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Problem: Klinische Krebsregister sind angehalten, die jeweils veröffentlichten leitlinienbasierten Qualitätsindikatoren zu berechnen und den Leistungserbringenden zurückzuspiegeln (Kriterium 3.03 zur Förderung klinischer Krebsregister des GKV-Spitzenverbands). Bei der Berechnung [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Climate change is altering nutrient cycling within the Arctic Ocean, having knock-on effects to Arctic ecosystems. Primary production in the Arctic is principally nitrogen-limited, particularly in the western Pacific-dominated regions where denitrification exacerbates nitrogen loss. The nutrient status of the eastern Eurasian Arctic remains under debate. In the Barents Sea, primary production has increased by 88% since 1998. To support this rapid increase in productivity, either the standing stock of nutrients has been depleted, or the external nutrient supply has increased. Atlantic water inflow, enhanced mixing, benthic nitrogen cycling, and land–ocean interaction have the potential to alter the nutrient supply through addition, dilution or removal. Here we use new datasets from the Changing Arctic Ocean program alongside historical datasets to assess how nitrate and phosphate concentrations may be changing in response to these processes. We highlight how nutrient dynamics may continue to change, why this is important for regional and international policy-making and suggest relevant research priorities for the future. Supplementary Information The online version contains supplementary material available at 10.1007/s13280-021-01673-0.

Objective: The Popeye domain containing 3 (POPDC3) gene encodes a membrane protein involved in cAMP signaling. Besides gastric cancer, no disease association has been described. We here describe a new myopathy associated with this gene. Methods: 1,500 patients with unidentified cause of limb girdle weakness or hyperCKemia were screened for pathogenic POPDC3 variants. Five patients carrying POPDC3 variants were examined by muscle MRI, muscle biopsy and cardiac examination. We performed functional analyses in a zebrafish popdc3 knockdown model and heterologous expression of the mutant proteins in Xenopus laevis oocytes to measure TREK-1 current. Results: We identified homozygous POPDC3 missense variants (p.Leu155His, p.Leu217Phe and p.Arg261Gln) in five patients from three ethnically distinct families. Variants affected highly conserved residues in the Popeye (p.Leu155 and p.Leu217) and carboxy-terminal (p.Arg261) domains. The variants were absent from control populations. Probands’ muscle biopsies were dystrophic and serum creatine kinase levels were elevated (1,050-9,200 U/L). Muscle weakness was proximal with adulthood onset in most patients, affecting lower limbs earlier than upper. Muscle MRI revealed fat replacement of paraspinal and proximal leg muscles, while cardiac investigations were unremarkable. Knockdown of popdc3 in zebrafish, using two different splice-site blocking morpholinos, resulted in larvae with tail curling and dystrophic muscle features. All three mutants cloned in Xenopus oocytes caused an aberrant modulation of the mechano-gated potassium channel, TREK-1. Interpretation: Our findings point to an important role of POPDC3 for skeletal muscle function and suggest that pathogenic variants in POPDC3 are responsible for a novel type of autosomal recessive limb girdle muscular dystrophy.

Hintergrund: Das am 09.04.2013 in Kraft getretene Krebsfrüherkennungs- und -registergesetz (KFRG) verpflichtet die Länder, eine flächendeckende klinische Krebsregistrierung aufzubauen – mit dem langfristigen Ziel der Verbesserung der Behandlungs- und Versorgungqualität[zum vollständigen Text gelangen Sie über die oben angegebene URL], 18. Deutscher Kongress für Versorgungsforschung (DKVF)

