemic mastocytosis.

Background Mast cells and basophils share similar morphologic and functional properties; however, it is not known whether they are derived from a bilineage (basophil/mast cell)–restricted progenitor. Objective To assess whether basophils and mast cells are derived from common committed progenitors using the c- kit D816V mutation as a biologic signature. Methods The D816V c- kit mutation found in mast cells of patients with systemic mastocytosis is used as a trackable genetic marker to assess the lineage relationship between mast cells and basophils. Blood and bone marrow aspirates were collected from 33 consecutive patients with mastocytosis with different disease severity. Peripheral blood basophils, monocytes and neutrophils were sorted by immunomagnetic beads. Presence of the D816V c- kit mutation was analyzed by restriction fragment length polymorphism in the genomic DNA and mRNA from sorted cells in all patients and in the genomic DNA of individual basophils of 1 patient. Results The c- kit D816V mutation was detectable in basophils of 5 patients (15%). All 5 patients had the c- kit mutation also detectable in monocytes and thus had multilineage involvement. Single cell analysis of the genomic DNA in 1 patient showed a similar degree of clonal expansion in basophils, monocytes, and neutrophils. Mutated c- kit was expressed at the mRNA level in all 5 patients. There was no difference in surface Kit expression levels in basophils. Conclusion Basophils carrying the D816V c- kit mutation in mastocytosis were detected only in the context of a multilineage involvement. These results argue against the presence of a bilineage-restricted committed progenitor for mast cells and basophils.

In this study, the possibility of obtaining high quality feldspar concentrate from syenite samples of Bursa-Orhaneli district is investigated. Following the mineralogical characterization, the sample is subjected to high intensity dry magnetic separation at -300|j.m; high intensity wet magnetic separation at -212, -106 and -74jim; flotation at -106 and -74)o,m; flotation+wet magnetic separation at -106 and - 74(j,m for the removal of coloring impurities. The best results are obtained by flotation followed by high intensity wet magnetic separation of -106 (im size fraction. Although the concentrate provides white firing color, due to the removal of 43.37% of the feed as tails and K20:Na20 ratio being low (i.e., 1.77), an investment on a beneficiation plant for Bursa-Orhaneli syenites can be stated as "risky" in terms of today's market conditions., Bu çalışmada, Bursa-Orhaneli bölgesinden alınan siyenit numunelerinden kaliteli feldispat konsantresi elde edilebilirliği araştırılmıştır. Numunenin mineralojik karakterizasyonunun ardından, renk verici safsızlıkların ayrılması amacıyla, -300^m tane boyutunda yüksek alan şiddetli kuru manyetik ayırma; - 212, -106 ve -74p,m tane boyutlarında yüksek alan şiddetli yaş manyetik ayırma; -106 ve -74(xm tane boyutlarında flotasyon; -106 ve -74 um tane boyutlarında flotasyon + yaş manyetik ayırma testleri uygulanmıştır. En iyi sonuçlar -106 |im tane boyutunda flotasyon ve flotasyon konsantresinin yüksek alan şiddetli yaş manyetik ayırıcıdan geçirilmesi ile elde edilmektedir. Elde edilen konsantrenin beyaz pişme rengi vermesine karşın, malzemenin toplam %43,37'sinin atılması ve elde edilen konsantre K20:Na20 oranının 1,77 gibi görece düşük değerlerde kalması nedenleriyle söz konusu cevherin zenginleştirilmesi amacıyla kurulacak bir tesisin günümüz pazar koşullarında "riskli" sayılabilecek bir yatırım olacağı düşünülmektedir.

The possibilities of the production of high quality potassium feldspar in ceramics and porcelain industry from Kırşehir district (Balışeyh, Ağaçören, Başköy) were investigated. The results showed that it is possible to produce a first quality K-feldspar containing %10,4-11,5 K20, %2,1-2,8 Na20, %0,6-1,3 CaO, %0,01-0,2 MgO, %0,18-0,24 Fe203 and %0,01-0,03 Ti02 from coarse fractions which were wet screened and ground to -0,6 mm by dry magnetic separation. Moreover, high quality K-feldspar containing %13,01 K20, %2,28 Na20, %0,61 CaO, %0,01 MgO, % 0,16 Fe203 ve %0,002 Ti02 was also produced from the samples taken from Balışeyh, Beyobası district by flotation. The undersize fraction (-5,6 mm) which is not suitable for production of high quality potassium feldspar can be used as plaster sand and slime fraction (-75 urn) may be used as raw material in brick and tile production, Bu çalışmada, Kırşehir masifinin değişik bölgelerinden (Balışeyh, Ağaçören, Başköy) alınan "altere granit" numunelerinden seramik ve porselen endüstrilerinde kullanılan kaliteli potasyum feldispatın üretilebilirliği araştırılmıştır. Sonuçlar, özellikle yaş elenerek ayrılan iri fraksiyonların (örneğin, +5,6 mm ve bazı bölgelerde +9 mm), -0,6mm'ye öğütüldükten sonra kuru manyetik ayırma ile %10,4-11,5 K20, %2,1-2,8 Na20, %0,6-1,3 CaO, %0,01-0,2 MgO, %0,18-0,24 Fe203 ve %0,01-0,03 Tİ02 içeren birinci kalite sırlık potasyum feldispat üretilebileceğini göstermektedir. Ayrıca, Balışeyh, Beyobası bölgesindeki iri fraksiyonların -0,3 mm'ye öğütülmesini takiben yapılan flotasyon çalışmaları ile %13,01 K20, %2,28 Na20, %0,61 CaO, %0,01 MgO, % 0,16 Fe203 ve %0,002 Ti02 içeren birinci kalite sırlık potasyum feldispat üretilebilmektedir. Bu çalışma sonunda ince fraksiyon olarak ayrılan -5,6 mm'nin sıva kumu, şlam olarak ayrılan -75um fraksiyonun da kiremit-tuğla hammaddesi olarak kullanılması mümkündür

