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Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5-8, 2022, experts in the field of immunometabolism met for the Keystone symposium "Immunometabolism at the Crossroads of Obesity and Cancer" to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.

Beyaz, Serbulent Gokhan/0000-0001-9263-7823; ERGONENC, Tolga/0000-0002-4325-695X WOS: 000367506700021 PubMed: 26712188 Objective: To evaluate percutaneous dilatational tracheostomy with and without the use of the bronchoscope and compare the safety and complications of the procedure. Methods: The prospective, randomised-controlled study was conducted at the Professor A. Ilhan Ozdemir State Hospital, Giresun, Turkey, between October 2013 and February 2014, and comprised patients >= 18 years of age who were dependent on mechanical ventilation for an extended duration and were scheduled to undergo percutaneous dilatational tracheostomy with Griggs technique. The patients were randomly divided into two groups; group A received standard c that was opened without using fiberoptic bronchoscopy, while group B received percutaneous dilatational tracheostomy that was opened using fiberoptic bronchoscopy. Complications and number of applied needle approaches were recorded. Results: Of the 60 patients, 35(58.3%) were women. The patients were divided into two groups of 30(50%) each. None of the patients developed pneumothorax, subcutaneous emphysema, or oesophageal perforation. The numbers of needle interventions and total complications were significantly higher in group A than group B (p

Complete atrioventricular block is a rare complication in noncardiac operations of children, though it is life threatening. Complete atrioventicular block may occur secondary to many causes and it does not response to medical treatments. An 11 years-old girl was brought to our hospital with fever and abdominal pain fi nally diagnosed as acute appendicitis. Anamnesis, physical examination, laboratory fi ndings and radiological fi ndings were found to be normal. After anesthesia induction, the mask ventilation has been applied. Intubation was performed after giving muscle relaxants. After fi rst surgical incision multiple arrhythmias were monitored. Cardiac arrhythmias continue long time and complete A-V block developed. Arrhythmias did not respond to medical treatment. The patient showed no hemodynamic instability and she awakened after completion of surgical operation. She was sent to intensive care unit because of complete A-V block. Pacemaker was not applied because of not having any symptom. A patient who was diagnosed as congenital complete AV block has been followed up with regular intervals., Çocuklarda kalp dısı ameliyatlarda AV tam blok nadir bir komplikasyon olmasına karsın yasamı tehdit edicidir; AV tam blok pek çok nedenle olusabilmekte ve medikal tedaviye yanıt vermemektedir. Karın agrısı, ates nedeniyle hastanemize basvuran 11 yasında kız hasta, akut apandisit ön tanısıyla operasyona alındı. Anamnez, fi zik muayene, laboratuar ve radyolojik bulguları normaldi. Anestezi indüksiyonundan sonra maske ile ventilasyona geçildi. Kas gevsetici verildi ve yeterli süre beklendikten sonra entübasyonu yapılıp ventilatöre baglanarak cerrahiye verildi. Ilk insizyon sonrasında monitörde multipl aritmiler gözlenmeye baslandı. Kardiyak aritmiler uzun sürdü ve A-V tam blok gelisti. Yapılan medikasyonlara yanıt alınamadı. Hemodinamik instabilite yasanmayan hastanın ameliyatı tamamlandıktan sonra uyandırıldı ancak A-V tam blogun devam etmesi üzerine yogun bakıma çıkarıldı. Takiplerinde semptomsuz olması nedeniyle pacemaker takılmadı. Konjenital intermittan A-V tam blok tanısı konulan hasta düzenli aralıklarla takibe alındı.

International audience; Analysis of hydrogen purification process by adsorption in the dehydrated Na-LSX zeolite is described. New measurements of hydrogen and nitrogen adsorption selectivity of this zeolite have been performed up to a pressure of 20 MPa and at temperatures of 273, 293 and 313 K, by using a gravimetric-volumetric method. Structural characterizations were realized by helium density displacement, nuclear magnetic resonance, X-ray diffraction and scanning electronic microscopy. Furthermore, Monte Carlo simulations of gas adsorption were performed in a zeolite model of Na-LSX, using pair potentials to represent the interaction between gas molecules and zeolite atoms. Comparison of simulation results and experimental data enabled testing of the validity of such a modeling of the gas-zeolite interaction.