1. The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study
- Author
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Shea, MK, Kritchevsky, SB, Hsu, F-C, Nevitt, M, Booth, SL, Kwoh, CK, McAlindon, TE, Vermeer, C, Drummen, N, Harris, TB, Womack, C, Loeser, RF, and Health ABC Study
- Subjects
Male ,Aging ,Vitamin K ,Epidemiology ,Clinical Sciences ,Biomedical Engineering ,Decarboxylation ,Matrix gla protein ,Cohort Studies ,Clinical Research ,Health ABC Study ,Phylloquinone ,Osteoarthritis ,Odds Ratio ,Humans ,2.1 Biological and endogenous factors ,Knee ,Longitudinal Studies ,Phosphorylation ,Aetiology ,Aged ,Nutrition ,Extracellular Matrix Proteins ,Incidence ,Arthritis ,Calcium-Binding Proteins ,Pain Research ,Osteophyte ,Vitamin K 1 ,Human Movement and Sports Sciences ,Magnetic Resonance Imaging ,Arthritis & Rheumatology ,Cartilage ,Cross-Sectional Studies ,Tibial ,Musculoskeletal ,Menisci ,Disease Progression ,Vitamin K Deficiency ,Female ,Chronic Pain ,Articular - Abstract
BackgroundVitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.ObjectiveTo clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).MethodsPlasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ± SD age = 74 ± 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.ResultsLongitudinally, participants with very low plasma PK (
- Published
- 2015