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Phage-displayed immunoprecipitation sequencing (PhIP-seq) has enabled high-throughput profiling of human antibody repertoires. However, a comprehensive overview of environmental and genetic determinants shaping human adaptive immunity is lacking. In this study, we investigated the effects of genetic, environmental, and intrinsic factors on the variation in human antibody repertoires. We characterized serological antibody repertoires against 344,000 peptides using PhIP-seq libraries from a wide range of microbial and environmental antigens in 1,443 participants from a population cohort. We detected individual-specificity, temporal consistency, and co-housing similarities in antibody repertoires. Genetic analyses showed the involvement of the HLA, IGHV, and FUT2 gene regions in antibody-bound peptide reactivity. Furthermore, we uncovered associations between phenotypic factors (including age, cell counts, sex, smoking behavior, and allergies, among others) and particular antibody-bound peptides. Our results indicate that human antibody epitope repertoires are shaped by both genetics and environmental exposures and highlight specific signatures of distinct phenotypes and genotypes.

In this study we consider the flow over airfoils with leading-edge roughness, designed to mimic the ice depositions that may occur on an aircraft in flight. The focus of this investigation is the effect of the angle of attack on the mean-flow three-dimensionality. In our previous work (Kumar et al., Journal of Turbulence, Vol. 22, No. 11, 2021, pp. 735–760), we found stationary spanwise inhomogeneities in the form of alternating regions of fast- and slow-moving fluid, which were termed “flow channels.” In the present study we investigate further this phenomenon. We observe the formation of hairpin vortices downstream of the roughness elements, which eventually merge; this causes the formation of wider channels that remain coherent and affect the trailingedge separation. With increasing angle of attack, the intensity of flow channeling can increase or decrease depending on the topology of the leading-edge roughness. Its effect on the trailing-edge separation remains, however, significant. The mean-separation line is highly distorted, and the separation length can vary by up to 30% of the chord length along the span. Vishal Kumar acknowledges the financial support by Mitacs, Bombardier Aerospace, and CARIC/CRIAQ. Ugo Piomelli acknowledges the support from the Natural Science and Engineering Research Council of Canada under the Discovery Grant program. This research was enabled in part by computational support provided by Compute Ontario (https://www.computeontario.ca) and Southern Ontario Smart Computing Innovation Platform (https://www.soscip.org).

Functional hydrogels are three-dimensional polymeric networks with potential applicability in the field of wearable electronics. However, hydrogels are often used to develop devices with only one functionality. In this work, a multifunctional hydrogel consisting of poly(3,4-ethylenedioxythiophene) (PEDOT), alginate (Alg), carbon nanoparticles (CNPs), and manganese oxide has been manufactured for devices that can simultaneously store energy (supercapacitor) and sense temperature. The Alg and PEDOT interpenetration allows for obtaining a flexible and electrically conductive hydrogel with an open and interconnected porous structure. The incorporation of CNPs improves electrical conductivity and confers synergies with manganese oxide, which provide energy storage capability. Furthermore, the resistance of the hydrogel varies linearly with the temperature, this behavior being observed consistently and without hysteresis throughout consecutive heating and cooling cycles. Thus, the PEDOT/Alg/CNP/MnO2 hydrogel shows good capacitance (42 mF cm–2), capacitance retention (87%), and good temperature sensitivity (-1.05% °C–1).

Monkeypox DNA has been detected in skin lesions, saliva, oropharynx, urine, semen, and stool of patients infected during the 2022 clade IIb outbreak; however, the viral dynamics within these compartments remain unknown. We aimed to characterise the viral load kinetics over time in various parts of the body.This was an observational, prospective, multicentre study of outpatients diagnosed with monkeypox in two hospitals and two sexual health clinics in Spain between June 28, 2022, and Sept 22, 2022. Men and women aged over 18 years were eligible if they reported having symptom onset within the previous 10 days of presentation, and were ineligible if disease was severe enough to be admitted to hospital. Samples were collected from five body locations (skin lesions, oropharynx, rectum, semen or vagina, and a dried blood spot) at six time points up to 57 days after the screening visit. Samples were analysed by quantitative PCR and a subset by cell culture. The primary endpoint was time from symptom onset to viral DNA clearance.Overall, 1663 samples were collected from 77 study participants. 75 (97%) participants were men, the median age was 35·0 years (IQR 29·0-46·0), and 39 (51%) participants were living with HIV. The median time from symptom onset to viral clearance was 25 days (95% CI 23-28) in the skin lesions, 16 days (13-19) in the oropharynx, 16 days (13-23) in the rectum, 13 days in semen (9-18), and 1 day in blood (0-5). The time from symptom onset to viral clearance for 90% of cases was 41 days (95% CI 34-47) in skin lesions and 39 days (27-56) in semen. The median viral load in skin lesions was 7·3 logIn immunocompetent patients with mild monkeypox disease, PCR data alone would suggest a contact isolation period of 3 to 6 weeks but, based on detection of replication-competent virus, this time could be reduced. Based on findings from this cohort of patients, semen testing and prolonged use of condoms after recovery from monkeypox might not be necessary.University Hospital Germans Trias i Pujol and the YoMeCorono.For the Spanish translation of the abstract see Supplementary Materials section.

