32 results on '"Arun Hs"'
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2. Analysis of ChatGPT Tool to Assess the Potential of its Utility for Academic Writing in Biomedical Domain
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Arun HS Kumar
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Polymers and Plastics - Published
- 2023
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3. Inaccurate Labelling of Melatonin Gummies: A Concerning Trend
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Arun HS Kumar
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Polymers and Plastics - Published
- 2023
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4. Contamination of Food by Nitrosamines and the Associated Public Health Risks
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Arun HS Kumar
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Polymers and Plastics - Published
- 2023
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5. Pharmacological Targets of Asundexian Relevant to its Therapeutic Efficacy in Treating Cardiovascular Diseases
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Arun HS Kumar
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Polymers and Plastics - Abstract
Background Oral anticoagulant which don’t interfere with haemostasis physiology have potential application in management of acute cardiovascular events. Asundexian is once such oral anticoagulant, which is reported to be beneficial by minimising the rate of ischemic events. This study examined the pharmacological basis for cardiovascular benefits of asundexian. Materials and Methods All potential targets of asundexian in humans were identified by Insilco screening in the SwissTargetPrediction server and analysed. Results Unexpectedly factor XI or Xia was not observed to be targeted by asundexian in this study. However factor XII and thrombin were observed to be targeted by asundexian. In addition several GPCR’s, ion channels, enzymes and kinases relevant to positive modulation of cardiovascular physiology were observed to be targeted by asundexian. Conclusion The anticoagulant effects of asundexian is likely to be by indirect inhibition of factor XI or Xia by interfering with factor XII and/or thrombin. The cardiovascular benefits of asundexian is likely mediated by broader relevant off target effects.
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- 2022
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6. Comparative Pharmacology of Direct Oral Anticoagulants and Vitamin K Antagonist
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Arun HS Kumar
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Polymers and Plastics - Published
- 2022
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7. PTPRC, KDM5C, GABBR1 and HDAC1 are the Major Targets of Valproic Acid in Regulation of its Anticonvulsant Pharmacological Effects
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Arun HS Kumar
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Polymers and Plastics - Published
- 2022
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8. Protein Binding and Differential Distribution of Calcitonin in the Sub-compartments of Blood: An in vitro Study
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Alex Bryan and Arun HS Kumar
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Polymers and Plastics - Abstract
The pharmacodynamics effects of therapeutically administered calcitonin is observed for extended duration much beyond its reported short half-life. The rationale for this pharmacodynamic-pharmacokinetics mismatch of calcitonin is not known. Hence in this study the hypothesis on sub-compartmentalization of calcitonin in blood to explain the extended pharmacodynamics effects of calcitonin was evaluated in vitro using the sheep blood model. A relatively higher proportion of calcitonin concentration was observed in the WBC compartment. The partition coefficient analysis showed levels of calcitonin to be higher on WBC membrane compared to intracellular. Molecular modelling to assess the binding of calcitonin with protein in plasma and WBC membranes indicated physiologically relevant higher affinity with beta-2-microglobulin’s in plasma and glycoproteins (CD44), sushi domains (CD25), fibronectins (CD206) and siglecs (CD22) on WBC membrane. The physiologically relevant higher affinity with several proteins on WBC membrane and plasma can be responsible for extended pharmacodynamics effects observed for therapeutically administered calcitonin.
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- 2022
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9. Unveiling the Mysteries of Gut CrAssphages: A Step Forward in Understanding the Human Virobiome
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Arun HS Kumar
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Polymers and Plastics - Published
- 2023
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10. Network Pharmacology Analysis of Orally Bioavailable SARS-CoV-2 Protease Inhibitor Shows Synergistic Targets to Improve Clinical Efficacy
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Arun HS Kumar
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Polymers and Plastics - Published
- 2021
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11. Analysing the role of SERPINE1 network in the pathogenesis of human glioblastoma
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Zahra Khosravi, Chandrasekaran Kaliaperumal, and Arun HS Kumar
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BackgroundGlioblastoma multiforme (GBM) is one of the most aggressive and difficult to treat brain tumour in humans with a 5 year survival rate of less than 6%. SERPINE1 is a novel tumour receptor found on GBM that modulates the progression of this cancer through growth signals and remodelling of the extracellular matrix. Hence, we investigated the role of SERPINE1 and its network proteins in pathogenesis of GBM and assessed its targetability.Material and methodsNetwork proteins of SERPINE1 in homo sapiens was identified using the String database, and the affinity of the protein-protein interaction of this network was analysed using Chimera software. The expression profile of SERPINE1 in the different brain regions was evaluated to correlate its relevance to GBM pathology. Selected small molecules fromCalotropis giganteawere screened using AutoDock vina to assess targetability of human SERPINE1.ResultsVTN, PLG, TGFB1, VWF, FGF2 and CXCR1 were identified as the major network proteins of SERPINE1. The strongest interaction was observed between SERPINE1 and FGF2 (42884 H-bonds) followed by CXCR1 (20279 H-bonds). Our results suggest that SERPINE1 and its network proteins identified here play a vital role in GBM development and progression through brain parenchyma by creating the prime microenvironment for carcinogenesis, tumour invasion and migration. The highest expression of SERPINE1 was observed in the pons, medulla, midbrain, corpus callosum and spinal cord. Expression of SERPINE1 was consistent with high grade lesions of GBM, suggesting association of SERPINE1 with advanced stages of GBM. The selected small molecules fromCalotropis giganteawere observed to have therapeutically feasible binding affinity (140 - 550 μM) and predicted efficacy (290 - 1115 μM) against human SERPINE1.ConclusionSERPINE1 plays a vital role in the progression of GBM through its critical network proteins identified in this study. The expression of SERPINE1 aligns with the advanced stages of GBM. Small molecules fromCalotropis giganteatested in this study can serve as lead compounds for developing novel anti-SERPINE1 therapeutics for advanced stages of GBM.