Einleitung: Durch die zentrale Bedeutung histopathologischer Befunde im Diagnose- und Therapieprozess der allermeisten bösartigen Neubildungen stellen die Pathologen für die Krebsregistrierung eine sehr wichtige Informationsquelle dar. Bisher werden Befundergebnisse in den meisten Fällen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Rationale: Altered gut microbial composition has been linked to cardiovascular diseases (CVDs), but its functional links to host metabolism and immunity in relation to CVD development remain unclear. Objectives: To systematically assess functional links between the microbiome and the plasma metabolome, cardiometabolic phenotypes, and CVD risk and to identify diet-microbe-metabolism-immune interactions in well-documented cohorts. Methods and Results: We assessed metagenomics-based microbial associations between 231 plasma metabolites and microbial species and pathways in the population-based LLD (Lifelines DEEP) cohort (n=978) and a clinical obesity cohort (n=297). After correcting for age, sex, and body mass index, the gut microbiome could explain ≤11.1% and 16.4% of the variation in plasma metabolites in the population-based and obesity cohorts, respectively. Obese-specific microbial associations were found for lipid compositions in the VLDL, IDL, and LDL lipoprotein subclasses. Bacterial L-methionine biosynthesis and a Ruminococcus species were associated to cardiovascular phenotypes in obese individuals, namely atherosclerosis and liver fat content, respectively. Integration of microbiome-diet-inflammation analysis in relation to metabolic risk score of CVD in the population cohort revealed 48 microbial pathways associated to CVD risk that were largely independent of diet and inflammation. Our data also showed that plasma levels rather than fecal levels of short-chain fatty acids were relevant to inflammation and CVD risk. Conclusions: This study presents the largest metagenome-based association study on plasma metabolism and microbiome relevance to diet, inflammation, CVD risk, and cardiometabolic phenotypes in both population-based and clinical obesity cohorts. Our findings identified novel bacterial species and pathways that associated to specific lipoprotein subclasses and revealed functional links between the gut microbiome and host health that provide a basis for developing microbiome-targeted therapy for disease prevention and treatment.

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press.

Hintergrund: Der teilweise zu wenig reflektierte Einsatz von Antibiotika sowie der zu hohe Verbrauch nicht-indizierter Breitspektrum-Antibiotika in der Human- und Veterinärmedizin führen zu Therapieversagen, Todesfällen und steigenden Gesundheitskosten. Ziel von ARena (ISRCTN 58150046)[zum vollständigen Text gelangen Sie über die oben angegebene URL], 52. Kongress für Allgemeinmedizin und Familienmedizin

Hintergrund: In der BMG geförderten Studie „Verbesserung des Umgangs mit Antibiotika bei akuten Atemwegsinfekten in der deutschen Primärversorgung (Change-3)“ arbeiten Wissenschaftler des allgemeinmedizinischen Instituts der Universitätsmedizin Rostock mit Hochschullehrern[zum vollständigen Text gelangen Sie über die oben angegebene URL], 52. Kongress für Allgemeinmedizin und Familienmedizin

International audience

The cyclic 3’,5’-adenosine monophosphate (cAMP) signalling pathway constitutes an ancient signal transduction pathway present in prokaryotes and eukaryotes. Previously, it was thought that in eukaryotes three effector proteins mediate cAMP signalling, namely protein kinase A (PKA), exchange factor directly activated by cAMP (EPAC) and the cyclic-nucleotide gated channels. However, recently a novel family of cAMP effector proteins emerged and was termed the Popeye domain containing (POPDC) family, which consists of three members POPDC1, POPDC2 and POPDC3. POPDC proteins are transmembrane proteins, which are abundantly present in striated and smooth muscle cells. POPDC proteins bind cAMP with high affinity comparable to PKA. Presently, their biochemical activity is poorly understood. However, mutational analysis in animal models as well as the disease phenotype observed in patients carrying missense mutations suggests that POPDC proteins are acting by modulating membrane trafficking of interacting proteins. In this review, we will describe the current knowledge about this gene family and also outline the apparent gaps in our understanding of their role in cAMP signalling and beyond.