Pregnancy prevention programme; Prescribing medicinal products; Valproate Programa de prevenció de l'embaràs; Prescripció de medicaments; Valproat Programa de prevención de embarazo; Prescripción de medicamentos; Valproato Introduction Due to established teratogenicity of valproates, the EU risk minimisation measures (RMMs) with a pregnancy prevention programme (PPP) for valproate were updated in March 2018. Objectives To investigate the effectiveness of the 2018 EU RMMs on valproate utilisation in five European countries/regions. Methods A multi-database, times series study of females of childbearing potential (12–55 years) was conducted using electronic medical records from five countries/regions (01.01.2010–31.12.2020): Denmark, Tuscany (Italy), Spain, the Netherlands, and the UK. Clinical and demographic information from each database was transformed to the ConcePTION Common Data Model, quality checks were conducted and a distributed analysis was performed using common scripts. Incident and prevalent use of valproate, proportion of discontinuers and switchers to alternative medicine, frequency of contraception coverage during valproate use, and occurrence of pregnancies during valproate exposure were estimated per month. Interrupted time series analyses were conducted to estimate the level or trend change in the outcome measures. Results We included 69,533 valproate users from 9,699,371 females of childbearing potential from the five participating centres. A significant decline in prevalent use of valproates was observed in Tuscany, Italy (mean difference post-intervention −7.7%), Spain (−11.3%), and UK (−5.9%) and a non-significant decline in the Netherlands (−3.3%), but no decline in incident use after the 2018 RMMs compared to the period before. The monthly proportion of compliant valproate prescriptions/dispensings with a contraceptive coverage was low (

El presente artículo, en forma de ensayo, reflexiona sobre cual podría ser la programación de una hipotética asignatura de Història de la Catalunya actual (1980-2020) en el sí del debate sobre la presencia de la Historia Actual en los grados universitarios. Más allá de ordenar cronológicamente las décadas o los hechos, el artículo debate la propia historia de Cataluña y su interacción y necesaria inclusión en los marcos español y europeo para poder transmitir la traducción de los últimos cuarenta años mundiales a través del prisma catalán. Se adentra en opciones como la fusión de asignaturas de Historia Contemporánea, la politización del debate, además de plantear una programación que situé al estudiante en el momento de cambio de era global presente, pero también en un escenario catalán lleno de incertidumbres con relación al análisis historiográfico que, con matices, se ha producido en el último siglo.

The purpose of this research was to test whether the neuromotricity activities of the BAPNE method based on the dual task could improve selective attention and concentration in 5th grade primary school pupils. A quantitative approach was used, with a quasi-experimental design between subjects and with repeated measures before and after the intervention (pretest-intervention-posttest). The research was carried out in two schools in Alicante (Spain). The sample consisted of N=114 students between 10 and 11 years of age with similar socio-economic and cultural characteristics. A non-probabilistic convenience sampling was used, dividing the sample into an experimental group (n=66) and a control group (n=48). The Spanish adaptation of the d2 attention test was used as the assessment instrument. Statistical data were processed using SPSS, JASP and Excel. Statistical decision-making was based on a significance level of alpha=0.05. Samples were tested for normality, parametric and non-parametric tests were applied, and effect sizes were calculated. The main results of the intra-subjects analysis were statistically significant in favour of the experimental group in the variables TRPOST (p=

