1. Modeling and Controlling Epidemic Outbreaks: The Role of Population Size, Model Heterogeneity and Fast Response in the Case of Measles
- Author
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Benjamin Armbruster and Kezban Yagci Sokat
- Subjects
population size ,0301 basic medicine ,medicine.medical_specialty ,Computer science ,General Mathematics ,Population ,Measles ,infectious disease modeling ,03 medical and health sciences ,0302 clinical medicine ,Stochastic simulation ,fast response ,Computer Science (miscellaneous) ,medicine ,Econometrics ,030212 general & internal medicine ,OR in health services ,education ,Engineering (miscellaneous) ,education.field_of_study ,lcsh:Mathematics ,Population size ,Public health ,Simulation modeling ,Outbreak ,vaccination ,simulation ,lcsh:QA1-939 ,medicine.disease ,Vaccination ,030104 developmental biology ,coronavirus disease 2019 (COVID-19) ,heterogeneity - Abstract
Modelers typically use detailed simulation models and vary the fraction vaccinated to study outbreak control. However, there is currently no guidance for modelers on how much detail (i.e., heterogeneity) is necessary and how large a population to simulate. We provide theoretical and numerical guidance for those decisions and also analyze the benefit of a faster public health response through a stochastic simulation model in the case of measles in the United States. Theoretically, we prove that the outbreak size converges as the simulation population increases and that the outbreaks are slightly larger with a heterogeneous community structure. We find that the simulated outbreak size is not sensitive to the size of the simulated population beyond a certain size. We also observe that in case of an outbreak, a faster public health response provides benefits similar to increased vaccination. Insights from this study can inform the control and elimination measures of the ongoing coronavirus disease (COVID-19) as measles has shown to have a similar structure to COVID-19.
- Published
- 2020
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