Optics express 24(20), 22917-22929 (2016). doi:10.1364/OE.24.022917, Published by OSA, Washington, DC

The experiment was conducted to (i) determine the excretion pattern of an indigestible marker for sheep, (ii) compare three different techniques used to determine intake, (iii) determine the crude protein (CP) and digestible organic matter (DOM) intake of wethers and reproducing ewes grazing medic pasture, and (iv) evaluate their production. The percentage of chromium excreted during the determination of the excretion pattern varied between 82,5 and 108,2 when expressed as percentages of representative grab samples taken throughout the day. The diurnal variation in the percentage of chromium excreted (y) was described by the equation, y = 310,9 - 30,44x + 1,03x2 (R2 = 0,67; n = 40), where x. represents the time of sampling. Intake of DOM estimated by the total collection of faeces was significantly (P ≤ 0,01) lower than values obtained by the total collection of chromium and 11h00 chromium grab samples, possibly due to losses of faeces from the bags. No significant difference occurred between the latter two techniques, which resulted in DOM intake results that were highly correlated (r = 0,80). Significant (P≤ 0,01) differences in DOM (variation between 370 and 716 g/d) and CP intake (variation between 55 and 227 g/d) by Merino wethers were observed between months, and a seasonal pattern was observed. The same trend was found with the reproducing South African Mutton Merino (SAMM) ewes; DOM intake varying between 445 and 1008 g/d, while CP intakes varied between 48 and 333 g/d. The live mass of the wethers (variation between 48 and 84 kg) and ewes (variation between 64 and 85 kg) differed significantly (P≤ 0,01) between months, generally following a seasonal trend corresponding to DOM and CP intakes. Wool production of the Merino wethers (6,5 sheep/ha) was 60,5 (1981) and 39,7 (1982) kg greasy wool/ha for two year periods, SAMM ewes (5,2 ewes/ha) produced 23,4 kg greasy woolf ha (1981), while meat production was 62,4 (1981) and 90,4 (1982) kg/ha. Lambs were weaned (ca. 100 days) at 31,8 (1981) and 33,8 (1982) kg, with average daily gains of 263 and 294 g/d in the respective years.Die eksperiment is uitgevoer om (i) die uitskeidingspatroon van 'n onverteerbare merker vir skape te bepaal, (ii) drie verskillende tegnieke van'innamebepaling te vergelyk, (iii) ruprote'ien(RP)- en verteerbare oganiese materiaal(VOM)- inname van Merinohamels asook van reproduserende Suid-Afrikaanse Vleismerino(SAVM)-ooie op medicweiding te bepaal, en (iv) hul gepaardgaande produksie te evalueer. Die persentasie chroom in die grypmonsters soos in die uitskeidingskurwe .bepaal, het tussen 82,5 en 108,2 gevarieer. Die persentasie chroom in die grypmonsters (y) is beskryf deur die vergelyking, y = 310,9 - 30,44x + 1,03x2 (R2 = 0,67; n = 40), waar x die tyd van monsterneming verteenwoordig. Die VOM-inname is betekenisvol (P≤0.01) laer deur die totale miskolleksietegniek beraam, moontlik as gevolg van verliese uit die missakke, Geen verskille het voorgekom tussen VOM-inname soos met die 11h00-chroomgrypmonsters en totale chroomkolleksie bepaal nie, met 'n hoogsbetekenisvol korrelasie tussen VOM-inname beraam volgens die metodes (r = 0,80). Betekenisvolle (P ≤ 0,01) verskille in YOM (variasie tussen 370 en 716 g/d)- en RP (variasie tussen 55 en 227 g/d)-inname by Merinohamels is tussen maande waargeneem, en inname het 'n tipiese seisoenale patroon gevolg. Dieselfde tendens het .by die SAVM-ooie voorgekom (VOM-inname het tussen 445 en 1008 g/d gevarieer terwyl RP-inname tussen 48 en 333 g/d gevarieer het). Liggaamsmassa van die hamels (48 tot 84 kg) en ooie (64 tot 85 kg) het betekenisvol (P≤0,01) tussen maande gevarieer, en dieselfde seisoenale tendens as inname gevolg. Rouwolproduksie van die hamels (veebelading van 6,5 skape/ha) was 60,5 (1981) en 39,7 (1982) kg/ha onderskeidelik vir twee jare, terwyl die ooie (5,2 ooie/ha) 23,4 kg rouwol/ha (1981) geproduseer het. Lamsvleisproduksie deur ooie het 62,4 (1981) en 90,4 (1982) kg/ha bedra. Die 100-dae-speenmassas van die lammers was 31,8 (1981) en 33,8 (1982) kg, terwyl die ooreenstemmende gemiddelde daaglikse toenames van die lammers 263 en 294 g /d vir die onderskele jare was.Kewords: Medicago spp, legume, medics, excretion pattern, chromium oxide, intake, sheep

