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23 results on '"Cai, Jia-Bin"'

3. TM2D1 contributes the epithelial-mesenchymal transition of hepatocellular carcinoma via modulating AKT/β-catenin axis

Author

Hu, Jin-Wu, Yin, Yue, Gao, Yang, Nie, Yan-Yan, Fu, Pei-Yao, Cai, Jia-Bin, Zhu, Kai, Huang, Cheng, Huang, Xiao-Wu, Yang, Xin-Rong, Cao, Ya, Qiu, Shuang-Jian, Fan, Jia, and Zhou, Jian

Subjects
Original Article
Abstract

Various epidemiology studies showed the correlation between Alzheimer's disease (AD) and low incidence of cancer. However, the etiology underlying etiology of AD-related carcinogenesis remains largely elusive. Our study focused on characterizing the role of TM2D1 (TM2 domain containing 1) in hepatocellular carcinoma. TM2D1 is also known as β-amyloid peptide binding protein and is critical to the pathogenesis of AD. We found that TM2D1 is increasingly expressed in HCC tumors relative to the peritumoral tissues of the matched tumors and high TM2D1 expression predicts unfavorable clinical outcomes. TM2D1 overexpression induced HCC cell proliferation, migration and invasion, which was related to the epithelial-mesenchymal transition (EMT) observed in these cells. Conversely, TM2D1 depletion led to opposite phenotype in HCC. Mechanistically, we found that TM2D1 promoted Akt and β-catenin hyper-activation, which corresponded with molecular marker change in EMT signaling pathway. Taken together, our results indicated that TM2D1 played an important role in the EMT process in HCC cells by activating AKT and β-catenin signaling and may become a promising therapeutic target in HCC.

Published
2021

9. Additional file 5: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Author

Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Chuan-Yuan Wei, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Dou-Sheng Bai, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Subjects
fungi
Abstract

Figure S3. The AHNAK expression in HCCLM3 and HCCLM3-siAHNAK cells. Western blot showed that the expression of AHNAK after transfecting the short interfering RNA to HCCLM3. (PDF 152 kb)

Published
2019
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10. Additional file 7: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Author

Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Chuan-Yuan Wei, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Dou-Sheng Bai, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Abstract

Table S2. SILAC of differential proteins in HepG2-RNF38 and HepG2-vector (Up-regulated) (DOCX 43 kb)

Published
2019
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12. Additional file 3: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Author

Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Chuan-Yuan Wei, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Dou-Sheng Bai, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Abstract

Figure S1. Analysis RNF38 mRNA level in gastrointestinal tumor vs. normal tissues. A-D. RNF38 mRNA level was up-regulated in colon cancer, gastric cancer, and liver cancer, compared to normal tissues (All data retrieved from www.oncomine.org ). (PDF 114 kb)

Published
2019
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16. Additional file 6: of Circular RNA circTRIM33–12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression

Author

Zhang, Peng-Fei, Chuan-Yuan Wei, Huang, Xiao-Yong, Peng, Rui, Yang, Xuan, Lu, Jia-Cheng, Zhang, Chi, Gao, Chao, Cai, Jia-Bin, Gao, Ping-Ting, Gao, Dong-Mei, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Subjects
neoplasms, digestive system diseases
Abstract

Figure S1. circTRIM33–12 expression in HCC cells. Figure S2. circTRIM33–12 regulated the progression of HCC cells in vitro. Figure S3. TET1 binds to miR-191 in HCC cells. Figure S4. Forced or reduced TET1 expression in HCC cells. Figure S5. TET1 regulated the progression of HCC cells in vitro. Figure S6. circTRIM33–12 and TET1 regulate the expression of several same genes in HCC cells. (DOCX 3576 kb)

Published
2019
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18. Additional file 4: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Author

Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Chuan-Yuan Wei, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Dou-Sheng Bai, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Abstract

Figure S2. Confocal microscopy images of RNF38 and AHNAK. Shown are HCCLM3-NC cells (blue, DAPI; green, RNF38; red, AHNAK). Scale: 2000 × . (PDF 113 kb)

Published
2019
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19. Additional file 3: of Circular RNA circTRIM33â 12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression

Author

Zhang, Peng-Fei, Chuan-Yuan Wei, Huang, Xiao-Yong, Peng, Rui, Yang, Xuan, Lu, Jia-Cheng, Zhang, Chi, Gao, Chao, Cai, Jia-Bin, Gao, Ping-Ting, Gao, Dong-Mei, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Subjects
endocrine system, endocrine system diseases, nutritional and metabolic diseases, digestive system, hormones, hormone substitutes, and hormone antagonists
Abstract

Table S2. Antibody for western blotting, immunofluorescence, RIP, and immunohistochemistry. (DOCX 17 kb)

Published
2019
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21. Additional file 6: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Author

Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Chuan-Yuan Wei, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Dou-Sheng Bai, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Abstract

Figure S4. Clinical relevance of RNF38 and/or AHNAK expression. A. The correlation between RNF38 and AHNAK were assessed by the Pearson correlation. B. RNF38 and AHNAK IOD relative value of 102 patients had negative correlation. C. HCC patients with low AHNAK had the lowest survival rate and the highest recurrence rate. D. HCC patients with high RNF38 and low AHNAK had the most unfavorable prognosis including the OS and recurrence. Group 1, patients of RNF38 low and AHNAK high (n = 30). Group 2, patients of both RNF38 and AHNAK low or high (n = 36), Group 3, patients of RNF38 high and AHNAK low (n = 36). (PDF 132 kb)

Published
2019
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22. Additional file 8: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Author

Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Chuan-Yuan Wei, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Dou-Sheng Bai, Shi, Guo-Ming, Ke, Ai-Wu, and Fan, Jia

Abstract

Table S3. SILAC of differential proteins in HepG2-RNF38 and HepG2-vector (Down-regulated) (DOCX 37 kb)

Published
2019
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23. Additional file 1: of NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells

Author

Hu, Bo, Ding, Guang-Yu, Pei-Yao Fu, Zhu, Xiao-Dong, Ji, Yuan, Shi, Guo-Ming, Ying-Hao Shen, Cai, Jia-Bin, Yang, Zhen, Zhou, Jian, Fan, Jia, Hui-Chuan Sun, Kuang, Ming, and Huang, Cheng

Subjects
digestive system diseases
Abstract

Table S1. Different expressed genes related to PI3K-AKT signaling pathway in Huh7 cells after NLRX1 knock-down. (DOCX 15Â kb)

Published
2018
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