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Metal ion doping and MXene encapsulation for stimulating electron-withdrawing effect are harnessed to boost charge separation towards solar-to-hydrogen conversion.

The core factors affecting the efficiency of photocatalysis are predominantly centered on controllable modulation of anisotropic spatial charge separation/transfer and regulating vectorial charge transport pathways in photoredox catalysis, yet it still meets with limited success. Herein, we first conceptually demonstrate the rational design of unidirectional cascade charge transfer channels over transition metal chalcogenide nanosheets (TMC NSs: ZnIn2S4, CdS, CdIn2S4, and In2S3), which is synergistically enabled by a solid-state non-conjugated polymer, i.e., poly(diallyldimethyl ammonium chloride) (PDDA), and MXene quantum dots (MQDs). In such elaborately designed photosystems, an ultrathin PDDA layer functions as an intermediate charge transport mediator to relay the directional electron transfer from TMC NSs to MQDs that serve as the ultimate electron traps, resulting in a considerably boosted charge separation/migration efficiency. The suitable energy level alignment between TMC NSs and MQDs, concurrent electron-withdrawing capabilities of the ultrathin PDDA interim layer and MQDs, and the charge transport cascade endow the self-assembled TMC/PDDA/MQD heterostructured photosystems with conspicuously improved photoactivities toward anaerobic selective reduction of nitroaromatics to amino derivatives and photocatalytic hydrogen evolution under visible light irradiation. Furthermore, we ascertain that this concept of constructing a charge transfer cascade in such TMC-insulating polymer-MQD photosystems is universal. Our work would afford novel insights into smart design of spatial vectorial charge transport pathways by precise interface modulation via non-conjugated polymers for solar energy conversion., Electron relay of interim polymer layer boosts photocatalytic organic transformation.

Tunable charge transport over atomically precise metal nanoclusters is stimulated in layer-by-layer-assembled multilayered photoanodes for solar energy conversion.

Transition metal chalcogenides quantum dots (TMCs QDs) demonstrate emerging potential in solar energy conversion owing to marvelous physicochemical properties, such as quantum size effect, large extinction coefficient, and multiple excitons generation. Nevertheless, TMCs QDs as photosensitizers are unstable owing to high surface energy, and moreover, substantial trap states of TMCs QDs annihilate the photo-induced charge carriers, thus resulting in ultra-short charge lifetime and inferior photoactivities. Herein, 0D/2D TMCs QDs/MXene heterostructures were designed by a ligand-initiated electrostatic self-assembly strategy, wherein positively charged TMCs QDs were anchored on the negatively charged ultrathin Ti 3C2Tx nanosheets (NSs) framework, which promotes the anisotropic unidirectional electron transport from TMCs QDs to MXene NSs. MXene functions as an effective charge mediator to decrease the charge recombination and prolong the charge lifetime for photocatalytic hydrogen generation and anaerobic reduction of nitroaromatics to amino compounds under visible light irradiation. Our work would shed new insights on the role of MXene in tuning the directional charge transport for solar energy conversion.

Oxaliplatin (OXA) is a third-generation, platinum-based anticancer agent that is reported to induce cell toxicity in normal cells, which severely limits its applications. Its instability in aqua so...

Ionic liquids (IL) technology provides a useful platform to achieve the topical delivery of therapeutic agents, because of its capability to improve skin permeability. While the majority of the researches aimed to achieve local action by topical IL delivery, systemic action of therapeutic agents by local topical application has rarely been reported. In the present work, Gliclazide (GLI), a second-generation sulfonylurea drug was transformed into an IL with tributyl(tetradecyl)phosphonium for the first time. The physicochemical properties of this IL were systematically characterized by DSC, TGA, FT-IR, NMR, and HPLC. The transdermal patch based on this IL was further prepared using DURO-TAK®87-4098. The fabricated gliclazide based ionic liquid [P6,6,6,14][GLI] transdermal patch displayed satisfactory in vitro and in vivo performance. The [P6,6,6,14][GLI] patch released 88.17% of the loaded drug within a 3-day period in the in vitro dissolution test, confirming its sustained release property. Meanwhile, GLI effectively permeated through the artificial skin from [P6,6,6,14][GLI] transdermal patch in the in vitro skin permeation test, with the permeation rate and lag time of 16.571 ± 0.328 μg/cm2/h and 3.027 ± 0.154 h respectively. The [P6,6,6,14][GLI] transdermal patch showed favorable PK profile in rat as compared with GLI oral suspension. The relative bioavailability of GLI reached 92.06% of GLI oral suspension, while the Cmax was significantly reduced. Most importantly, [P6,6,6,14][GLI] transdermal patch demonstrated superior hypoglycemic effect to the oral suspension both in the fasted and fed condition, confirming the feasibility of systemic action by local topical delivery of IL. In addition, the [P6,6,6,14][GLI] transdermal patch caused no skin irritation based on histopathological analysis.

