3,947 results on '"Baumert, A."'
Search Results
2. Associations between individual depressive symptoms and immunometabolic characteristics in major depression
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Woo Ri Chae, Jens Baumert, Julia Nübel, Jelena Brasanac, Stefan M. Gold, Ulfert Hapke, and Christian Otte
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Pharmacology ,Psychiatry and Mental health ,Neurology ,Pharmacology (medical) ,Neurology (clinical) ,Biological Psychiatry - Published
- 2023
3. Precautionary Allergen Labeling: What Advice Is Available for Health Care Professionals, Allergists, and Allergic Consumers?
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Sébastien La Vieille, Jonathan O’B. Hourihane, and Joseph L. Baumert
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Immunology and Allergy - Published
- 2023
4. Association between psychotropic medication and sleep microstructure: evidence from large population studies
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Simon, Hartmann, Liborio, Parrino, Kristine, Ensrud, Katie L, Stone, Susan, Redline, Scott, Clark, and Mathias, Baumert
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Pulmonary and Respiratory Medicine ,Neurology ,Neurology (clinical) - Abstract
To assess the association between psychotropic medications and sleep microstructure in large community-based cohorts of older people.We analyzed overnight polysomnograms of 381 women from the Study of Osteoporotic Fractures (SOF) and 2,657 men from the Osteoporotic Fractures in Men Sleep Study (MrOS), who either used no psychotropic medication (n=2,819), only benzodiazepines (n=112), or only selective serotonin reuptake inhibitors (SSRI) (n=107). Sleep microstructure (cyclic alternating pattern, CAP) was compared between the no medication group and psychotropic medication groups using the Mann-Whitney U-test. Significant differences were investigated using multivariable linear regression adjusted for confounders.CAP rate, arousal index, apnea-hypopnea index, and the frequency of slow, low-amplitude electroencephalography activation phases were significantly lower in MrOS participants using benzodiazepines than participants not taking psychotropic medication. SSRI users in MrOS experienced no altered sleep microstructure compared to those with no psychotropic use. SOF participants using benzodiazepines did not show similar associations with sleep microstructure. However, SSRI users from SOF had a significantly higher frequency of rapid, high-amplitude electroencephalography activation phases (A2 + 3) and periodic limb-movement index than participants not taking psychotropic medication. Multivariable linear regression adjusted for demographic, lifestyle, mood disorders, and health variables indicated additional significant associations between CAP rate and A2 + 3 index, respectively, and benzodiazepine usage in older men, and between CAP rate and SSRI usage in older women.We identified significant associations between sleep microstructure and psychotropic drugs in MrOS and SOF highlighting the importance of comprehensive sleep analysis, including CAP. Our results may help to better understand the differences in sleep-wake mechanisms based on psychotropic usage.Registry: ClinicalTrials.gov; Title: Outcomes of Sleep Disorders in Older Men; Identifier: NCT00070681; URL: https://clinicaltrials.gov/ct2/show/record/NCT00070681.
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- 2023
5. Perceived Chronic Stress Is Associated With the German Diabetes Risk Score Among Adults Without Known Diabetes in Germany
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Julia Nübel, Yong Du, Jens Baumert, Ulfert Hapke, Francesca Färber, Christin Heidemann, and Christa Scheidt-Nave
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Psychiatry and Mental health ,Applied Psychology - Published
- 2023
6. Sleep Arousal-Related Ventricular Repolarization Lability Is Associated With Cardiovascular Mortality in Older Community-Dwelling Men
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Sobhan Salari Shahrbabaki, Dominik Linz, Susan Redline, Katie Stone, Kristine Ensrud, Mathias Baumert, RS: Carim - H08 Experimental atrial fibrillation, Cardiologie, and MUMC+: MA Med Staf Spec Cardiologie (9)
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Pulmonary and Respiratory Medicine ,QT variability index ,cardiovascular mortality ,all-cause mortality ,sleep arousal ,Cardiology and Cardiovascular Medicine ,Critical Care and Intensive Care Medicine ,sleep apnea ,ventricular repolarization - Abstract
Background: Sleep is fragmented by brief arousals, and excessive arousal burden has been linked to increased cardiovascular (CV) risk, but mechanisms are poorly understood. Research Question: Do arousals trigger cardiac ventricular repolarization lability that may predispose people to long-term cardiovascular mortality? Study Design and Methods: This study analyzed 407,541 arousals in the overnight polysomnograms of 2,558 older men in the Osteoporotic Fractures in Men sleep study. QT and RR intervals were measured beat-to-beat starting 15 s prior to arousal onset until 15 s past onset. Ventricular repolarization lability was quantified by using the QT variability index (QTVi). Results: During 10.1 ± 2.5 years of follow-up, 1,000 men died of any cause, including 348 CV deaths. During arousals, QT and RR variability increased on average by 5 and 55 ms, respectively, resulting in a paradoxical transient decrease in QTVi from 0.07 ± 1.68 to –1.00 ± 1.68. Multivariable Cox proportional hazards analysis adjusted for age, BMI, cardiovascular and respiratory risk factors, sleep-disordered breathing and arousal, diabetes, and Parkinson disease indicated that excessive QTVi during arousal was independently associated with all-cause and CV mortality (all-cause hazard ratio, 1.20 [95% CI, 1.04-1.38; P = .012]; CV hazard ratio, 1.29 [95% CI, 1.01 -1.65; P = .043]). Interpretation: Arousals affect ventricular repolarization. A disproportionate increase in QT variability during arousal is associated with an increased all-cause and CV mortality and may reflect ventricular repolarization maladaptation to the arousal stimulus. Whether arousal-related QTVi can be used for more tailored risk stratification warrants further study, including evaluating whether arousal suppression attenuates ventricular repolarization lability and reduces subsequent mortality. Clinical Trial Registration: ClinicalTrials.gov; No.: NCT00070681; URL: www.clinicaltrials.gov
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- 2023
7. A replication study to assess CLIL effects on second language learning in Germany: more than selection and preparation effects?
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Maja Feddermann, Jürgen Baumert, and Jens Möller
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Linguistics and Language ,Language and Linguistics ,Education - Published
- 2023
8. Acute effects of concurrent muscle power and sport-specific endurance exercises on markers of immunological stress response and measures of muscular fitness in highly trained youth male athletes
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Adrian Markov, Jens Bussweiler, Norman Helm, Fabian Arntz, Thomas Steidten, Lars Krohm, Arnau Sacot, Philipp Baumert, Christian Puta, and Helmi Chaabene
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Physiology ,Physiology (medical) ,Public Health, Environmental and Occupational Health ,Orthopedics and Sports Medicine ,General Medicine - Abstract
Purpose To examine the acute effects of concurrent muscle power and sport-specific endurance exercises order on immunological stress responses, muscular-fitness, and rating-of-perceived-exertion (RPE) in highly trained youth male judo athletes. Methods Twenty male participants randomly performed two concurrent training (CT) sessions; power-endurance and endurance-power. Measures of immune response (e.g., white blood cells), muscular-fitness (i.e., counter-movement-jump [CMJ]), RPE, blood-lactate, and -glucose were taken at different time-point (i.e., pre, mid, post, and post6h). Results There were significant time*order interactions for white blood cells, lymphocytes, granulocytes, granulocyte-lymphocyte-ratio, and systemic-inflammation-index. Power-endurance resulted in significantly larger pre-to-post increases in white blood cells and lymphocytes while endurance-power resulted in significantly larger pre-to-post increases in the granulocyte-lymphocyte-ratio and systemic-inflammation-index. Likewise, significantly larger pre-to-post6h white blood cells and granulocytes increases were observed following power-endurance compared to endurance-power. Moreover, there was a significant time*order interaction for blood-glucose and -lactate. Following endurance-power, blood-lactate and -glucose increased from pre-to-mid but not from pre-to-post. Meanwhile, in power-endurance blood-lactate and -glucose increased from pre-to-post but not from pre-to-mid. A significant time*order interaction was observed for CMJ-force with larger pre-to-post decreases in endurance-power compared to power-endurance. Further, CMJ-power showed larger pre-to-mid performance decreases following power-endurance, compared to endurance-power. Regarding RPE, significant time*order interactions were noted with larger pre-to-mid values following endurance-power and larger pre-to-post values following power-endurance. Conclusion CT induced acute and delayed order-dependent immune cell count alterations in highly trained youth male judo athletes. In general, power-endurance induced higher acute and delayed immunological stress responses compared to endurance-power. CMJ-force and RPE fluctuated during both CT sessions but went back to baseline 6 h post-exercise.