Sulfur dioxide is the most used additive today for preventing browning in grape musts and wines. However, since wine consumers are increasingly interested in healthier wines, the wine industry is keen to reduce its use. Some promising alternatives to sulfur dioxide have been proposed in recent years, including glutathione, both pure and in the form of inactivated yeasts, and Metschnikowia pulcherrima used as a bioprotective agent. Some information exists about the protective effect against oxidation of glutathione but there is very few about the use of bioprotection for that purpose. Supplementation with glutathione, regardless of the commercial form, reduced oxygen consumption and browning intensity when laccase was not present in the grape juice. Metschnikowia pulcherrima also reduced browning intensity in the absence of laccase but increased the total oxygen consumption. However, in the presence of laccase, glutathione and Metschnikowia pulcherrima were not effective enough to adequately prevent the grape juice from browning. Glutathione, both pure and in the form of inactivated yeasts, and Metschnikowia pulcherrima are interesting tools for protecting grape must against browning, and thus reducing the use of sulfur dioxide.

Introduction: Autism is a neurodevelopmental disorder characterized by intolerance of change, empathy deficits, misunderstandings, and emotional dysregulation. Core symptoms can determine criminal behaviour and subsequent interactions with the penal system. A significant presence of such symptoms is detected in forensic settings. The objective of this study is to analyze the characteristics of autism within the prison context, summarizing and updating the knowledge in this field. Material and method: Systematic review through databases on studies that analyze the socio-demographic, clinical, and judicial characteristics of prisoners diagnosed with autism spectrum disorder. Results: Autistic traits constitute an independent risk factor for incarceration. Those inmates with autism spectrum disorder frequently present a psychiatric comorbidity, especially substance use disorder, psychotic disorders, and other neuro-developmental disorders. They are associated with a greater probability of self-harming thoughts and disruptive behaviours, which are not predicted by the usual evaluation tools. Discussion: Prisoners with autism spectrum disorder have a differential socio-demographic, clinical, and criminal profile. A specific approach that is different from the one provided for neurotypical prisoners should be offered to these inmates. Infrastructures should be adapted to reduce fragility, make the environment more flexible and specific methods for evaluation and treatment should be developed.

14 Páginas.-- 7 Figuras, Societal Impact Statement Escobedia grandiflora is a medicinal hemiparasite that occurs naturally in non-forested communities in Central and South America. Parasitic plants accumulate high levels of a water-soluble orange pigment in roots that was once among the most important food dyes in the Andean region. We conclusively address the chemical identification of this pigment and provide molecular and cellular insights on its biosynthesis and possible function. Summary The herbaceous hemiparasite Escobedia grandiflora (Orobanchaceae) is used in traditional medicine in the Andean region. Escobedia roots accumulate high levels of an orange pigment with a significant relevance as a cooking dye that exhibits antioxidant and cardioprotective properties. Here, we aimed to confirm the chemical identity of the pigment and investigate its biosynthesis and function in Escobedia roots. We combined metabolic and cytological analyses with de novo transcriptome assembly, gene expression studies, and phylogenetic analyses. The pigment was conclusively shown to be azafrin, an apocarotenoid likely derived from the cleavage of β-carotene. RNA-seq supported by multispecies comparative transcriptome analysis and qRT-PCR allowed to propose candidate genes for the production of azafrin in Escobedia roots. We also showed that azafrin is delivered to the root apoplast and that it accumulates in the area where the Escobedia haustorium contacts the host's root. Our data suggest that azafrin production might rely on a carotenoid cleavage dioxygenase (CCD) different from CCD7 and that this apocarotenoid might function in the parasitism process. Together, our work represents an unprecedented step forward in our understanding of the Escobedia parasitization system., Spanish MCIN/AEI/10.13039/501100011033. Grant Numbers: PCI2021-121941, PGC2018-099449-A-I00, PID2020-115810GB-I00, RYC-2017-23645, UToPIQ-PCI2021-121941 National Council for Scientific and Technological Development, Brazil. Grant Number: 303902/2017-5 Consejo Superior de Investigaciones Científicas. Grant Number: 202040E299 Generalitat Valenciana. Grant Numbers: AGROALNEXT/2022/067, PROMETEU/2021/056

