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18 results on '"Boots, Annemieke M. H."'

1. Additional file 1 of Angiopoietin-2/-1 ratios and MMP-3 levels as an early warning sign for the presence of giant cell arteritis in patients with polymyalgia rheumatica

Author

van Sleen, Yannick, Therkildsen, Philip, Nielsen, Berit Dalsgaard, van der Geest, Kornelis S. M., Hansen, Ib, Heeringa, Peter, Posthumus, Marcel D., Sandovici, Maria, Toonen, Erik J. M., Zijlstra, Jannik, Boots, Annemieke M. H., Hauge, Ellen-Margrethe, and Brouwer, Elisabeth

Subjects
immune system diseases, education, cardiovascular system, cardiovascular diseases, skin and connective tissue diseases
Abstract

Additional file 1: Supplementary Table S1. Technical details of the assays used to detect the biomarkers in the Aarhus cohort and the GPS cohort. Supplementary Table S2. Cohort differences in biomarkers concentrations of GCA and PMR patients. Supplementary Table S3. ROC analyses for biomarker levels in overlapping GCA/PMR patients as compared to isolated PMR patients. Supplementary Table S4. ROC analyses for biomarker levels for GCA patients as compared to non-GCA disease control groups.

Published
2022
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2. A distinct subset of YKL-40 expressing macrophages drive tissue destruction and neovascularisation in giant cell arteritis

Author

Sleen, Yannick, Jiemy, William Febry, Pringle, Sarah, Geest, Kornelis S. M., Abdulahad, Wayel H., Sandovici, Maria, Brouwer, Elisabeth, Peter Heeringa, Boots, Annemieke M. H., Translational Immunology Groningen (TRIGR), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Groningen Kidney Center (GKC), and Microbes in Health and Disease (MHD)

Subjects
myeloid cells, Autoinflammation, chronic inflammation and fibrosis, cytokines and mediators, inflammatory disease
Published
2021

3. Additional file 1 of Effect of age and sex on immune checkpoint expression and kinetics in human T cells

Author

Reitsema, Rosanne D., Cadena, Rebeca Hid, Nijhof, Sander H., Wayel H. Abdulahad, Huitema, Minke G., Paap, Davy, Brouwer, Elisabeth, Boots, Annemieke M. H., and Heeringa, Peter

Abstract

Additional file 1: Table S1 Overview of the Study population and samples used. Table S2 Fluorescent-conjugated monoclonal antibodies. Table S3 Results of factorial ANOVA to determine interaction effects of age and sex. Fig. S1 Absolute cell counts in peripheral blood of females and males. Fig. S2 Ratios of memory/naive CD4+ T cells in young and older adults and effect of CMV serostatus. Fig. S3 Kinetics of immune checkpoint expression in females and males. Fig. S4 PD-1 and CD40L expression by naive and memory CD4+ T cells in young and older CMV+ and CMV- adults. Fig. S5 Flow cytometric strategy for determining IC expression by CD4+ and CD8+ T cells and B cells. Fig. S6 Proportions of memory and naive fractions within CD4+ T cells in young and older adults. Fig. S7 Percentages of CD40L+ cells within fractions of CD4+ T cells in young and older adults. Fig. S8 Percentages of PD-1+ cells within total, naive and memory CD4+ T cells in older males and females.

Published
2020
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4. Mechanisms of naive CD4+ T cell maintenance in the elderly and its implications for Autoimmunity

Author

van der Geest, Kornelis, Brouwer, Elisabeth, Abdulahad, Wayel, Boots, Annemieke M. H., Fulop, Tamas, Franceschi, Claudio, Hirokawa, Katsuiku, Pawelec, Graham, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), and Microbes in Health and Disease (MHD)

Subjects
medicine.anatomical_structure, Immune system, Antigen, Immunity, T cell, Immunology, T-cell receptor, medicine, Biology, medicine.disease_cause, CD8, Homeostasis, Autoimmunity
Abstract

CD4+ T cells are critical players in the immune system. CD4+ T cells coordinate both innate and adaptive immune responses. When naive CD4+ T cells become activated via their antigen-specific T cell receptor in the presence of costimulation, these cells differentiate into effector and memory T cells. Maintenance of a large and diverse naive CD4+ T cell repertoire over time is thus essential for developing immunity to a multitude of novel antigens. Despite a strong decline in thymic production of naive CD4+ T cells with aging, the circulating pool of naive CD4+ T cells is well-maintained in elderly humans. The preservation of naive CD4+ T cells in aged subjects contrasts sharply with that of naive CD8+ T cells, which decline markedly with age. In the current chapter, the mechanisms facilitating the remarkable maintenance of the naive CD4+ T cell pool with age are discussed. Important mechanisms include recognition of self-peptides by T cell receptors and stimulation by homeostatic cytokines, including interleukin-7 and interleukin-2. Furthermore, we address the implications of naive CD4+ T cell maintenance for the development of autoimmune diseases in the elderly. Lastly, two models for the development of aging-associated autoimmunity are proposed, and suggestions for further investigation are provided.