Trabajo presentado a la XXVI Astronomical Data Analysis Software and Systems Conference, celebrada del 16 al 20 de octubre de 2016 en Trieste, Italy., SIRENA is the software package developed to reconstruct the energy of the X-ray events detected by the X-IFU instrument of the Athena observatory. It is currently integrated in a larger project for end-to-end simulations. Data are simulated and inititally triggered by the SIXTE and afterwards the energy is reconstructed by SIRENA. While the baseline implementation is based on the optimal filtering technique, we present some other algorithms that are also being considered, such as covariance matrices or resistance space analysis. The performace of these algorithms should be finally analyzed in terms of energy resolution and computing resources. The integration of SIRENA into SIXTE allows an integral study of different triggering algorithms, reconstruction techniques, and instrument configurations, and their optimization for in-flight use. The best performance algorithms for event triggering and energy determination will be finally implemented on board in the X-IFU Digital Readout Electronics (DRE) unit., This work has been funded by the Spanish Ministry MINECO under projects AYA2012-39767-C02-01, ESP2013-48637-C2-1-P and ESP2014-53672-C3-1-P.

Blood vessel epicardial substance (BVES/Popdc1) is a junctional-associated transmembrane protein that is underexpressed in a number of malignancies and regulates epithelial-to-mesenchymal transition. We previously identified a role for BVES in regulation of the Wnt pathway, a modulator of intestinal stem cell programs, but its role in small intestinal (SI) biology remains unexplored. We hypothesized that BVES influences intestinal stem cell programs and is critical to SI homeostasis after radiation injury. At baseline, Bves–/– mice demonstrated increased crypt height, as well as elevated proliferation and expression of the stem cell marker Lgr5 compared to wild-type (WT) mice. Intercross with Lgr5-EGFP reporter mice confirmed expansion of the stem cell compartment in Bves–/– mice. To examine stem cell function after BVES deletion, we used ex vivo 3D-enteroid cultures. Bves–/– enteroids demonstrated increased stemness compared to WT, when examining parameters such as plating efficiency, stem spheroid formation, and retention of peripheral cystic structures. Furthermore, we observed increased proliferation, expression of crypt-base columnar “CBC” and “+4” stem cell markers, amplified Wnt signaling, and responsiveness to Wnt activation in the Bves–/– enteroids. Bves expression was downregulated after radiation in WT mice. Moreover, after radiation, Bves–/– mice demonstrated significantly greater SI crypt viability, proliferation, and amplified Wnt signaling in comparison to WT mice. Bves–/– mice also demonstrated elevations in Lgr5 and Ascl2 expression, and putative damage-responsive stem cell populations marked by Bmi1 and TERT. Therefore, BVES is a key regulator of intestinal stem cell programs and mucosal homeostasis.