Patients with Fontan circulation (FC) have a high incidence of clinical complications. However, no biomarker is able to accurately stratify risk. The aim of this study was to analyze the relationship between biomarkers and clinical complications, including carbohydrate antigen 125 (CA125) for the first time, and to propose a risk estimation based on a combination of biomarkers.Cross-sectional study of patients with FC. The clinical endpoint was the combination of heart failure, atrial arrhythmias, veno-venous fistulae, protein-losing enteropathy, or plastic bronchitis. Demographic, clinical, and laboratory variables were analyzed, including CA125, NT-proBNP, renal and liver function, and red cell distribution width (RDW). We performed univariate and multivariate analyses of the relationship between these variables and the composite endpoint. Cutoff values were calculated by ROC curves.We included 56 patients (27.4±7.8 years). A total of 34% showed the composite endpoint, with significantly higher CA125 levels (30.1 IU/mL vs 12.6 IU/mL; P=.001). In the multivariate model, the biomarkers related to the endpoint were LnCA125 (OR, 5.1; 95%CI, 1.2-22), RDW (OR, 1.8; 95%CI, 1.1-3.1), and FIB4 (OR, 38, 95%CI, 1.7-855). The cutoff points were CA125 ≥ 20 U/mL, FIB4 ≥ 0.75, and RDW ≥ 14.5%, and the probability of the occurrence of the endpoint was 81% if ≥ 2 biomarkers were elevated.CA125 elevation is associated with a higher prevalence of complications in patients with Fontan-type circulation. CA125 levels ≥ 20U/mL, FIB4 ≥ 0.75 and RDW ≥ 14.5% identify with a high probability the clinical failure of FC.

BACKGROUND: Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with COVID-19, but uncertainty remains about the determinants of in-hospital mortality and data on post-discharge outcomes are scarce. The aims of this study were to investigate the variables associated with in-hospital outcomes in patients who received ECMO during the first wave of COVID-19 and to describe the status of patients 6 months after ECMO initiation.METHODS: EuroECMO-COVID is a prospective, multicentre, observational study developed by the European Extracorporeal Life Support Organization. This study was based on data from patients aged 16 years or older who received ECMO support for refractory COVID-19 during the first wave of the pandemic-from March 1 to Sept 13, 2020-at 133 centres in 21 countries. In-hospital mortality and mortality 6 months after ECMO initiation were the primary outcomes. Mixed-Cox proportional hazards models were used to investigate associations between patient and management-related variables (eg, patient demographics, comorbidities, pre-ECMO status, and ECMO characteristics and complications) and in-hospital deaths. Survival status at 6 months was established through patient contact or institutional charts review. This study is registered with ClinicalTrials.gov, NCT04366921, and is ongoing.FINDINGS: Between March 1 and Sept 13, 2020, 1215 patients (942 [78%] men and 267 [22%] women; median age 53 years [IQR 46-60]) were included in the study. Median ECMO duration was 15 days (IQR 8-27). 602 (50%) of 1215 patients died in hospital, and 852 (74%) patients had at least one complication. Multiorgan failure was the leading cause of death (192 [36%] of 528 patients who died with available data). In mixed-Cox analyses, age of 60 years or older, use of inotropes and vasopressors before ECMO initiation, chronic renal failure, and time from intubation to ECMO initiation of 4 days or more were associated with higher in-hospital mortality. 613 patients did not die in hospital, and 547 (95%) of 577 patients for whom data were available were alive at 6 months. 102 (24%) of 431 patients had returned to full-time work at 6 months, and 57 (13%) of 428 patients had returned to part-time work. At 6 months, respiratory rehabilitation was required in 88 (17%) of 522 patients with available data, and the most common residual symptoms included dyspnoea (185 [35%] of 523 patients) and cardiac (52 [10%] of 514 patients) or neurocognitive (66 [13%] of 512 patients) symptoms.INTERPRETATION: Patient's age, timing of cannulation (FUNDING: None.

This paper aims to introduce a computationally efficient and user-friendly toolbox, called VIBWAY, able to predict vibration and re-radiated noise levels in two situations. On the one hand, it can predict levels in existing buildings due to new lines or after the application of mitigation measures in existing ones. Thus, it can be used to assess the performance of vibration countermeasures applied at the track, vehicle and/or the building. On the other hand, it can predict levels in new buildings to be constructed close to an existing railway line. The VIBWAY toolbox is based on a non-interface 2.5D FEM-SBM approach for the wave propagation on the soil, on semi-analytical approaches for the track and the building and on multibody modelling of the train vehicle.

