1. Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes
- Author
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Sok, Nicolas, Bernhard, Claire, Désogère, Pauline, Goze, Christine, Rousselin, Yoann, Boschetti, Frédéric, Baglin, Isabelle, Denat, Franck, Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC), CheMatech - Macrocycle Design Technologies, Département de Pharmacie [CHU d'Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre National de la Recherche Scientifique (CNRS), University of Burgundy, and Conseil Regional de Bourgogne through the 3MIM Project
- Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry ,Bisaminal ,amd3100 ,copper(ii) complexes ,fluorescent sensor ,ligand ,cyclam derivatives ,inhibition ,Multifunctional chelating agents ,Regioselectivity ,macrocycles ,tetraazamacrocycles ,Cyclization ,cxcr4 ,radiopharmaceuticals - Abstract
International audience; An efficient route has been developed for the synthesis of multifunctional tetraazacycloalkanes (in particular 1,4,7,10-tetraazacyclotridecane) incorporating an aminomethyl pendant arm on the carbon skeleton. Starting from the appropriate C-functionalized bisaminal-protected intermediate, the target macrocycles were easily obtained by means of a step-by-step introduction of the desired functional groups onto the free primary amine group, followed by deprotection of the bisaminal intermediates. This straightforward and versatile synthetic approach paves the way for the design of a new family of multifunctional chelators.
- Published
- 2018
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