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- 2023
9. GABAergic Involvement in Selective Attention
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Kaja Faßbender, Philine M. Baumert, Maximilian W. M. Wintergerst, Jan H. Terheyden, Behrem Aslan, Wolf M. Harmening, and Ulrich Ettinger
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Cognitive Neuroscience - Abstract
Animals need to cope with abundant sensory information, and one strategy is to selectively direct attention to only the most relevant part of the environment. Although the cortical networks of selective attention have been studied extensively, its underlying neurotransmitter systems, especially the role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), remain less well understood. Increased GABAA receptor activity because of administration of benzodiazepines such as lorazepam is known to slow reactions in cognitive tasks. However, there is limited knowledge about GABAergic involvement in selective attention. Particularly, it is unknown whether increased GABAA receptor activity slows the build-up of selectivity or generally widens attentional focus. To address this question, participants (n = 29) received 1 mg lorazepam and placebo (within-subjects, double-blind) and performed an extended version of the flanker task. The spatial distribution of selective attention was studied by systematically manipulating number and position of incongruent flankers; the temporal build-up was characterized using delta plots. An online task version was presented to an independent, unmedicated sample (n = 25) to verify task effects. Under placebo and in the unmedicated sample, only the number of incongruent flankers, but not their position, influenced RTs. Incongruent flankers impaired RTs more strongly under lorazepam than placebo, especially when adjacent to the target. Delta plot analyses of RT showed that this effect persisted even when participants reacted slowly, indicating that lorazepam-induced impairments in selective attention do not result from simply slowed down build-up of selectivity. Instead, our data indicate that increased GABAA receptor activity widens the attentional focus.
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- 2023
10. Observation of a Long-lived Electronic Coherence Modulated by Vibrational Dynamics in Molecular Nd³+- Complexes at Room Temperature
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Ghosh, Jayanta, Gheibi, Mirali, Kalas, Tillmann, Sarpe, Cristian, Zielinski, Bastian, Ciobotea, Ramela, Morscher, Christoph Burghard, Koehne, Ingo, Pietschnig, Rudolf, Senftleben, Arne, Baumert, Thomas, and Braun, Hendrike
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electronic coherence ,Wellenpaket ,Lanthanoide ,femtochemistry ,lanthanides ,fluorescence ,wave packets ,Kohärenz ,Fluoreszenz - Abstract
Gefördert im Rahmen des Projekts DEAL
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- 2023
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11. Thomas OLECHOWSKI, Hans Kelsen: Biographie eines Rechtswissenschaftlers
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Renaud Baumert
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General Social Sciences - Published
- 2022
12. Selective Excitation of Higher Harmonic Coherent Acoustic Phonons in a Graphite Nanofilm
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Arne Ungeheuer, Ahmed S. Hassanien, Mashood T. Mir, Lukas Nöding, Thomas Baumert, and Arne Senftleben
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General Energy ,Physical and Theoretical Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2022
13. Mobile app-based symptom-rhythm correlation assessment in patients with persistent atrial fibrillation
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Hermans, Astrid N. L., Gawalko, Monika, Slegers, Daniek P. J., Andelfinger, Nora, Pluymaekers, Nikki A. H. A., Verhaert, Dominique V. M., van der Velden, Rachel M. J., Betz, Konstanze, Evens, Stijn, Luermans, Justin G. L. M., den Uijl, Dennis W., Baumert, Mathias, Nguyen, Hien L., Isaksen, Jonas L., Kantes, Jorgen, Kanters, Jurgen K., Rienstra, Michiel, Vernooy, Kevin, Gelder, Isabelle C. Van, Hendriks, Jeroen M., Linz, Dominik, Cardiologie, RS: Carim - H01 Clinical atrial fibrillation, MUMC+: MA Med Staf Artsass Cardiologie (9), MUMC+: MA Med Staf Spec Cardiologie (9), MUMC+: MA Cardiologie (3), RS: Carim - H06 Electro mechanics, RS: Carim - H08 Experimental atrial fibrillation, and Cardiovascular Centre (CVC)
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Male ,CATHETER ABLATION ,Telemonitoring ,Time Factors ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Medizin ,Electric Countershock ,Middle Aged ,Mobile Applications ,Atrial fibrillation ,Symptom -rhythm correlation ,Electrical cardioversion ,Heart Rate ,MANAGEMENT ,Humans ,Female ,Mobile health ,Cardiology and Cardiovascular Medicine ,Aged - Abstract
Contains fulltext : 283519.pdf (Publisher’s version ) (Open Access) BACKGROUND: The assessment of symptom-rhythm correlation (SRC) in patients with persistent atrial fibrillation (AF) is challenging. Therefore, we performed a novel mobile app-based approach to assess SRC in persistent AF. METHODS: Consecutive persistent AF patients planned for electrical cardioversion (ECV) used a mobile app to record a 60-s photoplethysmogram (PPG) and report symptoms once daily and in case of symptoms for four weeks prior and three weeks after ECV. Within each patient, SRC was quantified by the SRC-index defined as the sum of symptomatic AF recordings and asymptomatic non-AF recordings divided by the sum of all recordings. RESULTS: Of 88 patients (33% women, age 68 ± 9 years) included, 78% reported any symptoms during recordings. The overall SRC-index was 0.61 (0.44-0.79). The study population was divided into SRC-index tertiles: low (
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- 2022
14. Porto, une ville qui a du goût
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Philippe Baumert
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- 2022
15. Selected cardiac biomarkers in newborns with perinatal asphyxia symptoms
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Małgorzata Baumert, Olga Wojnarowicz, and Piotr Surmiak
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Pediatrics, Perinatology and Child Health ,Family Practice - Abstract
Perinatal hypoxia is one of the more common complications of the early adaptation period. This condition is defined as a disorder of tissue oxygenation during labour and is responsible for approximately 23% of neonatal mortality. Perinatal hypoxia can cause injury and failure of many organs, including the brain, heart and kidneys, mainly in the mechanism of the ischaemic-reperfusion injury. Currently, biochemical markers are more frequently incorporated in neonatal diagnostics. Routinely used in adult patients, these organ-specific chemicals enable diagnosis with high sensitivity and specificity. The manuscript presents a review of research on the use of cardiac markers (N-terminal fragment of pro-B-type natriuretic peptide, cardiac troponins I and T, and cardiac creatine kinase isoenzyme) in selected neonatal diseases. Still, no cutoff values have been established for any of the markers described in this paper. Therefore, for routine use of cardiac markers in the neonatal population, further studies are needed to determine the range of cutoff values and factors that may cause their fluctuation.
