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Background: Movement behaviours (physical activity, sedentary behaviour, and sleep) are important for pre-school children’s health and development. Currently, no tools with appropriate content validity exist that concurrently capture these movement behaviours in young children. The aim of this study was to co-design and assess the content validity of a novel tool to concurrently measure movement behaviours in pre-school aged children (aged 3-4 years). Methods: We followed four distinct steps to develop and assess the content validity of Movement Measurement in the Early Years (MoveMEY): 1) We conducted an extensive literature search, to identify pre-existing proxy measurement tools (questionnaires and diaries) to inform the design of a novel tool, which aimed to effectively capture movement behaviour guidelines of pre-school aged children. 2) We facilitated focus group discussions with parents and carers of pre-school aged children (n=11) and 3) a qualitative survey with free text responses was completed by topic relevant researchers (n=6), to co-design the measurement tool. 4) We assessed the content validity of the developed tool, MoveMEY, through interviews with parents of pre-school aged children (n=12) following piloting of the tool. Results: We developed an initial version of MoveMEY based on the format of an existing questionnaire and by mapping the content of questions to the guidelines. Co-design of MoveMEY resulted in changes to the format (e.g. short questionnaire to a seven-day diary) and content (e.g. inclusion of ‘general information’ questions on illness, disabilities and sleep disturbances; question on screen time before bed). Content validity assessment demonstrated that the items of MoveMEY were relevant and comprehensive for the assessment of children’s movement behaviours. MoveMEY was felt to be comprehensible, however, parental suggestions were implemented to finalise and improve MoveMEY (e.g. adding examples to questions aiming to detect moderate to vigorous physical activity). Conclusion: MoveMEY is the first co-designed measurement tool that has relevance for assessing the movement behaviour guidelines of pre-school aged children. Parent/carer and topic relevant researcher involvement throughout the development process resulted in a seven-day daily reported activity diary that is comprehensive of children’s movement behaviours and comprehensible to parents and carers.

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Summary Introduction Ready-to-eat meals sold by food outlets that are accessible to the general public are an important target for public health intervention. We conducted a systematic review to assess the impact of such interventions. Methods Studies of any design and duration that included any consumer-level or food-outlet-level before-and-after data were included. Results Thirty studies describing 34 interventions were categorized by type and coded against the Nuffield intervention ladder: restrict choice = trans fat law (n = 1), changing pre-packed children's meal content (n = 1) and food outlet award schemes (n = 2); guide choice = price increases for unhealthier choices (n = 1), incentive (contingent reward) (n = 1) and price decreases for healthier choices (n = 2); enable choice = signposting (highlighting healthier/unhealthier options) (n = 10) and telemarketing (offering support for the provision of healthier options to businesses via telephone) (n = 2); and provide information = calorie labelling law (n = 12), voluntary nutrient labelling (n = 1) and personalized receipts (n = 1). Most interventions were aimed at adults in US fast food chains and assessed customer-level outcomes. More ‘intrusive’ interventions that restricted or guided choice generally showed a positive impact on food-outlet-level and customer-level outcomes. However, interventions that simply provided information or enabled choice had a negligible impact. Conclusion Interventions to promote healthier ready-to-eat meals sold by food outlets should restrict choice or guide choice through incentives/disincentives. Public health policies and practice that simply involve providing information are unlikely to be effective.

This chapter aims to contextualize the special circumstances of Roma children’s early education and support needs, with particular reference to the high level of exclusion experienced by members of the communities in Central and Eastern Europe. It presents the impact on households of the social determinants of health which potentially affect child development and well-being. Regardless of ethnicity, the lack of early childhood education leads to serious problems in terms of subsequent educational attainment. In the case of Roma children throughout Central and Eastern Europe this challenge is accentuated by a range of issues, including language, segregation, exclusion and outright racism. Cultural stigmatization has historically led to deep suspicions regarding public bodies and public education on the part of Roma parents, who are themselves likely to have been on the receiving end of discrimination and a poor-quality education. Throughout Europe Roma children are severely under-represented in educational statistics and families frequently report discrimination at all stages of the school system.

The Roma children of Transylvania are probably the most materially deprived in Europe. They often live in one-room shacks made from wood and mud, with no running water, no sanitation, and sometimes no heating. Many rely on charity for their food and medicines. But, are they play deprived? This paper summarises an observational study of the play behaviours of children in a small Roma village. It highlights the striking contrast between the abject poverty that characterises their lives and the general happiness of the children. These children live their limited lives to the full. They ‘play everywhere and with everything’, but not in the generally accepted sense of that phrase. The usual niceties of privacy, personal possessions and property boundaries are irrelevant here. Their play is rich in imagination and creativity; it is living proof of Nicholson’s theory of loose parts.

Over the duration of my teaching career I have witnessed the intensification of attitudes devaluing play, and now in my role as a university professor I have visited many school sites that offer little time for child-initiated play. These personal experiences painted a bleak picture for the inclusion of play in the daily lives of children. So while attending The Association for the Study of Play’s conference in 2006, I sought out sessions that focused on issues of play advocacy. As it turned out, a session offered by Fraser Brown titled Children Without Play was just what the doctor ordered. At that presentation I was introduced to the field of Playwork and became intrigued by a profession whose underlying principles were well suited to address the societal factors devaluing children’s play in America.