A field experiment was conducted to study the effects of different ratios of chemical fertilizer nitrogen substitution by biogas slurry on yield, growth characteristics(development progress, plant height dynamic, population dynamic and dry matter accumulation dynamic), quality and heavy metal content of winter wheat. The results showed that winter wheat yield increased significantly(P-2, 18.14% higher than the treatment with total chemical fertilizer nitrogen(Ncf). There were no significant differences between the yields of 100%Nbs and Ncf(P>0.05). The 1000-kernels weight presented a significant declining trend(PPPPP>0.05). The contents of these grain heavy metal of each treatment were lower than the maximum levels of contaminants in foods. When the ratio of chemical fertilizer nitrogen substitution by biogas slurry raised above 50%, because of the prolonged growth duration and the increased basal internode length could lead to lodge and yield reduction, and because of greater use of biogas slurry could lead to the risk of secondary pollution. Therefore, in our preliminary study, in this experiment, the optimal ratio of chemical fertilizer nitrogen substitution by biogas slurry was 50%.

Zhi-Fei Jing,1,2 Jian-Bin Bi,1,2 Ze-Liang Li,1,2 Xian-Kui Liu,1,2 Jun Li,1,2 Yu-Yan Zhu,1,2 Xiao-Tong Zhang,1,2 Zhe Zhang,1,2 Zhen-Hua Li,1,2 Chui-Ze Kong1,2 1Department of Urology, First Hospital of China Medical University, Shenyang, Liaoning 110001, People’s Republic of China; 2Institute of Urology, China Medical University, Shenyang 110001, People’s Republic of China Background: The non-receptor tyrosine kinase Fyn-related kinase (FRK) has been reported to affect cell proliferation in several cancer types. However, its effect on the proliferation of clear cell renal cell carcinoma (ccRCC) remains largely unknown.Purpose: The objective of this study was to investigate the expression pattern and function of FRK in ccRCC. We further determined how FRK interacted with other molecules to regulate ccRCC proliferation.Patients and methods: The expression of FRK in ccRCC samples and paired normal renal tissues from 30 patients were analyzed by immunoblotting, immunohistochemistry and quantitative PCR. Then the role of FRK in ccRCC proliferation was analyzed by Cell Counting Kit-8, colony formation assay and EdU incorporation assay. In addition, the miRNA targeting FRK was predicted through a bioinformatic approach and validated by quantitative PCR, immunoblotting and luciferase reporter assay. Finally, the underlying mechanism of FRK regulation of ccRCC proliferation was also determined.Results: Low expression of FRK was detected in ccRCC samples and predicted poor survival for ccRCC patients. FRK inhibited the proliferation of ccRCC cells via phosphorylating downstream PTEN. miR-19 was identified as a novel suppressor of FRK in renal cancer cells and it promoted the proliferation of ccRCC by inhibiting the FRK–PTEN axis.Conclusion: Our results unravel a new regulatory mechanism involved in ccRCC proliferation and may be useful in the identification of therapeutic targets for ccRCC. Keywords: clear cell renal cell carcinoma, miR-19, miR-17~92 cluster, FRK, PTEN, proliferation, oncomiR-1

Domain-specific Knowledge Graph in Military Field is a bridge to connect all kinds of battle factors, such as combat forces, command system, weapon platforms. It’s also an important means to break through the information gap between different areas of different services. Most of the existing knowledge graph is general knowledge graph for general fields, but there is no mature method of knowledge graph construction and expression for the industry data of military specific fields. So based on the special needs for military knowledge acquisition, storage, representation, query and other technologies in the future information and intelligent operations, and application scenarios, this paper discusses the current opportunities and challenges of the knowledge graph in military domain. Then the construction of knowledge graph in military domain and application technology framework are proposed.