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- 2022
16. Pomalidomide in relapsed and refractory multiple myeloma: multicenter retrospective study
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V. G. Potapenko, E. V. Baumert, A. A. Bobrova, R. V. Vashchenkov, N. V. Dorofeeva, K. D. Kaplanov, E. V. Karyagina, A. N. Levanov, A. S. Luchinin, S. I. Moiseev, A. V. Novitskii, A. S. Nizamutdinova, О. V. Pirogova, S. A. Povzun, М. V. Platonov, V. V. Porunova, D. А. Ptashnikov, V. V. Ryabchikova, S. Ya. Simeniv, I. А. Skorokhod, Е. А. Ukrainchenko, D. А. Chaginskaya, T. V. Shelekhova, M. N. Shirokova, A. A. Shutylev, and N. V. Medvedeva
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Oncology ,Hematology - Abstract
Background. The treatment options for patients with multiple myeloma who refractory to previous bortezomib and lenalidomide therapy are limited. Pomalidomide is ап immunomodulatory agent that was registered for the treatment of patients with double refractory multiple myeloma.Aim. To evaluate efficacy, safety and optimal course of the therapy with pomalidomide in routine practice in patients with double refractory multiple myeloma.Materials and methods. Overall, 71 patients with double refractory multiple myeloma were included in the retrospective analysis. There were 36 males and 35 females. The median age was 61 years (range 35-79). According to Durie-Salmon staging system, there were 53 (79.1 %) patients in stage III, 13 (19.4 %) - stage II, and 1 (1.5 %) - stage I.The stage was unknown in 4 patients. Kidney impairment at the onset was in 10 (15 %) patients, the normal function was in 57 (85 %) patients and 4 patients had no data. Most patients (n = 68, 95.8 %) received pomalidomide in one therapy line, in 3 (4.2 %) patients - drug was given in two lines, totally 74 episodes of use. Median number of drugs prescribed prior to pomalidomide were 4 (2-9) drugs, including target ones - 2 (2-5). In the first remission 31 (43.6 %) patients received high-dose therapy with autologous stem cell transplantation. pomalidomide was administered in combination with low doses of dexamethasone (PomDex, n = 44; 59.4 %) and as a part of triple regimens (n = 30; 40.6 %). previously exposed (n = 22; 73.3 %) and new drugs (n = 8; 26.7 %) were used in the combination treatment. In 44 (61.9 %) patients pomalidomide was administered more than 3 years after the onset of the disease, median 63.5 (37-184) months. In 27 (38.1 %) patients it was given within less than 3 years after the onset, median 21 (6-36) months. The primary endpoint was progression-free survival. Secondary endpoints - pomalidomide tolerability, response rate and optimal third drug in the triple regimen. The dependence of progression-free survival, frequency of response and adverse events from the pretreatment, the choice of the third drug, gender, age, immunochemical variant, stage according to the International Staging System and to Durie-Salmon classification was studied.Results. The median time from the diagnosis to the start of pomalidomide therapy was 44.5 (6-184) months. The median of cycles with pomalidomide was 3 (1-30). The response was achieved in 52 (70 %) patients. The median progression-free survival was 4 (1-30) months, overall survival - 6 (0.5-42) months. Adverse effects were noted in 34 (46.5 %) patients. The most frequent adverse events were neutropenia grade III-IV (n = 14; 41.3 %), infection (n = 7; 20.7 %) and fatigue with limitation of daily activity (n = 6; 20.6 %). The rate of adverse events was higher in patients with triplets than doublets regimens of therapy: 43.3 % (n = 13) and 27.2 % (n = 12) respectively (p = 0.008). There were no statistically significant differences in progression-free survival between pomalidomide treatment options (two- or three-component regimen).Conclusion. Compared to the three-component therapy consisting of drugs to which refractoriness was previously diagnosed the PomDex scheme is less toxic and equally effective. Therapy with pomalidomide is effective in the majority of patients with double refractory multiple myeloma even in heavily pretreated. The toxicity is acceptable.
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- 2022
17. Memories of Stress: The Imprinted Cancer Risk After HCV Cure
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Lupberger, J. (Joachim) and Baumert, Thomas F.
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Sciences du Vivant [q-bio]/Médecine humaine et pathologie - Published
- 2023
18. Personality processes of everyday moral courage
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Baumert, A., Mentrup, F., Klümper, L., and Sasse, J.
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- 2023
19. Individually endorsed and socially shared normative beliefs on acculturation: Resources and risk factors for academic and psychosocial adjustment in mid-adolescence
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Jürgen Baumert, Malte Jansen, Michael Becker, Marko Neumann, Olaf Köller, and Kai Maaz
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Developmental and Educational Psychology ,Education - Published
- 2023
20. Unraveling human, rodent and snakeKolmioviridaereplication to anticipate cross-species transmission
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Pierre Khalfi, Zoé Denis, Giovanni Merolla, Carine Chavey, José Ursic-Bedoya, Lena Soppa, Leonora Szirovicza, Udo Hetzel, Jeremy Dufourt, Cedric Leyrat, Nora Goldmann, Kaku Goto, Eloi Verrier, Thomas F. Baumert, Dieter Glebe, Valérie Courgnaud, Damien Grégoire, Jussi Hepojoki, and Karim Majzoub
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The recent discovery of Hepatitis D (HDV)-likeviruses across a wide range of taxa led to the establishment of theKolmioviridaefamily. Recent studies suggest that kolmiovirids can be satellites of viruses other than Hepatitis B virus (HBV), challenging the strict HBV/HDV-association dogma. Studying whether kolmiovirids are able to replicate in any animal cell they enter is essential to assess their zoonotic potential. Here, we compared replication of three kolmiovirids: HDV, rodent (RDeV) and snake deltavirus (SDeV)in vitroandin vivo. We show that SDeV has the narrowest and RDeV the broadest host cell range. High resolution imaging of infected cells revealed nuclear viral hubs with a peculiar RNA-protein organization. Finally,in vivohydrodynamic delivery of infectious clones showed that both HDV and RDeV, but not SDeV, efficiently replicate in mouse liver, forming massive nuclear viral hubs. Our comparative analysis lays the foundation for the discovery of specific host factors controllingKolmioviridaehost-shifting.