Objective Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD. Design We determined BVES promoter methylation status using an Infinium HumanMethylation450 array screen of patients with UC with and without CAC. We also measured BVES mRNA levels in a tissue microarray consisting of normal colons and CAC samples. Bves−/− and wild-type mice (controls) were administered azoxymethane (AOM) and dextran sodium sulfate (DSS) to induce tumour formation. Last, we used a yeast twohybrid screen to identify BVES interactors and performed mechanistic studies in multiple cell lines to define how BVES reduces c-Myc levels. Results BVES mRNA was reduced in tumours from patients with CAC via promoter hypermethylation. Importantly, BVES promoter hypermethylation was concurrently present in distant non-malignant-appearing mucosa. As seen in human patients, Bves was underexpressed in experimental inflammatory carcinogenesis, and Bves−/− mice had increased tumour multiplicity and degree of dysplasia after AOM/DSS administration. Molecular analysis of Bves−/− tumours revealed Wnt activation and increased c-Myc levels. Mechanistically, we identified a new signalling pathway whereby BVES interacts with PR61α, a protein phosphatase 2A regulatory subunit, to mediate c-Myc destruction. Conclusion Loss of BVES promotes inflammatory tumourigenesis through dysregulation of Wnt signalling and the oncogene c-Myc. BVES promoter methylation status may serve as a CAC biomarker.

Póster presentado a la XXV Astronomical Data Analysis Software and Systems Conference, celebrada en Sydney, Australia del 25 al 30 de octubre de 2015., SIRENA is the software aimed at performing the on board event energy reconstruction for the Athena calorimeter X-IFU. This on board processing will be done in the X-IFU Digital Readout Electronics (DRE) unit and it will consist in an initial triggering of event pulses followed by an analysis (with the SIRENA package) to determine the energy content of such events., This work has been funded by the Spanish Ministries MICINN and MINECO under projects ESP2006-13608-C02-01, AYA2009-08059, AYA2010-21490-C02-01, AYA2012-39767-C02-01,ESP2013-48637-C2-1-P,ESP2014-53672-C3-1-P.

Trabajo presentado a la Conferencia: Exploring the Hot and Energetic Universe: The first scientific conference dedicated to the Athena X-ray observatory; celebrada en Madrid (España) del 8 a 10 de septiembre de 2015.-- et al., We are using end-to-end simulations to quantify the bright source capabilities of the Athena WFI and X-IFU instrument. For this purpose source images and spectra are used as input to fully simulate the predicted events on the detector, which are then converted to event lists, spectra, and images. This contribution will explain the different pile-up effects for both instruments and analyse their impact on the efficiency of the detector and the spectral shape. With this approach we are able to estimate limiting fluxes, below which spectra are not significantly affected by pile-up effects. Additionally, the direct impact of pile-up on estimated parameters for core science cases such as measuring the spin of black holes or absorption by the WHIM is investigated., This work has been funded by the Bundesministerium für Wirtschaft und Energie under Deutsches Zentrum für Luft- und Raumfahrt grant 50 QR 1402.

Trabajo presentado a la Conferencia: Exploring the Hot and Energetic Universe: The first scientific conference dedicated to the Athena X-ray observatory; celebrada en Madrid (España) del 8 a 10 de septiembre de 2015., This contribution describes the status and technical details of the SIRENA package, the software currently in development to perform the on board event energy reconstruction for the Athena calorimeter X-IFU. This on board processing will be done in the X-IFU DRE unit and it will consist in an initial triggering of event pulses followed by an analysis (with the SIRENA package) to determine the energy content of such events.The current algorithm used by SIRENA is the optimal filtering technique (also used by ASTRO-H processor) although some other algorithms are also being tested.Here we present these studies and some preliminary results about the energy resolution of the instrument based on simulations done with the SIXTE simulator (http://www.sternwarte.uni-erlangen.de/research/sixte/) in which SIRENA is integrated., This work has been funded by the Spanish Ministries MICINN and MINECO under projects ESP2006-13608-C02-01, AYA2009-08059, AYA2010-21490-C02-01, AYA2012-39767-C02-01, ESP2013-48637-C2-1-P, ESP2014-53672-C3-1-P.