Resistance training is recommended for preventing sarcopenia, but the benefits for the quality and quantity of muscle mass are uncertain.To assess the effects of high-intensity resistance training (HIRT) on clinical and magnetic resonance imaging (MRI) parameters in women with sarcopenia.A researcher-blinded randomized clinical trial was conducted. Community-dwelling older women with sarcopenia were randomized to six months of HIRT or a control group (CG). Body composition was assessed with bioimpedance equipment, and participants underwent strength and functional performance tests (short physical performance battery [SPPB] and gait speed). MRI scans of the thigh were taken to quantify muscle mass and quality.Thirty-eight women completed the study (20 in the HIRT group). Sarcopenia remitted in 50 % of the HIRT group. HIRT elicited a significant group × time interaction effect for muscle mass (p = 0.027; ȠHIRT led to the remission of sarcopenia in half of the older women, as seen in muscle mass, strength, and functional performance and MRI biomarkers, with significant increases in muscle quality. REGISTERED IN CLINICALTRIALS.GOV: NCT03834558.

Altres ajuts: acords transformatius de la UAB Altres ajuts: this work was supported by the European Union "NextGenerationEU"/PRTR (EUR2020-112294). Ammonia (NH) is among the world's most widely produced bulk chemicals, given its extensive use in diverse sectors such as agriculture; however, it poses environmental and health risks at low concentrations. Therefore, there is a need for developing new technologies and materials to capture and store ammonia safely. Herein, we report for the first time the use of metal-organic polyhedra (MOPs) as ammonia adsorbents. We evaluated three different rhodium-based MOPs: [Rh(bdc)] (where bdc is 1,3-benzene dicarboxylate); one functionalized with hydroxyl groups at its outer surface [Rh(OH-bdc)] (where OH-bdc is 5-hydroxy-1,3-benzene dicarboxylate); and one decorated with aliphatic alkoxide chains at its outer surface [Rh(CO-bdc)] (where CO-bdc is 5-dodecoxybenzene-1,3-benzene dicarboxylate). Ammonia-adsorption experiments revealed that all three Rh-MOPs strongly interact with ammonia, with uptake capacities exceeding 10 mmol/g. Furthermore, computational and experimental data showed that the mechanism of the interaction between Rh-MOPs and ammonia proceeds through a first step of coordination of NH to the axial site of the Rh(II) paddlewheel cluster, which triggers the adsorption of additional NH molecules through H-bonding interaction. This unique mechanism creates H-bonded clusters of NH on each Rh(II) axial site, which accounts for the high NH uptake capacity of Rh-MOPs. Rh-MOPs can be regenerated through their immersion in acidic water, and upon activation, their ammonia uptake can be recovered for at least three cycles. Our findings demonstrate that MOPs can be used as porous hosts to capture corrosive molecules like ammonia, and that their surface functionalization can enhance the ammonia uptake performance.

Purpose To examine the acute effects of concurrent muscle power and sport-specific endurance exercises order on immunological stress responses, muscular-fitness, and rating-of-perceived-exertion (RPE) in highly trained youth male judo athletes. Methods Twenty male participants randomly performed two concurrent training (CT) sessions; power-endurance and endurance-power. Measures of immune response (e.g., white blood cells), muscular-fitness (i.e., counter-movement-jump [CMJ]), RPE, blood-lactate, and -glucose were taken at different time-point (i.e., pre, mid, post, and post6h). Results There were significant time*order interactions for white blood cells, lymphocytes, granulocytes, granulocyte-lymphocyte-ratio, and systemic-inflammation-index. Power-endurance resulted in significantly larger pre-to-post increases in white blood cells and lymphocytes while endurance-power resulted in significantly larger pre-to-post increases in the granulocyte-lymphocyte-ratio and systemic-inflammation-index. Likewise, significantly larger pre-to-post6h white blood cells and granulocytes increases were observed following power-endurance compared to endurance-power. Moreover, there was a significant time*order interaction for blood-glucose and -lactate. Following endurance-power, blood-lactate and -glucose increased from pre-to-mid but not from pre-to-post. Meanwhile, in power-endurance blood-lactate and -glucose increased from pre-to-post but not from pre-to-mid. A significant time*order interaction was observed for CMJ-force with larger pre-to-post decreases in endurance-power compared to power-endurance. Further, CMJ-power showed larger pre-to-mid performance decreases following power-endurance, compared to endurance-power. Regarding RPE, significant time*order interactions were noted with larger pre-to-mid values following endurance-power and larger pre-to-post values following power-endurance. Conclusion CT induced acute and delayed order-dependent immune cell count alterations in highly trained youth male judo athletes. In general, power-endurance induced higher acute and delayed immunological stress responses compared to endurance-power. CMJ-force and RPE fluctuated during both CT sessions but went back to baseline 6 h post-exercise.