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- 2023
21. Longitudinal analysis using NEPS data
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Hans-Günther Roßbach, Jürgen Baumert, and Cordula Artelt
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Education - Published
- 2023
22. Nocturnal pulse wave amplitude attenuations are associated with long-term cardiovascular events
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Shahrbabaki, Sobhan Salari, Linz, Dominik, and Baumert, Mathias
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Cardiovascular disease ,Photoplethysmography ,Pulse wave ,Sleep ,Cardiology and Cardiovascular Medicine - Abstract
Objectives: Photoplethysmography (PPG) is an established technology for detecting pulse rate and pulse wave irregularities. However, whether temporal variations in pulse wave amplitudes, reflecting a combination of acute hemodynamic or autonomic responses to changes in overall vascular function, carry prognostic information remains unclear. To quantify nocturnal temporal pulse wave amplitude (PWA) attenuations and evaluate its association with long-term cardiovascular (CV) events in a large, racially diverse sample of men and women. Methods: Temporal PWA attenuations were determined based on the slopes between the upper and lower envelopes of PPGs derived from overnight polysomnography of 1957 participants (899 men, 1058 women, mean age 68.2 ± 9.1 years) of the Multi-Ethnic Study of Atherosclerosis. The nocturnal PWA attenuation index was defined as the cumulative duration of all PWA attenuation events relative to total sleep duration. Results: Nocturnal PWA attenuation index was greater in men than in women by almost 13% (16.3 ± 8.9% vs. 14.4 ± 7.9%, p < 0.001). The nocturnal PWA attenuation index was highest in Chinese-American participants (17.9 ± 9.2%) and lowest in African-Americans (13.5 ± 8.1%). During a median follow-up of 4.9 years, 94 CV events occurred. In multivariable Cox proportional hazard analysis adjusted for typical confounders, the nocturnal PWA attenuation index
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- 2023
23. Class a capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation
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Dieudonné Buh Kum, Hannah Vanrusselt, Abel Acosta Sanchez, Valerio Taverniti, Eloi R. Verrier, Thomas F. Baumert, Cheng Liu, Jerome Deval, Nikky Corthout, Sebastian Munck, Leonid Beigelman, Lawrence M. Blatt, Julian A. Symons, Pierre Raboisson, Andreas Jekle, Sandrine Vendeville, and Yannick Debing
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Hepatology - Published
- 2023
24. Observation of a Long‐lived Electronic Coherence Modulated by Vibrational Dynamics in Molecular Nd 3+ ‐Complexes at Room Temperature
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Jayanta Ghosh, Mirali Gheibi, Tillmann Kalas, Cristian Sarpe, Bastian Zielinski, Ramela Ciobotea, Christoph Burghard Morscher, Ingo Koehne, Rudolf Pietschnig, Arne Senftleben, Thomas Baumert, and Hendrike Braun
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Physical and Theoretical Chemistry ,Atomic and Molecular Physics, and Optics - Published
- 2023
25. Outpatient health service utilization among adults with selected chronic diseases during the COVID-19 pandemic in Germany - results of the GEDA studies between 2019 and 2021
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Yong Du, Jens Baumert, Stefan Damerow, Alexander Rommel, Hannelore Neuhauser, and Christin Heidemann
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Background: Fear of SARS-CoV-2 infection and lockdown measures may have an impact on health care utilization particularly for people with chronic diseases. We investigated changes in outpatient utilization behavior in pandemic phases among people with selected chronic diseases in Germany. Methods: The nationwide telephone surveys GEDA 2019/2020-EHIS (April 2019 to September 2020) and GEDA 2021 (July to December 2021) covered 4 out of 7 pandemic phases from the pre-pandemic to the 4th pandemic wave. Data on hypertension, major cardiovascular diseases (CVD) and diabetes in the past 12 months and visiting a general practitioner (GP) or a specialist (excluding dentist) in the past 4 weeks was collected using a standardized questionnaire. Proportions and odds ratios were derived from logistic regression models adjusted for age, sex, education and federal state. Results: Among 27,967 participants aged ≥16 years, 8,449, 1,136 and 2,497 individuals had hypertension, major CVD and diabetes. Participants with these chronic diseases visited a GP or specialist significantly more often than the overall study population, irrespective of pandemic phases. Compared to the pre-pandemic phase, a significant reduction in specialist-visiting was found in the 1st pandemic wave among people with hypertension (34.3% vs. 24.1%), major CVD (41.9% vs. 25.6%) and diabetes (39.5% vs. 25.5%). GP-visiting was lower only among people with hypertension (53.0% vs. 46.0%). No difference in GP or specialist visiting was found in the 4th pandemic wave compared to the pre-pandemic phase. Conclusions: The observed decrease particularly in specialist utilization among people with the selected chronic diseases at the beginning of the pandemic was not observed for the second half of 2021 despite the ongoing pandemic. Further studies are required to examine whether the temporary changes in the utilization of ambulatory health care have affected the disease management of people with chronic diseases.
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- 2023
26. Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers
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Magda Rybicka, Eloi R. Verrier, Thomas F. Baumert, and Krzysztof Piotr Bielawski
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Multidisciplinary ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie - Abstract
The study enrolled 284 patients with chronic hepatitis B virus infection. Participants included people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.5%), cirrhotic lesions (22%), hepatocellular carcinoma (HCC) in 5%, and people with no fibrotic lesions in 13%. Eleven SNPs within DIO2, PPARG, ATF3, AKT, GADD45A, and TBX21 were genotyped by mass spectrometry. The rs225014 TT (DIO2) and rs10865710 CC (PPARG) genotypes were independently associated with susceptibility to advanced liver fibrosis. However, cirrhosis was more prevalent in individuals with the GADD45A rs532446 TT and ATF3 rs11119982 TT genotypes. In addition, the rs225014 CC variant of DIO2 was more frequently found in patients with a diagnosis of HCC. These findings suggest that the above SNPs may play a role in HBV-induced liver damage in a Caucasian population.
