777 results on '"Bökenkamp A"'
Search Results
2. Hypertension in long-term childhood cancer survivors after treatment with potentially nephrotoxic therapy; DCCSS-LATER 2
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Esmee C.M. Kooijmans, Helena J.H. van der Pal, Saskia M.F. Pluijm, Dorine Bresters, Eline van Dulmen-den Broeder, Margriet van der Heiden-van der Loo, Marry M. van den Heuvel-Eibrink, Leontien C.M. Kremer, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J.C. Neggers, Maxime Pilon, Cécile Ronckers, Wim J.E. Tissing, Andrica C.H. de Vries, Gertjan J.L. Kaspers, Arend Bökenkamp, Margreet A. Veening, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Pediatrics, Internal Medicine, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), Paediatric Oncology, CCA - Cancer Treatment and Quality of Life, and Paediatrics
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Adult ,Cancer Research ,Adolescent ,Late effects ,Blood Pressure ,Pilot Projects ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,All institutes and research themes of the Radboud University Medical Center ,Cancer Survivors ,Oncology ,SDG 3 - Good Health and Well-being ,Neoplasms ,Hypertension ,Humans ,Ambulatory blood pressure monitoring ,Child ,Nephrotoxicity ,White Coat Hypertension ,Childhood cancer survivor - Abstract
Purpose: To evaluate the prevalence of and risk factors for hypertension in childhood cancer survivors (CCSs) who were treated with potentially nephrotoxic therapies.Methods: In the Dutch Childhood Cancer Survivor Study LATER cohort part 2 renal study, 1024 CCS ≥5 years after diagnosis, aged ≥18 years at study participation, treated between 1963 and 2001 with nephrectomy, abdominal radiotherapy, total body irradiation (TBI), cisplatin, carboplatin, ifosfamide, high-dose cyclophosphamide (≥1 g/m2 per single dose or ≥10 g/m2 total) or haematopoietic stem cell transplantation participated and 500 controls from Lifelines. Hypertension was defined as blood pressure (BP) (mmHg) systolic ≥140 and/or diastolic ≥90 or receiving medication for diagnosed hypertension. At the study visit, the CKD-EPI 2012 equation including creatinine and cystatin C was used to estimate the glomerular filtration rate (GFR). Multivariable regression analyses were used.For ambulatory BP monitoring (ABPM), hypertension was defined as BP daytime: systolic ≥135 and/or diastolic ≥85, night time: systolic ≥120 and/or diastolic ≥70, 24-h: systolic ≥130 and/or diastolic ≥80. Outcomes were masked hypertension (MH), white coat hypertension and abnormal nocturnal dipping (aND).Results: Median age at cancer diagnosis was 4.7 years (interquartile range, IQR 2.4–9.2), at study 32.5 years (IQR 27.7–38.0) and follow-up 25.5 years (IQR 21.4–30.3). The prevalence of hypertension was comparable in CCS (16.3%) and controls (18.2%). In 12% of CCS and 17.8% of controls, hypertension was undiagnosed. A decreased GFR (2) was associated with hypertension in CCS (OR 3.4, 95% CI 1.4–8.5). Risk factors were abdominal radiotherapy ≥20 Gy and TBI. The ABPM-pilot study (n = 77) showed 7.8% MH, 2.6% white coat hypertension and 20.8% aND.Conclusion: The prevalence of hypertension was comparable among CCS who were treated with potentially nephrotoxic therapies compared to controls, some of which were undiagnosed. Risk factors were abdominal radiotherapy ≥20 Gy and TBI. Hypertension and decreased GFR were associated with CCS. ABPM identified MH and a ND.
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- 2022
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3. Genotype and Phenotype Correlation in Patients With Dent's Disease Type 1-Clearing Muddy Waters
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Mannemuddhu, Sai Sudha, Bökenkamp, Arend, Pediatrics, and Amsterdam Reproduction & Development (AR&D)
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Nephrology - Published
- 2023
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4. Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome: an international cross-sectional study
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Verploegen, Maartje F A, Vargas-Poussou, Rosa, Walsh, Stephen B, Alpay, Harika, Amouzegar, Atefeh, Ariceta Iraola, Gema, Atmis, Bahriye, Bacchetta, Justine, Bárány, Peter, Baron, Stéphanie, Bayrakci, Umut Selda, Belge, Hendrica, Besouw, Martine, Blanchard, Anne, Bökenkamp, Arend, Boyer, Olivia, Burgmaier, Kathrin, Calò, Lorenzo A, Decramer, Stéphane, Devuyst, Olivier, van Dyck, Maria, Ferraro, Pietro Manuel, Fila, Marc, Francisco, Telma, Ghiggeri, Gian Marco, Gondra, Leire, Guarino, Stefano, Hooman, Nakysa, Hoorn, Ewout J, Houillier, Pascal, Kamperis, Konstantinos, Kari, Jameela A, Konrad, Martin, Levtchenko, Elena, Lucchetti, Laura, Lugani, Francesca, Marzuillo, Pierluigi, Mohidin, Barian, Neuhaus, Thomas J, Osman, Abdaldafae, Papizh, Svetlana, Perelló, Manel, Rookmaaker, Maarten B, Conti, Valerie Said, Santos, Fernando, Sawaf, Ghalia, Serdaroglu, Erkin, Szczepanska, Maria, Taroni, Francesca, Topaloglu, Rezan, Trepiccione, Francesco, Vidal, Enrico, Wan, Elizabeth R, Weber, Lutz, Yildirim, Zeynep Yuruk, Yüksel, Selçuk, Zlatanova, Galia, Bockenhauer, Detlef, Emma, Francesco, Nijenhuis, Tom, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Verploegen MFA] Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands. [Vargas-Poussou R] Department of Genetics, Centre de Références MARHEA, Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris, Paris, France. [Walsh SB] Department of Renal Medicine, University College London, London, UK. [Alpay H] Division of Paediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey. [Amouzegar A] Division of Nephrology, Department of Medicine, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran. [Ariceta G] Servei de Nefrologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Perelló M] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Verploegen M. F. A., Vargas-Poussou R., Walsh S. B., ALPAY H., Amouzegar A., Ariceta G., ATMIŞ B., Bacchetta J., Barany P., Baron S., et al., Verploegen, Maartje F A, Vargas-Poussou, Rosa, Walsh, Stephen B, Alpay, Harika, Amouzegar, Atefeh, Ariceta, Gema, Atmis, Bahriye, Bacchetta, Justine, Bárány, Peter, Baron, Stéphanie, Bayrakci, Umut Selda, Belge, Hendrica, Besouw, Martine, Blanchard, Anne, Bökenkamp, Arend, Boyer, Olivia, Burgmaier, Kathrin, Calò, Lorenzo A, Decramer, Stéphane, Devuyst, Olivier, van Dyck, Maria, Ferraro, Pietro Manuel, Fila, Marc, Francisco, Telma, Ghiggeri, Gian Marco, Gondra, Leire, Guarino, Stefano, Hooman, Nakysa, Hoorn, Ewout J, Houillier, Pascal, Kamperis, Konstantino, Kari, Jameela A, Konrad, Martin, Levtchenko, Elena, Lucchetti, Laura, Lugani, Francesca, Marzuillo, Pierluigi, Mohidin, Barian, Neuhaus, Thomas J, Osman, Abdaldafae, Papizh, Svetlana, Perelló, Manel, Rookmaaker, Maarten B, Conti, Valerie Said, Santos, Fernando, Sawaf, Ghalia, Serdaroglu, Erkin, Szczepanska, Maria, Taroni, Francesca, Topaloglu, Rezan, Trepiccione, Francesco, Vidal, Enrico, Wan, Elizabeth R, Weber, Lutz, Yildirim, Zeynep Yuruk, Yüksel, Selçuk, Zlatanova, Galia, Bockenhauer, Detlef, Emma, Francesco, Nijenhuis, Tom, and UCL - SSS/IREC/NEFR - Pôle de Néphrologie
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Internal Diseases ,Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Parathyroid Hormone [CHEMICALS AND DRUGS] ,Homeòstasi ,urologic and male genital diseases ,Sağlık Bilimleri ,İç Hastalıkları ,Clinical Medicine (MED) ,Bartter syndomr ,Transplantasyon ,Gitelman Syndrome/complications ,salt losing tubulopathies ,Homeostasis ,HYPERCALCIURIA ,Klinik Tıp (MED) ,Child ,enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::defectos congénitos del transporte tubular renal::síndrome de Gitelman [ENFERMEDADES] ,Klinik Tıp ,Hyperparathyroidism ,Tıp ,Nefroloji ,fenómenos fisiológicos::homeostasis [FENÓMENOS Y PROCESOS] ,Nephrology ,Üroloji ,Medicine ,Gitelman syndrome ,Ronyons - Malalties - Malformacions ,Urology ,CALCIUM ,Phosphates ,UROLOGY & NEPHROLOGY ,Health Sciences ,Humans ,parathyroid hormone ,HYPERPARATHYROIDISM ,ÜROLOJİ VE NEFROLOJİ ,hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas peptídicas::hormona paratiroidea [COMPUESTOS QUÍMICOS Y DROGAS] ,phosphate ,Transplantation ,Internal Medicine Sciences ,Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Tubular Transport, Inborn Errors::Bartter Syndrome [DISEASES] ,Dahili Tıp Bilimleri ,Hormones peptídiques ,CLINICAL MEDICINE ,GENE ,Bartter syndrome ,Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Tubular Transport, Inborn Errors::Gitelman Syndrome [DISEASES] ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,Cross-Sectional Studies ,Calcium ,Bartter Syndrome/complications ,Physiological Phenomena::Homeostasis [PHENOMENA AND PROCESSES] ,enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::defectos congénitos del transporte tubular renal::síndrome de Bartter [ENFERMEDADES] - Abstract
European Reference Network for Rare Kidney Diseases (ERKNet) - European Union; Dutch Kidney Foundation [19OI06], Verploegen MFA, Vargas-Poussou R, Walsh SB, Alpay H, Amouzegar A, Ariceta G, Atmis B, Bacchetta J, Bárány P, Baron S, Bayrakci US, Belge H, Besouw M, Blanchard A, Bökenkamp A, Boyer O, Burgmaier K, Calò LA, Decramer S, Devuyst O, van Dyck M, Ferraro PM, Fila M, Francisco T, Ghiggeri GM, Gondra L, Guarino S, Hooman N, Hoorn EJ, Houillier P, Kamperis K, Kari JA, Konrad M, Levtchenko E, Lucchetti L, Lugani F, Marzuillo P, Mohidin B, Neuhaus TJ, Osman A, Papizh S, Perelló M, Rookmaaker MB, Conti VS, Santos F, Sawaf G, Serdaroglu E, Szczepanska M, Taroni F, Topaloglu R, Trepiccione F, Vidal E, Wan ER, Weber L, Yildirim ZY, Yüksel S, Zlatanova G, Bockenhauer D, Emma F, Nijenhuis T
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- 2022
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5. Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa
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Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Björk, Natalie Ebert, Björn O Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bökenkamp, Ulla B Berg, Kajsa Åsling-Monemi, Anna Åkesson, Anders Larsson, Etienne Cavalier, R Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehlé, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P Strogoff-de-Matos, Justine B Bukabau, Ernest K Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, and Martin Flamant
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Transplantation ,glomerular filtration rate ,Nephrology ,creatinine ,race - Abstract
Background A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts. Methods Standardized creatinine and measured glomerular filtration rate (GFR) from the European EKFC cohorts (n = 13 856 including 6031 individuals in the external validation cohort), from France (n = 4429, including 964 Black Europeans), from Brazil (n = 100) and from Africa (n = 508) were used to test the performances of the equations. A matched analysis between White Europeans and Black Africans or Black Europeans was performed. Results In White Europeans (n = 9496), both the EKFC and LMREV equations outperformed CKD-EPIAS (bias of –0.6 and –3.2, respectively versus 5.0 mL/min/1.73 m², and accuracy within 30% of 86.9 and 87.4, respectively, versus 80.9%). In Black Europeans and Black Africans, the best performance was observed with the EKFC equation using a specific Q-value (= concentration of serum creatinine in healthy males and females). These results were confirmed in matched analyses, which showed that serum creatinine concentrations were different in White Europeans, Black Europeans and Black Africans for the same measured GFR, age, sex and body mass index. Creatinine differences were more relevant in males. Conclusion In a European and African cohort, the performances of CKD-EPIAS remain suboptimal. The EKFC equation, using usual or dedicated population-specific Q-values, presents the best performance in the whole age range in the European and African populations included in this study.
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- 2023
6. Cystatin C as a Marker for Glomerular Filtration Rate in Critically Ill Neonates and Children:Validation Against Iohexol Plasma Clearance
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Smeets, Nori J. L., Bökenkamp, A., Grubb, Anders, de Wildt, Saskia N., and Schreuder, Michiel F.
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- 2023
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7. Long-term multi-wavelength study of 1ES 0647+250
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MAGIC Collaboration, Acciari, V. A., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., González, J. Becerra, Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Carosi, R., Carretero-Castrillo, M., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Ramazani, V. Fallah, Fariña, L., Fattorini, A., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Inada, T., Iotov, R., Ishio, K., Iwamura, Y., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Lyard, E., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Aguilar, A. Mas, Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Moreno, V., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Rosillo, M. Nievas, Nigro, C., Nilsson, K., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Persic, M., Pihet, M., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sitarek, J., Sliusar, V., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Acosta-Pulido, J. A., D'Ammando, F., Hovatta, T., Kiehlmann, S., Liodakis, I., Leto, C., Max-Moerbeck, W., Pacciani, L., Perri, M., Readhead, A. C. S., Reeves, R. A., Verrecchia, F., University of La Laguna, National Institute for Astrophysics, University of Udine, Max-Planck-Institut für Physik, University of Padova, Institute for High Energy Physics, The University of Tokyo, Dortmund University, University of Zagreb, Universidad Complutense de Madrid, Centro Brasileiro de Pesquisas Físicas, University of Łódź, Metsähovi Radio Observatory, Aalto-yliopisto, and Aalto University
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High Energy Astrophysical Phenomena (astro-ph.HE) ,galaxies [Gamma rays] ,individual: 1ES 0647+250 [BL Lacertae objects] ,galaxies: active ,FOS: Physical sciences ,Astronomy and Astrophysics ,galaxies: jets ,BL Lacertae objects: individual: 1ES 0647+250 ,Active [Galaxies] ,Space and Planetary Science ,gamma rays: galaxies ,Galaxies: active, BL Lacertae objects: individual: 1ES 0647+250, galaxies: jets, gamma rays: galaxies ,jets [Galaxies] ,Astrophysics - High Energy Astrophysical Phenomena ,active ,BL Lacertae objects: individual: 1ES 0647+250 [galaxies] - Abstract
Context. The BL Lac object 1ES 0647+250 is one of the few distant γ-ray emitting blazars detected at very high energies (VHEs; ≳100 GeV) during a non-flaring state. It was detected with the MAGIC telescopes during a period of low activity in the years 2009−2011 as well as during three flaring activities in the years 2014, 2019, and 2020, with the highest VHE flux in the last epoch. An extensive multi-instrument data set was collected as part of several coordinated observing campaigns over these years. Aims. We aim to characterise the long-term multi-band flux variability of 1ES 0647+250, as well as its broadband spectral energy distribution (SED) during four distinct activity states selected in four different epochs, in order to constrain the physical parameters of the blazar emission region under certain assumptions. Methods. We evaluated the variability and correlation of the emission in the different energy bands with the fractional variability and the Z-transformed discrete correlation function, as well as its spectral evolution in X-rays and γ rays. Owing to the controversy in the redshift measurements of 1ES 0647+250 reported in the literature, we also estimated its distance in an indirect manner through a comparison of the GeV and TeV spectra from simultaneous observations with Fermi-LAT and MAGIC during the strongest flaring activity detected to date. Moreover, we interpret the SEDs from the four distinct activity states within the framework of one-component and two-component leptonic models, proposing specific scenarios that are able to reproduce the available multi-instrument data. Results. We find significant long-term variability, especially in X-rays and VHE γ rays. Furthermore, significant (3−4σ) correlations were found between the radio, optical, and high-energy (HE) γ-ray fluxes, with the radio emission delayed by about ∼400 days with respect to the optical and γ-ray bands. The spectral analysis reveals a harder-when-brighter trend during the non-flaring state in the X-ray domain. However, no clear patterns were observed for either the enhanced states or the HE (30 MeV < E < 100 GeV) and VHE γ-ray emission of the source. The indirect estimation of the redshift yielded a value of z = 0.45 ± 0.05, which is compatible with some of the values reported in the literature. The SEDs related to the low-activity state and the three flaring states of 1ES 0647+250 can be described reasonably well with the both one-component and two-component leptonic scenarios. However, the long-term correlations indicate the need for an additional radio-producing region located about 3.6 pc downstream from the gamma-ray producing region., Astronomy & Astrophysics, 670, ISSN:0004-6361, ISSN:1432-0746
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- 2023
8. Letter to the Editor
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Esmee C.M. Kooijmans, Helena J.H. van der Pal, Margreet A. Veening, Arend Bökenkamp, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, Pediatrics, and Amsterdam Reproduction & Development (AR&D)
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Nephrology - Published
- 2023
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9. sj-docx-1-pch-10.1177_21501351231168829 - Supplemental material for Combining Congenital Heart Surgical and Interventional Cardiology Outcome Data in a Single Database: The Development of a Patient-Centered Collaboration of the European Congenital Heart Surgeons Association (ECHSA) and the Association for European Paediatric and Congenital Cardiology (AEPC)
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Jacobs, Jeffrey P, Krasemann, Thomas, Herbst, Claudia, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, Ebels, Tjark, Vida, Vladimiro L, Mattila, Ilkka, Kansy, Andrzej, Asfour, Boulos, Hörer, Jürgen, Lotto, Attilio A, Çiçek, M Sertaç, Liuba, Petru, Dittrich, Sven, Chessa, Massimo, Bökenkamp, Regina, Sharland, Gurleen, Hanséus, Katarina, Blom, Nico A, and Sarris, George E
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Cardiology ,Paediatrics ,Surgery - Abstract
Supplemental material, sj-docx-1-pch-10.1177_21501351231168829 for Combining Congenital Heart Surgical and Interventional Cardiology Outcome Data in a Single Database: The Development of a Patient-Centered Collaboration of the European Congenital Heart Surgeons Association (ECHSA) and the Association for European Paediatric and Congenital Cardiology (AEPC) by Jeffrey P Jacobs, Thomas Krasemann, Claudia Herbst, Zdzislaw Tobota, Bohdan Maruszewski, Jose Fragata, Tjark Ebels, Vladimiro L Vida, Ilkka Mattila, Andrzej Kansy, Boulos Asfour, Jürgen Hörer, Attilio A Lotto, M Sertaç Çiçek, Petru Liuba, Sven Dittrich, Massimo Chessa, Regina Bökenkamp, Gurleen Sharland, Katarina Hanséus, Nico A Blom and George E Sarris in World Journal for Pediatric and Congenital Heart Surgery
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- 2023
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10. A lower bound on intergalactic magnetic fields from time variability of 1ES 0229+200 from MAGIC and Fermi/LAT observations
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Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Artero, M., Asano, K., Baack, D., Babic, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batkovic, I., González, J. Becerra, Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fariña, L., Fattorini, A., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Inada, T., Iotov, R., Ishio, K., Iwamura, Y., Martínez, I. Jiménez, Jormanainen, J., Jouvin, L., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Liodakis, I., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., de Oliveira Fraga, B. Machado, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Mariotti, M., Martínez, M., Aguilar, A. Mas, Mazin, D., Menchiari, S., Mender, S., Micanovic, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Nievas Rosillo, M., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sitarek, J., Šnidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Striškovic, J., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zaric, D., Neronov, A., Semikoz, D., Korochkin, A., MAGIC Collaboration, Département de Physique des Particules (ex SPP) (DPhP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), MAGIC, and HEP, INSPIRE