A nitrogen/sulfur-doped porous carbon material (NSPC) was synthesized using petroleum asphalt as both carbon and sulfur sources, and graphitic carbon nitride (g-C3N4) as a template and nitrogen source. Its use as the counter electrode (CE) of dye-sensitized solar cells (DSSCs) was investigated. Results indicated that g-C3N4 was totally decomposed during carbonization, giving the NSPC abundant N dopants and nanopores. The NSPC had a high electrocatalytic activity for the reduction of I3- without any Pt catalyst and delivered a high power conversion efficiency of 7.91% as the CE of a DSSC, which is slightly superior to that of Pt CE. The NSPC had an ultrahigh pore volume (4.49 cm3/g) and excellent wettability, providing abundant accessible surface area and facilitated the fast mass transport of reactants. NSPC has potential as a low-cost and efficient CE material for the large-scale use of DSSCs, and provides a new way to add value to low-cost petroleum asphalt.

According to agricultural resource endowment of Jiangsu Province, this paper created kinds of double-chain eco-agricultural model and integrated supporting system based on 'waterfowl, marine lives, aquatic vegetable and paddy rice', 'special food and economic crops with livestock’and‘special food and economic crops with livestock and marine lives’, which were suitable for extension and application in Jiangsu Province. Besides, it set 12 provincial standards and established preliminary technical standard system of‘double-chain’eco-agricultural model. In addition, it explored that‘the leading agricultural enterprises (agricultural co-operatives or family farms)+demonstration zones+farmer households’was adopted as operating mechanism of industrialization of eco-agricultural model, which pushed forward rapid development of standardization and industrialization of‘double-chain’eco-agricultural model.

In order to improve the network lifetime and energy efficiency, an uneven clustering routing protocol based on energy load balancing (ELBUC) is proposed. In the cluster head selection phase, sensor nodes are selected as candidate cluster heads by turns in ELBUC; in the data transmission phase, it proposes a least energy consumption routing strategy, which comprehensively considers the candidate routing node’s energy and the number of its members, so that the cluster head which has fewer nodes in the cluster become the rely node. Simulation results show that ELBUC protocol not only significantly prolongs the lifetime of the network, but also effectively balance the energy consumption between nodes, and improve the network energy efficiency.

This paper constructed a wireless sensor network model which includes multi hop mechanism based on the theory of complex network. In the non uniform clustering algorithm, the selection of the competitive radius affects the lifetime of the whole network. The optimal hop mechanism is added into the growth phase of the scale free network model, which makes the probability of the link between the nodes relate to the actual distance between nodes. This paper also discusses how parameters C and parameters Rmax affect the degree distribution, network coverage, and the number of cluster heads in the entire network model. We use the theory to analyze the degree distribution of the network along with the growth of network. And we also use the software to simulate the network performance parameters. We find that with the increase of parameters C, the network of competitive radius is more heterogeneous, the number of cluster heads are lager, and the proportion of the value between (2,10) of nodes degree in the network are large, but the coverage rate of the network are low. We also found that with the increasing of the parameters Rmax, the number of cluster heads in the network are smaller, and the proportion of the value between (2, 10) of nodes degree in the network, and the coverage rate of the network would increase.

This paper adopts large finite element software ANSYS to establish finite element model of twin-tower building with enlarged base, uses dynamic time history analysis method for seismic response calculation, compare and analyze the calculation results of twin-tower building with enlarged base under elastic boundary conditions and rigid boundary conditions. The results showe that dynamic response for model under elastic boundary conditions is larger than dynamic response for model under rigid boundary conditions, and elastic boundary conditions is more close to the actual situation.