WOS: 000074405600060 …

International Conference on Luminescence and Optical Spectroscopy of Condensed Matter (ICL'08) -- JUL 07-11, 2008 -- Univ Lumiere Lyon 2, Lyon, FRANCE, WOS: 000281959600018, Room and low temperature cathodoluminescence (CL) of rare earth doped Bi4Ge3O12 (BGO) has been recorded. Luminescence signals noted in the wavelength range (300 - 800 nm) include intrinsic broad emission bands and signals related to Eu3+, Nd3+, and Tm3+. CL measurements made on Bi4Ge3O12 (BGO) doped with rare earth ions are reported for the temperature range 40 to 300 K with different CL excitation modulation frequencies. Dopant levels used in the present study are 1.1, 0.4, and 0.3 wt% Nd, 0.4 wt% Tm and 3 ppm Eu. All dopant levels exhibited different CL spectra with evidence for lines due to the rare-earth dopants intra-4f transitions. The temperature dependence of the intensity of the emission band is discussed., Lyon 1, CNRS, LPCM, Univ Lyon, Claude Bernard, Ministry of Higher Educ, Region Rhone Alpes, Conseil Gen Rhone, City of Lyon, DGA, Saint-Gobain & Philips

Objective: In 2011, Turkey started the nationwide \"Smoking Cessation Treatment Support Program\" via Smoking Cessation Clinics (SCC). This study examined the accessibility of these clinics using Levesque’s framework of access to healthcare services. From the (potential) users’ perspectives, it was aimed to find the challenges they face in accessing these clinics, and it proposed solutions for better implementation. Methods: This study was conducted among 304 smokers who visited four Family Health Centers in a geographically defined area in Istanbul, Turkey, in 2018. Result: In this study, it was found that 74% of smokers wished to quit smoking. Within them, 21% didn’t know of SCCs, and half of them didn’t know what services were provided there. Among those who knew of SCCs, 30% used them to quit smoking. The majority (75.7%) of the SCC users found the medications expensive; 41% didn’t use them, and 64% didn’t re-visit the clinics for follow-ups. Eventually, 4.3% of smokers quit smoking through SCCs. Utilization of these clinics were significantly higher among women (35%) than men (18.6%) (p=0.024). T; and there was no other differences in terms of age, marital status, income, and education level. Conclusion: Smoking cessation programs in Turkey and other countries can be implemented more efficiently if the sufficient number of clinics are opened and are accessible at the local level; more health professionals are trained to practice; the clinics are made more visible; smoking cessation medications are made available constantly; and closer monitoring of service users is ensured. Keywords: Smoking Cessation, Access To Health Care, Health Plan Implementations, Turkey

WOS: 000378835200012, In this study, manganese (Mn) doped Calcium Tetraborate (CaB4O7) samples were prepared by the wet chemical method. Under beta irradiated, CaB4O7:Mn showed thermally stimulated luminescence (TSL) glow peaks at approximately 85 degrees C and 220 degrees C with a heating rate of 5 degrees C/s. Peak shape (PS) and various heating rates (VHR) methods were applied for determining the trap parameters such as order of kinetic (b), activation energy (E) and frequency factor (s). The results indicate that the main dosimetric peak of CaB4O7:Mn follows the second-order kinetic model. The thermal fading ratio of the material is around 15% at the end of one month period of storage. The results of the TL studies carried out on the CaB4O7:Mn dosimeter revealed that it has high sensitivity, which makes it very valuable in various dosimetric applications like space, medical, personal dosimetry and dating. Radioluminescence (RL) of CaB4O7:Mn was also studied. It is shown that the RL spectrum contains a wide band centered at 530 nm assigned to Mn2+ ion emission. A broad band emission feature peaked at 350 nm assigned to the non-bridging oxygen hole center (NBOHC) is also discussed and a model is proposed to explain this broad band feature. (C) 2016 Elsevier B.V. All rights reserved.