Published
2018

5. B Cells in Giant Cell Arteritis: A Novel Target for Treatment?

Author

Graver, Jacoba C., Sandovici, Maria, Abdulahad, Wayel H., Haacke, Erlin A., Boots, Annemieke M. H., Brouwer, Elisabeth, Translational Immunology Groningen (TRIGR), Microbes in Health and Disease (MHD), and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Published
2017

8. Altered distribution of monocyte subsets in giant cell arteritis

Author

Wang, Qi, Sleen, Yannick, Geest, Kornelis S. M., Westra, Johanna, Abdulahad, Wayel H., Peter Heeringa, Boots, Annemieke M. H., Brouwer, Elisabeth, Translational Immunology Groningen (TRIGR), Groningen Kidney Center (GKC), Microbes in Health and Disease (MHD), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Groningen Institute for Organ Transplantation (GIOT)

Published
2017

12. Active PMR and GCA Is Associated with Changes in Monocyte Subset Composition

Author

Wang, Qi, van der Geest, Kornelis S. M., Abdulahad, Wayel H., Westra, Johanna, Boots, Annemieke M. H., Brouwer, Elisabeth, Translational Immunology Groningen (TRIGR), Microbes in Health and Disease (MHD), and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Published
2015

13. GIANT CELL ARTERITIS: B CELLS REVISITED

Author

van der Geest, Kornelis S. M., Abdulahad, Wayel H., Horst, Gerda, Roozendaal, Caroline, Rutgers, Abraham, Boots, Annemieke M. H., Brouwer, Elisabeth, Microbes in Health and Disease (MHD), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Translational Immunology Groningen (TRIGR)

Published
2014

14. Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis

Author

Marijnissen, Renoud J., Roeleveld, Debbie M., Young, Deborah, Nickerson-Nutter, Cheryl, Abdollahi-Roodsaz, Shahla, de Aquino, Sabrina Garcia, van de Loo, Fons A. J., van Spriel, Annemiek B., Boots, Annemieke M. H., van den Berg, Wim B., Koenders, Marije I., Microbes in Health and Disease (MHD), and Translational Immunology Groningen (TRIGR)

Subjects
ACTIVATION, PATHWAY, DIFFERENTIATION, INFLAMMATION, IL-21, T(H)17 CELLS, MURINE ARTHRITIS, EXPANSION, RHEUMATOID-ARTHRITIS, GENERATION
Abstract

OBJECTIVE: The cytokine interleukin-21 (IL-21) can have both proinflammatory and immunosuppressive effects. The purpose of this study was to investigate the potential dual role of IL-21 in experimental arthritis in relation to Th17 cells. METHODS: Antigen-induced arthritis (AIA) and chronic streptococcal cell wall (SCW) arthritis were induced in IL-21 receptor-deficient (IL-21R(-/-) ) and wild-type mice. Knee joints, synovial tissue, and serum were analyzed for arthritis pathology and inflammatory markers. RESULTS: During AIA and chronic SCW arthritis, IL-21R deficiency protected against severe inflammation and joint destruction. This was accompanied by suppressed serum IgG1 levels and antigen-specific T cell responses. Levels of IL-17 were reduced during AIA, and synovial lymphocytes isolated during SCW arthritis for flow cytometry demonstrated that mainly IL-17+ interferon-γ (IFNγ)-positive T cells were reduced in IL-21R(-/-) mice. However, during the acute phases of SCW arthritis, significantly higher joint swelling scores were observed, consistent with enhanced tumor necrosis factor and IL-6 expression. Interestingly, IL-21R(-/-) mice were significantly less capable of up-regulating suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 messenger RNA. IL-21 stimulation also affected the Toll-like receptor 2 (TLR-2)/caspase recruitment domain 15 response to SCW fragments in vitro, indicating that impaired SOCS regulation in the absence of IL-21 signaling might contribute to the increased local activation during SCW arthritis. CONCLUSION: In contrast to the proinflammatory role of IL-21 in adaptive immunity, which drives IL-17+IFN+ cells and joint pathology during chronic experimental arthritis, IL-21 also has an important immunosuppressive role, presumably by inhibiting TLR signaling via SOCS-1 and SOCS-3. If this dual role of IL-21 in various immune processes is present in human disease, it could make IL-21 a difficult therapeutic target in rheumatoid arthritis.

Published
2014

17. Association of dendritic cell frequencies and phenotypes with aging and frailty

Author

Reitsema, Rosanne D., Hesselink, Bernd-Cornel, Geest, Kornelis S. M., Peter Heeringa, Brouwer, Elisabeth, Boots, Annemieke M. H., Sleen, Yannick, Translational Immunology Groningen (TRIGR), Groningen Kidney Center (GKC), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Microbes in Health and Disease (MHD)

Subjects
Ageing, antigen processing and presentation, dendritic cells

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