Porcine ceruloplasmin was labeled with tritium by the Wilzbach procedure. After purification, the tritiated protein was injected intravenously into rats and the biological half-life, turnover rate, and other parameters were determined. Under these conditions, a half-life of 3.2 days was calculated for ceruloplasmin. The tritiated protein was lost from rat plasma at the same rate whether injected intravenously or intraperitoneally. After subcutaneous injection it was lost at twice the rate as after intravenous injection.The ratio of total exchangeable ceruloplasmin to plasma ceruloplasmin was calculated to be about 14, indicating a large extravascular pool. Radioactivity excreted in the urine was associated mostly with H2O and neutral salts.

Cystathionine synthase which has been purified about 1000-fold from rat liver has absorbance maxima at 280, 360, and 428 mμ. Treating the enzyme with cysteine apparently affects the removal of pyridoxal phosphate and destroys the enzyme activity. So does reduction with borohydride. However, in neither case is the spectrum affected. These observations suggest that pyridoxal phosphate may be bound to cystathionine synthase in an atypical fashion.Mercuric ions strongly inhibit the enzyme, but not in the presence of serine; hydroxylamine inhibits, but not in the presence of substrates. Other carbonyl reagents inhibit little if at all. Sulfate ions activate the enzyme.A new assay procedure for cystathionine synthase has been devised. In the presence of 5,5′-dithiobis-(2-nitrobenzoic acid), the enzyme catalyzes the degradation of cystathionine to serine and homocysteine. The rate of increase in absorbance at 412 mμ is a measure of enzyme concentration.

Albino rats were fed diets which were deficient in tryptophan, niacin, or both, until severe deficiency symptoms appeared. The brains were analyzed for their content of oxidized and reduced nicotinamide adenine dinucleotides (NAD), which are derived from dietary tryptophan and niacin. Deficiencies of tryptophan or niacin had little or no effects on the levels of NAD in rat brain. The injection of niacinamide in massive doses caused a 50 to 75% increase in the NAD levels. Reserpine had no significant effect on brain NAD. No "tranquilizing" or depressing effects were noticed after niacinamide injection.

INTRODUCTION: Ready-to-eat meals sold by food outlets that are accessible to the general public are an important target for public health intervention. We conducted a systematic review to assess the impact of such interventions. METHODS: Studies of any design and duration that included any consumer-level or food-outlet-level before-and-after data were included. RESULTS: Thirty studies describing 34 interventions were categorized by type and coded against the Nuffield intervention ladder: restrict choice = trans fat law (n = 1), changing pre-packed children's meal content (n = 1) and food outlet award schemes (n = 2); guide choice = price increases for unhealthier choices (n = 1), incentive (contingent reward) (n = 1) and price decreases for healthier choices (n = 2); enable choice = signposting (highlighting healthier/unhealthier options) (n = 10) and telemarketing (offering support for the provision of healthier options to businesses via telephone) (n = 2); and provide information = calorie labelling law (n = 12), voluntary nutrient labelling (n = 1) and personalized receipts (n = 1). Most interventions were aimed at adults in US fast food chains and assessed customer-level outcomes. More 'intrusive' interventions that restricted or guided choice generally showed a positive impact on food-outlet-level and customer-level outcomes. However, interventions that simply provided information or enabled choice had a negligible impact. CONCLUSION: Interventions to promote healthier ready-to-eat meals sold by food outlets should restrict choice or guide choice through incentives/disincentives. Public health policies and practice that simply involve providing information are unlikely to be effective.

$\textbf{Background:}$ Ready-to-eat meals (to eat in, to take away or to be delivered) sold by food outlets are often more energy dense and nutrient poor compared with meals prepared at home, making them a reasonable target for public health intervention. The aim of the research presented in this paper was to systematically identify and describe interventions to promote healthier ready-to-eat meals (to eat in, to take away, or to be delivered) sold by specific food outlets in England. $\textbf{Methods:}$ A systematic search and sift of the literature, followed by evidence mapping of relevant interventions, was conducted. Food outlets were included if they were located in England, were openly accessible to the public and, as their main business, sold ready-to-eat meals. Academic databases and grey literature were searched. Also, local authorities in England, topic experts, and key health professionals and workers were contacted. Two tiers of evidence synthesis took place: type, content and delivery of each intervention were summarised (Tier 1) and for those interventions that had been evaluated, a narrative synthesis was conducted (Tier 2). $\textbf{Results:}$ A total of 75 interventions were identified, the most popular being awards. Businesses were more likely to engage with cost neutral interventions which offered imperceptible changes to price, palatability and portion size. Few interventions involved working upstream with suppliers of food, the generation of customer demand, the exploration of competition effects, and/or reducing portion sizes. Evaluations of interventions were generally limited in scope and of low methodological quality, and many were simple assessments of acceptability. $\textbf{Conclusions:}$ Many interventions promoting healthier ready-to-eat meals (to eat in, to take away, or to be delivered) sold by specific food outlets in England are taking place; award-type interventions are the most common. Proprietors of food outlets in England that, as their main business, sell ready-to-eat meals, can be engaged in implementing interventions to promote healthier ready-to-eat-food. These proprietors are generally positive about such interventions, particularly when they are cost neutral and use a health by stealth approach.