Trabajo presentado a la Conferencia: Exploring the Hot and Energetic Universe: The first scientific conference dedicated to the Athena X-ray observatory; celebrada en Madrid (España) del 8 a 10 de septiembre de 2015.-- et al., The focal plane assembly of the Athena X-ray Integral Field Unit (X-IFU) includes as the baseline an array of ~4000 single size calorimeters based on Transition Edge Sensors (TES). Other sensor array configurations could however be considered, combining TES of different properties (e.g. size). In attempting to improve the X-IFU performance in terms of field of view, count rate performance, and even spectral resolution, two alternative TES array configurations to the baseline have been simulated, each combining a small and a large pixel array. With the X-IFU end-to-end simulator, a sub-sample of the Athena core science goals, selected by the X-IFU science team as potentially driving the optimal TES array configuration, has been simulated for the results to be scientifically assessed and compared. In this contribution, we will describe the simulation set-up for the various array configurations, and highlight some of the results of the test cases simulated.

Trabajo presentado a la XXV Astronomical Data Analysis Software and Systems Conference, celebrada en Sydney, Australia del 25 al 30 de octubre de 2015., SIRENA is a software prototype package currently in development for the reconstruction of the energy of the X-ray events detected by the X-IFU instrument of the Athena observatory. During this development phase it is integrated in a larger project for Athena end-to-end simulations (SIXTE), where X-IFU data can be simu- lated, inititally triggered and finally, energy reconstructed, thus helping in the assesment of different instrument configurations. SIRENA implements different analysis and triggering algorithms with the aim of testing their performance in terms of energy resolution and computing resources. The best performance algorithms, optimized for in-flight use, will be finally implemented on board in the X-IFU Digital Readout Electronics (DRE) unit., This work has been funded by the MINECO under project ESP2014-53672-C3-1-P, co-funded by FEDER funds., XXV (2015)

George Bernard Shaw stated, 'The single biggest problem in communication is the illusion that it has taken place'. In the medical world, and especially one that involves children, this is unfortunately a reality.

Talking to children can be very daunting. Talking to a sick child can be even more daunting. How can we ensure that our message comes across in a way that is suitable and will not cause more harm than good?

Einleitung: Die rasante Entwicklung im Bereich der Hörsystemversorgung führt zunehmend zu Überschneidungen der Indikationsbereiche verschiedener Hörsysteme. Gerade in den Grenzbereichen zwischen Hörgerät und CI erschwert dieses die Wahl des Systems und macht eine Verbesserung[for full text, please go to the a.m. URL], 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Introduction: Thorough QT (TQT) studies are performed in accordance with the ICH E14 guidelines in order to demonstrate that new investigational drugs do not alter the corrected QT interval (QTc) of the electrocardiogram (ECG). We previously proposed a new crossover design for TQT studies, which used[for full text, please go to the a.m. URL], GMDS 2012; 57. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Background: We surveyed the quality of risk stratification politics and monitored the rate of entries to our company-wide protocol for venous thrombembolism (VTE) prophylaxis in order to identify safety concerns. Patients and methods: Audit in 464 medical and surgical patients to evaluate quality of VTE prophylaxis. Results: Patients were classified as low 146 (31 %), medium 101 (22 %), and high risk cases 217 (47 %). Of these 262 (56.5 %) were treated according to their risk status and in accordance with our protocol, while 9 more patients were treated according to their risk status but off-protocol. Overtreatment was identified in 73 (15.7 %), undertreatment in 120 (25,9 %) of all patients. The rate of incorrect prophylaxis was significantly different between the risk categories, with more patients of the high-risk group receiving inadequate medical prophylaxis (data not shown; p = 0.038). Renal function was analyzed in 392 (84.5 %) patients. In those patients with known renal function 26 (6.6 %) received improper medical prophylaxis. If cases were added in whom prophylaxis was started without previous creatinine control, renal function was not correctly taken into account in 49 (10.6 %) of all patients. Moreover, deterioration of renal function was not excluded within one week in 78 patients (16.8 %) and blood count was not re-checked in 45 (9.7 %) of all patients after one week. There were more overtreatments in surgical (n = 53/278) and more undertreatments in medical patients (n = 54/186) (p = 0.04). Surgeons neglected renal function and blood controls significantly more often than medical doctors (p-values for both < 0.05). Conclusions: We found a low adherence with our protocol and substantial over- and undertreatment in VTE prophylaxis. Besides, we identified disregarding of renal function and safety laboratory examinations as additional safety concerns. To identify safety problems associated with medical VTE prophylaxis and “hot spots” quality management-audits proved to be valuable instruments.