Photocyanine, a novel amphoteric phthalocyanine drug, showed favorable anticancer activity in vivo. Pharmacokinetic study in cancer patients is an important component in dose administration choice. In this study, a rapid, sensitive analytical method based on high-performance liquid chromatography with ultraviolet detection was developed and validated for the determination of four isomers of photocyanine (FD1-4) in cancer patients. Sample preparation involved liquid-liquid extraction with a combination of ultrasound and N,N-dimethyl formamide. Calibration curves (1/x(2)) offered satisfactory linearity for the four isomers of photocyanine. The lower limit of quantification (LLOQ) for FD1-3 isomers was 30 ng/mL, and LLOQ for FD-4 was 5 ng/mL. Inter- and intra-day accuracies for four isomers ranged from 96.6 to 105.5%, and 95.0 to 103.6%, respectively. Inter- and intra-day precision ranged from 4.8 to 8.9%, and 3.6 to 12.2%, respectively. Stability studies showed that photocyanine was stable. This method was successfully used to quantify photocyanine in a pharmacokinetic study in which a single-dose of photocyanine (0.1 mg/kg) was intravenously administered to patients with cancer. On the basis of the discovery that photocyanine has a half-life of 57.5 h in vivo, we suggest that avoiding light for a longer period is essential for patients undergoing photocyanine therapy.

Objective We conducted a study to understand the genetic effect of ERCC1 and RRM1 on the chemotherapy response and clinical outcome of Non-Small Cell Lung Cancer (NSCLC). Methods The relative cDNA quantification for ERCC1 and RRM1 was conducted using a fluorescence-based real-time detection method among 294 NSCLC patients. Results Compared with the internal reference gene β-action, the median levels of ERCC1 and RRM1 expression were 2.43×10(-2) and 0.11×10(-2), respectively. Our study showed response to platinum-containing regimen chemotherapy was high in those with high ERCC1 expression, and the OR (95% CI) were 1.73(1.06-2.81). An apparently high response to chemotherapy was decreased when patients were carrying both high expression of ERCC1 and RRM1, with OR (95% CI) of 2.57(1.21-4.90). Patients with high expression of ERCC1 were associated with a longer OS by multivariate Cox proportional hazards model. Moreover, those carrying both high levels of ERCC1 and RRM1 were seem to have a longer OS when compared with those with low expression (HR=0.31, 95% CI=0.13-0.62 for OS). Conclusion This observation could be used in personalized chemotherapy, increase the response rate and prolonged survival time, and could encourage to explore the predictive value of other genes.

The carmine spider mite, Tetranychus cinnabarinus (Boisduval) and the twospotted spider mite, Tetranychus urticae Koch, are serious pests of strawberries and many other horticultural crops. Control of these pests has been heavily dependent upon chemical acaricides. Objectives of this study were to determine the resistance status of these two pest species to commonly used acaricides on strawberries in a year-round intensive horticultural production region. LC90 of abamectin for adult carmine spider mites was 4% whereas that for adult twospotted spider mites was 24% of the top label rate. LC90s of spiromesifen, etoxazole, hexythiazox and bifenazate were 0.5%, 0.5%, 1.4% and 83% of their respective highest label rates for carmine spider mite eggs, 0.7%, 2.7%, 12.1% and 347% of their respective highest label rates for the nymphs. LC90s of spiromesifen, etoxazole, hexythiazox and bifenazate were 4.6%, 11.1%, 310% and 62% of their respective highest label rates for twospotted spider mite eggs, 3%, 13%, 432,214% and 15% of their respective highest label rates for the nymphs. Our results suggest that T. cinnabarinus have developed resistance to bifenazate and that the T. urticae have developed resistance to hexythiazox. These results strongly emphasize the need to develop resistance management strategies in the region.

Table tennis, as one of the most popular sports in China, has grown considerably since its developed in the 19th century in England. The biomechanics of the research methods in many sports has been widely used, for understanding of sports and technology and improve sports played an important role Fast break and curving ball technology is this game’s core technology. In this study, we based on fast break and curving ball features of kinematic to reveal the table tennis forehand techniques. Eight male volunteers were participated in this tests, the speed of the racket during the playing was recorded through Vicon Motion Capture System. The action was divided into three major phases: back swing, attack and follow through. At the end of back swing stage, break and curl technologies, the speed parameter shows some differences. While the peak speed in ball contact frame, the speed of curling ball was significantly higher than the fast break. Further study could be carried out in detailing analysis at sub-stage of the action for integral considering.