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,galaxies: active ,intergalactic magnetic fields ,FOS: Physical sciences ,Astronomy and Astrophysics ,early Universe ,magic ,fermi ,Space and Planetary Science ,gamma rays: galaxies ,ddc:520 ,intergalactic medium ,Early Universe ,Galaxies: active ,Gamma rays: galaxies ,Intergalactic medium ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph] ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Astronomy and astrophysics 670, A145 (2023). doi:10.1051/0004-6361/202244126, Context. Extended and delayed emission around distant TeV sources induced by the effects of propagation of γ ray s through the intergalactic medium can be used for the measurement of the intergalactic magnetic field (IGMF).Aims. We search for delayed GeV emission from the hard-spectrum TeV γ-ray emitting blazar 1ES 0229+200, with the goal of detecting or constraining the IGMF-dependent secondary flux generated during the propagation of TeV γ rays through the intergalactic medium.Methods. We analysed the most recent MAGIC observations over a 5 year time span, and complemented them with historic data of the H.E.S.S. and VERITAS telescopes, along with a 12-year-long exposure of the Fermi/LAT telescope. We used them to trace source evolution in the GeV–TeV band over a decade and a half. We used Monte Carlo simulations to predict the delayed secondary γ-ray flux, modulated by the source variability, as revealed by TeV-band observations. We then compared these predictions for various assumed IGMF strengths to all available measurements of the γ-ray flux evolution.Results. We find that the source flux in the energy range above 200 GeV experiences variations around its average on the 14-year time span of observations. No evidence for the flux variability is found in the 1 − 100 GeV energy range accessible to Fermi/LAT. The non-detection of variability due to delayed emission from electromagnetic cascade developing in the intergalactic medium imposes a lower bound of B > 1.8 × 10´$^{−17}$ G for the long-correlation-length IGMF and B > 10$^{−14}$ G for an IGMF of cosmological origin. Though weaker than the one previously derived from the analysis of Fermi/LAT data, this bound is more robust, being based on a conservative intrinsic source spectrum estimate and accounting for the details of source variability in the TeV energy band. We discuss implications of this bound for cosmological magnetic fields that might explain the baryon asymmetry of the Universe., Published by EDP Sciences, Les Ulis
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- 2023
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11. Strafbaarstelling van lijkschennis
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de Wilde, Bas, van Beers, Britta, Buisman, Sanne, and Bökenkamp, Daniel
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SDG 16 - Peace ,SDG 16 - Peace, Justice and Strong Institutions ,Justice and Strong Institutions - Abstract
Het doel van het onderzoek is om argumenten in kaart te brengen die relevant zijn voor de beantwoording van de vraag of het noodzakelijk is om bepaalde vormen van lijkschennis strafbaar te stellen dan wel bestaande strafbepalingen aan te passen en om op basis daarvan – indien het onderzoek daar aanleiding voor geeft – concrete aanbevelingen te doen voor aanpassing van de strafwetgeving. De centrale onderzoeksvraag luidt: Is het noodzakelijk om vormen van lijkschennis strafbaar te stellen die nog niet strafbaar zijn of om bestaande strafbepalingen ter zake van vormen van lijkschennis te wijzigen? Het onderzoek dat tot beantwoording van deze vraag leidt, is uitgevoerd aan de hand van de volgende deelvragen: Hoe wordt de integriteit van het gestorven lichaam buiten het strafrecht juridisch beschermd, zoals in de context van fundamentele rechten (art. 11 Grondwet en art. 3 en 8 EVRM), het privaatrecht en het gezondheidsrecht? Welke rechtsbeginselen en rechtsgoederen zijn daarbij relevant? Welke vormen van lijkschennis zijn naar huidig recht strafbaar of niet strafbaar in Nederland, hoe worden deze strafrechtelijk afgedaan en wat is de prevalentie ervan? Bestaat in Nederland draagvlak voor strafbaarstelling van vormen van lijkschennis die nog niet strafbaar zijn of voor wijziging van bestaande strafbepalingen ter zake van vormen van lijkschennis? Welke argumenten voor of tegen strafbaarstelling kunnen worden ontleend aan buitenlands recht? INHOUD Inleiding Criteria voor strafbaarstelling De juridische status van het lijk Strafbaarheid, afdoening en prevalentie van lijkschennis in Nederland Opvattingen over de strafbaarheid van lijkschennis in Nederland Rechtsvergelijking toepassing van de criteria voor strafbaarstelling op lijkschennis Conclusies
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- 2022
12. Strafbaarstelling van lijkschennis (WODC rapport)
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de Wilde, Bas, van Beers, Britta, Buisman, Sanne, Bökenkamp, Daniel, Legal Theory and Legal History, Boundaries of Law, Kooijmans Institute, Empirical and Normative Studies, and Criminal Law
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Strafbaarheid ,Schotland ,Persoonlijke levenssfeer ,Grafschennis ,Rechtsvergelijking ,Verenigde staten ,Organenhandel ,Zweden ,Duitsland ,Engeland ,Overlijden ,Mensenrechten ,Zedendelict ,Belgie ,Lichamelijke integriteit ,Frankrijk ,Strafvervolging ,Seksueel misbruik - Abstract
Het doel van het onderzoek is om argumenten in kaart te brengen die relevant zijn voor de beantwoording van de vraag of het noodzakelijk is om bepaalde vormen van lijkschennis strafbaar te stellen dan wel bestaande strafbepalingen aan te passen en om op basis daarvan – indien het onderzoek daar aanleiding voor geeft – concrete aanbevelingen te doen voor aanpassing van de strafwetgeving. De centrale onderzoeksvraag luidt: Is het noodzakelijk om vormen van lijkschennis strafbaar te stellen die nog niet strafbaar zijn of om bestaande strafbepalingen ter zake van vormen van lijkschennis te wijzigen? Het onderzoek dat tot beantwoording van deze vraag leidt, is uitgevoerd aan de hand van de volgende deelvragen: Hoe wordt de integriteit van het gestorven lichaam buiten het strafrecht juridisch beschermd, zoals in de context van fundamentele rechten (art. 11 Grondwet en art. 3 en 8 EVRM), het privaatrecht en het gezondheidsrecht? Welke rechtsbeginselen en rechtsgoederen zijn daarbij relevant? Welke vormen van lijkschennis zijn naar huidig recht strafbaar of niet strafbaar in Nederland, hoe worden deze strafrechtelijk afgedaan en wat is de prevalentie ervan? Bestaat in Nederland draagvlak voor strafbaarstelling van vormen van lijkschennis die nog niet strafbaar zijn of voor wijziging van bestaande strafbepalingen ter zake van vormen van lijkschennis? Welke argumenten voor of tegen strafbaarstelling kunnen worden ontleend aan buitenlands recht? INHOUD Inleiding Criteria voor strafbaarstelling De juridische status van het lijk Strafbaarheid, afdoening en prevalentie van lijkschennis in Nederland Opvattingen over de strafbaarheid van lijkschennis in Nederland Rechtsvergelijking toepassing van de criteria voor strafbaarstelling op lijkschennis Conclusies
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- 2022
13. Strafbaarstelling van lijkschennis
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de Wilde, Bas, van Beers, Britta, Buisman, Sanne, Bökenkamp, Daniel, Legal Theory and Legal History, Kooijmans Institute, Empirical and Normative Studies, Criminal Law, and Boundaries of Law
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SDG 16 - Peace, Justice and Strong Institutions - Abstract
Het doel van het onderzoek is om argumenten in kaart te brengen die relevant zijn voor de beantwoording van de vraag of het noodzakelijk is om bepaalde vormen van lijkschennis strafbaar te stellen dan wel bestaande strafbepalingen aan te passen en om op basis daarvan – indien het onderzoek daar aanleiding voor geeft – concrete aanbevelingen te doen voor aanpassing van de strafwetgeving. De centrale onderzoeksvraag luidt: Is het noodzakelijk om vormen van lijkschennis strafbaar te stellen die nog niet strafbaar zijn of om bestaande strafbepalingen ter zake van vormen van lijkschennis te wijzigen? Het onderzoek dat tot beantwoording van deze vraag leidt, is uitgevoerd aan de hand van de volgende deelvragen: Hoe wordt de integriteit van het gestorven lichaam buiten het strafrecht juridisch beschermd, zoals in de context van fundamentele rechten (art. 11 Grondwet en art. 3 en 8 EVRM), het privaatrecht en het gezondheidsrecht? Welke rechtsbeginselen en rechtsgoederen zijn daarbij relevant? Welke vormen van lijkschennis zijn naar huidig recht strafbaar of niet strafbaar in Nederland, hoe worden deze strafrechtelijk afgedaan en wat is de prevalentie ervan? Bestaat in Nederland draagvlak voor strafbaarstelling van vormen van lijkschennis die nog niet strafbaar zijn of voor wijziging van bestaande strafbepalingen ter zake van vormen van lijkschennis? Welke argumenten voor of tegen strafbaarstelling kunnen worden ontleend aan buitenlands recht? INHOUD Inleiding Criteria voor strafbaarstelling De juridische status van het lijk Strafbaarheid, afdoening en prevalentie van lijkschennis in Nederland Opvattingen over de strafbaarheid van lijkschennis in Nederland Rechtsvergelijking toepassing van de criteria voor strafbaarstelling op lijkschennis Conclusies
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- 2022
14. Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome: an international cross-sectional study
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Verploegen, Maartje F A, Vargas-Poussou, Rosa, Walsh, Stephen B, Alpay, Harika, Amouzegar, Atefeh, Ariceta, Gema, Atmis, Bahriye, Bacchetta, Justine, Bárány, Peter, Baron, Stéphanie, Bayrakci, Umut Selda, Belge, Hendrica, Besouw, Martine, Blanchard, Anne, Bökenkamp, Arend, Boyer, Olivia, Burgmaier, Kathrin, Calò, Lorenzo A, Decramer, Stéphane, Devuyst, Olivier, van Dyck, Maria, Ferraro, Pietro Manuel, Fila, Marc, Francisco, Telma, Ghiggeri, Gian Marco, Gondra, Leire, Guarino, Stefano, Hooman, Nakysa, Hoorn, Ewout J, Houillier, Pascal, et al, and University of Zurich
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570 Life sciences ,biology ,610 Medicine & health ,10052 Institute of Physiology - Published
- 2022
15. Correction to: Levamisole causes a transient increase in plasma creatinine levels but does not affect kidney function based on cystatin C (Pediatric Nephrology, (2022), 37, 10, (2515-2519), 10.1007/s00467-022-05547-9)
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Veltkamp, Floor, Bökenkamp, Arend, Slaats, Jeroen, Hamer, Henrike, Bouts, Antonia H. M., Graduate School, AII - Inflammatory diseases, Paediatric Nephrology, and Amsterdam Reproduction & Development (AR&D)
- Abstract
The original version of this article unfortunately contained a mistake. During the process of typesetting, the institutional author attribution “on behalf of the LEARNS consortium” was left out of the author group. The correct attribution is as shown above. The publisher apologizes for this mistake. The original article was updated.
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- 2022
16. Levamisole causes a transient increase in plasma creatinine levels but does not affect kidney function based on cystatin C
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Veltkamp, Floor, Bökenkamp, Arend, Slaats, Jeroen, Hamer, Henrike, Bouts, Antonia H. M., Graduate School, Pathology, Paediatric Nephrology, ARD - Amsterdam Reproduction and Development, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), and Clinical chemistry
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Nephrotic Syndrome ,Kidney ,urologic and male genital diseases ,Levamisole ,Nephrology ,Creatinine ,Pediatrics, Perinatology and Child Health ,Humans ,Kidney Diseases ,Estimated glomerular filtration rate ,Cystatin C ,Child ,Biomarkers ,Glomerular Filtration Rate - Abstract
Background In pediatric patients treated with levamisole to prevent relapses of idiopathic nephrotic syndrome (INS), a transient and non-progressive rise in creatinine levels has been observed. It has been suggested that levamisole affects tubular secretion of creatinine. However, other potential mechanisms — nephrotoxicity and interference with the analytical assay for creatinine — have never been thoroughly investigated. Methods In three steroid-sensitive nephrotic syndrome (SSNS) patients with elevated plasma creatinine levels, treated with levamisole 2.5 mg/kg every other day, serum cystatin C was determined. The glomerular filtration rate (GFR) was estimated using the full age spectrum for creatinine and the full age spectrum for cystatin C equations. Interference of levamisole with the enzymatic creatinine assay was tested using spare human plasma of different creatinine concentrations spiked with levamisole (4, 20, and 100 µM). Results Three patients who received levamisole with elevated plasma creatinine levels had normal serum cystatin C levels and corresponding estimated GFR. There was no assay interference. Conclusion Levamisole increases plasma creatinine levels, which is most probably due to impaired tubular secretion of creatinine since there was no assay interference and patients had normal eGFR based on serum cystatin C. However, interference of metabolites of levamisole could not be excluded. To monitor GFR, cystatin C in addition to creatinine should be used and be measured before and during levamisole use.
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- 2022
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17. Relationship Between Maximal Left Ventricular Wall Thickness and Sudden Cardiac Death in Childhood Onset Hypertrophic Cardiomyopathy
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Gabrielle Norrish, Tao Ding, Ella Field, Elena Cervi, Lidia Ziółkowska, Iacopo Olivotto, Diala Khraiche, Giuseppe Limongelli, Aris Anastasakis, Robert Weintraub, Elena Biagini, Luca Ragni, Terrence Prendiville, Sophie Duignan, Karen McLeod, Maria Ilina, Adrián Fernández, Chiara Marrone, Regina Bökenkamp, Anwar Baban, Peter Kubus, Piers E.F. Daubeney, Georgia Sarquella-Brugada, Sergi Cesar, Sabine Klaassen, Tiina H. Ojala, Vinay Bhole, Constancio Medrano, Orhan Uzun, Elspeth Brown, Ferran Gran, Gianfranco Sinagra, Francisco J. Castro, Graham Stuart, Gabriele Vignati, Hirokuni Yamazawa, Roberto Barriales-Villa, Luis Garcia-Guereta, Satish Adwani, Katie Linter, Tara Bharucha, Pablo Garcia-Pavia, Ana Siles, Torsten B. Rasmussen, Margherita Calcagnino, Caroline B. Jones, Hans De Wilde, Toru Kubo, Tiziana Felice, Anca Popoiu, Jens Mogensen, Sujeev Mathur, Fernando Centeno, Zdenka Reinhardt, Sylvie Schouvey, Costas O’Mahony, Rumana Z. Omar, Perry M. Elliott, Juan Pablo Kaski, Institut Català de la Salut, [Norrish G] Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom. Institute of Cardiovascular Sciences, University College London, United Kingdom. [Ding T] Department of Statistical Science, University College London, United Kingdom. [Field E, Cervi E] Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom. [Ziółkowska L] The Children’s Memorial Health Institute, Warsaw, Poland. [Olivotto I] Careggi University Hopsital, Florence, Italy. [Gran F] Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, University of Helsinki, Clinicum, Children's Hospital, HUS Children and Adolescents, Norrish, Gabrielle, Ding, Tao, Field, Ella, Cervi, Elena, Ziółkowska, Lidia, Olivotto, Iacopo, Khraiche, Diala, Limongelli, Giuseppe, Anastasakis, Ari, Weintraub, Robert, Biagini, Elena, Ragni, Luca, Prendiville, Terrence, Duignan, Sophie, Mcleod, Karen, Ilina, Maria, Fernandez, Adrian, Marrone, Chiara, Bökenkamp, Regina, Baban, Anwar, Kubus, Peter, Daubeney, Piers E F, Sarquella-Brugada, Georgia, Cesar, Sergi, Klaassen, Sabine, Ojala, Tiina H, Bhole, Vinay, Medrano, Constancio, Uzun, Orhan, Brown, Elspeth, Gran, Ferran, Sinagra, Gianfranco, Castro, Francisco J, Stuart, Graham, Vignati, Gabriele, Yamazawa, Hirokuni, Barriales-Villa, Roberto, Garcia-Guereta, Lui, Adwani, Satish, Linter, Katie, Bharucha, Tara, Garcia-Pavia, Pablo, Siles, Ana, Rasmussen, Torsten B, Calcagnino, Margherita, Jones, Caroline B, De Wilde, Han, Kubo, Toru, Felice, Tiziana, Popoiu, Anca, Mogensen, Jen, Mathur, Sujeev, Centeno, Fernando, Reinhardt, Zdenka, Schouvey, Sylvie, O'Mahony, Costa, Omar, Rumana Z, Elliott, Perry M, and Kaski, Juan Pablo
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Hypertrophy, Left Ventricular/complications ,sistema cardiovascular::corazón::ventrículos cardíacos [ANATOMÍA] ,Heart Ventricles ,FEATURES ,enfermedades cardiovasculares::enfermedades cardíacas::paro cardíaco::muerte súbita cardíaca [ENFERMEDADES] ,Cardiomyopathy, Hypertrophic/complications ,CHILDREN ,Heart Ventricles/diagnostic imaging ,DIAGNOSIS ,Cor - Hipertròfia - Complicacions ,Risk Assessment ,LONG-TERM OUTCOMES ,3123 Gynaecology and paediatrics ,Risk Factors ,death ,Physiology (medical) ,ADOLESCENTS ,human ,cardiovascular diseases ,humans ,death, sudden ,Death, Sudden, Cardiac/epidemiology ,Retrospective Studies ,sudden ,child ,IDENTIFICATION ,Mort sobtada ,adult ,Defibrillators, Implantable/adverse effects ,Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Cardiomyopathy, Hypertrophic [DISEASES] ,Cardiomyopathy, Hypertrophic ,Cardiovascular Diseases::Heart Diseases::Heart Arrest::Death, Sudden, Cardiac [DISEASES] ,hypertrophic cardiomyopathy ,Defibrillators, Implantable ,heart ventricle ,enfermedades cardiovasculares::enfermedades cardíacas::miocardiopatías::miocardiopatía hipertrófica [ENFERMEDADES] ,Death, Sudden, Cardiac ,Cardiovascular and Metabolic Diseases ,3121 General medicine, internal medicine and other clinical medicine ,RISK-FACTORS ,SURVIVAL ,cardiovascular system ,Hypertrophy, Left Ventricular ,hypertrophy ,Cardiology and Cardiovascular Medicine ,TASK-FORCE ,Cor - Ventricle esquerre ,Cardiovascular System::Heart::Heart Ventricles [ANATOMY] - Abstract
Background: Maximal left ventricular wall thickness (MLVWT) is a risk factor for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). In adults, the severity of left ventricular hypertrophy has a nonlinear relationship with SCD, but it is not known whether the same complex relationship is seen in childhood. The aim of this study was to describe the relationship between left ventricular hypertrophy and SCD risk in a large international pediatric HCM cohort. Methods: The study cohort comprised 1075 children (mean age, 10.2 years [±4.4]) diagnosed with HCM (1–16 years) from the International Paediatric Hypertrophic Cardiomyopathy Consortium. Anonymized, noninvasive clinical data were collected from baseline evaluation and follow-up, and 5-year estimated SCD risk was calculated (HCM Risk-Kids). Results: MLVWT Z score was Z scores were associated with heart failure symptoms, unexplained syncope, left ventricular outflow tract obstruction, left atrial dilatation, and nonsustained ventricular tachycardia. One hundred twenty-two patients (71.3%) with MLVWT Z score ≥20 had coexisting risk factors for SCD. Over a median follow-up of 4.9 years (interquartile range, 2.3–9.3), 115 (10.7%) had an SCD event. Freedom from SCD event at 5 years for those with MLVWT Z scores Z score, peaking at Z score +23. The presence of coexisting risk factors had a summative effect on risk. Conclusions: In children with HCM, an inverted U-shaped relationship exists between left ventricular hypertrophy and estimated SCD risk. The presence of additional risk factors has a summative effect on risk. While MLVWT is important for risk stratification, it should not be used either as a binary variable or in isolation to guide implantable cardioverter defibrillator implantation decisions in children with HCM.
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- 2022
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18. Biallelic variants in the SLC13A1 sulfate transporter gene cause hyposulfatemia with a mild spondylo-epi-metaphyseal dysplasia
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Jiddeke M. van de Kamp, Arend Bökenkamp, Desiree E. C. Smith, Mirjam M. C. Wamelink, Erwin E. W. Jansen, Eduard A. Struys, Quinten Waisfisz, Marieke Verkleij, Michaela F. Hartmann, Rong Wang, Stefan A. Wudy, Chiara Paganini, Antonio Rossi, Martijn J. J. Finken, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Gastroenterology Endocrinology Metabolism, Pediatrics, Amsterdam Reproduction & Development (AR&D), Genetic Metabolic Diseases, AGEM - Inborn errors of metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Laboratory Medicine, Psychiatry, and Clinical chemistry
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Genetics ,Genetics (clinical) - Abstract
Sulfate is the fourth most abundant anion in human plasma but is not measured in clinical practice and little is known about the consequences of sulfate deficiency. Nevertheless, sulfation plays an essential role in the modulation of numerous compounds, including proteoglycans and steroids. We report the first patient with a homozygous loss-of-function variant in the SLC13A1 gene, encoding a renal and intestinal sulfate transporter, which is essential for maintaining plasma sulfate levels. The homozygous (Arg12Ter) variant in SLC13A1 was found by exome sequencing performed in a patient with unexplained skeletal dysplasia. The main clinical features were enlargement of joints and spondylo-epi-metaphyseal radiological abnormalities in early childhood, which improved with age. In addition, autistic features were noted. We found profound hyposulfatemia due to complete loss of renal sulfate reabsorption. Cholesterol sulfate was reduced. Intravenous N-acetylcysteine administration temporarily restored plasma sulfate levels. We conclude that loss of the SLC13A1 gene leads to profound hypersulfaturia and hyposulfatemia, which is mainly associated with abnormal skeletal development, possibly predisposing to degenerative bone and joint disease. The diagnosis might be easily missed and more frequent.
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- 2022
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19. Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate
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Hans Pottel, Lola Jacquemont, Lionel Rostaing, Stephen T. Turner, Jonas Björk, Christophe Mariat, Andrew D. Rule, Anders Grubb, Kajsa Åsling-Monemi, Ulla B. Berg, Anna Åkesson, Lionel Couzi, Cyril Garrouste, Anders Larsson, Edmund J. Lamb, Per-Ola Sundin, Christophe Legendre, Elke Schaeffner, Luciano Selistre, Magnus Hansson, Toralf Melsom, Karin Littmann, Laurence Dubourg, Nassim Kamar, Arend Bökenkamp, François Gaillard, R Neil Dalton, Bjørn Odvar Eriksen, Pierre Delanaye, Natalie Ebert, Marie Courbebaisse, Ulf Nyman, Pediatric surgery, and Amsterdam Reproduction & Development (AR&D)
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medicine.medical_specialty ,Creatinine ,Cross-sectional study ,business.industry ,010102 general mathematics ,Urology ,External validation ,Renal function ,General Medicine ,medicine.disease ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,Internal Medicine ,medicine ,Pooled data ,030212 general & internal medicine ,0101 mathematics ,Young adult ,Internal validation ,business ,Kidney disease - Abstract
Background The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtration rate (GFR). However, these equations, as well as their combination, have limitations, notably the problem of implausible changes in GFR during the transition from adolescence to adulthood and overestimation of GFR in young adults. The full age spectrum (FAS) equation addresses these issues but overestimates GFR when SCr levels are low. Objective To develop and validate a modified FAS SCr-based equation combining design features of the FAS and CKD-EPI equations. Design Cross-sectional analysis with separate pooled data sets for development and validation. Setting Research and clinical studies (n = 13) with measured GFR available. Patients 11 251 participants in 7 studies (development and internal validation data sets) and 8378 participants in 6 studies (external validation data set). Measurements Clearance of an exogenous marker (reference method), SCr level, age, sex, and height were used to develop a new equation to estimate GFR. Results The new European Kidney Function Consortium (EKFC) equation is a FAS equation with low bias (-1.2 mL/min/1.73 m2 [95% CI, -2.7 to 0.0 mL/min/1.73 m2] in children and -0.9 mL/min/1.73 m2 [CI, -1.2 to -0.5 mL/min/1.73 m2] in adults) across the FAS (2 to 90 years) and SCr range (40 to 490 µmol/L [0.45 to 5.54 mg/dL]) and with fewer estimation errors exceeding 30% (6.5% [CI, 3.8% to 9.1%] in children and 3.1% [CI, 2.5% to 3.6%] in adults) compared with the CKiD and CKD-EPI equations. Limitation No Black patients were included. Conclusion The new EKFC equation shows improved accuracy and precision compared with commonly used equations for estimating GFR from SCr levels. Primary funding source Swedish Research Council (Vetenskapsradet).
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- 2021
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20. Transmission of Antibiotic-Susceptible Escherichia coli Causing Urinary Tract Infections in a Fecal Microbiota Transplantation Recipient: Consequences for Donor Screening?
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Karuna E W Vendrik, Tim G J de Meij, Arend Bökenkamp, Rogier E Ooijevaar, Bas Groenewegen, Antoni P A Hendrickx, Elisabeth M Terveer, Ed J Kuijper, Joffrey van Prehn, Pediatrics, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), and Gastroenterology and hepatology
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FMT ,Infectious Diseases ,ESBL ,uropathogen ,Oncology ,fecal microbiota transplantation ,MDRO ,urinary tract infection - Abstract
Fecal microbiota transplantation (FMT) has been reported to decrease the incidence of recurrent urinary tract infections (UTIs), presumably by restoring microbiome diversity and/or uropathogen competition. We report a 16-year-old female with recurrent UTIs caused by multidrug-resistant Klebsiella pneumoniae, for which frequent intravenous broad-spectrum antibiotic treatment was necessary. The patient was treated with FMT from a well-screened healthy donor without multidrug-resistant bacteria in the feces. After FMT, she developed several UTIs with an antibiotic-susceptible Escherichia coli that could be treated orally. The uropathogenic E. coli could be cultured from donor feces, and whole genome sequencing confirmed donor-to-recipient transmission. Our observation should stimulate discussion on long-term follow-up of all infections after FMT and donor fecal screening for antibiotic-susceptible Enterobacterales.
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- 2022
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21. Clinical features and natural history of preadolescent nonsyndromic hypertrophic cardiomyopathy
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Gabrielle Norrish, Aoife Cleary, Ella Field, Elena Cervi, Olga Boleti, Lidia Ziółkowska, Iacopo Olivotto, Diala Khraiche, Giuseppe Limongelli, Aris Anastasakis, Robert Weintraub, Elena Biagini, Luca Ragni, Terence Prendiville, Sophie Duignan, Karen McLeod, Maria Ilina, Adrian Fernandez, Chiara Marrone, Regina Bökenkamp, Anwar Baban, Peter Kubus, Piers E.F. Daubeney, Georgia Sarquella-Brugada, Sergi Cesar, Sabine Klaassen, Tiina H. Ojala, Vinay Bhole, Constancio Medrano, Orhan Uzun, Elspeth Brown, Ferran Gran, Gianfranco Sinagra, Francisco J. Castro, Graham Stuart, Hirokuni Yamazawa, Roberto Barriales-Villa, Luis Garcia-Guereta, Satish Adwani, Katie Linter, Tara Bharucha, Esther Gonzales-Lopez, Ana Siles, Torsten B. Rasmussen, Margherita Calcagnino, Caroline B. Jones, Hans De Wilde, Toru Kubo, Tiziana Felice, Anca Popoiu, Jens Mogensen, Sujeev Mathur, Fernando Centeno, Zdenka Reinhardt, Sylvie Schouvey, Perry M. Elliott, Juan Pablo Kaski, University of Helsinki, Clinicum, Children's Hospital, HUS Children and Adolescents, Institut Català de la Salut, [Norrish G] Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom. Institute of Cardiovascular Sciences, University College London, London, United Kingdom. [Cleary A, Field E, Cervi E] Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom. [Boleti O] Institute of Cardiovascular Sciences, University College London, London, United Kingdom. [Ziółkowska L] The Children’s Memorial Health Institute, Warsaw, Poland. [Gran F] Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Death, Sudden, Cardiac/prevention & control ,Cardiovascular Diseases::Heart Diseases::Heart Failure [DISEASES] ,phenotype ,Miocardi - Malalties - Diagnòstic ,Otros calificadores::/diagnóstico [Otros calificadores] ,intervenciones quirúrgicas::procedimientos quirúrgicos cardiovasculares::procedimientos quirúrgicos cardíacos::trasplante de corazón [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Insuficiència cardíaca ,Outcomes ,outcomes ,Childhood hypertrophic cardiomyopathy ,Age ,Cor - Hipertròfia - Diagnòstic ,Other subheadings::/diagnosis [Other subheadings] ,Humans ,Heart Transplantation/adverse effects ,Child ,Heart Failure ,Surgical Procedures, Operative::Cardiovascular Surgical Procedures::Cardiac Surgical Procedures::Heart Transplantation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Defibrillators, Implantable/adverse effects ,Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Cardiomyopathy, Hypertrophic [DISEASES] ,Cardiomyopathy, Hypertrophic/diagnosis ,Cardiomyopathy, Hypertrophic ,enfermedades cardiovasculares::enfermedades cardíacas::insuficiencia cardíaca [ENFERMEDADES] ,Defibrillators, Implantable ,enfermedades cardiovasculares::enfermedades cardíacas::miocardiopatías::miocardiopatía hipertrófica [ENFERMEDADES] ,Phenotype ,Death, Sudden, Cardiac ,age ,Cardiovascular and Metabolic Diseases ,childhood hypertrophic cardiomyopathy ,3121 General medicine, internal medicine and other clinical medicine ,Heart Transplantation ,Heart Failure/epidemiology ,Cardiology and Cardiovascular Medicine - Abstract
Childhood hypertrophic cardiomyopathy; Outcomes; Phenotype Miocardiopatía hipertrófica infantil; Resultados; Fenotipo Miocardiopatia hipertròfica infantil; Resultats; Fenotip Background Up to one-half of childhood sarcomeric hypertrophic cardiomyopathy (HCM) presents before the age of 12 years, but this patient group has not been systematically characterized. Objectives The aim of this study was to describe the clinical presentation and natural history of patients presenting with nonsyndromic HCM before the age of 12 years. Methods Data from the International Paediatric Hypertrophic Cardiomyopathy Consortium on 639 children diagnosed with HCM younger than 12 years were collected and compared with those from 568 children diagnosed between 12 and 16 years. Results At baseline, 339 patients (53.6%) had family histories of HCM, 132 (20.9%) had heart failure symptoms, and 250 (39.2%) were prescribed cardiac medications. The median maximal left ventricular wall thickness z-score was 8.7 (IQR: 5.3-14.4), and 145 patients (27.2%) had left ventricular outflow tract obstruction. Over a median follow-up period of 5.6 years (IQR: 2.3-10.0 years), 42 patients (6.6%) died, 21 (3.3%) underwent cardiac transplantation, and 69 (10.8%) had life-threatening arrhythmic events. Compared with those presenting after 12 years, a higher proportion of younger patients underwent myectomy (10.5% vs 7.2%; P = 0.045), but fewer received primary prevention implantable cardioverter-defibrillators (18.9% vs 30.1%; P = 0.041). The incidence of mortality or life-threatening arrhythmic events did not differ, but events occurred at a younger age. Conclusions Early-onset childhood HCM is associated with a comparable symptom burden and cardiac phenotype as in patients presenting later in childhood. Long-term outcomes including mortality did not differ by age of presentation, but patients presenting at younger than 12 years experienced adverse events at younger ages. This work was supported by the British Heart Foundation (grant FS/16/72/32270) to Drs Norrish and Kaski. This work is (partly) funded by the National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre. Dr Norrish is supported by Great Ormond Street Hospital Children’s Charity. Drs Field and Kaski are supported by Max’s Foundation and Great Ormond Street Hospital Children’s Charity. Dr Kaski is supported by a Medical Research Council–National Institute for Health Research Clinical Academic Research Partnership award. This work was financially supported by the Foundation for Paediatric Research of Finland (Dr Ojala). Dr Fernandez has received speaker fees from Sanofi-Genzyme. Dr Kubus is supported by MH CZ – DRO, Motol University Hospital (00064203). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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- 2022
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22. Proteinuria—take a closer look!
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Arend Bökenkamp
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Nephrology ,medicine.medical_specialty ,Kidney Glomerulus ,Urology ,Review ,urologic and male genital diseases ,Internal medicine ,Biopsy ,medicine ,Low molecular weight proteins ,Humans ,Selectivity ,Glomerular disease ,Kidney ,Proteinuria ,medicine.diagnostic_test ,Reabsorption ,business.industry ,urogenital system ,Acute kidney injury ,Tubulointerstitial disease ,medicine.disease ,female genital diseases and pregnancy complications ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Kidney Diseases ,medicine.symptom ,business ,Tubulointerstitial Disease ,Kidney disease - Abstract
Proteinuria is a hallmark of kidney disease. Therefore, measurement of urine protein content plays a central role in any diagnostic work-up for kidney disease. In many cases, proteinuria analysis is restricted to the measurement of total protein content knowing that very high levels of proteinuria (nephrotic proteinuria) are characteristic of glomerular disease. Still, proteinuria can also be a manifestation of impaired tubular protein reabsorption or even be physiological. This review will discuss the physiology of renal protein handling and give guidance on a more sophisticated analysis of proteinuria differentiating albumin, low-molecular weight proteins and immunoglobulins. These non-invasive tests are available in most routine clinical laboratories and may guide the clinician in the diagnostic process before ordering far more expensive (molecular genetic testing) and/or invasive (kidney biopsy) diagnostics.
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- 2020
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23. Combined dark matter searches towards dwarf spheroidal galaxies with Fermi-LAT, HAWC, H.E.S.S., MAGIC, and VERITAS
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Charles, E., Di Mauro, M., Giuri, C., Salazar-Gallegos, D., Zitzer, B., Abeysekara, A. U., Albert, A., Alfaro, R., Alvarez, C., Álvarez, J. D., Angeles Camacho, J. R., Arteaga-Velázquez, J. C., Arunbabu, K. P., Avila Rojas, D., Ayala Solares, H. A., Babu, R., Baghmanyan, V., Barber, A. S., Becerra Gonzalez, J., Belmont-Moreno, E., Benzvi, S. Y., Berley, D., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Chaparro-Amaro, O., Cotti, U., Cotzomi, J., Coutiño León, S., La Fuente, E., León, C., Diaz-Cruz, L., Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Durocher, M., Duvernois, M. A., Ellsworth, R. W., Engel, K., Espinoza, C., Fan, K. L., Fang, K., Fernández Alonso, M., Fick, B., Fleischhack, H., Flores, J. L., Fraija, N. I., Garcia, D., García-González, J. A., García-Luna, J. L., García-Torales, G., Garfias, F., Giacinti, G., Goksu, H., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Herzog, I., Hinton, J., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hui, C. M., Humensky, B., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Jhee, H., Joshi, V., Kieda, D., Kunde, G. J., Kunwar, S., Lara, A., Lee, J., Lee, W. H., Lennarz, D., León Vargas, H., Linnemann, J., Longinotti, A. L., López-Coto, R., Luis-Raya, G., Lundeen, J., Malone, K., Marandon, V., Martinez, O., Martinez-Castellanos, I., Martínez-Huerta, H., Martínez-Castro, J., Matthews, J. A. J., Mcenery, J., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Peisker, A., Pérez Araujo, Y., Pérez-Pérez, E. G., Rho, C. D., Rivière, C., Rosa-Gonzalez, D., Ruiz-Velasco, E., Ryan, J., Salazar, H., Salesa Greus, F., Sandoval, A., Schneider, M., Schoorlemmer, H., Serna-Franco, J., Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Taboada, I., Tanner, M., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Villaseñor, L., Wang, X., Watson, I. J., Weisgarber, T., Werner, F., Willox, E., Wood, J., Yodh, G. B., Zepeda, A., Zhou, H., Abdallah, H., Adam, R., Aharonian, F., Ait Benkhali, F., Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., Bony Lavergne, M., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Chand, T., Chandra, S., Chen, A., Cotter, G., Curyło, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P, Feijen, K., Fegan, S., Fiasson, A., Fichet Clairfontaine, G., Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H, Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu, Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P, Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marchegiani, P., Marcowith, A., Mares, A., Martì-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O’brien, P., Odaka, H., Ohm, S., Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schüssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., Walt, D. J., Eldik, C., Rensburg, C., Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., White, R., Wierzcholska, A., Wong, Y. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S., Zorn, J., Zouari, S., Z̀ywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D’amico, G., D’elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Do-Minis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Dorota Sobczynska, Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Adams, C. B., Archer, A., Benbow, W., Brill, A., Buckley, J. H., Capasso, M., Christiansen, J. L., Chromey, A. J., Errando, M., Falcone, A., Farrell, A., Feng, Q., Foote, G. M., Fortson, L., Furniss, A., Gent, A., Gillanders, G. H., Gueta, O., Hanna, D., Hervet, O., Holder, J., Humensky, T. B., Jin, W., Kaaret, P., Kertzman, M., Kleiner, T. K., Kumar, S., Lang, M. J., Lundy, M., Maier, G., Mcgrath, C. E., Moriarty, P., Mukherjee, R., Nieto, D., Nievas-Rosillo, M., O’brien, S., Ong, R. A., Otte, A. N., Patel, S. R., Patel, S., Pfrang, K., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Roache, E., Ryan, J. L., Sadeh, I., Santander, M., Sembroski, G. H., Shang, R., Tak, D., Vassiliev, V. V., Weinstein, A., Williams, D. A., Williamson, T. J., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Hess, HAWC, VERITAS, MAGIC, H.E.S.S., Fermi-LAT, Naurois , Mathieu, Ona-Wilhelmi , Emma, and Bony , Mathieu
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data analysis method ,talk: Berlin 2021/07/15 ,FOS: Physical sciences ,dark matter: signature ,dark matter: direct detection ,WIMP: dark matter ,channel cross section: upper limit ,annihilation [dark matter] ,GLAST ,High Energy Physics - Experiment ,dark matter [WIMP] ,WIMP: annihilation ,High Energy Physics - Experiment (hep-ex) ,Tellurium compounds ,Germanium compounds ,HESS ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Dark Matter ,ddc:530 ,annihilation [WIMP] ,ComputingMilieux_MISCELLANEOUS ,direct detection [dark matter] ,High Energy Astrophysical Phenomena (astro-ph.HE) ,energy: high ,upper limit [channel cross section] ,background ,Gamma rays ,dark matter: annihilation ,Berlin 2021/07/15 [talk] ,sensitivity ,Galaxies ,Maximum likelihood estimation ,MAGIC ,mass dependence ,Dark matter searches ,high [energy] ,VERITAS ,galaxy ,signature [dark matter] ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,HAWC ,experimental results - Abstract
Cosmological and astrophysical observations suggest that 85% of the total matter of the Universe is made of Dark Matter (DM). However, its nature remains one of the most challenging and fundamental open questions of particle physics. Assuming particle DM, this exotic form of matter cannot consist of Standard Model (SM) particles. Many models have been developed to attempt unraveling the nature of DM such as Weakly Interacting Massive Particles (WIMPs), the most favored particle candidates. WIMP annihilations and decay could produce SM particles which in turn hadronize and decay to give SM secondaries such as high energy γ rays. In the framework of indirect DM search, observations of promising targets are used to search for signatures of DM annihilation. Among these, the dwarf spheroidal galaxies (dSphs) are commonly favored owing to their expected high DM content and negligible astrophysical background. In this work, we present the very first combination of 20 dSph observations, performed by the Fermi-LAT, HAWC, H.E.S.S., MAGIC, and VERITAS collaborations in order to maximize the sensitivity of DM searches and improve the current results. We use a joint maximum likelihood approach combining each experiment’s individual analysis to derive more constraining upper limits on the WIMP DM self-annihilation cross-section as a function of DM particle mass. We present new DM constraints over the widest mass range ever reported, extending from 5 GeV to 100 TeV thanks to the combination of these five different γ-ray instruments., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference
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- 2022
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24. Searching for VHE gamma-ray emission associated with IceCube neutrino alerts using FACT, H.E.S.S., MAGIC, and VERITAS
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Konstancja, Satalecka, Acciari, Victor A., Stefano, Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel, Artero, Katsuaki, Asano, Dominik, Baack, Ana, Babic, Andr('(e))s, Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana, Batkovi('(c)), Josefa Becerra Gonzalez, Wlodek, Bednarek, Lorenzo, Bellizzi, Elisa, Bernardini, Maria-Isabel, Bernardos, Alessio, Berti, Jürgen, Besenrieder, Wrijupan, Bhattacharyya, Ciro, Bigongiari, Adrian, Biland, Oscar, Blanch, Hendrik, Bökenkamp, Giacomo, Bonnoli, Zeljka, Bosnjak, Giovanni, Busetto, Roberto, Carosi, Giovanni, Ceribella, Matteo, Cerruti, Yating, Chai, Ashot, Chilingarian, Stefan, Cikota, Sidika Merve Colak, Eduardo, Colombo, Jose Luis Contreras, Juan, Cortina, Stefano, Covino, Giacomo D( extquotesingle)Amico, Valerio D( extquotesingle)Elia, Paolo Da Vela, Francesco, Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel, Delfino, Jordi, Delgado, Carlos Delgado Mendez, Davide, Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espi(~(n))eira, Dijana Dominis Prester, Alice, Donini, Daniela, Dorner, Michele, Doro, Dominik, Elsaesser, Vandad Fallah Ramazani, Alicia, Fattorini, Maria Victoria Fonseca, Lluis, Font, Christian, Fruck, Satoshi, Fukami, Yasushi, Fukazawa, Garc('(i))a L('(o))pez, Ramon J., Markus, Garczarczyk, Sargis, Gasparyan, Markus, Gaug, Giglietto, Nicola, Francesco, Giordano, Pawel, Gliwny, Nikola, Godinovic, David, Green, Jarred Gershon Green, Daniela, Hadasch, Alexander, Hahn, Lea, Heckmann, Javier, Herrera, John, Hoang, Dario, Hrupec, Moritz, Hütten, Tomohiro, Inada, Kazuma, Ishio, Yuki, Iwamura, Irene Jim('(e))nez Mart('(i))nez, Jenni, Jormanainen, L('(e))a, Jouvin, Marie, Karjalainen, Daniel, Kerszberg, Yukiho, Kobayashi, Hidetoshi, Kubo, Junko, Kushida, Alessandra, Lamastra, Damir, Lelas, Francesco, Leone, Elina, Lindfors, Lena, Linhoff, Saverio, Lombardi, Francesco, Longo, Ruben, Lopez-Coto, Marcos, L('(o))pez-Moya, Alicia, L('(o))pez-Oramas, Loporchio, Serena, Bernardo Machado de Oliveira Fraga, Camilla, Maggio, Pratik, Majumdar, Martin, Makariev, Manuela, Mallamaci, Galina, Maneva, Marina, Manganaro, Karl, Mannheim, Laura, Maraschi, Mos(`(e)), Mariotti, Manel, Martinez, Daniel, Mazin, Stefano, Menchiari, Simone, Mender, Sa( (s))a Mi('(c))anovi('(c)), Davide, Miceli, Tjark, Miener, Jose Miguel Miranda, Razmik, Mirzoyan, Edgar, Molina, Abelardo, Moralejo, Daniel, Morcuende, Victoria, Moreno, Elena, Moretti, Takeshi, Nakamori, Lara, Nava, Vitaly, Neustroev, Cosimo, Nigro, Kari, Nilsson, Kyoshi, Nishijima, Koji, Noda, Seiya, Nozaki, Yoshiki, Ohtani, Tomohiko, Oka, Jorge, Otero-Santos, Simona, Paiano, Michele, Palatiello, David, Paneque, Riccardo, Paoletti, Paredes, Josep M., Lovro, Pavleti('(c)), Pablo, Pe(~(n))il, Massimo, Persic, Marine, Pihet, Pier Giorgio Prada Moroni, Elisa, Prandini, Chaitanya, Priyadarshi, Ivica, Puljak, Wolfgang, Rhode, Marc, Rib('(o)), Javier, Rico, Chiara, Righi, Andrea, Rugliancich, Narek, Sahakyan, Takayuki, Saito, Shunsuke, Sakurai, Francesco Gabriele Saturni, Bernd, Schleicher, Kevin, Schmidt, Thomas, Schweizer, Julian, Sitarek, Iva, ( (S))nidari('(c)), Dorota, Sobczy('(n))ska, Alessia, Spolon, Antonio, Stamerra, Jelena Stri( (s))kovi('(c)), Derek, Strom, Marcel, Strzys, Yusuke, Suda, Tihomir, Suri('(c)), Mitsunari, Takahashi, Ryuji, Takeishi, Fabrizio, Tavecchio, Petar, Temnikov, Tomislav, Terzic, Masahiro, Teshima, Luca, Tosti, Stefano, Truzzi, Antonio, Tutone, Santiago, Ubach, Juliane van Scherpenberg, Gaia, Vanzo, Monica VAZQUEZ ACOSTA, Sofia, Ventura, Vassil, Verguilov, Carlo Francesco Vigorito, Vincenzo, Vitale, Ievgen, Vovk, Martin, Will, Carolin, Wunderlich, Tokonatsu, Yamamoto, Darko, Zari('(c)), Matteo, Balbo, Thomas, Bretz, Jens, Buss, Laura, Eisenberger, Dorothee, Hildebrand, Roman, Iotov, Adelina, Kalenski, Dominik, Neise, Maximilian, Noethe, Aleksander, Paravac, Vitalii, Sliusar, Roland, Walter, Rasha, Abbasi, Markus, Ackermann, Jenni, Adams, Juanan, Aguilar, Ahlers, M., Maryon, Ahrens, Cyril Martin Alispach, Antonio Augusto Alves Junior, Najia Moureen Binte Amin, Rui, An, Karen, Andeen, Tyler, Anderson, Gisela, Anton, Carlos, Arguelles, Yosuke, Ashida, Spencer, Axani, Xinhua, Bai, Aswathi Balagopal, V., Anastasia Maria Barbano, Barwick, S. W., Benjamin, Bastian, Vedant, Basu, Sebastian, Baur, Bay, R. C., Beatty, J. J., Becker, K. -H., Julia Becker Tjus, Chiara, Bellenghi, Segev, Benzvi, Berley, D., Besson, D. Z., Gary, Binder, Daniel, Bindig, Blaufuss, E., Summer, Blot, Matthias, Boddenberg, Federico, Bontempo, Jurgen, Borowka, Boser, S., Olga, Botner, Jakob, Bottcher, Etienne, Bourbeau, Federica, Bradascio, Braun, J., Stephanie, Bron, Jannes, Brostean-Kaiser, Sally-Ann, Browne, Alexander, Burgman, Ryan, Burley, Raffaela, Busse, Michael, Campana, Erin, Carnie-Bronca, Chujie, Chen, Dmitry, Chirkin, Koun, Choi, Bryanlee, Clark, Kenneth, Clark, Lew, Classen, Alan, Coleman, Gabriel, Collin, Conrad, J. M., Paul, Coppin, Pablo, Correa, Cowen, D. F., Cross, R., Christian, Dappen, Pranav, Dave, Catherine DE CLERCQ, James, Delaunay, Hans, Dembinski, Kunal, Deoskar, Sam De Ridder, Abhishek, Desai, Paolo, Desiati, Krijn de Vries, Gwenhaël de Wasseige, Meike De With, Tyce, Deyoung, Sukeerthi, Dharani, Alejandro, Diaz, Juan Carlos Diaz-Velez, Markus, Dittmer, Hrvoje, Dujmovic, Matt, Dunkman, Michael, Duvernois, Emily, Dvorak, Thomas, Ehrhardt, Philipp, Eller, Ralph, Engel, Hannah, Erpenbeck, John, Evans, Evenson, P. A., Kwok Lung Fan, Fazely, A. R., Sebastian, Fiedlschuster, Aaron, Fienberg, Kirill, Filimonov, Chad, Finley, Leander, Fischer, Derek, B Fox, Anna, Franckowiak, Elizabeth, Friedman, Alexander, Fritz, Philipp, Furst, Gaisser, T. K., Jay, Gallagher, Erik, Ganster, Alfonso, Garcia, Simone, Garrappa, Gerhardt, L., Ava, Ghadimi, Christian, Glaser, Theo, Glauch, Thorsten, Glusenkamp, Goldschmidt, A., Javier, Gonzalez, Sreetama, Goswami, Darren, Grant, Timoth('(e))e, Gr('(e))goire, Spencer, Griswold, Mehmet, Gunduz, Christoph, Günther, Christian, Haack, Allan, Hallgren, Halliday, R., Halve, L., Halzen, F., Martin Ha Minh, Kael, Hanson, John, Hardin, Harnisch, Alexander A., Andreas, Haungs, Simon, Hauser, Dustin, Hebecker, Helbing, K., Felix, Henningsen, Hettinger, Emma C., Stephanie, Hickford, Joshua, Hignight, Colton, Hill, Hill, G. C., Kara, Hoffman, Ruth, Hoffmann, Tobias, Hoinka, Benjamin, Hokanson-Fasig, Hoshina, K., Feifei, Huang, Matthias, Huber, Thomas, Huber, Klas, Hultqvist, Mirco, Hunnefeld, Raamis, Hussain, Seongjin, In, Nad(`(e))ge, Iovine, Aya, Ishihara, Matti, Jansson, George, Japaridze, Minjin, Jeong, Ben, Jones, Donghwa, Kang, Woosik, Kang, Xinyue, Kang, Alexander, Kappes, David, Kappesser, Timo, Karg, Martina, Karl, Karle, A., Katz, U., Kauer, M., Moritz, Kellermann, Kelley, J. L., Ali, Kheirandish, Ken( extquotesingle)ichi Kin, Thomas, Kintscher, Joanna, Kiryluk, Spencer, Klein, Ramesh, Koirala, Hermann, Kolanoski, Tomas, Kontrimas, Lutz, Kopke, Claudio, Kopper, Sandro, Kopper, Koskinen, D. J., Paras, Koundal, Michael, Kovacevich, Marek, Kowalski, Tetiana, Kozynets, Emma, Kun, Naoko, Kurahashi, Neha, Lad, Cristina Lagunas Gualda, Justin, Lanfranchi, Michael, J Larson, Frederik Hermann Lauber, Jeffrey, Lazar, Jiwoong, Lee, Kayla, Leonard, Agnieszka, Leszczy('(n))ska, Yijia, Li, Massimiliano, Lincetto, Qinrui, Liu, Maria, Liubarska, Elisa, Lohfink, Cristian Jesus Lozano Mariscal, Lu, Lu, Francesco, Lucarelli, Andrew, Ludwig, William, Luszczak, Yang, Lyu, Wing Yan Ma, James, Madsen, Kendall, Mahn, Yuya, Makino, Sarah, Mancina, Ioana Codrina Maris, Maruyama, Reina H., Mase, K., Thomas, Mcelroy, Frank, Mcnally, James Vincent Mead, Meagher, K., Andres, Medina, Maximilian, Meier, Stephan, Meighen-Berger, Jessie, Micallef, Daniela, Mockler, Teresa, Montaruli, Roger, Moore, Morse, R., Marjon, Moulai, Richard, Naab, Ryo, Nagai, Uwe, Naumann, Jannis, Necker, Le Viet Nguyen, Hans, Niederhausen, Mehr, Nisa, Sarah, Nowicki, Dave, Nygren, Anna Obertacke Pollmann, Marie, Oehler, Olivas, A., Erin O( extquotesingle)Sullivan, Hershal, Pandya, Daria, Pankova, Nahee, Park, Grant, Parker, Ek Narayan Paudel, Larissa, Paul, Carlos Perez de los Heros, Lilly, Peters, Saskia, Philippen, Damian, Pieloth, Sarah, Pieper, Martin, Pittermann, Pizzuto, A., Plum, M., Yuiry, Popovych, Alessio, Porcelli, Maria Prado Rodriguez, Buford Price, P., Brandom, Pries, Gerald, Przybylski, Christoph, Raab, Amirreza, Raissi, Mohamed, Rameez, Rawlins, K., Immacolata Carmen Rea, Abdul, Rehman, Ren('(e)), Reimann, Giovanni, Renzi, Elisa, Resconi, Simeon, Reusch, Mike, Richman, Benedikt, Riedel, Ella, Roberts, Sally, Robertson, Gerrit, Roellinghoff, Martin, Rongen, Carsten, Rott, Tim, Ruhe, Dirk, Ryckbosch, Devyn Rysewyk Cantu, Ibrahim, Safa, Julian, Saffer, Sebastian Sanchez Herrera, Alexander, Sandrock, Joakim, Sandroos, Marcos, Santander, Subir, Sarkar, Sourav, Sarkar, Maximilian Karl Scharf, Merlin, Schaufel, Harald, Schieler, Sebastian, Schindler, Schlunder, P., Torsten, Schmidt, Austin, Schneider, Judith, Schneider, Schröder, Frank G., Lisa Johanna Schumacher, Georg, Schwefer, Steve, Sclafani, Seckel, D., Surujhdeo, Seunarine, Ankur, Sharma, Shefali, Shefali, Manuel, Silva, Barbara, Skrzypek, Ben, Smithers, Robert, Snihur, Jan, Soedingrekso, Dennis, Soldin, Christian, Spannfellner, Glenn, Spiczak, Christian, Spiering, Juliana, Stachurska, Michael, Stamatikos, Stanev, T., Robert, Stein, Joeran, Stettner, Steuer, A., Stezelberger, T., Timo, Sturwald, Thomas, Stuttard, Sullivan, G. W., Taboada, I., Frederik, Tenholt, Samvel, Ter-Antonyan, Tilav, S., Franziska, Tischbein, Kirsten, Tollefson, Christoph, Tönnis, Simona, Toscano, Delia, Tosi, Alexander, Trettin, Maria, Tselengidou, Chunfai, Tung, Andrea, Turcati, Roxanne, Turcotte, Colin, Turley, Jean Pierre Twagirayezu, Bunheng, Ty, Martin Unland Elorrieta, Nora, Valtonen-Mattila, Justin, Vandenbroucke, Nick van Eijndhoven, David, Vannerom, Jakob van Santen, Stef, Verpoest, Matthias, Vraeghe, Walck, C., Timothyblake, Watson, Chris, Weaver, Philip, Weigel, Andreas, Weindl, Matthew, Weiss, Jan, Weldert, Chris, Wendt, Johannes, Werthebach, Mark, Weyrauch, Nathan, Whitehorn, Wiebusch, C. H., Dawn, Williams, Martin, Wolf, Kurt, Woschnagg, Gerrit, Wrede, Johan, Wulff, Xianwu, Xu, Yiqian, Xu, Juan Pablo Yanez, Yoshida, S., Shiqi, Yu, Tianlu, Yuan, Zelong, Zhang, Weidong, Jin, Hassan, Abdalla, Felix, Aharonian, Faical, Ait-Benkhali, Oguzhan, Anguener, Cornelia, Arcaro, Celine, Armand, Tom, Armstrong, Halim, Ashkar, Michael, Backes, Vardan, Baghmanyan, Victor Barbosa Martins, Anna, Barnacka, Monica, Barnard, Rowan, Batzofin, Yvonne, Becherini, David, Berge, Konrad, Bernlöhr, Baiyang, Bi, Markus, Boettcher, Catherine, Boisson, Julien, Bolmont, Mathieu de Bony, Mischa, Breuhaus, Robert, Brose, Francois, Brun, Tomasz, Bulik, Thomas, Bylund, Floriane, Cangemi, Sami, Caroff, Sabrina, Casanova, Jaqueline, Catalano, Pauline, Chambery, Tej Bahadur Chand, Andrew, Chen, Garret, Cotter, Malgorzata, Curlo, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James, Davies, Justine, Devin, Arache, Djannati-Ataï, Anton, Dmytriiev, Axel, Donath, Victor, Doroshenko, Lente, Dreyer, Louis Du Plessis, Connor, Duffy, Kathrin, Egberts, Sabrina, Einecke, Gabriel, Emery, Jean-Pierre, Ernenwein, Steven, Fegan, Kirsty, Feijen, Armand, Fiasson, Gaëtan Fichet de Clairfontaine, Gerard, Fontaine, Lott, Frans, Matthias, Fuessling, Stefan, Funk, Stefano, Gabici, Yves, Gallant, Shahede, Ghafourizade, Gianluca, Giavitto, Luca, Giunti, Dorit, Glawion, Jean-Francois, Glicenstein, Marie-H('(e))l(`(e))ne, Grondin, Sumari, Hattingh, Maria, Haupt, German, Hermann, Jim, Hinton, Werner, Hofmann, Clemens, Hoischen, Tim, Holch, Markus, Holler, Dieter, Horns, Zhiqiu, Huang, David, Huber, Mario, Hörbe, Marek, Jamrozy, Felix, Jankowsky, Vikas, Joshi, Ira, Jung, Eli, Kasai, Krzysztof, Katarzynski, Ul(`(i)), Katz, Dmitry, Khangulyan, Bruno, Khelifi, Stefan, Klepser, Wlodek, Kluzniak, Nukri, Komin, Ruslan, Konno, Karl, Kosack, Dmitriy, Kostunin, Michael, Kreter, Ga( (s))per Kukec Mezek, Anu, Kundu, Giovanni, Lamanna, S('(e))bastien Le Stum, Anne, Lemiere, Marianne, Lemoine-Goumard, Jean-Philippe, Lenain, Fabian, Leuschner, Christelle, Levy, Thomas, Lohse, Anna, Luashvili, Iryna, Lypova, Jonathan, Mackey, Jhilik, Majumdar, Denys, Malyshev, Dmitry, Malyshev, Vincent, Marandon, Paolo, Marchegiani, Alexandre, Marcowith, Arnaud, Mares, Guillem Marti( extquotesingle)i-Devesa, Ramin, Marx, Gilles, Maurin, Pieter, Meintjes, Manuel, Meyer, Alison, Mitchell, Rafal, Moderski, Lars, Mohrmann, Alessandro, Montanari, Chris, Moore, Paul, Morris, Emmanuel, Moulin, Jacques, Muller, Thomas, Murach, Kaori, Nakashima, Mathieu Naurois (de), Amid, Nayerhoda, Hambeleleni, Ndiyavala, Jacek, Niemiec, Angel, Noel, Paul O( extquotesingle)Brien, Laenita Lorraine Oberholzer, Stefan, Ohm, Laura, Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal, Ostrowski, Sebastian, Panny, Michael, Panter, Dan, Parsons, Giada, Peron, Santiago, Pita, Vincent, Poireau, Dmitry, Prokhorov, Heike, Prokoph, Gerd, Puehlhofer, Michael, Punch, Andreas, Quirrenbach, Patrick, Reichherzer, Anita, Reimer, Olaf, Reimer, Quentin, Remy, Matthieu, Renaud, Brian, Reville, Frank, Rieger, Carlo, Romoli, Gavin, Rowell, Bronislaw, Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan, Sahakian, Simon, Sailer, Heiko, Salzmann, David, Sanchez, Andrea, Santangelo, Manami, Sasaki, Johannes, Schaefer, Hester, Schutte, Ullrich, Schwanke, Fabian, Schüssler, Mohanraj, Senniappan, Albert, Seyffert, Shapopi, Jimmy N. S., Kleopas, Shiningayamwe, Rachel, Simoni, Atreyee, Sinha, Helene, Sol, Hugh, Spackman, Andreas, Specovius, Samuel Timothy Spencer, Marion, Spir-Jacob, Lukasz, Stawarz, Riaan, Steenkamp, Christian, Stegmann, Simon, Steinmassl, Constantin, Steppa, Lei, Sun, Tadayuki, Takahashi, Takaaki, Tanaka, Thomas, Tavernier, Andrew, Taylor, Regis, Terrier, Hannes, Thiersen, Charles, Thorpe-Morgan, Martin, Tluczykont, Lenka, Tomankova, Michelle, Tsirou, Naomi, Tsuji, Richard, Tuffs, Yasunobu, Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George, Vasileiadis, Johannes, Veh, Christo, Venter, Pascal, Vincent, Jacco, Vink, Völk, Heinrich J., Stefan, Wagner, Jason John Watson, Felix, Werner, Richard, White, Alicja, Wierzcholska, Yu Wun Wong, Hend, Yassin, Anke, Yusafzai, Michael, Zacharias, Roberta, Zanin, Davit, Zargaryan, Andrzej, Zdziarski, Andreas, Zech, Sylvia, Zhu, Andreas, Zmija, Samuel, Zouari, Natalia, Zywucka, The FACT Collaboration, The H.E.S.S. Collaboration, The IceCube Collaboration, The MAGIC Collaboration, The VERITAS Collaboration, and Współautorami artykułu są członkowie Magic Collaboration, IceCube Collaboration, FACT Collaboration, H.E.S.S. Collaboration, VERITAS Collaboration w liczbie 808
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Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Point source ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,IACT ,Astrophysics ,law.invention ,High Energy Physics - Experiment ,Telescope ,High Energy Physics - Experiment (hep-ex) ,law ,HESS - Abteilung Hinton ,ddc:530 ,High Energy Physics::Experiment ,MAGIC (telescope) ,Neutrino ,Blazar ,Astrophysics - High Energy Astrophysical Phenomena ,Cherenkov radiation - Abstract
The realtime follow-up of neutrino events is a promising approach to search for astrophysical neutrino sources. It has so far provided compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 observed in coincidence with the high-energy neutrino IceCube-170922A detected by IceCube. The detection of very-high-energy gamma rays (VHE, $\mathrm{E} > 100\,\mathrm{GeV}$) from this source helped establish the coincidence and constrained the modeling of the blazar emission at the time of the IceCube event. The four major imaging atmospheric Cherenkov telescope arrays (IACTs) - FACT, H.E.S.S., MAGIC, and VERITAS - operate an active follow-up program of target-of-opportunity observations of neutrino alerts sent by IceCube. This program has two main components. One are the observations of known gamma-ray sources around which a cluster of candidate neutrino events has been identified by IceCube (Gamma-ray Follow-Up, GFU). Second one is the follow-up of single high-energy neutrino candidate events of potential astrophysical origin such as IceCube-170922A. GFU has been recently upgraded by IceCube in collaboration with the IACT groups. We present here recent results from the IACT follow-up programs of IceCube neutrino alerts and a description of the upgraded IceCube GFU system., Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06966 for all IceCube contributions. See arXiv:2108.05257 for all H.E.S.S. contributions
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- 2022
25. Consolidation of the clinical and genetic definition of a SOX4-related neurodevelopmental syndrome
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Marco Angelozzi, Anirudha Karvande, Arnaud N Molin, Alyssa L Ritter, Jacqueline M M Leonard, Juliann M Savatt, Kristen Douglass, Scott M Myers, Mina Grippa, Dara Tolchin, Elaine Zackai, Sarah Donoghue, Anna C E Hurst, Maria Descartes, Kirstin Smith, Danita Velasco, Andrew Schmanski, Amy Crunk, Mari J Tokita, Iris M de Lange, Koen van Gassen, Hannah Robinson, Katie Guegan, Mohnish Suri, Chirag Patel, Marie Bournez, Laurence Faivre, Frédéric Tran-Mau-Them, Janice Baker, Noelle Fabie, K Weaver, Amelle Shillington, Robert J Hopkin, Daniela Q C.M Barge-Schaapveld, Claudia AL Ruivenkamp, Regina Bökenkamp, Samantha Vergano, Maria Noelia Seco Moro, Aranzazu Díaz de Bustamante, Vinod K Misra, Kelly Kennelly, Caleb Rogers, Jennifer Friedman, Kristen M Wigby, Jerica Lenberg, Claudio Graziano, Rebecca C Ahrens-Nicklas, and Veronique Lefebvre
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Micrognathism ,neonatal diseases ,congenital ,Syndrome ,DNA ,gene expression regulation ,Article ,SOXC Transcription Factors ,Phenotype ,Neurodevelopmental Disorders ,Intellectual Disability ,genetic variation ,Genetics ,Humans ,abnormalities ,Hand Deformities, Congenital ,hereditary ,Genetics (clinical) - Abstract
BackgroundA neurodevelopmental syndrome was recently reported in four patients withSOX4heterozygous missense variants in the high-mobility-group (HMG) DNA-binding domain. The present study aimed to consolidate clinical and genetic knowledge of this syndrome.MethodsWe newly identified 17 patients withSOX4variants, predicted variant pathogenicity using in silico tests and in vitro functional assays and analysed the patients’ phenotypes.ResultsAll variants were novel, distinct and heterozygous. Seven HMG-domain missense and five stop-gain variants were classified as pathogenic or likely pathogenic variant (L/PV) as they precluded SOX4 transcriptional activity in vitro. Five HMG-domain and non-HMG-domain missense variants were classified as of uncertain significance (VUS) due to negative results from functional tests. When known, inheritance was de novo or from a mosaic unaffected or non-mosaic affected parent for patients with L/PV, and from a non-mosaic asymptomatic or affected parent for patients with VUS. All patients had neurodevelopmental, neurological and dysmorphic features, and at least one cardiovascular, ophthalmological, musculoskeletal or other somatic anomaly. Patients with L/PV were overall more affected than patients with VUS. They resembled patients with other neurodevelopmental diseases, including theSOX11-related and Coffin-Siris (CSS) syndromes, but lacked the most specific features of CSS.ConclusionThese findings consolidate evidence of a fairly non-specific neurodevelopmental syndrome due toSOX4haploinsufficiency in neurogenesis and multiple other developmental processes.
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- 2022
26. ESPN2021: Interactive hybrid-the future of medical congresses?
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Arend Bökenkamp, Michiel Schreuder, Jaap Groothoff, Paediatric Nephrology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), and Pediatric surgery
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Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,Nephrology ,Pediatrics, Perinatology and Child Health - Abstract
Contains fulltext : 283112.pdf (Publisher’s version ) (Closed access)
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- 2022
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27. Upper limits on the WIMP annihilation cross section from a joint analysis of dwarf spheroidal satellite galaxy observations with the MAGIC telescopes
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Maggio, C., Kerzsberg, D., Ninci, D., Vitale, V., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Almeida, U. B., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D’elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Oliveira Fraga, B. M., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.
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- 2022
28. Upper limits on the very high energy emission from GRBs observed by MAGIC
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Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D Elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.
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- 2022
29. Proton acceleration in thermonuclear nova explosions revealed by gamma rays
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MAGIC Collaboration, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., González, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. Fallah, Alonso, L. Fariña, Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Martínez, I. Jiménez, Jormanainen, J., Jouvin, L., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Aguilar, A. Mas, Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Rosillo, M. Nievas, Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Moroni, P. G. Prada, Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Ambrosino, F., Cecconi, M., Catanzaro, G., Ferrara, C., Frasca, A., Munari, M., Giustolisi, L., Alonso-Santiago, J., Giarrusso, M., Munari, U., Valisa, P., German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Ciencia e Innovación (España), Department of Atomic Energy (India), University of Tokyo, Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Ministry of Education and Science (Bulgaria), Generalitat de Catalunya, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, and European Commission
- Subjects
High Energy Astrophysical Phenomena (astro-ph.HE) ,Astrophysics::High Energy Astrophysical Phenomena ,Proton acceleration ,FOS: Physical sciences ,Proton acceleration, nova, gamma rays, MAGIC, Imaging Atmospheric Cherenkov Telescopes, RS Oph ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,MAGIC ,gamma-rays: novae ,IACTs ,proton acceleration: RS Ophiuchi ,nova ,gamma rays ,High-energy astrophysics ,Imaging Atmospheric Cherenkov Telescopes ,RS Oph ,Astrophysics::Solar and Stellar Astrophysics ,Física nuclear ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Compact astrophysical objects ,Astrophysics::Galaxy Astrophysics - Abstract
Acciari, V. A., et al (MAGIC Collaboration). Este artículo tiene una corrección 2022NatAs...6..760A., Classical novae are cataclysmic binary star systems in which the matter of a companion star is accreted on a white dwarf. Accumulation of hydrogen in a layer eventually causes a thermonuclear explosion on the surface of the white dwarf, brightening the white dwarf to ~10 solar luminosities and triggering ejection of the accumulated matter. Novae provide the extreme conditions required to accelerate particles, electrons or protons, to high energies. Here we present the detection of gamma rays by the MAGIC telescopes from the 2021 outburst of RS Ophiuchi, a recurrent nova with a red giant companion, which allowed us to accurately characterize the emission from a nova in the 60 GeV to 250 GeV energy range. The theoretical interpretation of the combined Fermi LAT and MAGIC data suggests that protons are accelerated to hundreds of gigaelectronvolts in the nova shock. Such protons should create bubbles of enhanced cosmic ray density, of the order of 10 pc, from the recurrent novae. © 2022, The Author(s), under exclusive licence to Springer Nature Limited., The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovación (MICINN) (PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-104114RB-C33, PID2019-105510GB-C31,PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-400/18.12.2020, and the Academy of Finland grant number 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia Severo Ochoa (SEV-2016-0588, SEV-2017-0709, CEX2019-000920-S), the Unidad de Excelencia María de Maeztu (CEX2019-000918-M, MDM-2015-0509-18-2) and the CERCA programme of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) project IP-2016-06-9782 and the University of Rijeka Project uniri-prirod-18-48; by the DFG Collaborative Research Centres SFB823/C4 and SFB876/C3; by the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ. The TJO of the Montsec Observatory (OdM) is owned by the Catalan Government and operated by the Institute for Space Studies of Catalonia (IEEC). We acknowledge with thanks the variable star observations from the AAVSO International Database contributed by observers worldwide and used in this research. We gratefully acknowledge the prompt response to the alert and the data provided by the CAOS Team. We acknowledge with thanks the ARAS database27 (https://aras-database.github.io/database/index.html). The observers who contributed worldwide data used in this research are O. Garde, V. Lecoq, L. Franco, F. Teyssier, O. Thizy, C. Boussin, P. A. Dubovsky and D. Boyd. We thank G. Principe for the advice in extending the Fermi LAT analysis below 100 MeV and F. D’Ammando for his comments on the manuscript. R.L.-C.’s work was financially supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 754496—FELLINI.
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- 2022
30. Understanding the origin of the extended γ-ray emission and the physical nature of HESS J1841-055 using observations at TeV energies with the MAGIC telescopes
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Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D Elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, D., Green, J. G., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., and Saha, L.
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- 2022
31. MAGIC observations of HESS J1809-193 using the Very Large Zenith Angle technique at energies above TeV
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Wrijupan Bhattacharyya, Chiara Righi, Jordi Delgado, M. I. Martínez, Giacomo D'Amico, Chaitanya Priyadarshi, Manuel Artero, Francesco Longo, Katsuaki Asano, Andrés Baquero, Tomislav Terzić, Maria Victoria Fonseca, Kevin Schmidt, Yusuke Suda, Sidika Merve Colak, Carlo Vigorito, Daniel Kerszberg, Jarred Gershon Green, Davide Depaoli, Monica Vazquez Acosta, Nikola Godinovic, Elia Do Souto Espiñeira, Lena Linhoff, Pratik Majumdar, Leonardo Di Venere, Louis Antonelli, Jürgen Besenrieder, Francesco Giordano, Antonio Tutone, Stefano Menchiari, Michele Palatiello, Paolo Da Vela, Junko Kushida, David H. Green, Lovro Pavletić, Vandad Fallah Ramazani, Francesco Dazzi, Javier Rico, Tokonatsu Yamamoto, Martin Makariev, Josep M. Paredes, Antonio Stamerra, Martin Will, Vitaly Neustroev, Oscar Blanch, Tihomir Surić, Carolin Wunderlich, John Hoang, Marc Ribó, Santiago Ubach, Iva Šnidarić, Lorenzo Bellizzi, Jorge Otero-Santos, Luca Tosti, Ciro Bigongiari, Markus Garczarczyk, Kazuma Ishio, Seiya Nozaki, Manuel Delfino, Ulisses Barres de Almeida, Marina Manganaro, Manuela Mallamaci, Valerio D'Elia, Satoshi Fukami, Hidetoshi Kubo, Tomohiro Inada, Victor A. Acciari, Yating Chai, Dario Hrupec, Stefan Cikota, Alessandro De Angelis, G. Maneva, Abelardo Moralejo, Elisa Prandini, Elena Moretti, Pawel Gliwny, Nicola Giglietto, Mitsunari Takahashi, Masahiro Teshima, Massimo Persic, Adrian Biland, Konstancja Satalecka, Moritz Hütten, Juan Abel Barrio, Michele Doro, Serena Loporchio, Victoria Moreno, Karl Mannheim, Darko Zarić, Narek Sahakyan, Stefano Truzzi, Lluis Font, Tomohiko Oka, Ashot Chilingarian, Maria-Isabel Bernardos, Alice Donini, Josefa González, Alicia López-Oramas, Bernd Schleicher, Roberto Carosi, Carlos Delgado Mendez, Pablo Peñil, Marcel Strzys, Edgar Molina, Tjark Miener, Giacomo Bonnoli, Kyoshi Nishijima, David Paneque, Davide Miceli, Ana Babić, Simona Paiano, Thomas Schweizer, Simone Mender, Javier Herrera, P. G. Prada Moroni, Alessia Spolon, Alicia Fattorini, Léa Jouvin, Cosimo Nigro, Stefano Ansoldi, Jelena Strišković, Sofia Ventura, Alexander Hahn, Riccardo Paoletti, Markus Gaug, Lara Nava, Saša Mićanović, Alessandra Lamastra, Takeshi Nakamori, Daniel Morcuende, Jose Luis Contreras, Vassil Verguilov, Fabrizio Tavecchio, Barbara De Lotto, Camilla Maggio, Daniela Dorner, Alessio Berti, Eduardo Colombo, Ivana Batković, Vincenzo Vitale, Gaia Vanzo, Axel Arbet Engels, Juan Cortina, Marine Pihet, Petar Temnikov, Koji Noda, Elisa Bernardini, D. Dominis Prester, Hendrik Bökenkamp, Francesco Leone, Jenni Jormanainen, Sargis Gasparyan, Ryuji Takeishi, D. M. Strom, Kari Nilsson, Wolfgang Rhode, Bernardo Machado de Oliveira Fraga, Giovanni Busetto, Marcos López-Moya, Wlodek Bednarek, Federico Di Pierro, Ruben Lopez-Coto, Irene Jiménez Martínez, Shunsuke Sakurai, Jose Miguel Miranda, Juliane van Scherpenberg, Matteo Cerruti, Yasushi Fukazawa, Ievgen Vovk, Mosè Mariotti, Ivica Puljak, Saverio Lombardi, Andrea Rugliancich, Ramon J. García López, Marie Karjalainen, Dominik Elsaesser, Razmik Mirzoyan, Damir Lelas, Lea Heckmann, Francesco Gabriele Saturni, Dorota Sobczyńska, Zeljka Bosnjak, L. Maraschi, Elina Lindfors, Daniel Mazin, Stefano Covino, Giovanni Ceribella, Takashi Saito, Dominik Baack, Yukiho Kobayashi, Christian Fruck, Yuki Iwamura, Julian Sitarek, Daniela Hadasch, and Yoshiki Ohtani
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Astroparticle physics ,Physics ,Supernova ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,Cosmic ray ,MAGIC (telescope) ,Astrophysics ,Zenith - Abstract
The origin of Galactic Cosmic rays (GCRs), whose spectrum extends to PeV energies, is one of the longest-standing problems in astroparticle physics. One of the main sources of GCRs are regarded to be Supernova remnants (SNRs). While SNRs are known to accelerate protons, so far there is no evidence that SNRs can accelerate CRs to PeV energies. Providing that ~10% of the parent Cosmic ray energy is converted to gamma rays, the gamma-ray spectrum extending up to ~100 TeV would be a signature of a so-called Galactic PeVatron, an object responsible for the production of protons up to the knee of the Cosmic ray spectrum. The current multi-wavelength data indicate that HESS J1809-193 is one of the most promising Galactic PeVatron candidates. So far, no firm identification on the source nature has been established as there are several possible counterparts at lower energies; one of them being SNR G11.0−0.0. We report here the results of an observational campaign performed by the MAGIC telescopes on HESS J1809-193 since 2019 in the very-high-energy gamma-ray domain (E>100 GeV). The data were obtained with the Very Large Zenith Angle (VLZA) technique, which increased the collection area significantly to about one square kilometer. We used ~60 hours of collected VLZA data to explore the spectrum and the morphology of the source at energies above several TeV., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)
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- 2022
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32. Recent MAGIC results on Galactic binaries
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Pablo Peñil, Saša Mićanović, Ivana Batković, Francesco Longo, Sargis Gasparyan, Wolfgang Rhode, Giovanni Busetto, Daniel Kerszberg, Shunsuke Sakurai, Marie Karjalainen, Tomohiko Oka, Mosè Mariotti, Kyoshi Nishijima, Tihomir Surić, Giacomo Bonnoli, Takeshi Nakamori, P. G. Prada Moroni, Matteo Cerruti, Elia Do Souto Espiñeira, Pratik Majumdar, Barbara De Lotto, Yuki Iwamura, Camilla Maggio, Daniela Dorner, Alexander Hahn, Lena Linhoff, Tjark Miener, L. Maraschi, Elina Lindfors, Gaia Vanzo, Dominik Elsaesser, Razmik Mirzoyan, David Paneque, John Hoang, Christian Fruck, Thomas Schweizer, Marc Ribó, Daniel Mazin, Damir Lelas, Jelena Strišković, Yasushi Fukazawa, Daniel Morcuende, Jose Luis Contreras, Dario Hrupec, Manuela Mallamaci, Martin Will, Saverio Lombardi, Manuel Artero, Andrea Rugliancich, Stefano Ansoldi, Jorge Otero-Santos, Petar Temnikov, Koji Noda, Karl Mannheim, Massimo Persic, Lea Heckmann, Francesco Gabriele Saturni, Riccardo Paoletti, Marine Pihet, Marina Manganaro, Elisa Bernardini, Alessandro De Angelis, Markus Gaug, Martin Makariev, Hidetoshi Kubo, Tomohiro Inada, Dorota Sobczyńska, Mitsunari Takahashi, Oscar Blanch, Juan Cortina, Vandad Fallah Ramazani, Alicia López-Oramas, Josep M. Paredes, Louis Antonelli, Antonio Stamerra, Elena Moretti, D. Dominis Prester, Lluis Font, Tomislav Terzić, Seiya Nozaki, Konstancja Satalecka, Michele Doro, Julian Sitarek, Juliane van Scherpenberg, Michele Palatiello, Stefano Covino, Ivica Puljak, Serena Loporchio, Jenni Jormanainen, Daniela Hadasch, Katsuaki Asano, Giacomo D'Amico, Davide Depaoli, Hendrik Bökenkamp, Alice Donini, Bernardo Machado de Oliveira Fraga, Yoshiki Ohtani, Jordi Delgado, Maria Victoria Fonseca, Iva Šnidarić, Ž. Bošnjak, Roberto Carosi, Nikola Godinovic, Lara Nava, Ramon J. García López, Kevin Schmidt, Alessio Berti, Abelardo Moralejo, Giovanni Ceribella, Francesco Dazzi, Fabrizio Tavecchio, Ievgen Vovk, Davide Miceli, Jarred Gershon Green, Takashi Saito, Adrian Biland, Alessia Spolon, Eduardo Colombo, Junko Kushida, Lovro Pavletić, Léa Jouvin, Juan Abel Barrio, Marcel Strzys, Dominik Baack, Axel Arbet Engels, Narek Sahakyan, Vassil Verguilov, Yukiho Kobayashi, Carlos Delgado Mendez, Carolin Wunderlich, Ryuji Takeishi, Bernd Schleicher, Edgar Molina, D. M. Strom, Kari Nilsson, Simone Mender, Javier Herrera, Leonardo Di Venere, Andrés Baquero, Jürgen Besenrieder, Francesco Giordano, Antonio Tutone, Manuel Delfino, Ulisses Barres de Almeida, Ana Babić, Ciro Bigongiari, Yusuke Suda, Carlo Vigorito, Wrijupan Bhattacharyya, Javier Rico, Tokonatsu Yamamoto, Vitaly Neustroev, Luca Tosti, Valerio D'Elia, G. Maneva, Victor A. Acciari, Moritz Hütten, Paolo Da Vela, David H. Green, Marcos López-Moya, Wlodek Bednarek, Federico Di Pierro, Ruben Lopez-Coto, Irene Jiménez Martínez, Jose Miguel Miranda, Alessandra Lamastra, Vincenzo Vitale, Josefa González, M. I. Martínez, Maria-Isabel Bernardos, Simona Paiano, Alicia Fattorini, Sidika Merve Colak, Francesco Leone, Monica Vazquez Acosta, Yating Chai, Stefan Cikota, Pawel Gliwny, Nicola Giglietto, Victoria Moreno, Darko Zarić, Satoshi Fukami, Lorenzo Bellizzi, Masahiro Teshima, Cosimo Nigro, Sofia Ventura, Markus Garczarczyk, Kazuma Ishio, Santiago Ubach, Chiara Righi, Elisa Prandini, Chaitanya Priyadarshi, Ashot Chilingarian, Stefano Menchiari, and Stefano Truzzi
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Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,Binary number ,MAGIC (telescope) ,Astrophysics ,Compact star ,Radiation - Abstract
X-ray and gamma-ray binaries are systems consisting of a compact object and normally a non-degenerate companion star. Most of these sources have been shown to emit radiation in a broad frequency range, from radio up to X-rays and sometimes gamma rays. We report on recent results in very high-energy gamma rays above 100 GeV obtained by the MAGIC Collaboration for the Galactic X-ray binaries MAXI J1820+070 and 1A 0535+262, and the gamma-ray binary HESS J0632+057. Multiwavelength data at lower energies are also provided for a better contextualisation of the sources.
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- 2022
33. The complexity of kidney disease and diagnosing it - Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
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Linnea Malmgren, Carl Öberg, Emil den Bakker, Felicia Leion, Joanna Siódmiak, Anna Åkesson, Veronica Lindström, Erik Herou, Alain Dardashti, Liana Xhakollari, Gabriel Grubb, Helena Strevens, Magnus Abrahamson, Johanna Helmersson‐Karlqvist, Martin Magnusson, Jonas Björk, Ulf Nyman, Johan Ärnlöv, Peter Ridefelt, Torbjörn Åkerfeldt, Magnus Hansson, Anna Sjöström, Johan Mårtensson, Yoshihisa Itoh, David Grubb, Olav Tenstad, Lars‐Olov Hansson, Isleifur Olafsson, Araceli Jarquin Campos, Martin Risch, Lorenz Risch, Anders Larsson, Gunnar Nordin, Hans Pottel, Anders Christensson, Henrik Bjursten, Arend Bökenkamp, and Anders Grubb
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proteomics ,kidney disease ,Urologi och njurmedicin ,Internal Medicine ,Urology and Nephrology ,610 Medizin und Gesundheit - Abstract
Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous GFR-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterised by a selective reduction in the glomerular filtration of 5-30 kDa molecules, such as cystatin C, compared to the filtration of small molecules < 1kDa dominating the glomerular filtrate e.g., water, urea, creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine-based GFR-estimates. The syndromes are characterised by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor-blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C-based GFR-estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines. This article is protected by copyright. All rights reserved.
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- 2022
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34. Multiwavelength monitoring of gravitationally lensed blazar QSO B0218+357 between 2016 and 2020
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Julian, Sitarek, Acciari, Victor A., Stefano, Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel, Artero, Katsuaki, Asano, Dominik, Baack, Ana, Babic, Andres, Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana, Batkovic, Josefa Becerra Gonzalez, Wlodek, Bednarek, Lorenzo, Bellizzi, Elisa, Bernardini, Maria-Isabel, Bernardos, Alessio, Berti, Jürgen, Besenrieder, Wrijupan, Bhattacharyya, Ciro, Bigongiari, Adrian, Biland, Oscar, Blanch, Hendrik, Bökenkamp, Giacomo, Bonnoli, Zeljka, Bosnjak, Giovanni, Busetto, Roberto, Carosi, Giovanni, Ceribella, Matteo, Cerruti, Yating, Chai, Ashot, Chilingarian, Stefan, Cikota, Sidika Merve Colak, Eduardo, Colombo, Jose Luis Contreras, Juan, Cortina, Stefano, Covino, Giacomo, D'Amico, Valerio, D'Elia, Paolo Da Vela, Francesco, Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel, Delfino, Jordi, Delgado, Carlos Delgado Mendez, Davide, Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espineira, Dijana Dominis Prester, Alice, Donini, Daniela, Dorner, Michele, Doro, Dominik, Elsaesser, Vandad Fallah Ramazani, Alicia, Fattorini, Maria Victoria Fonseca, Lluis, Font, Christian, Fruck, Satoshi, Fukami, Yasushi, Fukazawa, Garcia Lopez, Ramon J., Markus, Garczarczyk, Sargis, Gasparyan, Markus, Gaug, Giglietto, Nicola, Francesco, Giordano, Pawel, Gliwny, Nikola, Godinovic, David, Green, Jarred Gershon Green, Daniela, Hadasch, Alexander, Hahn, Lea, Heckmann, Javier, Herrera, John, Hoang, Dario, Hrupec, Moritz, Hütten, Tomohiro, Inada, Kazuma, Ishio, Yuki, Iwamura, Irene Jimenez Martinez, Jenni, Jormanainen, Lea, Jouvin, Marie, Karjalainen, Daniel, Kerszberg, Yukiho, Kobayashi, Hidetoshi, Kubo, Junko, Kushida, Alessandra, Lamastra, Damir, Lelas, Francesco, Leone, Elina, Lindfors, Lena, Linhoff, Saverio, Lombardi, Francesco, Longo, Ruben, Lopez-Coto, Marcos, Lopez-Moya, Alicia, Lopez-Oramas, Loporchio, Serena, Bernardo Machado de Oliveira Fraga, Camilla, Maggio, Pratik, Majumdar, Martin, Makariev, Manuela, Mallamaci, Galina, Maneva, Marina, Manganaro, Karl, Mannheim, Laura, Maraschi, Mose, Mariotti, Manel, Martinez, Daniel, Mazin, Stefano, Menchiari, Simone, Mender, Sasa, Micanovic, Davide, Miceli, Tjark, Miener, Jose Miguel Miranda, Razmik, Mirzoyan, Edgar, Molina, Abelardo, Moralejo, Daniel, Morcuende, Victoria, Moreno, Elena, Moretti, Takeshi, Nakamori, Lara, Nava, Vitaly, Neustroev, Cosimo, Nigro, Kari, Nilsson, Kyoshi, Nishijima, Koji, Noda, Seiya, Nozaki, Yoshiki, Ohtani, Tomohiko, Oka, Jorge, Otero-Santos, Simona, Paiano, Michele, Palatiello, David, Paneque, Riccardo, Paoletti, Paredes, Josep M., Lovro, Pavletic, Pablo, Penil, Massimo, Persic, Marine, Pihet, Pier Giorgio Prada Moroni, Elisa, Prandini, Chaitanya, Priyadarshi, Ivica, Puljak, Wolfgang, Rhode, Marc, Ribo, Javier, Rico, Chiara, Righi, Andrea, Rugliancich, Narek, Sahakyan, Takayuki, Saito, Shunsuke, Sakurai, Konstancja, Satalecka, Francesco Gabriele Saturni, Bernd, Schleicher, Kevin, Schmidt, Thomas, Schweizer, Iva, Snidaric, Dorota, Sobczynska, Alessia, Spolon, Antonio, Stamerra, Jelena, Striskovic, Derek, Strom, Marcel, Strzys, Yusuke, Suda, Tihomir, Suric, Mitsunari, Takahashi, Ryuji, Takeishi, Fabrizio, Tavecchio, Petar, Temnikov, Tomislav, Terzic, Masahiro, Teshima, Luca, Tosti, Stefano, Truzzi, Antonio, Tutone, Santiago, Ubach, Juliane van Scherpenberg, Gaia, Vanzo, Monica VAZQUEZ ACOSTA, Sofia, Ventura, Vassil, Verguilov, Carlo Francesco Vigorito, Vincenzo, Vitale, Ievgen, Vovk, Martin, Will, Carolin, Wunderlich, Tokonatsu, Yamamoto, Darko, Zaric, Francesco de Palma, Filippo, D'Ammando, Anna, Barnacka, Kazuhiro, Hada, Sahu, Devendra K., Anne, Lähteenmäki, and And
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Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Cosmology and Extragalactic Astrophysics - Abstract
QSO B0218+357 is currently the only gravitationally lensed source from which very-high-energy (VHE, &100GeV) gamma-ray emission has been detected. We report the multiwavelength monitoring observations of this source performed between 2016 and 2020 in radio interferometry, optical, X-ray and gamma-ray bands. During the monitoring individual flares and hints of enhanced states in optical, X-ray and GeV bands have been observed, and the simultaneous data taken by the MAGIC telescopes allow us to search for the VHE gamma-ray emission associated with these events., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)
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- 2022
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35. Gamma rays reveal proton acceleration in thermonuclear novae explosions
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Magic, Collaboration, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fariña Alonso, L., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mas Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nievas Rosillo, M., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Ambrosino, F., Cecconi, M., Catanzaro, G., Ferrara, C., Frasca, A., Munari, M., Giustolisi, L., Alonso-Santiago, J., Giarrusso, M., Munari, U., and Valisa, P.
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very high energy gamma astrophysics galactic cosmic ray acceleration protons - Published
- 2022
36. Follow-up observations of GW170817 with the MAGIC telescopes
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Stamerra, A., Salafia, O. S., Berti, A., Covino, S., D Elia, V., Miceli, D., Nava, L., Patricelli, B., Righi, C., Inoue, S., Antonelli, L. A., Ansoldi, S., Lotto, B., Longo, F., Tavecchio, F., Acciari, V. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., D Amico, G., Da Vela, P., Dazzi, F., Angelis, A., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Dorota Sobczynska, Spolon, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.
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- 2022
37. Multi-messenger characterization of Mrk501 during historically low X-ray and gamma-ray activity
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Lluis Font, Marcel Strzys, Simone Mender, Javier Herrera, Stefano Covino, Christian Fruck, Tjark Miener, David Paneque, Francesco Dazzi, Andrés Baquero, Vandad Fallah Ramazani, Yusuke Suda, Josep M. Paredes, Antonio Stamerra, Cosimo Nigro, Carlo Vigorito, Jelena Strišković, M. I. Martínez, Giacomo D'Amico, Marcos López-Moya, Wlodek Bednarek, Jarred Gershon Green, Sofia Ventura, Javier Rico, Tokonatsu Yamamoto, Dario Hrupec, Mitsunari Takahashi, Giovanni Ceribella, Federico Di Pierro, Ruben Lopez-Coto, John Hoang, Lorenzo Bellizzi, Wrijupan Bhattacharyya, Vitaly Neustroev, Luca Tosti, Jordi Delgado, Manuel Artero, Kevin Schmidt, Marie Karjalainen, Irene Jiménez Martínez, Jose Miguel Miranda, Tihomir Surić, Michele Palatiello, Chiara Righi, Valerio D'Elia, Yuki Iwamura, Francesco Longo, Ciro Bigongiari, Tomislav Terzić, Daniela Dorner, Yating Chai, Stefan Cikota, Massimo Persic, Pawel Gliwny, Nicola Giglietto, G. Maneva, Iva Šnidarić, Giacomo Bonnoli, Gaia Vanzo, Lena Linhoff, P. G. Prada Moroni, Louis Antonelli, L. Maraschi, Elina Lindfors, Junko Kushida, Lovro Pavletić, Elia Do Souto Espiñeira, Alessandra Lamastra, Vincenzo Vitale, Juliane van Scherpenberg, Chaitanya Priyadarshi, Ivica Puljak, Karl Mannheim, Victoria Moreno, Alicia López-Oramas, Thomas Schweizer, Adrian Biland, Davide Depaoli, Marina Manganaro, Carolin Wunderlich, Darko Zarić, Daniel Mazin, Abelardo Moralejo, Satoshi Fukami, Francesco Leone, Ramon J. García López, Stefano Ansoldi, Julian Sitarek, Riccardo Paoletti, Martin Makariev, Petar Temnikov, Oscar Blanch, Leonardo Di Venere, Koji Noda, Elisa Bernardini, Daniela Hadasch, Katsuaki Asano, Ievgen Vovk, Markus Gaug, Masahiro Teshima, Maria Victoria Fonseca, Alessio Berti, Elena Moretti, Maria-Isabel Bernardos, Stefano Menchiari, Markus Garczarczyk, Konstancja Satalecka, Manuela Mallamaci, Jürgen Besenrieder, Dominik Elsaesser, Francesco Giordano, Antonio Tutone, Yoshiki Ohtani, Victor A. Acciari, Alessandro De Angelis, Bernd Schleicher, Edgar Molina, Paolo Da Vela, Razmik Mirzoyan, Josefa González, Michele Doro, Damir Lelas, Nikola Godinovic, Axel Arbet Engels, Sidika Merve Colak, Lea Heckmann, Francesco Gabriele Saturni, Monica Vazquez Acosta, Moritz Hütten, David H. Green, Takeshi Nakamori, Santiago Ubach, Barbara De Lotto, Dorota Sobczyńska, Zeljka Bosnjak, Tomohiko Oka, Roberto Carosi, Matteo Cerruti, Camilla Maggio, Simona Paiano, Kyoshi Nishijima, Alicia Fattorini, Kazuma Ishio, Yasushi Fukazawa, Elisa Prandini, Ashot Chilingarian, Davide Miceli, Alessia Spolon, Léa Jouvin, Vassil Verguilov, Pratik Majumdar, Daniel Kerszberg, Marc Ribó, Martin Will, Jorge Otero-Santos, Hidetoshi Kubo, Tomohiro Inada, Seiya Nozaki, Juan Abel Barrio, Narek Sahakyan, Carlos Delgado Mendez, Manuel Delfino, Ulisses Barres de Almeida, Ana Babić, Sargis Gasparyan, Daniel Morcuende, Jose Luis Contreras, Wolfgang Rhode, Giovanni Busetto, Juan Cortina, Stefano Truzzi, Pablo Peñil, Hendrik Bökenkamp, Saša Mićanović, Ivana Batković, Ryuji Takeishi, D. M. Strom, Kari Nilsson, Shunsuke Sakurai, Alice Donini, Lara Nava, Fabrizio Tavecchio, Eduardo Colombo, Serena Loporchio, D. Dominis Prester, Jenni Jormanainen, Bernardo Machado de Oliveira Fraga, Alexander Hahn, Marine Pihet, Takashi Saito, Dominik Baack, Yukiho Kobayashi, Mosè Mariotti, Saverio Lombardi, and Andrea Rugliancich
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Physics ,Active galactic nucleus ,media_common.quotation_subject ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,Flux ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Galaxy ,Universe ,Crab Nebula ,MAGIC (telescope) ,Blazar ,Astrophysics::Galaxy Astrophysics ,media_common - Abstract
Blazars, together with other active galactic nuclei, are the most luminous persistent sources in our universe; and therefore a prime candidate for very-high-energy (>0.2 TeV, VHE) gamma-ray observations. For the two MAGIC telescopes, the Mrk501 galaxy is among the brightest observed blazars due to its proximity. We report a multi-wavelength and multi-messenger study of Mrk501 with data from 2017 to 2020, when Mrk501 showed a VHE flux typically below 10% that of the Crab Nebula. During this time, we performed three long observations with NuSTAR, which characterized the hard X-ray emission during three different low-activity flux levels. This Mrk501 dataset provided the unprecedented opportunity to study multi-wavelength variability and correlations with sensitive instruments during historically low X-ray and VHE gamma-ray emission (below 5% of the Crab Nebula flux in the VHE range), which could be considered as the baseline emission of Mrk501. We complemented the broadband spectral energy distributions (SED) of the identified historically low X-ray and VHE gamma-ray flux with data published by IceCube, in order to evaluate the potential existence of a hadronic component that is stable (or slowly variable), and less visible than the leptonic component that may dominate the emission during typical and flaring activity. In this contribution, we will also describe the evolution of the broadband SED comparing different theoretical scenarios., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)
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- 2022
- Full Text
- View/download PDF
38. Legal Philosophy
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Bökenkamp, Daniel, Veraart, Wouter, Van den Herik, Larissa, Hondius, Ewoud, Voermans, Wim, Legal Theory and Legal History, Kooijmans Institute, and Boundaries of Law
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legal philosophy ,Netherlands - Abstract
In this chapter, we give an overview of some of the work on legal philosophy currently being done in the Netherlands. We explore: 1) work related to three classical approaches within legal philosophy: legal positivism, natural law theory and legal pragmatism; 2) work related to debates regarding the moral-legal foundations of society in late modernity; 3) work done on democracy and the rule of law in the globalized twenty-first century; 4) work related to legal argumentation and judicial decision-making; and 5) work in the field of legal methodology and legal ethics.
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- 2022
39. Legal Philosophy
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Daniel Bökenkamp, Wouter Veraart, Van den Herik, Larissa, Hondius, Ewoud, and Voermans, Wim
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legal philosophy ,Netherlands - Abstract
In this chapter, we give an overview of some of the work on legal philosophy currently being done in the Netherlands. We explore: 1) work related to three classical approaches within legal philosophy: legal positivism, natural law theory and legal pragmatism; 2) work related to debates regarding the moral-legal foundations of society in late modernity; 3) work done on democracy and the rule of law in the globalized twenty-first century; 4) work related to legal argumentation and judicial decision-making; and 5) work in the field of legal methodology and legal ethics.
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- 2022
40. Unveiling the complex correlation patterns in Mrk 421
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Arbet-Engels, A., Paneque, D., Heckmann, L., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D Elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Balbo, M., Bretz, T., Buss, J., Eisenberger, L., Hildebrand, D., Iotov, R., Kalenski, A., D Ammando, F., Horan, D., Lien, A. Y., Baloković, M., Madejski, G. M., Perri, M., Verrecchia, F., Leto, C., Lähteenmäki, A., Tornikoski, M., Ramakrishnan, V., Järvelä, E., Vera, R. J. C., Villata, M., Raiteri, C. M., Gupta, A. C., Pandey, A., Fuentes, A., Agudo, I., Casadio, C., Semkov, E., Ibryamov, S., Marchini, A., Bachev, R., Strigachev, A., Ovcharov, E., Bozhilov, V., Valcheva, A., Zaharieva, E., Damljanovic, G., Vince, O., Larionov, V. M., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionova, L. V., Morozova, D. A., Nikiforova, A. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Merkulova, O. A., Chen, W. P., Samal, M., Lin, H. C., Moody, J. W., Sadun, A. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Feige, M., Kania, J., Kopp, M., Kunkel, L., Reinhart, D., Scherbantin, A., Schneider, L., Lorey, C., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Nikolashvili, M. G., Chanishvili, R. G., Chigladze, R. A., Ivanidze, R. Z., Kimeridze, G. N., Sigua, L. A., Joner, M. D., Spencer, M., Giroletti, M., Marchili, N., Righini, S., and Rizzi, N.
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Physics ,education.field_of_study ,Astrophysics::High Energy Astrophysical Phenomena ,Population ,Flux ,Sigma ,Astrophysics ,Synchrotron ,Redshift ,law.invention ,law ,MAGIC (telescope) ,education ,Blazar ,Flare - Abstract
The blazar Mrk421 (redshift z=0.031) is one of the brightest and closest BL Lac type objects, making it an ideal target to probe blazar physics. We report on an extensive multi-wavelength observing campaign in 2017, during which the intra-band correlation patterns show some disparity and complex behaviours. Observations from several instruments are used to achieve an optimal temporal coverage from radio to TeV energies. In particular, four multi-hour NuSTAR observations organised simultaneously with MAGIC allow to obtain a precise measurement of the falling segments of the two spectral components. A detailed investigation of the very-high-energy (VHE; >100 GeV) versus X-ray flux correlation is performed, by binning the data into several sub-energy bands. A positively correlated variability is observed, but the correlation characteristics change substantially across the various bands probed. Furthermore, during the simultaneous MAGIC and NuSTAR observations a clear change of the Compton dominance is detected without a simultaneous change in the synchrotron regime, indicating "orphan gamma-ray activity". We also investigate an intriguing bright flare at VHE without a substantial flux increase in the X-rays. Within a leptonic scenario, this behaviour is best explained by the appearance of a second population of highly-energetic electrons spanning a narrow range of energies. Finally, our multi-wavelength correlation study also reveals an anti-correlation between the UV/optical and X-ray bands at a significance level above 3 sigma.
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- 2022
41. BL Lac object 1ES 0647+250, a decade of MWL observations
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Francesco Longo, John Hoang, Cosimo Nigro, Abelardo Moralejo, Elia Do Souto Espiñeira, Sofia Ventura, Lluis Font, Alessandra Lamastra, Josefa González, Alexander Hahn, Manuel Artero, Vincenzo Vitale, Chiara Righi, Martin Makariev, Oscar Blanch, Maria-Isabel Bernardos, Tomislav Terzić, Dominik Elsaesser, Razmik Mirzoyan, Marcel Strzys, Daniel Kerszberg, Marine Pihet, Ryuji Takeishi, D. M. Strom, Kari Nilsson, Serena Loporchio, Damir Lelas, Simone Mender, Javier Herrera, Mosè Mariotti, Francesco Leone, Pratik Majumdar, Julian Sitarek, Davide Depaoli, Stefano Truzzi, Bernd Schleicher, Takeshi Nakamori, Lea Heckmann, Francesco Gabriele Saturni, Saverio Lombardi, Alice Donini, Andrea Rugliancich, Edgar Molina, D. Dominis Prester, Marc Ribó, Katsuaki Asano, Chaitanya Priyadarshi, Alessio Berti, Barbara De Lotto, Daniela Hadasch, Dorota Sobczyńska, Zeljka Bosnjak, Sidika Merve Colak, Monica Vazquez Acosta, Tomohiko Oka, Simona Paiano, Giacomo D'Amico, Lara Nava, Vandad Fallah Ramazani, Maria Victoria Fonseca, Martin Will, Hidetoshi Kubo, Tomohiro Inada, Jorge Otero-Santos, Pablo Peñil, Leonardo Di Venere, Jürgen Besenrieder, Francesco Giordano, Antonio Tutone, Camilla Maggio, Satoshi Fukami, Alicia Fattorini, Fabrizio Tavecchio, Jenni Jormanainen, Josep M. Paredes, Louis Antonelli, L. Maraschi, Seiya Nozaki, Nikola Godinovic, Axel Arbet Engels, Eduardo Colombo, Adrian Biland, Antonio Stamerra, Elina Lindfors, Yoshiki Ohtani, Jordi Delgado, Marcos López-Moya, Ivica Puljak, Wlodek Bednarek, Federico Di Pierro, Giacomo Bonnoli, Kyoshi Nishijima, Bernardo Machado de Oliveira Fraga, Manuel Delfino, Ulisses Barres de Almeida, Tjark Miener, David Paneque, Daniel Mazin, Tihomir Surić, Ruben Lopez-Coto, Kazuma Ishio, Masahiro Teshima, Jarred Gershon Green, Yating Chai, Kevin Schmidt, P. G. Prada Moroni, Ramon J. García López, Stefan Cikota, Matteo Cerruti, Yusuke Suda, Irene Jiménez Martínez, Pawel Gliwny, Nicola Giglietto, Juan Abel Barrio, Narek Sahakyan, Carlo Vigorito, Ana Babić, Massimo Persic, Jelena Strišković, Marina Manganaro, Andrés Baquero, Jose Miguel Miranda, Victoria Moreno, Lena Linhoff, Saša Mićanović, Ivana Batković, Darko Zarić, Roberto Carosi, Daniel Morcuende, Carolin Wunderlich, Jose Luis Contreras, Elisa Prandini, Juan Cortina, Yasushi Fukazawa, Paolo Da Vela, Yuki Iwamura, Junko Kushida, Carlos Delgado Mendez, Karl Mannheim, Lovro Pavletić, Stefano Covino, Marie Karjalainen, David H. Green, Elena Moretti, Davide Miceli, Francesco Dazzi, Hendrik Bökenkamp, Daniela Dorner, Gaia Vanzo, Santiago Ubach, Konstancja Satalecka, Lorenzo Bellizzi, Alessia Spolon, Manuela Mallamaci, Ashot Chilingarian, Ievgen Vovk, Léa Jouvin, Michele Doro, Alessandro De Angelis, Dario Hrupec, M. I. Martínez, Michele Palatiello, Alicia López-Oramas, Giovanni Ceribella, Javier Rico, Tokonatsu Yamamoto, Vitaly Neustroev, Stefano Menchiari, Ciro Bigongiari, Mitsunari Takahashi, Vassil Verguilov, Luca Tosti, Petar Temnikov, Sargis Gasparyan, Koji Noda, Wrijupan Bhattacharyya, Valerio D'Elia, Iva Šnidarić, Elisa Bernardini, Markus Garczarczyk, G. Maneva, Takashi Saito, Juliane van Scherpenberg, Wolfgang Rhode, Giovanni Busetto, Dominik Baack, Yukiho Kobayashi, Christian Fruck, Shunsuke Sakurai, Thomas Schweizer, Stefano Ansoldi, Riccardo Paoletti, Victor A. Acciari, Markus Gaug, and Moritz Hütten
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Physics ,Crab Nebula ,Astrophysics::High Energy Astrophysical Phenomena ,Flux ,Spectral energy distribution ,MAGIC (telescope) ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Blazar ,Spectral line ,Redshift ,BL Lac object - Abstract
The high-peaked BL Lac object 1ES 0647+250 is one of the few distant blazars detected at very-high-energy (VHE, E>100 GeV) γ rays during non-flaring activity. Its redshift is still uncertain, with a recently proposed lower limit of z>0.29. This blazar was first detected by the MAGIC telescopes between 2009 and 2011 during its low state, displaying a flux of around 2% of the Crab Nebula above 100 GeV, but it has shown several periods of high activity, where the VHE γ-ray flux increased by more than one order of magnitude. The VHE spectra of four observed periods are characterized and the redshift of this source is estimated using the HE and VHE spectral shapes. The multi-wavelength data set collected from 2009 to 2020 introduced in this work will serve as the seed for further studies, including detailed studies of the broad-band spectral energy distribution for different activity levels and multi-band variability and correlation studies., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)
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- 2022
42. Combined searches for dark matter in dwarf spheroidal galaxies observed with the MAGIC telescopes, including new data from Coma Berenices and Draco
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MAGIC Collaboration, Acciari, V., Ansoldi, S., Antonelli, L., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres de Almeida, U., Barrio, J., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S., Colombo, E., Contreras, J., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M., Font, L., Fruck, C., Fukami, S., García López, R., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zarić, D., Département de Physique des Particules (ex SPP) (DPhP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), MAGIC, Département de Physique des Particules (ex SPP) (DPP), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Academy of Finland, German Research Foundation, European Commission, Ministerio de Economía y Competitividad (España), and Japan Society for the Promotion of Science
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Astrophysics and Astronomy ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Dark Matter ,Indirect searches ,Gamma Rays ,Dwarf spheroidal galaxies ,Imaging Atmospheric Cherenkov ,Telescopes ,01 natural sciences ,WIMP: annihilation ,Imaging Atmospheric Cherenkov Telescopes ,0103 physical sciences ,TeV ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,astro-ph.HE ,010308 nuclear & particles physics ,imaging ,Dark Matter Indirect searches Gamma Rays Dwarf spheroidal galaxies Imaging Atmospheric Cherenkov Telescopes ,Astronomy and Astrophysics ,dark matter: annihilation ,sensitivity ,MAGIC ,gamma ray: emission ,Cherenkov counter ,Space and Planetary Science ,quality ,Física nuclear ,galaxy ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] - Abstract
T.M. Collaboration, V.A. Acciari, S. Ansoldi et al., Milky Way dwarf spheroidal galaxies (dSphs) are among the best candidates to search for signals of dark matter annihilation with Imaging Atmospheric Cherenkov Telescopes, given their high mass-to-light ratios and the fact that they are free of astrophysical gamma-ray emitting sources. Since 2011, MAGIC has performed a multi-year observation program in search for Weakly Interacting Massive Particles (WIMPs) in dSphs. Results on the observations of Segue 1 and Ursa Major II dSphs have already been published and include some of the most stringent upper limits (ULs) on the velocity- averaged cross-section ⟨σannv⟩ of WIMP annihilation from observations of dSphs. In this work, we report on the analyses of 52.1 h of data of Draco dSph and 49.5 h of Coma Berenices dSph observed with the MAGIC telescopes in 2018 and in 2019 respectively. No hint of a signal has been detected from either of these targets and new constraints on the ⟨σannv⟩ of WIMP candidates have been derived. In order to improve the sensitivity of the search and reduce the effect of the systematic uncertainties due to the J-factor estimates, we have combined the data of all dSphs observed with the MAGIC telescopes. Using 354.3 h of dSphs good quality data, 95% CL ULs on ⟨σannv⟩ have been obtained for 9 annihilation channels. For most of the channels, these results reach values of the order of 10−24 cm3/s at ∼1 TeV and are the most stringent limits obtained with the MAGIC telescopes so far., he financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovación (MICINN) (PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-104114RB-C33, PID2019-105510GB-C31, PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-400/18.12.2020 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia ‘‘Severo Ochoa’’ (SEV-2016-0588, CEX2019-000920-S), the Unidad de Excelencia ‘‘María de Maeztu’’ (CEX2019-000918-M, MDM-2015-0509-18-2) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO- 2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq and FAPERJ. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754510.
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- 2022
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43. Investigating the Blazar TXS 0506+056 through Sharp Multiwavelength Eyes During 2017-2019
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MAGIC Collaboration, Acciari, V. A., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., González, J. Becerra, Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. Fallah, Fariña, L., Fattorini, A., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Iotov, R., Ishio, K., Iwamura, Y., Martínez, I. Jiménez, Jormanainen, J., Jouvin, L., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Mariotti, M., Martínez, M., Aguilar, A. Mas, Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Rosillo, M. Nievas, Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Moroni, P. G. Prada, Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Collaboration, OVRO, Hodges, M., Hovatta, T., Kiehlmann, S., Liodakis, I., Max-Moerbeck, W., Pearson, T. J., Readhead, A. C. S., Reeves, R. A., Collaboration, Metsähovi, Lähteenmaäki, A., Tornikoski, M., Tammi, J., D'Ammando, F., Marchini, A., Metsähovi Radio Observatory, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Ministerio de Ciencia e Innovación (España), European Commission, Federal Ministry of Education and Research (Germany), Istituto Nazionale di Astrofisica, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Department of Atomic Energy (India), Ministry of Education, Culture, Sports, Science and Technology (Japan), Ministry of Education and Science (Bulgaria), Academy of Finland, Generalitat de Catalunya, Croatian Science Foundation, and German Research Foundation
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High energy astrophysics ,Jets ,Blazars ,Gamma-rays ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics::High Energy Astrophysical Phenomena ,gamma ray, VHE ,FOS: Physical sciences ,Bethe-Heitler ,blazar ,IceCube ,X-ray ,optical ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Astronomy and Astrophysics ,neutrino, current ,MAGIC ,cascade ,flux ,Space and Planetary Science ,ddc:520 ,spectral ,Física nuclear ,photon neutrino - Abstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.--Full list of authors: Acciari, V. A.; Aniello, T.; Ansoldi, S.; Antonelli, L. A.; Arbet Engels, A.; Artero, M.; Asano, K.; Baack, D.; Babić, A.; Baquero, A.; Barres de Almeida, U.; Barrio, J. A.; Batković, I.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bökenkamp, H.; Bonnoli, G.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; Vela, P. Da; Dazzi, F.; De Angelis, A.; De Lotto, B.; Del Popolo, A.; Delfino, M.; Delgado, J.; Mendez, C. Delgado; Depaoli, D.; Di Pierro, F.; Di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Fallah Ramazani, V.; Fariña, L.; Fattorini, A.; Font, L.; Fruck, C.; Fukami, S.; Fukazawa, Y.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Hassan, T.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Iotov, R.; Ishio, K.; Iwamura, Y.; Jiménez Martínez, I.; Jormanainen, J.; Jouvin, L.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Linhoff, L.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Mariotti, M.; Martínez, M.; Mas Aguilar, A.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Nakamori, T.; Nava, L.; Neustroev, V.; Nievas Rosillo, M.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Persic, M.; Pihet, M.; Prada Moroni, P. G.; Prandini, E.; Priyadarshi, C.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schmuckermaier, F.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strišković, J.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Takeishi, R.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Viale, I.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Yamamoto, T.; Zarić, D.; Hodges, M.; Hovatta, T.; Kiehlmann, S.; Liodakis, I.; Max-Moerbeck, W.; Pearson, T. J.; Readhead, A. C. S.; Reeves, R. A.; Lähteenmäki, A.; Tornikoski, M.; Tammi, J.; D'Ammando, F.; Marchini, A.; MAGIC Collaboration; OVRO Collaboration; Metsahovi Collaboration., The blazar TXS 0506+056 got into the spotlight of the astrophysical community in 2017 September, when a high-energy neutrino detected by IceCube (IceCube-170922A) was associated at the 3σ level with a γ-ray flare from this source. This multi-messenger photon-neutrino association remains, as per today, the most significant association ever observed. TXS 0506+056 was a poorly studied object before the IceCube-170922A event. To better characterize its broadband emission, we organized a multiwavelength campaign lasting 16 months (2017 November to 2019 February), covering the radio band (Metsähovi, OVRO), the optical/UV (ASAS-SN, KVA, REM, Swift/UVOT), the X-rays (Swift/XRT, NuSTAR), the high-energy γ rays (Fermi/LAT), and the very high-energy (VHE) γ rays (MAGIC). In γ rays, the behavior of the source was significantly different from the behavior in 2017: MAGIC observations show the presence of flaring activity during 2018 December, while the source only shows an excess at the 4σ level during the rest of the campaign (74 hr of accumulated exposure); Fermi/LAT observations show several short (on a timescale of days to a week) flares, different from the long-term brightening of 2017. No significant flares are detected at lower energies. The radio light curve shows an increasing flux trend that is not seen in other wavelengths. We model the multiwavelength spectral energy distributions in a lepto-hadronic scenario, in which the hadronic emission emerges as Bethe-Heitler and pion-decay cascade in the X-rays and VHE γ rays. According to the model presented here, the 2018 December γ-ray flare was connected to a neutrino emission that was too brief and not bright enough to be detected by current neutrino instruments. © 2022. The Author(s). Published by the American Astronomical Society., The financial support of the German BMBF, MPG, and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovación (MICINN) (PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-104114RB-C33, PID2019-105510GB-C31,PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-400/18.12.2020 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia "Severo Ochoa" (SEV-2016-0588, SEV-2017-0709, CEX2019-000920-S), the Unidad de Excelencia "María de Maeztu" (CEX2019-000918-M, MDM-2015-0509-18-2) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq and FAPERJ. E.P. acknowledges funding from the Italian Ministry of Education, University and Research (MIUR) through the "Dipartimenti di eccellenza" project Science of the universe. M.C. has received financial support through the Postdoctoral Junior Leader Fellowship Programme from la Caixa Banking Foundation, grant No. LCF/BQ/LI18/11630012. This research has made use of data from the OVRO 40 m monitoring program, which was supported in part by NASA grants NNX08AW31G, NNX11A043G, and NNX14AQ89G, and NSF grants AST-0808050 and AST-1109911, and private funding from Caltech and the MPIfR. This publication makes use of data obtained at Metsähovi Radio Observatory, operated by Aalto University in Finland.
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44. Search for Gamma-ray Line emission from Dark Matter annihilation in the Galactic Centre with the MAGIC telescopes
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Tomohiro Inada, Ana Babic, Andrés Baquero, Ivana Batković, Josefa Becerra Gonzalez, Jürgen Besenrieder, Hendrik Bökenkamp, Zeljka Bosnjak, Elia Do Souto Espiñeira, Ramon J. García López, Nikola Godinovic, Moritz Hütten, Irene Jiménez Martínez, Ruben Lopez-Coto, Marcos López-Moya, Alicia López-Oramas, Mosè Mariotti, Manel Martinez, Saša Mićanović, Lovro Pavletić, Pablo Peñil, Marc Ribó, Iva Šnidarić, Jelena Strišković, Tihomir Surić, Tomislav Terzic, Darko Zarić, Victor A. Acciari, Stefano Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel Artero, Katsuaki Asano, Dominik Baack, Ana Babić, Ulisses Barres de Almeida, Juan Abel Barrio, Josefa Becerra González, Wlodek Bednarek, Lorenzo Bellizzi, Elisa Bernardini, Maria-Isabel Bernardos, Alessio Berti, Wrijupan Bhattacharyya, Ciro Bigongiari, Adrian Biland, Oscar Blanch, Giacomo Bonnoli, Željka Bošnjak, Giovanni Busetto, Roberto Carosi, Giovanni Ceribella, Matteo Cerruti, Yating Chai, Ashot Agassi Chilingarian, Stefan Cikota, Sidika Merve Colak, Eduardo Colombo, Jose Luis Contreras, Juan Cortina, Stefano Covino, Giacomo D'Amico, Valerio D'Elia, Paolo Da Vela, Francesco Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel Delfino, Jordi Delgado, Carlos Delgado Mendez, Davide Depaoli, Federico Di Pierro, Leonardo Di Venere, Dijana Dominis Prester, Alice Donini, Daniela Dorner, Michele Doro, Dominik Elsaesser, Vandad Fallah Ramazani, Alicia Fattorini, Maria Victoria Fonseca, Lluis Font, Christian Fruck, Satoshi Fukami, Yasushi Fukazawa, Markus Garczarczyk, Sargis Gasparyan, Markus Gaug, Nicola Giglietto, Francesco Giordano, Pawel Gliwny, Nikola Godinović, David Green, Jarred Gershon Green, Daniela Hadasch, Alexander Hahn, Lea Heckmann, Javier Herrera, John Hoang, Dario Hrupec, Kazuma Ishio, Yuki Iwamura, Irene Jimenez-Martinez, Jenni Jormanainen, Léa Jouvin, Marie Karjalainen, Daniel Kerszberg, Yukiho Kobayashi, Hidetoshi Kubo, Junko Kushida, Alessandra Lamastra, Damir LELAS, Francesco Leone, Elina Lindfors, Lena Linhoff, Saverio Lombardi, Francesco Longo, Rubén López-Coto, Serena Loporchio, Bernardo Machado de Oliveira Fraga, Camilla Maggio, Pratik Majumdar, Martin MAKARIEV, Manuela Mallamaci, Galina Maneva, Marina Manganaro, Karl Mannheim, Laura Maraschi, Manel Martínez, Daniel Mazin, Stefano Menchiari, Simone Mender, Davide Miceli, Tjark Miener, Jose Miguel Miranda, Razmik Mirzoyan, Edgar Molina, Abelardo Moralejo, Daniel Morcuende, Victoria Moreno, Elena Moretti, Takeshi Nakamori, Lara Nava, Vitaly Neustroev, Cosimo Nigro, Kari Nilsson, Kyoshi Nishijima, Koji Noda, Seiya Nozaki, Yoshiki Ohtani, Tomohiko Oka, Jorge Otero-Santos, Simona Paiano, Michele Palatiello, David Paneque, Riccardo Paoletti, Josep M. Paredes, Massimo Persic, Marine Pihet, Pier Giorgio Prada Moroni, Elisa Prandini, Chaitanya Priyadarshi, Ivica Puljak, Wolfgang Rhode, Javier Rico, Chiara Righi, Andrea Rugliancich, Narek Sahakyan, Takayuki Saito, Shunsuke Sakurai, Konstancja Satalecka, Francesco Gabriele Saturni, Bernd Schleicher, Kevin Schmidt, Thomas Schweizer, Julian Sitarek, Dorota Sobczyńska, Alessia Spolon, Antonio Stamerra, Derek Strom, Marcel C. Strzys, Yusuke Suda, Mitsunari Takahashi, Ryuji Takeishi, Fabrizio Tavecchio, Petar Temnikov, Tomislav Terzić, Masahiro Teshima, Luca Tosti, Stefano Truzzi, Antonio Tutone, Santiago Ubach, Juliane van Scherpenberg, Gaia Vanzo, Monica VAZQUEZ ACOSTA, Sofia Ventura, Vassil VERGUILOV, Carlo francesco Vigorito, Vincenzo Vitale, Ievgen Vovk, Martin Will, Carolin Wunderlich, Tokonatsu Yamamoto, and Daniele Ninci
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Physics ,Annihilation ,media_common.quotation_subject ,Astrophysics::High Energy Astrophysical Phenomena ,Dark matter ,Gamma ray ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Galaxy ,Spectral line ,Sky ,MAGIC (telescope) ,Zenith ,Astrophysics::Galaxy Astrophysics ,media_common - Abstract
We present the first search for dark matter (DM) spectral lines in the Galactic centre (GC) region with the MAGIC telescopes. The MAGIC telescopes, located on the Canary island of La Palma (Spain), are sensitive to gamma rays in the energy range from 50 GeV to 50 TeV. MAGIC has performed indirect DM searches in various astrophysical targets, such as dwarf spheroidal galaxies and clusters of galaxies. Observations at high zenith angles significantly increase the telescopes' collection area and sensitivity for gamma rays in the TeV regime. We present the results obtained with more than 200 hours of high-zenith angle observations of the GC region with MAGIC, which allow us to probe promising heavy SUSY models, and to obtain competitive limits to the DM annihilation cross-section at high DM particle mass, compared to existing constraints. We will discuss how we exploit the data from a complex sky region to search for a line-like DM signature., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)
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- 2022
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45. Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
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Jonas Björk, Marie Courbebaisse, Edmund J. Lamb, Christophe Mariat, Ulf Nyman, Anna Åkesson, Andrew D. Rule, Anders Grubb, Ulla B. Berg, Cyril Garrouste, Kajsa Åsling-Monemi, Lionel Couzi, Hans Pottel, Bjørn Odvar Eriksen, Natalie Ebert, Lola Jacquemont, Christophe Legendre, Elke Schaeffner, Nassim Kamar, Pierre Delanaye, François Gaillard, Lionel Rostaing, Anders Larsson, Toralf Melsom, Karin Littmann, R Neil Dalton, Luciano Selistre, Laurence Dubourg, Per-Ola Sundin, Magnus Hansson, Arend Bökenkamp, Pediatric surgery, and Amsterdam Reproduction & Development (AR&D)
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Pharmacology ,medicine.medical_specialty ,Creatinine ,glomerular filtration rate ,business.industry ,Urology ,Renal function ,Context (language use) ,Body Mass Index ,chemistry.chemical_compound ,Cross-Sectional Studies ,chemistry ,drug adjustment ,Medicine ,Humans ,Pharmacology (medical) ,Dosage adjustment ,Renal Insufficiency, Chronic ,business ,Body mass index ,chronic kidney disease ,Glomerular Filtration Rate - Abstract
This is the peer reviewed version of the following article: Delanaye, P., Björk, J., Courbebaisse, M., Couzi, L., Ebert, N., Eriksen, B.O., .... Nyman, U. (2021). Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment. British Journal of Clinical Pharmacology, which has been published in final form at https://doi.org/10.1111/bcp.15132. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. Aim: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. Methods: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disease-Epidemiology (CKD-EPI), Lund-Malmö-Revised (LMR) and European-Kidney-Function-Consortium (EKFC) equations. Validation focused on bias, imprecision and accuracy (percentage of estimates within ±30% of mGFR, P30), overall and stratified for mGFR, age and body mass index at mGFR Results: The CG equation performed worse than the other equations, overall and in mGFR, age and BMI subgroups in terms of bias (systematic overestimation), imprecision and accuracy except for patients ≥65 years where bias and P30 were similar to MDRD and CKD-EPI, but worse than LMR and EKFC. In subjects with mGFR 2, all equations performed similarly, and for BMI 2 CG and LMR had the best results though all equations had poor P30-accuracy. At BMI ≥ 25 kg/m2 the bias of the CG increased with increasing BMI (+17.2 mL/min at BMI ≥ 40 kg/m2). The four more recent equations also classified mGFR stages better than CG. Conclusions: The CG equation showed poor ability to estimate GFR overall and in analyses stratified for mGFR, age and BMI. CG was inferior to correctly classify the patients in the mGFR staging compared to more recent creatinine-based equations.
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- 2021
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46. Assessment of kidney function:clinical indications for measured GFR
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Ebert, Natalie, Bevc, Sebastjan, Bökenkamp, Arend, Gaillard, Francois, Hornum, Mads, Jager, Kitty J, Mariat, Christophe, Eriksen, Bjørn Odvar, Palsson, Runolfur, Rule, Andrew D, Van Londen, Marco, White, Christine, and Schaeffner, Elke
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urogenital system ,urologic and male genital diseases ,reproductive and urinary physiology ,female genital diseases and pregnancy complications - Abstract
In the vast majority of cases, glomerular filtration rate (GFR) is estimated using serum creatinine, which is highly influenced by age, sex, muscle mass, body composition, severe chronic illness and many other factors. This often leads to misclassification of patients or potentially puts patients at risk for inappropriate clinical decisions. Possible solutions are the use of cystatin C as an alternative endogenous marker or performing direct measurement of GFR using an exogenous marker such as iohexol. The purpose of this review is to highlight clinical scenarios and conditions such as extreme body composition, Black race, disagreement between creatinine- and cystatin C-based estimated GFR (eGFR), drug dosing, liver cirrhosis, advanced chronic kidney disease and the transition to kidney replacement therapy, non-kidney solid organ transplant recipients and living kidney donors where creatinine-based GFR estimation may be invalid. In contrast to the majority of literature on measured GFR (mGFR), this review does not include aspects of mGFR for research or public health settings but aims to reach practicing clinicians and raise their understanding of the substantial limitations of creatinine. While including cystatin C as a renal biomarker in GFR estimating equations has been shown to increase the accuracy of the GFR estimate, there are also limitations to eGFR based on cystatin C alone or the combination of creatinine and cystatin C in the clinical scenarios described above that can be overcome by measuring GFR with an exogenous marker. We acknowledge that mGFR is not readily available in many centres but hope that this review will highlight and promote the expansion of kidney function diagnostics using standardized mGFR procedures as an important milestone towards more accurate and personalized medicine.
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- 2021
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47. MAGIC detection of Geminga: an Inverse Compton tail?
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Daniela Dorner, Gaia Vanzo, Louis Antonelli, Giacomo D'Amico, Carolin Wunderlich, Juliane van Scherpenberg, Katsuaki Asano, Mosè Mariotti, Juan Abel Barrio, Petar Temnikov, Jarred Gershon Green, Koji Noda, Serena Loporchio, Narek Sahakyan, Elisa Bernardini, D. Dominis Prester, Jenni Jormanainen, Bernardo Machado de Oliveira Fraga, Maria Victoria Fonseca, Manuel Artero, L. Maraschi, Elina Lindfors, Santiago Ubach, Massimo Persic, Alice Donini, Carlos Delgado Mendez, Daniel Mazin, Alexander Hahn, Marina Manganaro, Saverio Lombardi, Marine Pihet, Nikola Godinovic, Alessio Berti, Ievgen Vovk, Lara Nava, Wrijupan Bhattacharyya, Tomislav Terzić, Andrea Rugliancich, Elena Moretti, Fabrizio Tavecchio, Chiara Righi, Davide Depaoli, Axel Arbet Engels, Eduardo Colombo, Daniel Morcuende, Jose Luis Contreras, Takeshi Nakamori, Jordi Delgado, Giacomo Bonnoli, Tihomir Surić, P. G. Prada Moroni, M. I. Martínez, Pratik Majumdar, Juan Cortina, Barbara De Lotto, Konstancja Satalecka, Markus Garczarczyk, Michele Doro, Marie Karjalainen, Javier Rico, Tokonatsu Yamamoto, Vitaly Neustroev, Josefa González, Chaitanya Priyadarshi, Leonardo Di Venere, Camilla Maggio, Martin Will, Victor A. Acciari, Kevin Schmidt, Lena Linhoff, Karl Mannheim, Stefano Menchiari, Jorge Otero-Santos, John Hoang, Hendrik Bökenkamp, Luca Tosti, Shunsuke Sakurai, Satoshi Fukami, Vandad Fallah Ramazani, Takashi Saito, Stefano Truzzi, Jürgen Besenrieder, Francesco Giordano, Antonio Tutone, Francesco Dazzi, Michele Palatiello, Alicia López-Oramas, Seiya Nozaki, Josep M. Paredes, Moritz Hütten, Matteo Cerruti, Pablo Peñil, Valerio D'Elia, Stefano Covino, Masahiro Teshima, Dominik Baack, Antonio Stamerra, Junko Kushida, Saša Mićanović, G. Maneva, Lluis Font, Lovro Pavletić, Cosimo Nigro, Ivana Batković, Yasushi Fukazawa, Roberto Carosi, Sofia Ventura, Francesco Longo, Adrian Biland, Kazuma Ishio, Maria-Isabel Bernardos, Ivica Puljak, Sidika Merve Colak, Iva Šnidarić, Monica Vazquez Acosta, Ryuji Takeishi, D. M. Strom, Kari Nilsson, Yukiho Kobayashi, Davide Miceli, Giovanni Ceribella, Julian Sitarek, Yusuke Suda, Elisa Prandini, Marcel Strzys, Simona Paiano, Alessia Spolon, Léa Jouvin, Alicia Fattorini, Christian Fruck, Ramon J. García López, Daniela Hadasch, Sargis Gasparyan, Manuela Mallamaci, Carlo Vigorito, Elia Do Souto Espiñeira, Ashot Chilingarian, Simone Mender, Javier Herrera, Alessandro De Angelis, Wolfgang Rhode, Giovanni Busetto, Yoshiki Ohtani, Manuel Delfino, Ulisses Barres de Almeida, Vassil Verguilov, Lorenzo Bellizzi, Tomohiko Oka, Kyoshi Nishijima, Ana Babić, Daniel Kerszberg, Martin Makariev, Oscar Blanch, Dominik Elsaesser, Razmik Mirzoyan, Tjark Miener, David Paneque, Yuki Iwamura, Yating Chai, Damir Lelas, Stefan Cikota, Pawel Gliwny, Nicola Giglietto, Marc Ribó, Lea Heckmann, Francesco Gabriele Saturni, Jelena Strišković, Victoria Moreno, Darko Zarić, Dorota Sobczyńska, Hidetoshi Kubo, Tomohiro Inada, Zeljka Bosnjak, Andrés Baquero, Thomas Schweizer, Stefano Ansoldi, Riccardo Paoletti, Markus Gaug, Ciro Bigongiari, Abelardo Moralejo, Bernd Schleicher, Edgar Molina, Dario Hrupec, Mitsunari Takahashi, Alessandra Lamastra, Vincenzo Vitale, Francesco Leone, Paolo Da Vela, David H. Green, Marcos López-Moya, Wlodek Bednarek, Federico Di Pierro, Ruben Lopez-Coto, Irene Jiménez Martínez, and Jose Miguel Miranda
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Physics ,Range (particle radiation) ,Pulsar ,Scattering ,Astrophysics::High Energy Astrophysical Phenomena ,Inverse ,MAGIC (telescope) ,Astrophysics ,Radiation ,Curvature ,Vela - Abstract
We report the detection of pulsed emission from the Geminga pulsar (PSR J0633+1746) with the MAGIC Telescopes. After the Crab and Vela pulsars, Geminga is the third one detected in the very high energy domain, and its estimated age of ~340 ky makes it the oldest one. The spectrum derived by MAGIC extends from ~15 GeV to 75 GeV and can be well modeled with a simple, soft power-law function. For energies below 40 GeV it overlaps with Fermi-LAT measurements. Joint fits to MAGIC and Fermi-LAT data disfavour the existence of a sub-exponential cut-off in this energy range. Our results are discussed in the framework of the outer gap accelerator model. Such power-law emission can be interpreted as the transition from curvature radiation to inverse Compton (IC) scattering of charges accelerated in the northern outer gap. The IC component is expected to continue towards higher energies. The model fails to fit the overall shape of the spectrum, indicating that a major review is required. The MAGIC Telescopes are two IACTs on the Canary Island of La Palma. In recent years they have significantly improved their performance below 100 GeV with the introduction of a novel trigger system, the Sum-Trigger-II, which halves the energy threshold of the system.
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- 2021
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48. MAGIC and H.E.S.S. detect VHE gamma rays from the blazar OT081 for the first time: a deep multiwavelength study
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Marina, Manganaro, Monica, Seglar-Arroyo, Josefa, Becerra-Gonz('(a))lez, David, Sanchez, Matteo, Cerruti, Fabrizio, Tavecchio, Vandad, Fallah-Ramazani, Ivan, Agudo, Stefano, Ciprini, Alexei Vladimir Filippenko, Esteban-Gutierrez, A., Talvikki, Hovatta, Helen, Jermak, Jorstad, Svetlana G., Kopatskaya, Evgenia N., Larionov, Valeri M., Larionova, L. V., Anne, Lähteenmäki, Alan, Marscher, Morozova, D. A., Marko, Pahljina, Merja, Tornikoski, Yuliya, Troitskaya, Troitsky, I., Francesco, Verrecchia, Xiao, H. B., Weaver, Z. R., Weikang, Zheng, Acciari, Victor A., Stefano, Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel, Artero, Katsuaki, Asano, Dominik, Baack, Ana, Babic, Andr('(e))s, Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana, Batkovi('(c)), Josefa Becerra Gonzalez, Wlodek, Bednarek, Lorenzo, Bellizzi, Elisa, Bernardini, Maria-Isabel, Bernardos, Alessio, Berti, Jürgen, Besenrieder, Wrijupan, Bhattacharyya, Ciro, Bigongiari, Adrian, Biland, Oscar, Blanch, Hendrik, Bökenkamp, Giacomo, Bonnoli, Zeljka, Bosnjak, Giovanni, Busetto, Roberto, Carosi, Giovanni, Ceribella, Yating, Chai, Ashot, Chilingarian, Stefan, Cikota, Sidika Merve Colak, Eduardo, Colombo, Jose Luis Contreras, Juan, Cortina, Stefano, Covino, Giacomo D( extquotesingle)Amico, Valerio D( extquotesingle)Elia, Paolo Da Vela, Francesco, Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel, Delfino, Jordi, Delgado, Carlos Delgado Mendez, Davide, Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espi(~(n))eira, Dijana Dominis Prester, Alice, Donini, Daniela, Dorner, Michele, Doro, Dominik, Elsaesser, Vandad Fallah Ramazani, Alicia, Fattorini, Maria Victoria Fonseca, Lluis, Font, Christian, Fruck, Satoshi, Fukami, Yasushi, Fukazawa, Garc('(i))a L('(o))pez, Ramon J., Markus, Garczarczyk, Sargis, Gasparyan, Markus, Gaug, Giglietto, Nicola, Francesco, Giordano, Pawel, Gliwny, Nikola, Godinovic, David, Green, Jarred Gershon Green, Daniela, Hadasch, Alexander, Hahn, Lea, Heckmann, Javier, Herrera, John, Hoang, Dario, Hrupec, Moritz, Hütten, Tomohiro, Inada, Kazuma, Ishio, Yuki, Iwamura, Irene Jim('(e))nez Mart('(i))nez, Jenni, Jormanainen, L('(e))a, Jouvin, Marie, Karjalainen, Daniel, Kerszberg, Yukiho, Kobayashi, Hidetoshi, Kubo, Junko, Kushida, Alessandra, Lamastra, Damir, Lelas, Francesco, Leone, Elina, Lindfors, Lena, Linhoff, Saverio, Lombardi, Francesco, Longo, Ruben, Lopez-Coto, Marcos, L('(o))pez-Moya, Alicia, L('(o))pez-Oramas, Loporchio, Serena, Bernardo Machado de Oliveira Fraga, Camilla, Maggio, Pratik, Majumdar, Martin, Makariev, Manuela, Mallamaci, Galina, Maneva, Karl, Mannheim, Laura, Maraschi, Mos(`(e)), Mariotti, Manel, Martinez, Daniel, Mazin, Stefano, Menchiari, Simone, Mender, Sa( (s))a Mi('(c))anovi('(c)), Davide, Miceli, Tjark, Miener, Jose Miguel Miranda, Razmik, Mirzoyan, Edgar, Molina, Abelardo, Moralejo, Daniel, Morcuende, Victoria, Moreno, Elena, Moretti, Takeshi, Nakamori, Lara, Nava, Vitaly, Neustroev, Cosimo, Nigro, Kari, Nilsson, Kyoshi, Nishijima, Koji, Noda, Seiya, Nozaki, Yoshiki, Ohtani, Tomohiko, Oka, Jorge, Otero-Santos, Simona, Paiano, Michele, Palatiello, David, Paneque, Riccardo, Paoletti, Paredes, Josep M., Lovro, Pavleti('(c)), Pablo, Pe(~(n))il, Massimo, Persic, Marine, Pihet, Pier Giorgio Prada Moroni, Elisa, Prandini, Chaitanya, Priyadarshi, Ivica, Puljak, Wolfgang, Rhode, Marc, Rib('(o)), Javier, Rico, Chiara, Righi, Andrea, Rugliancich, Narek, Sahakyan, Takayuki, Saito, Shunsuke, Sakurai, Konstancja, Satalecka, Francesco Gabriele Saturni, Bernd, Schleicher, Kevin, Schmidt, Thomas, Schweizer, Julian, Sitarek, Iva, ( (S))nidari('(c)), Dorota, Sobczy('(n))ska, Alessia, Spolon, Antonio, Stamerra, Jelena Stri( (s))kovi('(c)), Derek, Strom, Marcel, Strzys, Yusuke, Suda, Tihomir, Suri('(c)), Mitsunari, Takahashi, Ryuji, Takeishi, Petar, Temnikov, Tomislav, Terzic, Masahiro, Teshima, Luca, Tosti, Stefano, Truzzi, Antonio, Tutone, Santiago, Ubach, Juliane van Scherpenberg, Gaia, Vanzo, Monica VAZQUEZ ACOSTA, Sofia, Ventura, Vassil, Verguilov, Carlo Francesco Vigorito, Vincenzo, Vitale, Ievgen, Vovk, Martin, Will, Carolin, Wunderlich, Tokonatsu, Yamamoto, Darko, Zari('(c)), and And
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Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,Spectral energy distribution ,Quasar ,Astrophysics::Cosmology and Extragalactic Astrophysics ,MAGIC (telescope) ,Astrophysics ,Emission spectrum ,Light curve ,Blazar ,Astrophysics::Galaxy Astrophysics ,Fermi Gamma-ray Space Telescope - Abstract
OT 081 is a luminous blazar well known for its variability in many energy bands. The very-high-energy (VHE; E >100 GeV) gamma-ray emission from the source was discovered by MAGIC and H.E.S.S. during flaring activity in July 2016, after a trigger from the Large Area Telescope (LAT) onboard the Fermi satellite. By analysing the multiwavelength light curves andthe broadband spectral energy distribution (SED), we study the activity of the source and investigate four individual states of activity in the window from MJD 57575 to 57602. The intrinsic gamma-ray spectrum can be described by a power law with spectral indices of 3.27 ± 0.44(MAGIC)and 3.39 ± 0.58(H.E.S.S.) over energy ranges 60–300 GeV and 120–500 GeV, respectively. The combined contemporaneous high-energy (HE;E >100 MeV) through VHE SED shows curvatureand can be described by a log-parabola shape. A simple one-zone synchrotron self-Compton (SSC)model is not sufficient to describe the broadband SED. The presence of broad emission lines in the optical spectrum of the source challenges the categorisation of OT 081 as a BL Lac and, together with the emission scenarios tested, points to the possibility that the source is transitional in nature between a BL Lac and a flat-spectrum radio quasar.
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- 2021
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49. Extreme blazars under the eyes of MAGIC
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Arbet-Engels, A., Prandini, E., Ventura, S., Fallah Ramazani, V., Cerruti, M., Arcaro, C., Asano, K., Dorner, D., Manganaro, M., Bonnoli, G., D’ammando, F., Foffano, L., Tavecchio, F., Becerra-Gonzalez, J., Jormanainen, J., Da Vela, P., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Rugliancih, B., Artero, M., Asaoo, K., Back, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Bilaud, A., Blanch, O., Bökenkamp, H., Bonoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Ceruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D’amico, G., D’elia, V., Da Vala, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Doner, D., Doro, M., Elsaeser, D., Falah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormaninen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganro, M., Manheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Walter, R., Priyadarshi, C., Puljak, I., Rhade, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schlaicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Dorota Sobczynska, Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavechio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Sliusar, V., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Schleicher, B., Baack, D., Balbo, M., Biland, A., Bretz, T., Buss, J., Donor, D., Eisenberger, L., Elsaesser, D., Hildebrand, D., Iotov, R., Kalenski, A., Mannheim, K., Mitchell, A., Neise, D., Noethe, M., Paravac, A., and Rhode, W.
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Physics ,Astrophysics::High Energy Astrophysical Phenomena ,media_common.quotation_subject ,Astronomy ,Blazar ,Magic (paranormal) ,media_common - Abstract
Extreme high-frequency-peaked BL Lac objects (EHBLs) are the most energetic persistent sources in the universe. This contribution reports on long-term observing campaigns of tens of EHBLs that have been organized by the MAGIC collaboration to enlarge their population at VHE and understand the origin of their extreme properties. EHBLs are characterized by a spectral energy distribution (SED) featuring a synchrotron peak energy above 1 keV. Several EHBLs display a hard spectral index at very high energies (VHE; E>100 GeV), suggesting a gamma-ray SED component peaking significantly above 1 TeV. Such extreme properties are challenging current standard emission and acceleration mechanisms. Recent studies have also unveiled intriguing disparities in the temporal characteristics of EHBLs. Some sources seem to display a persistent EHBL behaviour, while others belong to the EHBL family only temporarily. We will focus on the recent results of the first hard-TeV EHBL catalog. The MAGIC observations are accompanied by an extensive multi-wavelength coverage to obtain an optimal determination of the SED. This allow us to investigate leptonic and hadronic scenarios for the emission. We will also present the recent detection of the EHBL 1RXS0812.0+0237 in the VHE band by MAGIC. Finally, we will discuss a broad multi-wavelength campaign on the BL Lac type object 1ES2344+514, which showed intermittent EHBL characteristics in August 2016., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)
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- 2021
- Full Text
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50. Follow-up observations of GW170817 with the MAGIC telescopes
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Antonio Stamerra, Om Sharan Salafia, Alessio Berti, Stefano Covino, Valerio D'Elia, Davide Miceli, Lara Nava, Barbara Patricelli, Chiara Righi, Susumu Inoue, Lucio Angelo Antonelli, Stefano Ansoldi, Barbara De Lotto, Francesco Longo, Fabrizio Tavecchio, Ana Babic, Josefa Becerra Gonzalez, Zeljka Bosnjak, Nikola Godinovic, Ruben Lopez-Coto, Manel Martinez, Tomislav Terzic, Victor A. Acciari, Axel Arbet Engels, Manuel Artero, Katsuaki Asano, Dominik Baack, Ana Babić, Andrés Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana Batković, Josefa Becerra González, Wlodek Bednarek, Lorenzo Bellizzi, Elisa Bernardini, Maria-Isabel Bernardos, Jürgen Besenrieder, Wrijupan Bhattacharyya, Ciro Bigongiari, Adrian Biland, Oscar Blanch, Hendrik Bökenkamp, Giacomo Bonnoli, Željka Bošnjak, Giovanni Busetto, Roberto Carosi, Giovanni Ceribella, Matteo Cerruti, Yating Chai, Ashot Agassi Chilingarian, Stefan Cikota, Sidika Merve Colak, Eduardo Colombo, Jose Luis Contreras, Juan Cortina, Giacomo D'Amico, Paolo Da Vela, Francesco Dazzi, Alessandro De Angelis, Manuel Delfino, Jordi Delgado, Carlos Delgado Mendez, Davide Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espiñeira, Dijana Dominis Prester, Alice Donini, Daniela Dorner, Michele Doro, Dominik Elsaesser, Vandad Fallah Ramazani, Alicia Fattorini, Maria Victoria Fonseca, Lluis Font, Christian Fruck, Satoshi Fukami, Yasushi Fukazawa, Ramon J. García López, Markus Garczarczyk, Sargis Gasparyan, Markus Gaug, Nicola Giglietto, Francesco Giordano, Pawel Gliwny, Nikola Godinović, David Green, Jarred Gershon Green, Daniela Hadasch, Alexander Hahn, Lea Heckmann, Javier Herrera, John Hoang, Dario Hrupec, Moritz Hütten, Tomohiro Inada, Kazuma Ishio, Yuki Iwamura, Irene Jiménez Martínez, Jenni Jormanainen, Léa Jouvin, Marie Karjalainen, Daniel Kerszberg, Yukiho Kobayashi, Hidetoshi Kubo, Junko Kushida, Alessandra Lamastra, Damir LELAS, Francesco Leone, Elina Lindfors, Lena Linhoff, Saverio Lombardi, Rubén López-Coto, Marcos López-Moya, Alicia López-Oramas, Serena Loporchio, Bernardo Machado de Oliveira Fraga, Camilla Maggio, Pratik Majumdar, Martin MAKARIEV, Manuela Mallamaci, Galina Maneva, Marina Manganaro, Karl Mannheim, Laura Maraschi, Mosè Mariotti, Manel Martínez, Daniel Mazin, Stefano Menchiari, Simone Mender, Saša Mićanović, Tjark Miener, Jose Miguel Miranda, Razmik Mirzoyan, Edgar Molina, Abelardo Moralejo, Daniel Morcuende, Victoria Moreno, Elena Moretti, Takeshi Nakamori, Vitaly Neustroev, Cosimo Nigro, Kari Nilsson, Kyoshi Nishijima, Koji Noda, Seiya Nozaki, Yoshiki Ohtani, Tomohiko Oka, Jorge Otero-Santos, Simona Paiano, Michele Palatiello, David Paneque, Riccardo Paoletti, Josep M. Paredes, Lovro Pavletić, Pablo Peñil, Massimo Persic, Marine Pihet, Pier Giorgio Prada Moroni, Elisa Prandini, Chaitanya Priyadarshi, Ivica Puljak, Wolfgang Rhode, Marc Ribó, Javier Rico, Andrea Rugliancich, Narek Sahakyan, Takayuki Saito, Shunsuke Sakurai, Konstancja Satalecka, Francesco Gabriele Saturni, Bernd Schleicher, Kevin Schmidt, Thomas Schweizer, Julian Sitarek, Iva Šnidarić, Dorota Sobczyńska, Alessia Spolon, Jelena Strišković, Derek Strom, Marcel C. Strzys, Yusuke Suda, Tihomir Surić, Mitsunari Takahashi, Ryuji Takeishi, Petar Temnikov, Tomislav Terzić, Masahiro Teshima, Luca Tosti, Stefano Truzzi, Antonio Tutone, Santiago Ubach, Juliane van Scherpenberg, Gaia Vanzo, Monica VAZQUEZ ACOSTA, Sofia Ventura, Vassil VERGUILOV, Carlo francesco Vigorito, Vincenzo Vitale, Ievgen Vovk, Martin Will, Carolin Wunderlich, Tokonatsu Yamamoto, and Darko Zarić
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Physics ,Neutron star ,Gravitational wave ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,MAGIC (telescope) ,Maximum flux ,Gamma-ray burst - Abstract
The discovery of the electromagnetic counterpart AT2017gfo and the GRB 170817A, associated to the binary neutron star merger GW170817, was one of the major advances in the study of gamma- ray bursts (GRBs) and the hallmark of the multi-messenger astronomy with gravitational waves. Another breakthrough in GRB physics is represented by the discovery of the highly energetic, teraelectronvolt (TeV) component in the GRB 190114C, possibly an universal component in all GRBs. This conclusion is also suggested by the hint of TeV emission in the short GRB 160821B and a few more events reported in the literature. The missing observational piece is the joint detection of TeV emission and gravitational waves from a short GRB and its progenitor. MAGIC observed the counterpart AT2017gfo as soon as the visibility conditions allowed it, namely from January to June 2018. These observations correspond to the maximum flux level observed in the radio and X-ray bands. The upper limits derived from TeV observations are compared with the modelling of the late non-thermal emission using the multi-frequency SED.
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- 2021
- Full Text
- View/download PDF
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