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Additional file 1: Figure S1. Cumulative distribution function of RS-Total Change score by PGIC in (A) 205832 and (B) 205715 studies. Table S1. Eligibility criteria for the qualitative study (N = 25). Table S2. Eligibility criteria for GSK 205832 included in the psychometric evaluation. Table S3. Eligibility criteria for GSK 205715 for inclusion in the psychometric evaluation. Table S4. Study visit schedule for PRO collection in 205832 and 205715. Table S5. Summary of clinical trials 205832 and 205715. Table S6. Confirmatory factor analysis of E-RS: COPD at Week 0 in 205832 and 205715 studies. Table S7. Distribution-based approaches for the E-RS: Asthma.