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- 2022
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12. Novel Referencing Style Based on DOI® for Digital Publications
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Mueen Ahmed KK and Arun HS Kumar
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Polymers and Plastics - Published
- 2022
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13. Influence of ambient day light variations and age on the Iris-pupillary area ratio in beef cattle
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Paulina Chojnacka and Arun HS Kumar
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Polymers and Plastics - Abstract
IntroductionIris-pupillary area ratio (IPR) is an objective and non-invasive index of autonomic nervous system activity and stress, which can be confounded by light intensity or age of an individual. Evaluating the influence of ambient light intensity variations or age on IPR is necessary to improve the validity of IPR for its clinical application in objective assessment of welfare and stress.Materials and MethodsIn this study we evaluated the influence of ambient light intensity variations and age on IPR in beef cattle breeds (Limousin, Belgian Blue and Charolais) and analysed the data using correlation statistics.ResultsThe correlation between the light intensity (20 to 500 lux; r = 0.22, p = 0.08) or age (10 to 145 months, r = 0.20, p = 0.12) and IPR was weak and statistically not significant. A sub-group analysis assessing the influence of gender on correlation between the light intensity and IPR also was not statistically significant.ConclusionOur results suggest that within the ambient light intensity (20 to 500 lux) and age (10 to 145 months) the variation in IPR is minimal. Hence our results validate the merit of IPR in objectively measuring autonomic activity/stress and demonstrate the practicality of using IPR for welfare assessment under ambient light conditions in wider age cohorts of beef cattle.
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- 2022
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14. Comparative study of surgical management versus conservative management of displaced fractures of the clavicle
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P V Manohar, Nagakumar Js, Abhijeet Salunkhe, and Arun Hs
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medicine.medical_specialty ,Conservative management ,business.industry ,medicine.medical_treatment ,Surgery ,law.invention ,Intramedullary rod ,medicine.anatomical_structure ,Clavicle ,law ,Shoulder girdle ,medicine ,Chi-square test ,Internal fixation ,business ,Reduction (orthopedic surgery) ,Fixation (histology) - Abstract
Back ground and objectives: Clavicle fracture accounts for approximately 2.6% of all the skeletal fractures. These fractures are often associated with shoulder girdle injuries in approximately 44% of cases. Non operative treatment has been a mainstay of a modality of treatment, and irrespective of the type of fracture and amount of comminution, all these fractures were treated non-operatively. Different surgical methods for clavicle midshaft fractures have been described and these are locking compression plate fixation, intramedullary K-wires, Steinmann pin fixation, and intramedullary nailing with TENS. Therefore in this study we have compared the functional outcome of displaced clavicle fractures treated by non-surgical management with that of surgical management by TENS and by open reduction and internal fixation with clavicular locking compression plate. Methods: 60 patients with clavicle fractures presenting to the Orthopaedic Department of R L Jalappa hospital from Nov. 2017 to April 2019 are included in the study after obtaining informed consent. Result: Among 60 patients with clavicle fractures, majority of the injury occurred in male patients- 45 cases (75%), whereas a total of 15 cases (25%) were seen in females. The functional outcome at the end of 6 months in 30 conservatively managed cases showed, 4 cases (13.3%) with excellent outcome; 6 cases (20%) had good outcome. 16 cases (53.3%) had fair and 4 cases (13.3%) had poor outcome. While in surgically managed 30 cases, the functional outcome at the end of 6months showed a total of 23(76.6%) cases with excellent outcome, 4 cases (13.3%) had good outcome 2 cases (6.6%) had a fair, and 1 case (3.33%) had poor outcome. At the end of 6 months, functional outcome of both the groups were compared by applying chi square test, the p value was
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- 2020
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15. A prospective study on role of hydraulic distension along with steroid under local anaesthesia in the management of frozen shoulder
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Roger Kennedy X and Arun Hs
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Elbow ,Adhesion (medicine) ,Frozen shoulder ,Physical examination ,Distension ,medicine.disease ,medicine.anatomical_structure ,Anesthesia ,Orthopedic surgery ,Medicine ,Presentation (obstetrics) ,business ,Prospective cohort study - Abstract
Introduction: Frozen shoulder” is a chronic condition characterized by gradually progressive, painful restriction of all shoulder joint movement, with slow spontaneous recovery of either partial or complete movement over a period of time. Although many treatment options have been proposed for the frozen shoulder syndrome, each has limitations. Hydro dilation technique was developed in order to loosen the reported contraction and adhesion. we evaluated the Range of movement and pain relief of shoulder following “Hydraulic distension under local anaesthesia along with a steroid” pre and post distension. Material and methods: A prospective observational study was conducted in the department of orthopaedics at RLJ hospital attached to Sri Devaraj Urs Medical College between June 2018 to November 2019 for a period of 1.5 year. All the Patients with Peri arthritis shoulder and age above 30 years were included in the study. After obtaining the informed consent from the patients, Demographic data, History, Clinical Examination and details of investigations were recorded in study proforma. The pain and functional scoring used as per “The society of American Shoulder and elbow surgeons” and follow-up was done at 3 weeks, 6 weeks and 12 weeks after procedure. IBM SPSS version 22 was used for statistical analysis. Results: Total 50 patients were included in the study. The average age of the study population was 52.68 ± 9.79. There were no patients with complete disability. Marked pain (grade 1) was observed on presentation in 46(92%) of the subjects. Post distension only 9(18%) had pain. Flexion, abduction, internal rotation, external rotation movements of the shoulder have improved post distention and were statistically significant at 3rd, 6th, 12 th week. The mean ASES was 36.04 ± 5.84 at base line, it was 67.6 ± 7.64 at 6th week and 91.04 ± 8.68 at 12th week. The differences in the ASES score at 6th week and 12th week follow up period with baseline value were statistically significant (P value