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- 2023
27. Unfolding the mechanism of hepatocyte injury of HBV precore and core promoter variants
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Nikolaus Jilg and Thomas F. Baumert
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Hepatology - Published
- 2023
28. Preliminary evidence of transcutaneous vagus nerve stimulation effects on sleep in veterans with <scp>post‐traumatic</scp> stress disorder
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Sarah A. Bottari, Damon G. Lamb, Eric C. Porges, Aidan J. Murphy, Amy B. Tran, Raffaele Ferri, Michael S. Jaffee, Maria I. Davila, Simon Hartmann, Mathias Baumert, and John B. Williamson
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Behavioral Neuroscience ,Cognitive Neuroscience ,General Medicine - Published
- 2023
29. Supplemental Figures 1-7 and Tables 1-2 from Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma
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Peter Sminia, Jan Theys, Bart A. Westerman, Brigitta G. Baumert, Lukas J.A. Stalpers, Daphne A. Haas-Kogan, Tom Würdinger, Ben J. Slotman, Jaap van den Berg, Rogier Dik, Hou Y.Y.E. Veldman, Tonny Lagerweij, Fleur M.G. Cornelissen, Paul L.G. Slangen, Ana Gasol, and Ravi S. Narayan
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Supplemental Figure 1. Chemical structures of non-FDA approved compounds used in the Study; Supplemental Figure 2. Effect of drugs on growth and target phosphorylation; Supplemental Figure 3. mTOR inhibition does not show dose dependent Radiosensitization; Supplemental Figure 4. MEK162 + RT abrogate spheroid regrowth; Supplemental Figure 5. MEK162 radiosensitizes GBM8 primary spheroid culture and increases γH2AX levels; Supplemental Figure 6. MEK162 abrogates BrdU washout and increases sub-G1 accumulation of BrdU+ cells; Supplemental Figure 7. MEK162 + RT in vivo; Supplemental Table 1: Antibodies used; Supplemental Table 2: Gene signature MEK+RT response
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- 2023
30. Data from Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma
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Peter Sminia, Jan Theys, Bart A. Westerman, Brigitta G. Baumert, Lukas J.A. Stalpers, Daphne A. Haas-Kogan, Tom Würdinger, Ben J. Slotman, Jaap van den Berg, Rogier Dik, Hou Y.Y.E. Veldman, Tonny Lagerweij, Fleur M.G. Cornelissen, Paul L.G. Slangen, Ana Gasol, and Ravi S. Narayan
- Abstract
Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K and MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not in combination with radiotherapy, which is a key component of the current standard treatment of GBM. In our study, GBM cell lines and patient representative primary cultures were grown as multicellular spheroids. Spheroids were treated with a panel of small-molecule drugs including MK2206, RAD001, BEZ235, MLN0128, and MEK162, alone and in combination with irradiation. Following treatment, spheroid growth parameters (growth rate, volume reduction, and time to regrow), cell-cycle distribution and expression of key target proteins were evaluated. In vivo, the effect of irradiation (3 × 2 Gy) without or with MEK162 (50 mg/kg) was studied in orthotopic GBM8 brain tumor xenografts with endpoints tumor growth and animal survival. The MAPK-targeting agent MEK162 was found to enhance the effect of irradiation as demonstrated by growth inhibition of spheroids. MEK162 downregulated and dephosphorylated the cell-cycle checkpoint proteins CDK1/CDK2/WEE1 and DNA damage response proteins p-ATM/p-CHK2. When combined with radiation, this led to a prolonged DNA damage signal. In vivo data on tumor-bearing animals demonstrated a significantly reduced growth rate, increased growth delay, and prolonged survival time. In addition, RNA expression of responsive cell cultures correlated to mesenchymal stratification of patient expression data. In conclusion, the MAPK inhibitor MEK162 was identified as a radiosensitizer in GBM spheroids in vitro and in orthotopic GBM xenografts in vivo. The data are supportive for implementation of this targeted agent in an early-phase clinical study in GBM patients. Mol Cancer Ther; 17(2); 347–54. ©2017 AACR.See all articles in this MCT Focus section, “Developmental Therapeutics in Radiation Oncology.”
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- 2023
31. Controlled Nanostructuring of Transparent Matter with Temporal Airy Pulses
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Thomas Winkler, Bastian Zielinski, Cristian Sarpe, Elena R. Ciobotea, Arne Senftleben, Thomas Baumert, and Rhodes, William T.
- Abstract
Ultrashort near-infrared femtosecond laser pulses have become the tool of choice for high-precision processing of transparent ultrawide bandgap materials, ranging from material ablation, amorphization, waveguide writing to optical data storage. The processing precision with ultrashort laser pulses is fundamentally limited in the lateral direction by diffraction, while self-absorption and self-reflection are limiting the achievable depth. In this chapter, we present one of the possible pathways to overcome these limits by utilizing temporal pulse-shaping technology. In the following, we review and discuss the main light-matter interaction mechanisms, multiphoton and avalanche excitation, and how ultrashort and temporally shaped femtosecond laser pulses address them differently, allowing the control over the spatial carrier distribution and the subsequent material processing. We demonstrate the potential of temporal pulse shaping as a tool for controlled nanostructuring below the typical limits by discussing our in situ and postmortem experimental and numerical studies on the spatial distribution of laser excitation in water, high-aspect-ratio structuring of fused silica, and the optoporation of cells.
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- 2023
32. Unraveling the role of the liver myeloid compartment during hepatitis C virus cure
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Emilie Crouchet, Thomas F. Baumert, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Les Hôpitaux Universitaires de Strasbourg (HUS), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-10-IAHU-0002,MIX-Surg,Institut de Chirurgie Mini-Invasive guidée par l'Image(2010), ANR-10-LABX-0028,HepSys,Functional genomics of viral hepatitis and liver disease(2010), ANR-21-RHUS-0001,DELIVER,Deliver therapeuthic innovation for advanced hepatic diseases(2021), and ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017)
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interferon-stimulated genes ,Hepatology ,exhaustion ,single cell RNA-Seq ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie ,Direct-acting antivirals ,innate immunity ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
No abstract available
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- 2023
33. Inhibiting cell-to-cell transmission to reach HDV cure: The importance of IFN-α
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Julie Lucifora, Eloi R. Verrier, Thomas F. Baumert, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Les Hôpitaux Universitaires de Strasbourg (HUS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), ANR-21-CE15-0035,DELTArget,Caractérisation de facteur cellulaires impliqués dans l'infection par le virus de l'hépatite D pour la caractérisation de nouvelles cibles antivirales(2021), European Project: 101021417,FIBCAN, and European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016)
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Hepatology ,Interferon-alpha ,Hepatitis Delta Virus ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
editorial research support, non-u.s. gov't 2022 Oct 2022 08 08 imported
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- 2022
34. The effects of high‐pressure homogenization, drying <scp>pH</scp> and propylene glycol on the emulsifying properties of pea protein powder
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Travis G. Burger, Caleb Mayfield, Joseph L. Baumert, and Yue Zhang
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Industrial and Manufacturing Engineering ,Food Science - Published
- 2022
35. Supplementary Data from Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial
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Martin J. van den Bent, Pim J. French, Thierry Gorlia, Brigitta G. Baumert, Vassilis Golfinopoulos, Kin Jip Cheung, Wilfred F.J. van IJcken, Rutger W.W. Brouwer, Hendrikus J. Dubbink, Peggy N. Atmodimedjo, Iris de Heer, Youri Hoogstrate, Andreas von Deimling, Pieter Wesseling, Johan M. Kros, Robert B. Jenkins, Kenneth Aldape, Myra E. van Linde, Catherine McBain, Michael Weller, Roberta Rudà, Walter Taal, Leland Rogers, Matthew Griffin, Sanjeev Gill, Olivier L. Chinot, Helen Wheeler, Warren P. Mason, Jean-Francois Baurain, Anna K. Nowak, Michael A. Vogelbaum, Sara C. Erridge, Paul M. Clement, Alba A. Brandes, Wolfgang Wick, Marc Sanson, and C. Mircea S. Tesileanu
- Abstract
Supplementary Data from Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial
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- 2023
36. Data from Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial
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Martin J. van den Bent, Pim J. French, Thierry Gorlia, Brigitta G. Baumert, Vassilis Golfinopoulos, Kin Jip Cheung, Wilfred F.J. van IJcken, Rutger W.W. Brouwer, Hendrikus J. Dubbink, Peggy N. Atmodimedjo, Iris de Heer, Youri Hoogstrate, Andreas von Deimling, Pieter Wesseling, Johan M. Kros, Robert B. Jenkins, Kenneth Aldape, Myra E. van Linde, Catherine McBain, Michael Weller, Roberta Rudà, Walter Taal, Leland Rogers, Matthew Griffin, Sanjeev Gill, Olivier L. Chinot, Helen Wheeler, Warren P. Mason, Jean-Francois Baurain, Anna K. Nowak, Michael A. Vogelbaum, Sara C. Erridge, Paul M. Clement, Alba A. Brandes, Wolfgang Wick, Marc Sanson, and C. Mircea S. Tesileanu
- Abstract
Purpose:In a post hoc analysis of the CATNON trial (NCT00626990), we explored whether adding temozolomide to radiotherapy improves outcome in patients with IDH1/2 wildtype (wt) anaplastic astrocytomas with molecular features of glioblastoma [redesignated as glioblastoma, isocitrate dehydrogenase–wildtype (IDH-wt) in the 2021 World Health Organization (WHO) classification of central nervous system tumors].Patients and Methods:From the randomized phase III CATNON study examining the addition of adjuvant and concurrent temozolomide to radiotherapy in anaplastic astrocytomas, we selected a subgroup of IDH1/2wt and H3F3Awt tumors with presence of TERT promoter mutations and/or EGFR amplifications and/or combined gain of chromosome 7 and loss of chromosome 10. Molecular abnormalities including MGMT promoter methylation status were determined by next-generation sequencing, DNA methylation profiling, and SNaPshot analysis.Results:Of the 751 patients entered in the CATNON study, 670 had fully molecularly characterized tumors. A total of 159 of these tumors met the WHO 2021 molecular criteria for glioblastoma, IDH-wt. Of these patients, 47 received radiotherapy only and 112 received a combination of radiotherapy and temozolomide. There was no added effect of temozolomide on either overall survival [HR, 1.19; 95% confidence interval (CI), 0.82–1.71] or progression-free survival (HR, 0.87; 95% CI, 0.61–1.24). MGMT promoter methylation was prognostic for overall survival, but was not predictive for outcome to temozolomide treatment either with respect to overall survival or progression-free survival.Conclusions:In this cohort of patients with glioblastoma, IDH-wt temozolomide treatment did not add benefit beyond that observed from radiotherapy, regardless of MGMT promoter status. These findings require a new well-powered prospective clinical study to explore the efficacy of temozolomide treatment in this patient population.
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- 2023
37. Supplementary Figure from Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial
- Author
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Martin J. van den Bent, Pim J. French, Thierry Gorlia, Brigitta G. Baumert, Vassilis Golfinopoulos, Kin Jip Cheung, Wilfred F.J. van IJcken, Rutger W.W. Brouwer, Hendrikus J. Dubbink, Peggy N. Atmodimedjo, Iris de Heer, Youri Hoogstrate, Andreas von Deimling, Pieter Wesseling, Johan M. Kros, Robert B. Jenkins, Kenneth Aldape, Myra E. van Linde, Catherine McBain, Michael Weller, Roberta Rudà, Walter Taal, Leland Rogers, Matthew Griffin, Sanjeev Gill, Olivier L. Chinot, Helen Wheeler, Warren P. Mason, Jean-Francois Baurain, Anna K. Nowak, Michael A. Vogelbaum, Sara C. Erridge, Paul M. Clement, Alba A. Brandes, Wolfgang Wick, Marc Sanson, and C. Mircea S. Tesileanu
- Abstract
Supplementary Figure from Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial
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- 2023
38. Impact of COVID-19 pandemic on older cancer patients: Proposed solution by the International Geriatric Radiotherapy Group
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Nam Phong Nguyen, Ulf Lennart Karlsson, David Lehrman, Thandeka Mazibuko, Tatul Saghatelyan, Juliette Thariat, Brigitta G. Baumert, Vincent Vinh-Hung, Olena Gorobets, Huan Giap, Sankalp Singh, Alexander Chi, Graciana Alessandrini, Abhinav Ahluwalia, Francis Durosinmi-Etti, Jorge Zegarra Cárdenas, Koniba Diabate, Joan Oboite, Eromosele Oboite, Tahir Mehmood, Te Vuong, Lyndon Kim, and Brandi R. Page
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Cancer Research ,Oncology - Abstract
Older cancer patients are disproportionally affected by the Coronavirus 19 (COVID-19) pandemic. A higher rate of death among the elderly and the potential for long-term disability have led to fear of contracting the virus in these patients. This fear can, paradoxically, cause delay in diagnosis and treatment that may lead to a poor outcome that could have been prevented. Thus, physicians should devise a policy that both supports the needs of older patients during cancer treatment, and serves to help them overcome their fear so they seek out to cancer diagnosis and treatment early. A combination of telemedicine and a holistic approach, involving prayers for older cancer patients with a high level of spirituality, may improve vaccination rates as well as quality of life during treatment. Collaboration between health care workers, social workers, faith-based leaders, and cancer survivors may be crucial to achieve this goal. Social media may be an important component, providing a means of sending the positive message to older cancer patients that chronological age is not an impediment to treatment.
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- 2023
39. Whole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics
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Mümtaz Köksal, Jonathan Baumert, Danny Jazmati, Felix Schoroth, Stephan Garbe, David Koch, Davide Scafa, Gustavo R. Sarria, Christina Leitzen, Gregor Massoth, Achilles Delis, Annkristin Heine, Tobias Holderried, Peter Brossart, Thomas Müdder, and Leonard C. Schmeel
- Subjects
Cancer Research ,Oncology ,General Medicine - Abstract
Background Intensity-modulated helical tomotherapy (HT) is a promising technique in preparation for bone marrow transplantation. Nevertheless, radiation-sensitive organs can be substantially compromised due to suboptimal delivery techniques of total body irradiation (TBI). To reduce the potential burden of radiation toxicity to organs at risk (OAR), high-quality coverage and homogeneity are essential. We investigated dosimetric data from kidney, lung and thorax, liver, and spleen in relation to peripheral blood kinetics. To further advance intensity-modulated total body irradiation (TBI), the potential for dose reduction to lung and kidney was considered in the analysis. Patients and methods 46 patients undergoing TBI were included in this analysis, partially divided into dose groups (2, 4, 8, and 12 Gy). HT was performed using a rotating gantry to ensuring optimal reduction of radiation to the lungs and kidneys and to provide optimal coverage of other OAR. Common dosimetric parameters, such as D05, D95, and D50, were calculated and analysed. Leukocytes, neutrophils, platelets, creatinine, GFR, haemoglobin, overall survival, and graft-versus-host disease were related to the dosimetric evaluation using statistical tests. Results The mean D95 of the lung is 48.23%, less than half the prescribed and unreduced dose. The D95 of the chest is almost twice as high at 84.95%. Overall liver coverage values ranged from 96.79% for D95 to 107% for D05. The average dose sparing of all patients analysed resulted in an average D95 of 68.64% in the right kidney and 69.31% in the left kidney. Average D95 in the spleen was 94.28% and D05 was 107.05%. Homogeneity indexes ranged from 1.12 for liver to 2.28 for lung. The additional significance analyses conducted on these blood kinetics showed a significant difference between the 2 Gray group and the other three groups for leukocyte counts. Further statistical comparisons of the dose groups showed no significant differences. However, there were significant changes in the dose of OAR prescribed with dose sparing (e.g., lung vs. rib and kidney). Conclusion Using intensity-modulated helical tomotherapy to deliver TBI is a feasible method in preparation for haematopoietic stem cell transplantation. Significant dose sparing in radiosensitive organs such as the lungs and kidneys is achievable with good overall quality of coverage. Peripheral blood kinetics support the positive impact of HT and its advantages strongly encourage its implementation within clinical routine.
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- 2023
40. Tumor microenvironment-derived serum markers as a new frontier of diagnostic and prognostic assessment in biliary tract cancers
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Romain Désert, Fabio Giannone, Catherine Schuster, Thomas F. Baumert, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-21-RHUS-0001,DELIVER,Deliver therapeuthic innovation for advanced hepatic diseases(2021), ANR-10-LABX-0028,HepSys,Functional genomics of viral hepatitis and liver disease(2010), ANR-10-IAHU-0002,MIX-Surg,Institut de Chirurgie Mini-Invasive guidée par l'Image(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017)
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Cancer Research ,Oncology ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,pathology ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie ,Sciences du Vivant [q-bio]/Cancer - Abstract
editorial research support, n.i.h., extramural research support, non-u.s. gov't 2023 Mar 01 2022 12 01 imported
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- 2023
41. Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter
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Sławomir Milczarek, Piotr Kulig, Alina Zuchmańska, Bartłomiej Baumert, Bogumiła Osękowska, Anna Bielikowicz, Ewa Wilk-Milczarek, and Bogusław Machaliński
- Subjects
non-hematological malignancy ,Cancer Research ,hematological malignancy ,auto-HSCT ,Oncology ,PICC ,allo-HSCT ,CICC ,high-dose chemotherapy - Abstract
The management of patients undergoing stem cell transplantation requires a multipurpose central venous catheter (CVC) to facilitate drug administration, parenteral nutrition, transfusion of blood products, and collection of blood samples. Peripherally inserted central venous catheters (PICCs) appear to meet these requirements but are rarely used for stem cell infusion. We aimed to retrospectively assess the safety and feasibility of stem cell infusion through PICC and to evaluate its impact on transplantation kinetics. We retrospectively analyzed the outcomes of peripheral blood stem cell (PBSC) transplantation in patients receiving cryopreserved autologous or allogeneic PBSC by PICCs and compared the results with patients receiving transplants through a conventionally inserted central venous catheter (CICC). Despite statistically significant differences in CD34+ dose, infusion rate, and total length of administration, the clinical outcomes of transplantation, exemplified by platelet and neutrophil engraftment, along with the length of hospitalization, were not affected by the prolonged infusion time and lower infusion velocity in the PICC group. Our study showed that the clinical outcomes of PBSC transplantation did not differ between the PICC and CICC groups, suggesting that both types of catheters can be implemented in a PBSC transplantation setting.
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- 2023
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42. DOS APLICACIONES DEL ANÁLISIS ECONÓMICO DEL DERECHO A LA LUCHA ANTITERRORISTA EN ESPAÑA
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Thomas Baumert and Mikel Buesa
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- 2023
43. LA LUCHA ECONÓMICA ANTITERRORISTA EN FRANCIA
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Geoffrey Ditta and Thomas Baumert
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- 2023
44. Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study
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Jesse A. Goodrich, Douglas I. Walker, Jingxuan He, Xiangping Lin, Brittney O. Baumert, Xin Hu, Tanya L. Alderete, Zhanghua Chen, Damaskini Valvi, Zoe C. Fuentes, Sarah Rock, Hongxu Wang, Kiros Berhane, Frank D. Gilliland, Michael I. Goran, Dean P. Jones, David V. Conti, and Leda Chatzi
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Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health - Published
- 2023
45. Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment
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Natascha Roehlen, Marion Muller, Zeina Nehme, Emilie Crouchet, Frank Jühling, Fabio Del Zompo, Sara Cherradi, Francois H.T. Duong, Nuno Almeida, Antonio Saviano, Mirian Fernández-Vaquero, Tobias Riedl, Houssein El Saghire, Sarah C. Durand, Clara Ponsolles, Marine A. Oudot, Romain Martin, Nicolas Brignon, Emanuele Felli, Patrick Pessaux, Antonin Lallement, Irwin Davidson, Simonetta Bandiera, Christine Thumann, Patrice Marchand, Solange Moll, Brandon Nicolay, Nabeel Bardeesy, Yujin Hoshida, Mathias Heikenwälder, Roberto Iacone, Alberto Toso, Markus Meyer, Greg Elson, Tamas Schweighoffer, Geoffrey Teixeira, Mirjam B. Zeisel, Patrice Laquerriere, Joachim Lupberger, Catherine Schuster, Laurent Mailly, Thomas F. Baumert, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nouvel Hôpital Civil de Strasbourg, L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre médical universitaire de Genève (CMU), Harvard Medical School [Boston] (HMS), University of Texas Southwestern Medical Center, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), and Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)
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tumor immune microenvironment ,Hepatology ,tight junction ,Aucun ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie ,resistance ,stemness ,pharmacology ,therapeutic use ,CLDN1 ,plasticity ,genetics ,HCC ,Liver cancer ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Despite recent approvals, the response to treatment and prognosis of patients with advanced hepatocellular carcinoma (HCC) remain poor. Claudin-1 (CLDN1) is a membrane protein that is expressed at tight junctions, but it can also be exposed non-junctionally, such as on the basolateral membrane of the human hepatocyte. While CLDN1 within tight junctions is well characterized, the role of non-junctional CLDN1 and its role as a therapeutic target in HCC remains unexplored. Using humanized monoclonal antibodies (mAbs) specifically targeting the extracellular loop of human non-junctional CLDN1 and a large series of patient-derived cell-based and animal model systems we aimed to investigate the role of CLDN1 as a therapeutic target for HCC. Targeting non-junctional CLDN1 markedly suppressed tumor growth and invasion in cell line-based models of HCC and patient-derived 3D ex vivo models. Moreover, the robust effect on tumor growth was confirmed in vivo in a large series of cell line-derived xenograft and patient-derived xenograft mouse models. Mechanistic studies, including single-cell RNA sequencing of multicellular patient HCC tumorspheres, suggested that CLDN1 regulates tumor stemness, metabolism, oncogenic signaling and perturbs the tumor immune microenvironment. Our results provide the rationale for targeting CLDN1 in HCC and pave the way for the clinical development of CLDN1-specific mAbs for the treatment of advanced HCC. Hepatocellular carcinoma (HCC) is associated with high mortality and unsatisfactory treatment options. Herein, we identified the cell surface protein Claudin-1 as a treatment target for advanced HCC. Monoclonal antibodies targeting Claudin-1 inhibit tumor growth in patient-derived ex vivo and in vivo models by modulating signaling, cell stemness and the tumor immune microenvironment. Given the differentiated mechanism of action, the identification of Claudin-1 as a novel therapeutic target for HCC provides an opportunity to break the plateau of limited treatment response. The results of this preclinical study pave the way for the clinical development of Claudin-1-specific antibodies for the treatment of advanced HCC. It is therefore of key impact for physicians, scientists and drug developers in the field of liver cancer and gastrointestinal oncology. journal article research support, non-u.s. gov't 2023 Feb 2022 10 27 imported
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- 2023
46. Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms
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Julie Lucifora, Dulce Alfaiate, Caroline Pons, Maud Michelet, Ricardo Ramirez, Floriane Fusil, Fouzia Amirache, Axel Rossi, Anne-Flore Legrand, Emilie Charles, Serena Vegna, Rayan Farhat, Michel Rivoire, Guillaume Passot, Nicolas Gadot, Barbara Testoni, Charlotte Bach, Thomas F. Baumert, Anastasia Hyrina, Rudolf K. Beran, Fabien Zoulim, Andre Boonstra, Hildegard Büning, Eloi R. Verrier, François-Loïc Cosset, Simon P. Fletcher, Anna Salvetti, David Durantel, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Gilead Sciences, Inc. [Foster City, CA, USA], Virus enveloppés, vecteurs et immunothérapie – Enveloped viruses, Vectors and Immuno-therapy (EVIR), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Institute of Experimental Hematology [Hannover, Germany], Hannover Medical School [Hannover] (MHH), Application des ultrasons à la thérapie (LabTAU), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre pour l'innovation en cancérologie de Lyon (CICLY), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre Léon Bérard [Lyon], Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Croix-Rousse [CHU - HCL], Gastroenterology and Hepatology, Erasmus University Medical Center [Rotterdam] (Erasmus MC), German Center for Infection Research - partner site Hannover-Braunschweig (DZIF), and Gastroenterology & Hepatology
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Hepatology ,SDG 3 - Good Health and Well-being ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie - Abstract
Background & Aims: Chronic coinfection with HBV and HDV leads to the most aggressive form of chronic viral hepatitis. Herein, we aimed to elucidate the molecular mechanisms underlying the widely reported observation that HDV interferes with HBV in most coinfected patients. Methods: Patient liver tissues, primary human hepatocytes, HepaRG cells and human liver chimeric mice were used to analyze the effect of HDV on HBV using virological and RNA-sequencing analyses, as well as RNA synthesis, stability and association assays. Results: Transcriptomic analyses in cell culture and mouse models of coinfection enabled us to define an HDV-induced signature, mainly composed of interferon (IFN)-stimulated genes (ISGs). We also provide evidence that ISGs are upregulated in chronically HDV/HBV-coinfected patients but not in cells that only express HDV antigen (HDAg). Inhibition of the hepatocyte IFN response partially rescued the levels of HBV parameters. We observed less HBV RNA synthesis upon HDV infection or HDV protein expression. Additionally, HDV infection or expression of HDAg alone specifically accelerated the decay of HBV RNA, and HDAg was associated with HBV RNAs. On the contrary, HDAg expression did not affect other viruses such as HCV or SARS-CoV-2. Conclusions: Our data indicate that HDV interferes with HBV through both IFN-dependent and IFN-independent mechanisms. Specifically, we uncover a new viral interference mechanism in which proteins of a satellite virus affect the RNA production of its helper virus. Exploiting these findings could pave the way to the development of new therapeutic strategies against HBV. Impact and implications: Although the molecular mechanisms remained unexplored, it has long been known that despite its dependency, HDV decreases HBV viremia in patients. Herein, using in vitro and in vivo models, we showed that HDV interferes with HBV through both IFN-dependent and IFN-independent mechanisms affecting HBV RNA metabolism, and we defined the HDV-induced modulation signature. The mechanisms we uncovered could pave the way for the development of new therapeutic strategies against HBV by mimicking and/or increasing the effect of HDAg on HBV RNA. Additionally, the HDV-induced modulation signature could potentially be correlated with responsiveness to IFN-α treatment, thereby helping to guide management of HBV/HDV-coinfected patients.
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- 2023
47. Technology Demonstration for System of Magnetically Aligning Reconfigurable Tiny Cube Satellites (SMARTCubeS)
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Ryan W. Oroke, Garrett Schmitz, Grant Maclachlan, Johnathan Neptune, Holly Young, Jake Thames, Cole Smith, Brody Austin, Jared Baumert, Corey Schroeder, Tom DiSarro, and Mieszko Salamon
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- 2023
48. Development of victim sensitivity
- Author
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Baumert, Anna, Maltese, Simona, and Lischetzke, Tanja
- Abstract
How does the momentary processing of injustice link to level and change in dispositional victim sensitivity?
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- 2023
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49. The scientific basis of combination therapy for chronic hepatitis B functional cure
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Seng Gee Lim, Thomas F. Baumert, Carolina Boni, Ed Gane, Massimo Levrero, Anna S. Lok, Mala K. Maini, Norah A. Terrault, and Fabien Zoulim
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Hepatology ,Gastroenterology ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie - Abstract
Functional cure of chronic hepatitis B (CHB) - or hepatitis B surface antigen (HBsAg) loss after 24 weeks off therapy - is now the goal of treatment, but is rarely achieved with current therapy. Understanding the hepatitis B virus (HBV) life cycle and immunological defects that lead to persistence can identify targets for novel therapy. Broadly, treatments fall into three categories: those that reduce viral replication, those that reduce antigen load and immunotherapies. Profound viral suppression alone does not achieve quantitative (q)HBsAg reduction or HBsAg loss. Combining nucleos(t)ide analogues and immunotherapy reduces qHBsAg levels and induces HBsAg loss in some patients, particularly those with low baseline qHBsAg levels. Even agents that are specifically designed to reduce viral antigen load might not be able to achieve sustained HBsAg loss when used alone. Thus, rationale exists for the use of combinations of all three therapy types. Monitoring during therapy is important not just to predict HBsAg loss but also to understand mechanisms of HBsAg loss using viral and immunological biomarkers, and in selected cases intrahepatic sampling. We consider various paths to functional cure of CHB and the need to individualize treatment of this heterogeneous infection until a therapeutic avenue for all patients with CHB is available. journal article review 2023 Jan 11 2023 01 11 imported
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- 2023
50. L-SeqSleepNet: Whole-cycle Long Sequence Modelling for Automatic Sleep Staging
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Phan, Huy, Lorenzen, Kristian P., Heremans, Elisabeth, Chén, Oliver Y., Tran, Minh C., Koch, Philipp, Mertins, Alfred, Baumert, Mathias, Mikkelsen, Kaare, and De Vos, Maarten
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Signal Processing (eess.SP) ,FOS: Computer and information sciences ,Computer Science - Machine Learning ,FOS: Electrical engineering, electronic engineering, information engineering ,Electrical Engineering and Systems Science - Signal Processing ,Machine Learning (cs.LG) - Abstract
Human sleep is cyclical with a period of approximately 90 minutes, implying long temporal dependency in the sleep data. Yet, exploring this long-term dependency when developing sleep staging models has remained untouched. In this work, we show that while encoding the logic of a whole sleep cycle is crucial to improve sleep staging performance, the sequential modelling approach in existing state-of-the-art deep learning models are inefficient for that purpose. We thus introduce a method for efficient long sequence modelling and propose a new deep learning model, L-SeqSleepNet, which takes into account whole-cycle sleep information for sleep staging. Evaluating L-SeqSleepNet on four distinct databases of various sizes, we demonstrate state-of-the-art performance obtained by the model over three different EEG setups, including scalp EEG in conventional Polysomnography (PSG), in-ear EEG, and around-the-ear EEG (cEEGrid), even with a single EEG channel input. Our analyses also show that L-SeqSleepNet is able to alleviate the predominance of N2 sleep (the major class in terms of classification) to bring down errors in other sleep stages. Moreover the network becomes much more robust, meaning that for all subjects where the baseline method had exceptionally poor performance, their performance are improved significantly. Finally, the computation time only grows at a sub-linear rate when the sequence length increases., 9 pages, 4 figures, updated affiliations
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- 2023
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