Ping Pong has been considered as one of the most popular sports in the world. Fast break and curving ball technology is this game’s core technology, it will be very important to deeply understand this through biomechanical study. In this research, we based on fast break and curving ball features of kinematic to reveal the table tennis forehand techniques. High speed motion analysis was recorded from eight male subjects. The action was divided into three major phases: back swing, attack and follow through. At the end of back swing stage, break and curl technologies, the speed parameter shows some differences. While the fastest speed in ball contact frame, the speed of curling ball was significantly higher than the fast break. Further study could be carried out in detailing analysis at sub-stage of the action for integral considering.

Knowledge of the vertical distribution of aerosols in the free troposphere is important for estimating their impact on climate. In this study, direct observations of the vertical distribution of aerosols in the free tropo- sphere are made using surface Micro-Pulse Lidar (MPL) measurements. The MPL measurements were made at the Loess Plateau (35.95°N, 104.1°E), which is near the major dust source regions of the Taklimakan and Gobi deserts. The vertical distribution of the MPL backscattering sug- gested that non-dust aerosols floated from ground level to an altitude of approximately 9 km around the source re- gions. Early morning hours are characterized by a shallow aerosol layer of a few hundred meters thick. As the day progresses, strong convective eddies transport the aero- sols vertically to more than 1500 m.

Organic materials of D-π-A type MR-X (MR-1: p-dimethylaminophenylethenetrica-rbonitrile and MR-2: p-diphenylaminophenylethene tricarbonitrile) were designed and synthesized. The device with a sandwich structure shows good rectificative phenomena. The highest rectification ratio 10000 was achieved in device Cu/MR-1/Ag, and about 100 in other device M/MR-X/M (M: Cu, Ag). It has been found that rectificative phenomena exist only in the atmosphere-liquid interface region by means of liquid adsorption, and electric field could help form the oriented molecular film.

A new algorithm for fault superimposed quantity (FSIQ) is presented and analyzed. The network equations are built up by combining fault superimposed networks (FSIN) with the boundary conditions of FSIQ at the fault point and are solved with the Newton iterative method. The algorithm has clear physical meaning and does not require an intermediate procedure to derive FSIQ. The algorithm is implemented by computer programming, and the results of calculations show that the algorithm is fast and accurate. The method can be used not only to calculate FSIQ in the complex power systems with simple or multiple faults, but also to analyze and evaluate the performance of the protective relays and automatic devices based on FSIQ.

Currently, the most widely used photoresists in optical lithography are organic-based resists. The major limitations of such resists include the photon accumulation severely affects the quality of photolithography patterns and the size of the pattern is constrained by the diffraction limit. Phase-change lithography, which uses semiconductor-based resists such as chalcogenide Ge2Sb2Te5 films, was developed to overcome these limitations. Here, instead of chalcogenide, we propose a metallic resist composed of Mg58Cu29Y13 alloy films, which exhibits a considerable difference in etching rate between amorphous and crystalline states. Furthermore, the heat distribution in Mg58Cu29Y13 thin film is better and can be more easily controlled than that in Ge2Sb2Te5 during exposure. We succeeded in fabricating both continuous and discrete patterns on Mg58Cu29Y13 thin films via laser irradiation and wet etching. Our results demonstrate that a metallic resist of Mg58Cu29Y13 is suitable for phase change lithography, and this type of resist has potential due to its outstanding characteristics.