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- 2020
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16. Clinical study of fixation of unstable inter-trochanteric femoral fractures with 95⁰ angle blade plate
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Arun Hs, Surendra Singh Rawat, Suraj Sankar, and Samarth Arya
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Clinical study ,Orthodontics ,Fixation (surgical) ,business.industry ,Medicine ,Blade plate ,business - Published
- 2020
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17. Effect of platelet rich plasma in osteoarthritis knee-A short term follow up
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Rammanohar Surepally, Nagakumar Js, and Arun Hs
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medicine.medical_specialty ,education.field_of_study ,WOMAC ,business.industry ,Population ,Arthritis ,Osteoarthritis ,medicine.disease ,Research centre ,Platelet-rich plasma ,Orthopedic surgery ,Physical therapy ,Medicine ,Observational study ,business ,education - Abstract
Introduction: Osteoarthritis (OA) is a painful chronic degenerative joint. As of now, there are less options available for patients with mild to moderate arthritis. Most of the approaches are palliative and address the symptoms rather than influencing the biochemical environment of the joint or the disease process.PRP is a newer treatment option emerging in the recent times and its efficacy needs to be examined in our population and hence the study.Materials and Methods: It is a prospective, observational, time bound, hospital-based study conducted from November 2017 to May 2019, after obtaining institutional Ethical committee approval. 60 primary OA knee joints, included in this study, selected from R L Jalappa Hospital and Research centre, Department of Orthopaedics, Kolar. Autologous PRP prepared and infiltration was done under strict aseptic conditions. Patients assessed with WOMAC scoring &VAS for pain, before giving the PRP injection & after giving the injection at periods of 1 month, 3 & 6 months. The decrease in WOMAC & VAS scores was suggestive of improvement in patient’s condition.Results: Significant difference was observed in mean VAS and WOMAC total scores. No local or systemic complications noted during the study period. The mean VAS score at baseline was 7.08 ± 0.79 and the decrease in mean VAS score continued up to six months follow-up that is 2.78 ±1.22 (P value
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- 2020
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18. The relationship between anterior cruciate ligament injuries and posterior tibial slope
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Prabhu Ethiraj, Arun Hs, and Abhijeet Salunkhe
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medicine.medical_specialty ,business.industry ,Radiography ,Anterior cruciate ligament ,Incidence (epidemiology) ,Retrospective cohort study ,musculoskeletal system ,medicine.disease ,ACL injury ,Surgery ,medicine.anatomical_structure ,Sample size determination ,medicine ,Clinical significance ,Risk factor ,business ,human activities - Abstract
Background: An injury to the anterior cruciate ligament (ACL) is a multifactorial injury and is influenced by intrinsic and extrinsic risk factors. Recently, study of variable anatomy of the proximal tibia has come up as a possible risk factor for an ACL injury. Increased posterior tibial slope (PTS) has been identified as a potential risk factor for anterior cruciate ligament (ACL) injury, but studies which have examined this relationship are inconclusive and sometimes results are contradictory. Methodology: In this study sample size of total 72 patients was included, in which 38 patients had non-contact ACL injury and rest 34 constituted as a control group, who has same demographic characteristics as patients in ACL injury group. This study was conducted in period of April 2017 – Feb 2019 at tertiary care hospital, R.L. Jalappa Hospital, Sduaher, Tamaka, Kolar. All patients included in the study were above 18 years of age and also were willing to participate in the study. Patients with open injury of ipsilateral knee and with previous history of surgery over knee were excluded from the study. The posterior tibial slope was measured from a lateral knee radiograph in all the 72 cases. The data was analyzed for the association between an increased posterior tibial slope and the incidence of ACL injury. Results: In injured group of 38 patients, 15 patients were female and 23 were male. The average age of the patients in this group was 26.7 years (±6.3 years). The control group consisted of 34 patients, in which 24 were men and10 were women. The average age of the control group was 26.2 years (±6.5 years). An ANOVA revealed significant differences in tibial slope angle between the 2 groups. Subjects in the noncontact ACL group had significantly greater tibial slope angles (8.81° ± 2.58°) when compared with control subjects (6.9° ± 2.67°). The trend toward greater tibial slope angles in the noncontact ACL group was also observed when each gender was examined independently; however, the difference was only statistically significant for women between the injury and control groups (8.9° ± 2.6° vs 7.2° ± 2.4°). Conclusion: Our results concluded that, in patients who had non contact ACL injury, had increased posterior tibial slope. But despite of these findings, the clinical significance of an increased tibial slope as an isolated risk factor for ACL injury still remains unanswered. The question also remains as to what degree of increased tibial slope should raise concerns about the increased risk for subsequent injury. Limitations of this study were less number of cases and the study included only non contact ACL injuries. Thus, a study with more number of subjects and also comprising of contact ACL injuries, probably give a better conclusion. Level of evidence: Case-control retrospective study; Level III.