Einleitung: Viele Patienten weisen bei vergleichbarer Tonhörschwelle deutliche Unterschiede im Sprachverstehen auf. Die rasante Entwicklung im Bereich der Hörsystemversorgung führt zur einer zunehmenden Überschneidung der Indikationsbereiche verschiedener Hörsysteme. Gerade [for full text, please go to the a.m. URL], Herbsttagung der Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie Regensburg mit wissenschaftlicher Unterstützung der ADANO 2011

Einleitung: Die quantitative Bestimmung eines Hörschadens im Rahmen der HNO-ärztlichen Begutachtung bei angezeigter beruflich bedingter Lärmschwerhörigkeit stützt sich hauptsächlich auf die Ergebnisse, die mit dem Freiburger Sprachtest in Ruhe ermittelt werden (Königsteiner[for full text, please go to the a.m. URL], 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

The goal of this study was to determine the effect of gender on visceral and subcutaneous fat distribution of Merino lambs finished off under feedlot conditions. The diet (16% protein, 10MJ ME/kg feed) was fed ad libitum and animals had free access to water. A total of 108 lambs (58 wethers, 50 ewes) were divided into six groups. Groups of lambs were slaughtered every three weeks at respectively 90, 111, 132, 153, 174 and 195 days of age. The visceral fat was removed, weighed and expressed as a percentage of carcass mass, while the subcutaneous fat thickness was measured at the 13th rib. A growth curve was calculated for each gender, and the effect of age on the different fat parameters determined. The growth rates of male and female lambs did not differ and were respectively 45.2 g and 43.2 g per day. Age had a positive effect on % visceral fat with an increase of 0.029% for wethers and 0.032% for ewes per day. Similarly, fat thickness increased at a rate of 0.070 mm for wethers and 0.053 mm for ewes per day, indicating that gender had an influence on the rate of fat deposition. However, the inverse rate of deposition between the genders(visceral fat versus subcutaneous fat) warrants further discussion.Keywords: Growth, fat thickness, sheep, age, feedlot

In Germany, the quantitative assessment of an occupational noise-induced hearing loss is mainly based on the Freiburg speech test [ref:1] in silence (Königsteiner Merkblatt [ref:2]). This approach has often been criticised, because it does not appropriately cover the problems[for full text, please go to the a.m. URL], 81st Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

Die Berechnung des prozentualen Hörverlustes aus dem Sprachaudiogramm im Rahmen der Begutachtung stützt sich bislang ausschließlich auf die Messung der Sprachverständlichkeit in Ruhe. Die alltägliche Kommunikation findet jedoch häufig bei Hintergrundgeräuschen statt,[for full text, please go to the a.m. URL], 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Hintergrund: Die etablierten audiometrischen Diagnostikverfahren gehen teilweise auf Entwicklungen von vor über 40 Jahren zurückgehen und bedürfen der Überarbeitung. Neue Tests werden zwar vereinzelt eingesetzt, sind jedoch noch nicht in der klinischen Routine verbreitet. Methode:[for full text, please go to the a.m. URL], 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Background: The audiometrical test procedures applied in the clinical practice are based on developments from more than 40 years ago and require revisions. New tests are being developed and applied sporadically, but are not established broadly in the clinical routine. Method: In this study two[for full text, please go to the a.m. URL], 80th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery