1. Additional file 6 of Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
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Williams, Tristan, Bathe, Tim, Vo, Quan, Sacilotto, Patricia, McFarland, Karen, Ruiz, Alejandra Jolie, Hery, Gabriela P., Sullivan, Patrick, Borchelt, David R., Prokop, Stefan, and Chakrabarty, Paramita
- Abstract
Additional file 6: Table S1. Detailed information of human brains used in the study. Individually characterized brains were obtained from the University of Florida Neuromedicine Human Brain and Tissue Bank. Experimental Group denotes the designation used in this study (Fig. 7). Dx1, primary diagnosis based on neuropathology; Dx2, Dx3, Dx4, secondary diagnoses based on neuropathology; Thal phase, burden of immunostained amyloid deposits in cortical and subcortical area; CERAD score, neuritic plaque frequency; AD, Alzheimer's disease; ARTAG, Aging-related tau astrogliopathy; CAA, cerebral amyloid angiopathy; CVD, cardiovascular disease; LATE-NC, limbic-predominant age-related TDP-43 encephalopathy neuropathological change; LBD, Lewy body dementia; PART, primary age-related tauopathy. Table S2. Transcriptome analysis of forebrains of PS19 mice homozygous for APOE2, APOE3 or APOE4 and corresponding APOE TR lines. RNAseq data has been deposited in GEO database. A selection of genes that are altered in each experimental group comparisons are presented. The corresponding tables show the DEG analysis from the following comparisons: Table S2A, E2H vs E3H; Table S2B, E4H vs E3H; Table S2C, E4H vs E2H; Table S2D, PS/E2H vs PS/E3H; Table S2E, PS/E4H vs PS/E3H; Table S2F, PS/E4H vs PS/E2H; Table S2G, PS/E4H vs E4H; Table S2H, PS/E3H vs E3H; Table S2I, PS/E2H vs E2H.
- Published
- 2023
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