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- 2020
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19. Network profiling of hepatocellular carcinoma targets for evidence based pharmacological approach to improve clinical efficacy
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Bhavya Manchukonda and Arun HS Kumar
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Polymers and Plastics - Abstract
IntroductionHepatocellular carcinoma (HCC) is the most prevalent malignancy of the liver with limited clinical efficacy of currently used drugs such as sorafenib. Hence in this study we assessed the network proteins of HCC targets to identify the target/s which can achieve optimal clinical efficacy.Materials and MethodsThe reported HCC targets and their network proteins were identified in the string database. The interactions of the network proteins based on the number of hydrogen bonds formed were evaluated using the chimera software and used to merit the network protein interactions. The merit of network protein interactions in clinical efficacy was assessed based on the expression pattern of the network proteins and corelating their targeting by sorafenib.Results22 potential HCC targets were identified along with their 152 unique network proteins. The following HCC targets; PDGFRB, IFNA2, VEGFR2, PD1, C-MET, RAR and IGF1R were observed to be among the top networks with the most number of hydrogen bond interactions between them. Among these, C-MET, RAR and IGF1R were significantly expressed in hepatocytes, making them relevant HCC targets. PD-1 and PD-L1, which are immune checkpoint regulators and hence used as part of immune therapy, were observed to form higher numbers of hydrogen bonds with HCC network proteins.ConclusionOur analysis suggest that selectively targeting IGF1R, C-MET and RAR in hepatocytes together with immunotherapy will result in optimal clinical efficacy in the management of HCC.
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- 2022
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20. Distal femur fracture, a comparative study of locking compression plate versus distal femur nail
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Prabhu E, Ajay Kurahatti, Sagar V Naik, and Arun Hs
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Condyle ,Surgery ,law.invention ,Intramedullary rod ,Distal femur ,Fixation (surgical) ,law ,medicine ,Internal fixation ,Femur ,Implant ,business ,Range of motion - Abstract
Background: Distal femoral fractures reportedly account for less than 1% of all fractures and comprise between 4%–6% of all femoral fractures. The current method of open reduction and internal fixation has become evident in the recent years with good results being obtained with the AO blade plate, dynamic condylar screw and other implant systems like intramedullary retrograde nails and recently locking compression plate. Controversy still remains regarding the optimum device for distal femur fixation. Objectives: To compare functional outcomes of fractures of distal femur operated with distal femur locking compression plate and distal femur nail using range of motion at knee and Neers knee scoring system and to compare rate of complications associated with both treatment modalities. Materials and methods: In this retrospective study, 60 patients with displaced distal femur fractures presented to our hospital were studied from January 2012-june 2017. 30 patients underwent fixation with locking compression plate and rest 30 underwent distal femur nailing. Outcomes were measured and assessed at 1 months, 3 months and 6 months using Neers knee scoring system.Results: Union was achieved in all patients with mean time to radiological union being 20 weeks in retrograde nailing patients and 24 weeks in locking compression plating. Neer scores were graded as excellent in 51.7 % in retrograde nailing patients and 56.6 % in plating patients. Mean range of motion was more (115 degree) in retrograde nailing patients compared to locking compression plating patients (114 degree) at the end of follow up.Conclusion: There were no statistically significant differences found in functional outcome of the patients between the two surgical methods. Locking compression plate is better implant in comminuted intra-articular fractures of distal end of femur, particularly in elderly patients with osteoporotic bone. Retrograde intramedullary nailing is a good operative technique for extra-articular distal third femoral fractures. However, both techniques require sufficient surgical experience and appropriate preoperative planning.
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- 2019
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21. A study of surgical management of peritrochanteric fracture of femur with proximal femoral nail
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Nagakumar Js, Arun Hs, Anil Kumar Sv, Wayal Utkarsha Ashok, and Vaibhav Mittal
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medicine.medical_specialty ,Femoral nail ,business.industry ,Biomechanics ,Retrospective cohort study ,medicine.disease ,Surgery ,Research centre ,Fracture (geology) ,medicine ,Femur ,Implant ,Malunion ,business - Abstract
Peritrochanteric fractures are devastating injuries that most commonly affect the elderly population and also the young. Peritrochanteric fracture is a leading cause of hospital admissions in elderly people. The number of such admissions is on a raise because of increasing life span and sedentary habits. Conservative methods of treatment results in malunion with shortening and limitation of hip movement as well as complications of prolonged immobilization. This study was done to analyze the surgical management of Peritrochanteric fractures using Proximal Femoral Nail. This is a retrospective study of 20 cases of trochanteric and subtrochanteric fractures admitted to R.L. Jalappa Hospital and Research Centre, S.D.U, M.C, Kolar, between July 2009 to October 2011. Patients with Peritrochanteric fracture above the age of 18yrs were included while pathological fractures and patients with associated co-morbidities posing a risk for surgery were excluded from the study. In our series of 20 cases, excellent results were seen in 50% cases, good in 33.3% cases, fair in 16.7% in trochanteric fractures. In subtrochanteric fractures, excellent results were seen in 64.3%, good in 21.4% cases and fair in 14.3%. From this sample study, we consider that PFN is an excellent implant for the treatment of Peritrochanteric fractures. The terms of successful outcome include a good understanding of fracture biomechanics, proper patient selection, good preoperative planning, accurate instrumentation, good image intensifier.
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- 2018
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22. A study of efficacy of locking versus dynamic compression plates for diaphyseal forearm fractures
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Cecil Fernando, Arun Hs, Mahesh Kumar K, and Ayanaksha Mallick
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Orthodontics ,business.industry ,medicine.medical_treatment ,Dynamic compression plate ,Retrospective cohort study ,Synostosis ,medicine.disease ,Fixation (surgical) ,medicine.anatomical_structure ,Forearm ,medicine ,Upper limb ,Internal fixation ,Malunion ,business - Abstract
Fractures of the forearm bones may result in severe loss of function unless adequately treated. Severe loss of function may result even though adequate healing of the fracture occurs 1, 4. Fractures of the forearm present a unique management problem for years. A forearm fracture involving both bones requires open anatomical reduction with stable fixation. 2, 3 various treatment modalities were introduced from time to time and each of them had some edge over the previous one. The forearm represents the critical anatomic unit of upper limb, permitting the effector organ of the upper limb, the hand, to perform multiaxial daily activities of living. Historically, the closed management of forearm fractures has been met with frustration in adults and resulted in poor functional outcome, hence perfect fracture reduction and rigid fixation is mandatory and achieved by plating. 3, 5, 7 The number of forearm fractures is increasing faster than the predicted rate due to increasing number of road traffic accidents, increased incidence of violence, rapid industrialization, and various sports activities. Conservative treatment has resulted in malunion, non-union, synostosis and ultimately poor functional outcome 4, 6, 7. compression techniques have a lower incidence of non-union and are found to hasten rehabilitation, with less joint stiffness.the various modalities of plating have developed each has edge over the other. there are very less studies on indian population this study has taken up to analyse the outcome between two most commonly used plates in forearm shaft fracture treatment i.e DCP (dynamic compression plate) and LCP (locking compression plate). Aims and Objectives of The Study: 1) To study and compare the functional and radiological outcome after surgical intervention by using and open reduction and internal fixation with dynamic compression plating vs locking compression plate in the treatment of closed diaphyseal fractures of forearm. 2) To study and compare the complications associated with these two modalities of the treatment. Materials And Methods: About 60 patients with both bone forearm fractures treated with LCP or DCP in RLJ hospital attached to Sri Devaraj Urs Medical College between maech 2013 to june 2017, will be taken up for the study after obtaining the informed consent. This is a retrospective study with follow up period of 6 months minimum. The functional outcome was assesed according to Anderson scoring system which included evaluation of the movements and the radiological union. Conclusions: Statistically, both LCP and DCP have similar outcomes in the treatment of diaphyseal fractures of both bones forearm. Whereas, LCP group had a faster recovery as compared to DCP group. Thus, we conclude that both LCP and DCP have similar results for the diaphyseal fractures.
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- 2018
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23. Functional outcome of displaced fracture neck of femur in elderly treated by bipolar hemiarthroplasty versus total hip arthroplasty
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Sachindra Nayak Kapadi, Arun Hs, Prabhu E, and Cecil Fernando
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musculoskeletal diseases ,medicine.medical_specialty ,Hip fracture ,business.industry ,Osteoporosis ,Bipolar hemiarthroplasty ,medicine.disease ,Surgery ,Fracture neck ,Blood loss ,medicine ,Operative time ,Femur ,business ,Total hip arthroplasty - Abstract
With a reversing ageing pyramid and an increasing incidence of osteoporosis, hip fracture especially fracture neck of femur is an established public health concern globally. The purpose of this study is to analyze and compare the role of total hip arthroplasty and bipolar hemiarthroplasty in elderly patients with displaced fracture neck of femur. The data of 54 elderly patients who underwent either total hip arthroplasty or bipolar hemiarthroplasty for displaced fracture neck of femur from June 2014to June 2016 fitting into the inclusion criteria were included in this parallel group comparative study. The peri-operative and post – operative data as well as the functional outcome at 4 and 12 months post operatively were obtained, analyzed and compared between the two groups. From our study it was found that the blood loss and the operative time was significantly more in the total hip arthroplasty group. However the functional outcome at the end of 12 months of follow up was significantly better in total hip arthroplasty group. We concluded that both total hip arthroplasty and bipolar hemiarthroplasty give satisfactory outcome in elderly patients with displaced fracture neck of femur. However total hip arthroplasty is superior to bipolar hemiarthroplasty in the treatment of mentally competent, independent active patients with relatively low co morbidities with displaced fracture neck of femur.