To evaluate the metastasis and survival of an intra-arterial infusion of 3-bromopyruvate (3-BrPA) on hepatic VX2 tumor in rabbits.VX2 tumor was implanted in left lateral lobe of liver of 18 white New Zealand rabbits. The animals were randomized into 3 groups (n = 6 each) and underwent an intra-arterial infusion of phosphate-buffered saline or 3-BrPA via hepatic artery at 14 days post-implantation. At 28 days post-implantation, 3 rabbits in each group were sacrificed. The abdomen of these rabbits was opened and inspected for metastases. Then the survival of the remaining rabbits was observed.At 28 days post-implantation, in PBS group, there were intrahepatic metastasis and abdominal cavity dissemination (n = 3), renal metastases (n = 2) and lung metastases (n = 2); in early 3-BrPA infusion group, intrahepatic metastasis (n = 2), abdominal cavity dissemination (n = 1) and lung metastases (n = 1); in late 3-BrPA infusion group, intrahepatic metastasis (n = 1) and lung metastases (n = 1). The survival of the remaining animals was observed. Rabbits in early 3-BrPA infusion group survived significantly longer than those in PBS group [(27 ± 5) vs (17 ± 3) days, P = 0.041]; rabbits in late 3-BrPA infusion group [(42 ± 6) days] survived significantly longer than those in early 3-BrPA infusion group (P = 0.007).An intra-arterial infusion of 3-BrPA could reduce metastasis and prolong survival in rabbits with hepatic VX2 tumor. The earlier the infusion, the better the outcome.

It is always a challenge for failure analysis engineer to localize leaky polysilicon gate. One of the common method is to use Passive Voltage Contrast (PVC). If the leakage is low and falls below luA (

The title compound, C9H10N4S, has been used as an inter­mediate in the synthesis of potassium channel openers, which show considerable biomolecular current-voltage rectification characteristics. In this crystal form, attractive C—H⋯N hydrogen bonds between neighboring mol­ecules form a centrosymmetric ten-membered ring. In addition, inter­molecular N—H⋯N hydrogen bonds form zigzag mol­ecular chains propagating in the b-axis direction.

The title compound, C12H20N4O2S, has been synthesized for use as an inter­mediate for antihypertensive agents, potential antimalarials and mol­ecular rectification materials. The inter­molecular S⋯N non-bonded separation within a column in the crystal structure is 3.308 (2) A, indicating a strong inter­molecular inter­action between the cyano groups and the S atoms. Attractive C—H⋯O hydrogen bonds are responsible for zigzag mol­ecular chains propagating in the a-axis direction; these types of inter­molecular inter­actions combine to form an extended three-dimensional network in the lattice.

The title compound, C17H21N3, is a chemically symmetric mol­ecule with one methyl group and three (pyrrol-1-yl)­methyl groups bonded to a central C atom. It crystallizes in the non-centrosymmetric space group P212121. The three (pyrrol-1-yl)­methyl groups are orientated differently with respect to one another and to the central C—CH3 bond; hence, the mol­ecule exhibits conformational chirality. The crystal structure is homochiral and contains just one type of enantiomer. In the crystal structure, a herring-bone packing of the supramolecular assemblies is revealed.

The title compound, C45H60N8, is a symmetric mol­ecule with four chemically identical substituents bonded to a central C atom. In the crystal structure, the 4-phenyl­piperazin-1-yl groups exhibit four different conformations, with no obvious pseudosymmetry.

Several techniques such as the electron beam technology and ion beam technology are employed to obtain the high resolution nanopatterns. However, these techniques cause some problems, for example, the vacuum installation, high voltage power supply and low throughput, which consequently make these techniques more expensive. On the other hand, the organic resists used for lithography are important to control the shape and size of the patterns. The reactivity of the resist is dominated by the total irradiation amounts of a beam, that is, the number of electrons or ions or photons absorbed by the resist. As a result, the precision control of the shape and size for nanopatterns become difficult due to their intrinsic accumulation effect of the absorption in the resists.

Maskless phase-change lithographic technology is developed as a photoresist of phase-change materials. The controllable growth behavior of the crystallization region on an amorphous thin film of Ge 2 Sb 2 Te 5 (GST) irradiated by a laser beam is investigated; the GST thin film is deposited on a silicon substrate by the sputtering method. The results of a series of the experiments and the simulations all show that the width of a crystalline pattern is not only closely related to laser power and pulse duration, but also is apparently affected by the interactive area between the focused laser spot and thin film. The width maintains a nonlinear growth with the enhancement of the laser power until the thin film approaches melting, whereas it gradually reaches a constant value due to the local thermal equilibrium. This equilibrium makes the width irrelevant to the moving velocity with certain constraints when the laser works in continuous-wave mode. Within a defocus range of 15 μ m , the widths of the crystalline patterns are obtained in a broad range from 690 nm to 8.13 μ m under a 0.4-NA objective lens. By adjusting the defocus amount, some crystalline square patterns with expected widths in a wide range are fabricated, and the mean percentage error between the expected and fabricated widths is only 1.495%.

