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Ethacridine Lactate (0.1%) has been tried in dogs to show it′s safety by clinical and histopathological examination of vas at dif-ferent time intervals. Also in vitro titration was carried out with normal human semen and serially diluted ethacridine lactate. With this preliminary study, 0.1% Ethacridine lactate was found to be safe and effective for flushing the distal vas at the time of vasectomy for producing immediate azoospermia. It was also found to cause instant immobilization and lysis of the spermatozoa.

Irrigation of the vas with 0.1% ethacridine during vasectomy flushes the sperms and causes lysis from the distal genital tract, without any serious complication or side effect. In the light of this experience, it is suggested that this method can be used in all vasec-tomy operations carried out for primary sterilisation so as to pro-duce immediate sterility.