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- 2018
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24. Plantar fasciitis treatment: What is better, oral nonsteroidal anti-inflammatory agents or locally injectable steroid?
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Vaibhav Mittal, Nagakumar Js, Arun Hs, and Wayal Utkarsha Ashok
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Heel ,medicine.drug_class ,business.industry ,medicine.medical_treatment ,Plantar fasciitis ,Anti-inflammatory ,Steroid ,Regimen ,medicine.anatomical_structure ,Pain assessment ,Anesthesia ,medicine ,Corticosteroid ,medicine.symptom ,Stage (cooking) ,business - Abstract
Plantar fasciitis is the one of the most common causes of painful heel in adults. It is assumed to be caused by inflammation and is typically precipitated by biomechanical stress. Conservative management is the mainstream treatment option for plantar fasciitis like non steroidal anti-inflammatory drugs (NSAIDs), steroid injections, PRP injection, stretching exercises. There is no consensus on the efficacy of any particular conservative treatment regimen. This study was taken with objective to compare the efficacy of NSAID and local steroid injection in treating plantar fasciitis. Method: Sixty patients were randomized into 2 groups, group I patients were treat with oral NSAIDs and group II patients were treated with local steroid injection. Patients of both groups are given common supportive measures such as soft heel and advised same stretching exercises. The patients were evaluated using VAS score for pain assessment at pre-treatment stage, 1 week, 2 weeks, 4 weeks, 2 months and 3 months. Results: 60 patients were randomized into 2 groups, both groups had similar demographics. The VAS scores at pre treatment level in group I was 6.60±1.14 and in group II was 6.46±1.05. The VAS score reduced to 3.10±1.18 in group II after injection and in group I reduced to 4.9±1.33 after a starting oral NSAIDs. The VAS scores consistently reduced in both the groups till 4 weeks of follow up but group II VAS scores were always lower than group I (p-value < 0.001). After 4 weeks, a trend towards increase in VAS scores was noted in both groups, patients had complaints of relapse of pain or increase in intensity of it. Conclusion : With this study we concluded that as compared to NSAIDs the use of local injection of steroid gives better and more sustained pain relief with fewer complications and lesser recurrences of heel pain in cases of plantar fasciitis.
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- 2018
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25. Management of Seinsheimer type IIB and type IIIA subtrochanteric fracture with proximal femoral nail (PFN) versus proximal femoral locking compression plate (PF-LCP): Prospective comparative study
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Eswara Reddy G, Arun Hs, and Nagakumar J S
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Hip fracture ,medicine.medical_specialty ,Femoral nail ,business.industry ,medicine.medical_treatment ,Osteoporosis ,Knee replacement ,medicine.disease ,Compression (physics) ,Surgery ,Type iib ,Hip replacement ,medicine ,Femur ,business - Abstract
Introduction: Seinsheimer subtrochanteric fracture of femur are important to treat and associated with high rate of complications. Among all fractures of hip upto 34% present in subtrochanteric area. Objectives: Comparison of clinical outcome in Seinsheimer type IIB and type IIIA subtrochanteric fractures treated with proximal femoral nail (PFN) versus proximal femoral locking compression plate (PF-LCP). Materials and Methods: Patients presented with Seinsheimer subtrochanteric fracture at our hospital i.e, R L Jalappa Hospital, Tamaka, Kolar, Karnataka, India between May 2018 to June 2019 among which fourty patients were included as per the inclusion criteria. In which twenty patients were treated with Proximal Femoral Nail and twenty patients with Proximal Femoral Locking Compression Plate. By using Modified Harris Hip Score results were assessed at final follow up. Results: Group PFN shows at final follow up 45% excellent outcome, 45% good outcome and 10% fair outcome whereas group PF-LCP shows 60% good outcome, 20% fair outcome and 20% poor. Conclusion: For Seinsheimer subtrochanteric fractures proximal femoral nail shows better results compared to plating group with respect to functional outcome and clinical outcome. Keywords: Subtrochanteric fracture, Seinsheimer, PFN, PF-LCP.
