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The purpose of this article is to analyse the Elegy I 1 from the Elegiarum libri quattuor Jana Kochanowskiego, both in the 1584 printed edition and in the manuscript version of Elegiarum libri duo, from the manuscrIpt Osmólski (1562-1564). The study also considers the epigrams Ad lectorem (introducing the elegies as well as the whole book) and the epigram Ad Myscovium, the proemial text of the collection of epigrams Foricoenia, printed in the same book, from the plainness of constant allusions – in the opening poems of Kochanowski – to particular texts, author, motifs (e.g., the author constantly refers to both satirical images and authors like Persius and Horace). In addition to the study of loci paralleli, especially focused on the presence of neolatin poetry in the elegy by Kochanowski, the article studies the way in which Kochanowski re-elaborated the elegy, preparing it for publication. From the manuscript to the edition of 1584 the poem did not undergo considerable modifications, as is the case of other elegies (el. II 3 = I 3 Osmólski). Kochanowski only wanted to give his work a higher degree of narrative coherence and to underline the meta-literary meaning of some images more strongly (e.g. the allusion to Horace’s Ars Poetica before the couplets on the Hercules labour)., Altre Modernità, 2015: NUMERO SPECIALE Finestre: sguardi e riflessi, trasparenze e opacità

Colorectal cancer (CRC) develops through the accumulation of both genetic and epigenetic alterations. However, while the former are already used as prognostic and predictive biomarkers, the latter are less well characterized. Here, performing global methylation analysis on both CRCs and adenomas by Illumina Infinium HumanMethylation450 Bead Chips, we identified a panel of 74 altered CpG islands, demonstrating that the earliest methylation alterations affect genes coding for proteins involved in the crosstalk between cell and surrounding environment. The panel discriminates CRCs and adenomas from peritumoral and normal mucosa with very high specificity (100%) and sensitivity (99.9%). Interestingly, over 70% of the hypermethylated islands resulted in downregulation of gene expression. To establish the possible usefulness of these non-invasive markers for detection of colon cancer, we selected three biomarkers and identified the presence of altered methylation in stool DNA and plasma cell-free circulating DNA from CRC patients.

This work presents the critical edition with commentary of Jan Kochanowski's "Elegiarum Libri Quattuor". The commentary is focused on the classical heritage which emerge from the reading of the texts. Although the presence of Propertius is undeniable (as the critics already pointed out), it's evident the substantial presence of Tibullus, Ovid and of greek poets as Pindar and Homer.

The purpose of my article is to discuss the new book on Jan Kochanowski by Jörg Schulte. The german scholar shows a wide-ranging erudition, discussing the sources of the polish poet, sometimes proposing really interesting texts, not registered by the critics yet. What is more problematic to accept, and what I discuss more deeply, is the presence, in Kochanowski’s works, of italian authors, especially Petrarca, or, sometimes, the direct relation among neo-latin poets and Kochanowski (I’m thinking about Erasm), without considering the more evident presence of texts from the ancient latin literature., Studi Slavistici, Studi Slavistici X • 2013

Background The use of point-of-care ultrasonography (POC US) in paediatrics is increasing. This study investigated the diagnostic accuracy of POC US in children accessing the emergency department (ED) when performed by paediatricians under the remote guidance of radiologists (TELE POC). Methods Children aged 0 to 18 years accessing the ED of a third level research hospital with eight possible clinical scenarios and without emergency/severity signs at the triage underwent three subsequent US tests: by a paediatrician guided remotely by a radiologist (TELE POC); by the same radiologist (UNBLIND RAD); by an independent blinded radiologist (BLIND RAD). Tele-radiology was implemented using low cost “commercial off-the-shelf” (COTS) equipment and open-source software. Data were prospectively collected on predefined templates. Results Fifty-two children were enrolled, for a total of 170 ultrasound findings. Sensitivity, specificity, positive and negative predictive values of TELE POC were: 93.8, 99.7, 96.8, 99.4 when compared to UNBLIND RAD and 88.2, 99.7, 96.8, 98.7 when compared to BLIND RAD. The inter-observers agreement between the paediatricians and either the unblind or blind radiologist was excellent (k = 0.93). The mean duration of TELE POC was 6.3 minutes (95% CI 4.1 to 8.5). Technical difficulties occurred in two (3.8%) cases. Quality of the transmission was rated as fair, good, very good and excellent in 7.7%, 15.4%, 42.3% and 34.6% of cases respectively, while in no case was it rated as poor. Conclusions POC US performed by paediatricians in ED guided via tele-radiology by an expert radiologist (TELE POC) produced reliable and timely diagnoses. Findings of this study, especially for the rarer conditions under evaluation, need further confirmation. Future research should investigate the overall benefits and the cost savings of using tele-ultrasound to perform US “at children’s bedsides”, under remote guidance of expert radiologists.

Minimally invasive techniques have been introduced to reduce morbidity related to standard laparoscopic procedures. One such approach is laparoendoscopic single-site surgery. The aim of the study was to present our initial clinical experience of using this technique for elective splenectomy. We carried out single access laparoscopic splenectomy (SALS) for an 8 cm cystic lesion of the spleen, involving the hilum, on a 38-year-old woman. The procedure was performed with a single-port device (4-channel) via a 2.5-cm umbilical incision. A flexible 5-mm optic and straight laparoscopic instruments were used. The operative time was 75 min. There was no blood loss. No complications were observed. The postoperative period was uneventful. Although substantial development of the instruments and skills is needed, this SALS technique appears to be feasible and safe. Nevertheless, further experience and observations are necessary.