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4 results on '"Baquero, Eduard"'

1. Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller

Author

Molinos-Albert, Luis, Baquero, Eduard, Bouvin-Pley, Mélanie, Lorin, Valerie, Charre, Caroline, Planchais, Cyril, Dimitrov, Jordan, Monceaux, Valérie, Vos, Matthijn, Group, Anrs Visconti, Hocqueloux, Laurent, Berger, Jean-Luc, Seaman, Michael, Braibant, Martine, Avettand-Fenoël, Véronique, Sáez-Cirión, Asier, Mouquet, Hugo, Immunologie humorale - Humoral Immunology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Plateforme technologique Nanoimagerie / Nanoimaging Technological Platform, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Morphogénèse et antigénicité du VIH et du virus des Hépatites (MAVIVH - U1259 Inserm - CHRU Tours ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Réservoirs viraux et contrôle immunitaire / Viral reservoirs and immune control, HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Hôpital La Source [Orléans] (HLSO), Centre Hospitalier Universitaire de Reims (CHU Reims), Beth Israel Deaconess Medical Center [Boston] (BIDMC), and Harvard Medical School [Boston] (HMS)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; HIV-1 broadly neutralizing antibodies (bNAbs) can decrease viremia but are usually unable to counteract autologous viruses escaping the antibody pressure. Nonetheless, bNAbs may contribute to natural HIV-1 control in individuals off antiretroviral therapy (ART). Here, we describe a bNAb B cell lineage elicited in a post-treatment controller (PTC) that exhibits broad seroneutralization and show that a representative antibody from this lineage, EPTC112, targets a quaternary epitope in the glycan-V3 loop supersite of the HIV-1 envelope glycoprotein. The cryo-EM structure of EPTC112 complexed with soluble BG505 SOSIP.664 envelope trimers revealed interactions with N301- and N156-branched N-glycans and the 324GDIR327 V3 loop motif. Although the sole contemporaneous virus circulating in this PTC was resistant to EPTC112, it was potently neutralized by autologous plasma IgG antibodies. Our findings illuminate how cross-neutralizing antibodies can alter the HIV-1 infection course in PTCs and may control viremia off-ART, supporting their role in functional HIV-1 cure strategies.

Published
2023
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2. SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

Author

Huot, Nicolas, Rascle, Philippe, Petitdemange, Caroline, Contreras, Vanessa, Stürzel, Christina M., Baquero, Eduard, Harper, Justin L., Passaes, Caroline, Legendre, Rachel, Varet, Hugo, Madec, Yoann, Sauermann, Ulrike, Stahl-Hennig, Christiane, Nattermann, Jacob, Saez-Cirion, Asier, Le Grand, Roger, Keith Reeves, R., Paiardini, Mirko, Kirchhoff, Frank, Jacquelin, Beatrice, Müller-Trutwin, Michaela, Varet, Hugo, Organisation et montée en puissance d'une Infrastructure Nationale de Génomique - - France-Génomique2010 - ANR-10-INBS-0009 - INBS - VALID, Infrastructures - Infrastructure nationale pour la modélisation des maladies infectieuses humaines - - IDMIT2011 - ANR-11-INBS-0008 - INBS - VALID, Développment d'une infrastructure française distribuée coordonnée - - France-BioImaging2010 - ANR-10-INBS-0004 - INBS - VALID, HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Institut Pasteur [Paris] (IP), Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University of Ulm (UUlm), Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Yerkes National Primate Research Center [Lawrenceville, GA], Emory University [Atlanta, GA], Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Pôle Biomics (C2RT), Centre de Ressources et de Recherche Technologique - Center for Technological Resources and Research (C2RT), Institut Pasteur [Paris] (IP)-Institut Pasteur [Paris] (IP), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), German Primate Center - Deutsches Primatenzentrum -- Leibniz Insitute for Primate Research -- [Göttingen, Allemagne] (GPC - DPZ), Universitätsklinikum Bonn (UKB), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard Medical School [Boston] (HMS), Emory University School of Medicine, The Biomics Platform (C2RT, Institut Pasteur) is supported by France Génomique (ANR-10-INBS-09-09) and IBISA NH was supported by the VRI Labex, the Fondation Jacquelin Beytout and Institut Pasteur, and PR was recipient of a PhD fellowship from the University Paris Diderot, Sorbonne Paris Cité. C.P. was supported by a MSDAvenir Postdoctoral Fellowship Grant. FK was supported by the DFG (CRC 1279 and SPP 1923. We would like to acknowledge grant support from ANRS, the Fondation Jacqueline Beytout, and the Fondation Les Ailes to M.M.T., from the NIH (R01AI143457) to M.M.T. and R.K.R. and from MSDAvenir to A.S.C. and M.M.T., J.L.H. and M.P. were supported by NIH grant R01AI116379 to M.P. and by ORIP/OD award P51OD011132 to Yerkes National Primate Research Center. J.N. was supported by the DFG (SPP 1937, SFB TR57), the Hector Foundation, and the DZIF (TTU-HIV). We gratefully acknowledge the support to IDMIT from the French government: Investments for the Future program for infrastructures (PIA) through the ANR-11-INBS-0008 grant as well as from the PIA grant ANR-10-EQPX-02-01 to the FlowCyTech facility at IDMIT. We equally acknowledge the Investments for Future grant ANR-10–INSB–04 to support the UtechS Photonic BioImaging (Imagopole) and C2RT facilities at Institut Pasteur., ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), ANR-11-INBS-0008,IDMIT,Infrastructure nationale pour la modélisation des maladies infectieuses humaines(2011), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), HIV, Inflammation et persistance, Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Institut Pasteur [Paris], Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
CD4-Positive T-Lymphocytes, Male, MESH: Killer Cells, Natural, MESH: Cell Differentiation, Lymphoid Tissue, Science, animal diseases, [SDV]Life Sciences [q-bio], MESH: Simian Immunodeficiency Virus, Simian Acquired Immunodeficiency Syndrome, Fluorescent Antibody Technique, MESH: Algorithms, MESH: Lymph Nodes, MESH: Flow Cytometry, NK cells, Article, MESH: Chlorocebus aethiops, Chlorocebus aethiops, Animals, Humans, MESH: Animals, MESH: Fluorescent Antibody Technique, MESH: K562 Cells, Retrovirus, MESH: Humans, MESH: Transcriptome, MESH: Macaca, MESH: CD4-Positive T-Lymphocytes, Cell Differentiation, Flow Cytometry, MESH: Male, Killer Cells, Natural, [SDV] Life Sciences [q-bio], MESH: NK Cell Lectin-Like Receptor Subfamily C, Viral infection, MESH: Lymphoid Tissue, Macaca, Lymph node, Female, Simian Immunodeficiency Virus, Lymph Nodes, MESH: Simian Acquired Immunodeficiency Syndrome, K562 Cells, NK Cell Lectin-Like Receptor Subfamily C, Transcriptome, MESH: Female, Algorithms
Abstract

Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues., NK cells control SIV infection in secondary lymphoid tissues in the natural host that typically doesn’t progress toward disease. Here the authors show that this control is associated with terminal NK cell differentiation and improved MHC-E-dependent activity lacking in pathogenic SIV infection.

Published
2021
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3. Exploring the communicative competence in reading and writing of lower intermediate students through the implementation of the suggested English curriculum at a rural school on the Caribbean Colombian context

Author

Salgado Baquero, Eduard Daniel, Tovío Flórez, María José, and Ferrer Ariza, Erica

Subjects
Planificación curricular, Competencias comunicativas, Inglés -- Enseñanza
Abstract

La enseñanza del inglés en el sector oficial colombiano ha sido un reto en ciertos contextos por décadas, debido a una variedad de razones tales como limitadas oportunidades para el desarrollo profesional de los profesores, poca infraestructura y falta de recursos. En relación con esta última, en el pasado, pocos materiales estaban disponibles para el uso o referencia de los (las) docentes en su labor de apoyo del desarrollo la Competencia Comunicativa en inglés de sus estudiantes. Hoy día, las entidades gubernamentales han tomado algunas acciones que apuntan al desarrollo de las competencias en inglés de los estudiantes, de tal manera que ellos sean capaces de utilizar sus habilidades para comunicarse en una lengua extranjera. En consecuencia, el material propuesto a docentes e instituciones para guiar la enseñanza del inglés motivo este estudio de investigación acción, ejecutado con el objetivo de explorar el desarrollo de la Competencia Comunicativa en lectura y escritura a través de la implementación de secuencias didácticas basadas en el Currículo Sugerido de inglés para Colombia expedido por el Ministerio de Educación Nacional. Los participantes de esta investigación fueron veinte seis estudiantes de décimo grado de una institución educativa pública localizada en el área rural de Sahagún, Córdoba. Los instrumentos utilizados para recolectar la información fueron: exámenes, entrevistas, encuestas y tareas escritas que los estudiantes tuvieron que completar. Los resultados principales revelaron que los estudiantes tuvieron un leve avance en su Competencia Comunicativa en lectura y escritura.

Published
2018

4. ACTIVIDAD ANTIBACTERIANA DE Diplostephium tolimense Cuatrec. (ASTERACEAE) FRENTE A Staphylococcus aureus

Author

ÁVILA, Liliana, BAQUERO, Eduard, VIÑA, Amparo, and MURILLO, Elizabeth

Subjects
actividad antibaceriana, bioassay guided fractionation, terpenos, terpenoids, flavonoides, Diplostephium, fraccionamiento biodirigido, Antibacterial activity
Abstract

Se presenta el estudio de la actividad antibacteriana de la especie vegetal Diplostephium tolimense Cuatrec. (Asteraceae), colectada en el páramo del nevado del Tolima, la cual cuenta con pocos estudios químicos y farmacológicos, al igual que muchas otras especies de este ecosistema. A partir de un extracto etanólico crudo y mediante partición biodirigida se obtiene la fracción más simple de mayor actividad frente a Staphylococcus aureus (ATCC 25923). Paralelamente se realizan análisis fitoquímicos a las porciones de mayor bioactividad obtenidas durante todo el proceso. Se observa que la acción antibacteriana se incrementa al aumentar la simplicidad química del extracto y que terpenos y flavonoides parecen estar relacionados con la acción revelada. Se trata del primer reporte, hasta la fecha conocido, de actividad antibacteriana in vitro para D. tolimense. A study of antibacterial activity of the Diplostephium tolimense Cuatrec (Asteraceae) vegetal species, which was collected in the paramo of Tolima, is presented. This species, as many others of this ecosystem, has had few chemical and pharmacological studies. The simplest fraction with the largest activity against Staphylococcus aureus (ATCC 25923), is obtained starting from a raw ethanol extract and by means of bioassay guided partition. Parallelly, phytochemical analyses to the portions of greater bioactivity, obtained during the whole process, are carried out. It is observed that antibacterial action increases as the chemical simplicity increases and that the presence of terpenes and flavonoids seems to be related with this action. This is the first report, so far well-known, of in vitro antibacterial activity for D. tolimense.

Published
2006

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