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- 2019
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26. Is intercrestal line and level of spine are same clinically and radiologically
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Madamanchi Harsha, Eswara Reddy G, and Arun Hs
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Spine (zoology) ,medicine.medical_specialty ,business.industry ,Medicine ,Radiology ,Line (text file) ,business - Published
- 2019
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27. A comparative study of efficacy and safety of flupirtine versus piroxicam in postoperative pain in patients undergoing lower limb surgery
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Chinnaiyan S, Sarala N, and Arun HS
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Postoperative pain ,lcsh:R5-920 ,orthopaedic surgeries ,piroxicam ,flupirtine ,lcsh:Medicine (General) - Abstract
Sowmya Chinnaiyan,1 Narayana Sarala,1 Heddur Shanthappa Arun2 1Department of Pharmacology, 2Department of Orthopaedics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India Background: Effective control of pain postoperatively is essential in providing enhanced patient care and a cost-effective hospital stay. Though many treatment modalities exist for postoperative pain management in orthopedic surgeries they are often accompanied by adverse effects. This study was carried out to assess the efficacy of flupirtine and piroxicam in postoperative pain reduction using visual analog scale (VAS) score. Materials and methods: An open-label, parallel group, comparative study was conducted on patients undergoing lower limb orthopedic surgery, randomized into two groups of 38 patients each. They received either flupirtine 100 mg or piroxicam 20 mg 6 hours after surgery and then twice daily orally for 5 days. Pain was measured using VAS score, total pain relief score (TOTPAR24), and patient satisfaction score(PSS); the other scales used were behavioral pain assessment scale (BPAS) and functional activity score (FAS). Rescue medication used was tramadol 100 mg intravenously. WHO causality scale was used for assessing adverse effects. Descriptive and inferential statistics were used for assessment of various parameters. Results: A total of 76 patients with mean ± standard deviation age of 35.08±10.3 years were recruited; 34 in the flupirtine and 37 in the piroxicam groups completed the study. Patients in both groups were comparable in baseline characteristics. Flupirtine and piroxicam reduced VAS score 48 hours postoperatively compared to baseline (p=0.006 and 0.001) and piroxicam produced significant reduction in pain at 8, 12, and 120 hours compared to flupirtine (p=0.028, 0.032, 0.021). TOTPAR24 and PSS at 24 hours were comparable between the treatments. BPAS scores at 24 hours were reduced significantly in patients receiving either drug (p=0.001). FAS improved at 72 hours in patients receiving piroxicam. Adverse effects were similar with both the medications. Conclusion: Flupirtine and piroxicam reduced pain effectively but the onset of pain relief was earlier with piroxicam. Keywords: postoperative pain, flupirtine, piroxicam, orthopedic surgeries, postoperative analgesia
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- 2017
28. Credibility of locking plate in treatment of distal end radius fractures with intra articular extension
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Arun Hs, Parvataneni Prathap, and Buddai Nagarjun
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medicine.medical_specialty ,Rehabilitation ,business.industry ,medicine.medical_treatment ,Soft tissue ,Hospital based ,Surgery ,Locking plate ,Fixation (surgical) ,Intra articular ,medicine ,Early mobilization ,Internal fixation ,business - Abstract
Background: The management of distal end radius has undergone an extraordinary evolution over the preceding twenty years. The technical advance of palmar locking plating has again changed the management of this fracture in a real and seemingly permanent way. Perhaps most importantly it is becoming increasingly apparent that operative intervention needs to be customized to the patient, fracture and expertise of the surgeon. Materials and Methods: The study is hospital based prospective study centered in R.L. Jalappa Hospital from November 2013 to April 2015 between which thirty patient patients with intra articular distal radius fractures are treated with locking compression plate and screws. Results: Patients were regularly followed-up post-operatively. Thirty cases were available for follow up. Excellent results were seen in 20 patients, good results in 5 patients, fair results in 3 patients and poor results in 2 patients. Conclusion: Open reduction and internal fixation with locking compression plate and screws gives better functional and anatomical results in intra articular distal radius fractures. The successful use of locking compression plate for intra articular distal radius fractures requires careful assessment of fracture pattern, appropriate patient selection, meticulous surgical techniques, appropriate choice of fixation, screw size, judicious augmentation with internal fixation, careful post-operative monitoring and aggressive early institution of rehabilitation. The final functional result of treatment not only depends of on anatomical reduction but also depends on surrounding soft tissue injuries and early mobilization.
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- 2017
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29. The efficacy of local steroid injection versus conservative management in Dequervain’s disease: A prospective randomised study
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Vaibhav Mittal, Nagakumar Js, Wayal Utkarsha Ashok, and Arun Hs
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Steroid injection ,medicine.medical_specialty ,Tenosynovitis ,Triamcinolone acetonide ,Conservative management ,business.industry ,Disease ,Wrist pain ,Wrist ,medicine.disease ,Surgery ,medicine.anatomical_structure ,medicine ,medicine.symptom ,business ,medicine.drug - Abstract
De Quervain’s tenosynovitis is a painful condition of the wrist which leads to difficulties in performing activities of daily living. Aim of the study is to examine the effectiveness of steroid injection therapy as compared to splinting and analgesics for treatment of de Quervain’s tenosynovitis in adults. In (Group 1) the conservative group, patients were advised a splint and NSAIDS. In (Group 2) steroid group, patients were given injection of triamcinolone mixed with 2% xylocaine into the sheath of the affected tendons, under aseptic conditions. We found that steroid injection group showed 83.33% excellent results compared to only 36.67% in conservative group. We conclude that steroid injection is an effective form of conservative management for de Quervain’s disease.
