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1. Association between osteocalcin and cognitive performance in healthy older adults

Author

Bradburn S, Jamie McPhee, Bagley L, Sipila S, Stenroth L, Mv, Narici, Pääsuke M, Gapeyeva H, Osborne G, Sassano L, Cg, Meskers, Ab, Maier, Jy, Hogrel, Barnouin Y, Butler-Browne G, Murgatroyd C, Neuromechanics, Research Institute MOVE, Rehabilitation medicine, MOVE Research Institute, and Internal medicine

Subjects
cognition, Male, Aging, osteopontin, very elderly, Cognitive decline, sclerostin, Neuropsychological Tests, older people, Executive Function, Absorptiometry, Photon, Bone Density, blood analysis, cognitive defect, photon absorptiometry, 80 and over, calcium blood level, dickkopf 1 protein, 25 hydroxyvitamin D, calcium, fibroblast growth factor 23, osteocalcin, osteoprotegerin, parathyroid hormone, biological marker, osteocalcin, adult, aged, Article, bone density, bone remodeling, controlled study, cross-sectional study, dual energy X ray absorptiometry, episodic memory, executive function, female, human, male, neuropsychological test, priority journal, working memory, adolescent, age, aging, blood, clinical trial, cognitive aging, comparative study, Europe, metabolic bone disease, multicenter study, psychology, sex difference, short term memory, young adult, Absorptiometry, Photon, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Biomarkers, Bone Diseases, Metabolic, Bone Remodeling, Cognition, Cognition Disorders, Cognitive Aging, Cross-Sectional Studies, Female, Humans, Memory, Episodic, Memory, Short-Term, Osteocalcin, Sex Factors, Young Adult, Ageing, Older people, adult, Photon, young adult, Bone Diseases, Episodic, Research Paper, Memory, Absorptiometry, cognitive decline, ikääntyminen, Short-Term, Metabolic
Abstract

INTRODUCTION: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.METHODS: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery.RESULTS: adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (β = 0.444, P < 0.001) and global cognition (β = 0.381, P = 0.001) in the older women.DISCUSSION: these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans.

Published
2016
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2. Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults

Author

Sillanpää, Elina, Stenroth, Lauri, Bijlsma, A.Y., Rantanen, Taina, McPhee, J. S., Maden-Wilkinson, T. M., Jones, D. A., Narici, M. V., Gapeyeva, H., Pääsuke, M., Barnouin, Y., Butler-Browne, G. S., Meskers, C. G., Maier, A. B., Törmäkangas, Timo, and Sipilä, Sarianna

Subjects
lower extremity muscle power, timed up and go test, handgrip strength, six-minute walk test, spirometria, spirometric pulmonary function, knee extension torque
Abstract

Background: Pathological obstruction in lungs leads to severe decreases in muscle strength and mobility in patients suffering from chronic obstructive pulmonary disease. The purpose of this study was to investigate the interdependency between muscle strength, spirometric pulmonary functions and mobility outcomes in healthy older men and women, where skeletal muscle and pulmonary function decline without interference of overt disease. Methods: 135 69 to 81‐yr‐old participants were recruited into the cross‐sectional study, which was performed as a part of European study MyoAge. Full, partial and no mediation models were constructed to assess the interdependency between muscle strength (handgrip strength, knee extension torque, lower extremity muscle power), spirometric pulmonary function (FVC, FEV1 and FEF50) and mobility (6‐min walk and Timed Up and Go tests). The models were adjusted for age, sex, total fat mass, body height and site of enrolment. Results: Partial mediation models, indicating both direct and pulmonary function mediated associations between muscle strength and mobility, fitted best to the data. Greater handgrip strength was significantly associated with higher FVC, FEV1 and FEF50 (p

Published
2014

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