WOS: 000374605100014, PubMed ID: 26943903, In this paper, the influence of a series of rare earth (Eu, Tm, Nd) and Cr ion doping on the optical properties of BGO was investigated by means of photoluminescence (PL) from visible to IR region in the 10-300 K temperature range using different types of detectors, namely, photomultiplier tube (PMT), InGaAs (IGA), and Si. Several samples were investigated having dopants concentrations of 03 wt%Nd, 0.4 wt%Tm, 0.06 wt% Cr and 3 ppm Eu. The PL spectra of the samples showed different luminescence behaviour which is assigned to the 4f intra shell transition from rare earth ions. The temperature dependence of the PL from rare earth doped BGO crystals is also examined. (C) 2016 Elsevier Ltd. All rights reserved.

WOS: 000429838900032, In this study, ZnB2O4:xSm(3+) (0.01 H-6(7/2) located at 606 nm can occur as hypersensitive transition having the selection rule Delta J = +/- 1. The observed peaks are in the region of yellow reddish light of Sm3+. Experimental results verify that the optimum Sm3+ content in terms of intense luminescence for this series of phosphors was 2%. Beyond 2% of Sm3+ ions concentration, luminescence quenching occurs due to an enhanced probability of the energy transfer from one Sm3+ to another that matches in energy via cross-relaxation and dipole-dipole interactions according to Dexter theory. A suitable energy transfer model between two adjacent Sm3+ ions in the ZnB2O4 phosphors was accomplished by the electric dipole-dipole interaction. The critical transfer distance (R-c) for non-radiative energy transfer was found to be 21.52 angstrom at 2 mol % Sm3+ doped ZnB2O4. Additionally, thermoluminescence (TL) glow curves of undoped and Sm activated ZnB2O4 under beta irradiation of 10 Gy are also discussed here. (C) 2018 Elsevier B.V. All rights reserved., Commission of Scientific Research Projects of Uludag University [OUAP(F)-2015/31]; Cukurova University, Turkey [FAY-2015-4735, FDK-2017-7905], This work was supported by the Commission of Scientific Research Projects of Uludag University, Project number OUAP(F)-2015/31 and the Research Fund of the Cukurova University, Turkey (Project Number: FAY-2015-4735 and FDK-2017-7905).

WOS: 000352663500055, The physical characterization and phosphor emission spectra are presented for CaSO4 doped with Tm and Cu. All spectral wavelengths are related to electronic transitions of Tm3+ ions. The powder X-ray diffraction pattern showed that the compound exhibits orthorhombic structure and all reflections were indexed without any other secondary impurity phases. Chemical and structural properties of the samples have been characterized by means of Raman spectroscopy and environmental scanning electron microscope (ESEM) with an attached X-ray energy dispersive system (EDS). Group frequencies concept is essential point to the interpretation of the bands due to the main SO4 vibrational units and these displayed main characteristic intensive Raman bands including typical strong intensity at 1016 cm(-1) that corresponds to v(1)SO(4) vibrational mode. From the spatially-resolved cathodoluminescence (CL) spectrum, main emission bands of Tm3+ centered at 346, 362, and 452 nm, due to the respective transitions of P-3(0) -> H-3(4), D-1(2) -> H-3(6), D-1(2) -> F-3(4) were clearly identified. The study is novel as no such CL-ESEM data are available for this doped compound. (C) 2015 Elsevier B.V. All rights reserved., TUBITAK - HAS European Scientific Exchange Program [2227], This research is partly supported by the grants from TUBITAK - HAS European Scientific Exchange Program (2227). The authors would like to thank Dr. I. Kasa from Centre for Energy Research, Hungary for the phosphor materials.

L. E. Muresan [et al.], Cerium and terbium activated white emitting yttrium silicate phosphors (Y2-x-yCexTbySiO5) having average size between 96 and 123 nm were synthesised by a gel-combustion, and their phase and crystal structures, morphologies and ultraviolet (UV)-visible spectroscopic properties were studied. All rare earth doped yttrium silicate (YSO) phosphors are well crystallized powders containing only monoclinic X2-Y2SiO5 phase. No significant changes in the cell parameters were observed with increasing of Tb amount as ionic radii of Tb3+ (0.923 Å) and Y3+ (0.9 Å) have almost the same. Under different excitations, YSO:Ce3+ exhibits blue emission due to the 5d-4f transitions of Ce3+ ions. The series of emission states at different wavelengths of YSO:Tb3+ associated to f-f transition of Tb3+ ion were detected from luminescence measurements. The emission observed at 544 nm (green) corresponding to 5D4 ¿ 7F5 of Tb3+ is strongest one. Incorporation of variable amounts of Tb3+ in the YSO host lattice determines the modification of emission colour from blue through light blue and eventually to bluish green. A possible energy transfer mechanism taking place from Ce3+ to Tb3+ was also discussed in terms of excitation and emission spectra. © 2015 Elsevier B.V.