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- 2018
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30. Functional outcome in surgical management of Bi- malleolar fractures in adults
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Hariprasad S, Anvesh Kondlapudi, Parvataneni Prathap, and Arun Hs
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Biomechanics ,medicine.disease_cause ,Malleolus ,Weight-bearing ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030202 anesthesiology ,Inclusion and exclusion criteria ,Medicine ,Internal fixation ,Intra-articular fracture ,Ankle ,business ,Prospective cohort study ,030217 neurology & neurosurgery - Abstract
Background: Malleolar injuries are the most common significant lower extremity fractures. These injuries gain importance, because the whole body weight is transmitted through the ankle, and locomotion depends on the stability of the ankle. Open reduction and internal fixation have become the mainstay of treatment for most of the unstable bimalleolar fractures, as these operative methods restores the anatomy, biomechanics and contact loading characteristics of the ankle. Objectives: To study the functional outcome of surgically managed bimalleolar fractures of ankle in adults. Methods: A prospective study of 30 cases of bimalleolar fractures of ankle in adults, managed surgically by various techniques in During the period from December 2014 to May 2016 were studied, satisfying the inclusion and exclusion criteria were studied. The functional outcome was evaluated using the Biard and Jackson’s ankle scoring system. Results: In our study we achieved 86.6% excellent to good results, 6.6% fair results, 6.6% poor results. The results were comparable to other studies. Interpretation & Conclusion: The operative results were satisfactory in 86.6% cases, with good to excellent functional outcome. Excellent results are obtained with stable fixation of fracture. Cancellous screws or malleolar screws are far better in internal fixation of medial malleolus compared to Kirschner -wire fixation and lateral plating was the best for fibular fractures. Good functional results are obtained by surgical management of bimalleolar ankle fractures. Early weight bearing and mobilisation is achieved in these patients. Anatomical reduction with restoration of the articular congruence is essential in all intra articular fractures, more so, if a weight bearing joint like ankle is involved. Open reduction and internal fixation restores the articular congruity of the ankle joint. TBW done for many PER and PA injuries showed promising results comparable to that with screw fixation and also lesser reports of skin irritation at the wound site. It is the method preferred for small transverse fragments and osteoporotic bones of both malleoli especially in the elderly.
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- 2016
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31. Functional outcome in surgical management of midshaft clavicle fractures fixed with precontoured plate in adults
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Arun Hs, Prabhu Ethiraj, Nagakumar Js, and Parvataneni Prathap
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Biomechanics ,Shoulder stiffness ,Surgery ,Fixation (surgical) ,medicine.anatomical_structure ,Clavicle ,Inclusion and exclusion criteria ,Shoulder girdle ,medicine ,Internal fixation ,business ,Prospective cohort study - Abstract
Background: Fractures of clavicle are one of the most common fractures in traumatic injury around shoulder girdle as the bone is sub cutaneous throughout. Fractures of middle third clavicle generally occur either by high energy or low energy impact. These fractures have been treated traditionally by non-operative methods. Although many close reduction methods have been described it has been recognised that complete reduction is practically impossible. Open reduction and internal fixation have become the mainstay of treatment for most of the midshaft fractures, as these operative methods restores the anatomy, biomechanics and contact loading characteristics of the clavicle. Objectives: To study the functional outcome of surgically managed clavicle fractures with precontoured locking plate. Methods: A prospective study of 60 cases of midshaft clavicle fractures in adults, Managed surgically by open reduction and fixation with precontoured plate during the period from May 2014 to April 2016 satisfying the inclusion and exclusion criteria were studied. The functional outcome was evaluated using the Constant and Murley scoring system. Results: In our study we achieved 93.4% excellent to good results, 5% fair results, 1.6% Poor results. The results were comparable to other studies. Interpretation & Conclusion: The operative results were satisfactory in 93.4% cases, with good to excellent functional outcome. This study shows rigid fixation with precontoured plate and screws for fresh displaced or comminuted middle third clavicle fracture gives good anatomical reduction, immediate pain relief and prevents the development of shoulder stiffness and non-union and thus on the whole shows good functional outcome by early mobilisation and hence patient to their functional activities.
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- 2016
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32. Contribution of controversies or difference of opinion to scientific advancement
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Arun Hs Kumar
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business.industry ,media_common.quotation_subject ,Fundamental rights ,Public relations ,Public domain ,Pleasure ,Politics ,Political science ,Openness to experience ,Mandate ,business ,Divergent thinking ,Publication ,media_common - Abstract
It’s my pleasure and delight to present the first issue of Journal of Contradictory Research in Science ( JCRSCI) to our global audience. Right through our basic education we are thought to follow written statements, so our minds are fundamentally tuned to follow. Occasionally some minds lack the necessary skills to follow and dare to take the alternative paths and many of them make big in life by becoming visionaries. In the scientific research profession as well several researchers experience outside the box events which puts them in crossroads of publication, wherein after failing to publish it a few journals it’s written off. Nevertheless research findings which don’t fall into the classical views in any research area at a given point of time, gets buried in the vast pool of unpublished data and never surfaces to public domain. As most research work is funded by taxpayers, the public has the fundamental right to know the outcome of research work funded by them. Although this is in general the outline of open/free access publication, which increasingly many journals are adopting nevertheless considerable number of scientific findings remain unpublished due to controversial nature of the results, differing opinions, lack of political mandate and many more. JCRSCI would like to provide a platform to bring all such scientific publications to public domain with the only aim of knowing the scientific truth and in the process promote innovations and divergent thinking in science. To achieve this we will adopt a new peer-review system which will involve very open and bi-directional communication between the authors and reviewers via the editors to avoid any issue of bias and emphasise openness in its true sense.
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- 2012
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