The combination of oxaliplatin (L-OHP), 5-fluorouracil (5-Fu) and folinic acid (FA), being one of the effective regimens for advanced gastric cancer, is used in form of chronomodulated chemotherapy for advanced gastric cancer to investigate its efficacy and safety.Twenty-six patients received a 4-day chronomodulated infusion of L-OHP, 5-Fu and FA. L-OHP (25 mg.m(-2).d(-1)) infused from 10:00 am to 22:00 pm, and followed by 5-Fu (600 mg.m(-2).d(-1)) and FA (300 mg.m(-2).d(-1)) from 22:00 pm to 10:00 am for 4 days using a multichannel programmable pump, every 2 weeks as an cycle for at least 2 cycles.Twenty-six patients with previously untreated advanced gastric cancer were eligible. Two complete and 13 partial remissions were observed with an overall response rate of 57.7%. Stable disease was observed in 6 patients (23.1%) and progressive disease in five (19.2%). Four of these patients underwent surgery. The median remission time was 3.5 months and time to tumor progression (TTP) was 4.5 months. The median overall survival time was 8 months. A total of 80 cycles were given without any grade 4 toxicity observed, but grade 3 thrombocytopenia (1.3%) and mucositis (1.3%) in one patient, two grade 3 neutropenia (2.5%) and nausea/vomiting (2.5%) in 2.Chronomodulated intravenous chemotherapy of oxaliplatin, 5-fluorouracil and folinic acid is effective and safe in the treatment of advanced gastric cancer.

One new species of diplectanid monogenean, Pseudorhabdosynochus summanoides n. sp., is reported and described from the marine fish Epinephelus coioides off Nan’ao Shenzhen, China. P. summanoides differs from its closest relative, P. summanae (Young, 1968), by the shape of its vaginal hard-parts, which have a tightly twisted distal region and an accessory patch on the proximal curve. During the course of this work, type-material of several species of Pseudorhabdosynochus was examined and aspects of the vagina and haptor are redescribed and/or figured. These species include P. americanus (Price, 1937), P. hargisi (Oliver & Paperna, 1984), P. amplidiscatus (Bravo-Hollis, 1954), P. epinepheli (Yamaguti, 1938), P. riouxi (Oliver 1986), P. melanesiensis (Laird, 1958), P. cupatus (Young, 1969), P. bocquetae (Oliver & Paperna, 1984), P. kritskyi Dyer et al., 1995, P. capurroi Vidal-Martinez, 1998, P. querni (Yamaguti, 1968) and P. summanae (Young, 1969). Several closely related species are considered in terms of their conspecificity: P. hargisi is proposed as a junior synonym of P. americanus; P. capurroi is suggested as a likely synonym of P. kritskyi; and it is suggested that P. cupatus and P. bocquetae may eventually be demonstrated to be consepcific with P. melanesiensis.

In this paper, the frame of AgentSeek, which is a search engine based on agent are introduced. It can find user interesting the user does want, thereby rates of recall and accuracy have been improved largely.

X-ray radiography is the first choice for detecting chest diseases. However, "visual obstacles" caused by the overlaps between ribs and lung in chest radiography affects the observation and analysis of chest diseases. The objective of this study was to investigate the value of direct digital radiography (DR) dual-energy technique in diagnosis of chest disease located in the overlaps between ribs and lung.Thirty-five cases of chest tubercular diseases located in the overlaps between ribs and lung were examined using direct digital radiography (DR) dual-energy technique.Ratings of dual-energy technique radiography in detecting chest tubercular diseases were 94.3% whereas the ratings of DR radiography were 45.7%. Bone and soft tissue can be separated in the radiography using dual-energy technique.DR dual-energy technique not only increases the visibility towards chest tubercular disease, but also discriminates the location (ribs or lung) of chest tubercular disease.