Introducción. Este artículo presenta las transformaciones que el concepto de democracia ha experimentado en la cultura escolar de un centro a lo largo de cuatro procesos de Investigación Acción Participativa. Su objetivo consiste en comprobar si la problematización de saberes entre los diferentes colectivos de la comunidad educativa así como las propias dinámicas de la IAP han provocado la construcción conjunta de conocimiento sobre el hecho democrático, y si esto a su vez ha producido transformaciones en las personas participantes y en la cultura del centro educativo. Método. Se trata de un estudio de caso cuyo análisis incluye la revisión de los resultados de cada proyecto y su contraste con la actual percepción de los actores implicados. Resultados. La democracia se ha inscrito en la cultura escolar de este centro construyendo su propio modelo inclusivo y participativo no exento de tensiones. El sentido de la educación democrática ha resignificado los fundamentos, las prácticas y la identidad del centro. Discusión. Los procesos de IAP posibilitan la definición colectiva de una cultura escolar emancipadora y contribuyen a que la escuela se incluya en su territorio como agente social proactivo y comprometido con la transformación social. Sin embargo, se constata que falta por avanzar en cuanto a la participación del alumnado en los espacios de decisión organizativa.

Taking a historical perspective, we analyze the economic growth of GAFA companies, and how they fit into the indicators that measure global human development. We explore the limits of growth -assuming that economic growth is inherent to good economic performance- by studying these cases, which are relevant insofar as they lead global economic growth in the new digital-based ("ethereal") economy. Our methodological approach contrasts the growth patterns of GAFA companies with general human growth parameters. This case-to-global study finds clear trends, suggesting that the ethereal economy is constrained only by the limits of human growth.

Background We aimed to evaluate icatibant, a competitive antagonist of the bradykinin B2 receptors, for the treatment of inpatients with coronavirus disease 2019 (COVID-19) pneumonia admitted in the early hypoxemic stage. Methods The randomized, open-label clinical trial of icatibant for COVID-19 pneumonia (ICAT·COVID, registered as NCT04978051 at ClinicalTrials.gov) was conducted in Barcelona. Inpatients requiring supplemental but not high-flow oxygen or mechanical ventilation were allocated (1:1) to treatment with either three 30-mg icatibant doses/d for 3 consecutive days plus standard care or standard care alone, and followed for up to 28 days after initial discharge. The primary and key secondary outcomes were clinical response on study day 10/discharge and clinical efficacy at 28 days from initial discharge, respectively. Results Clinical response occurred in 27 of 37 patients (73.0%) in the icatibant group and 20 of 36 patients (55.6%) in the control group (rate difference, 17.42; 95% confidence interval [CI], −4.22 to 39.06; P = .115). Clinical efficacy ensued in 37 patients (100.0%) in the icatibant group and 30 patients (83.3%) in the control group (rate difference, 16.67; 95% CI, 4.49-28.84; P = .011). No patient died in the icatibant group, compared with 6 patients (16.7%) in the control group (P = .011). All patients but 1 had adverse events, which were evenly distributed between study arms. No patient withdrew because of adverse events. Conclusions Adding icatibant to standard care was safe and improved both COVID-19 pneumonia and mortality in this proof-of-concept study. A larger, phase 3 trial is warranted to establish the clinical value of this treatment. Clinical Trials Registration NCT04978051.

The aim of this article is to propose a theoretical and practical justification on the work for the internalization of the body schema in relation to neuromotricity. For this purpose, a bibliographical review is established on the perceptual-motor variables related to the elaboration of the body schema, such as attitude, postural control, spatial structuring, temporal structuring, balance and coordination with practical exercises of body percussion for its application in the physical education sciences. In this way, applying practical resources focused on the work of cognitive and executive functions, we offer an innovative psycho-pedagogical method in the field of human motor skills. El objetivo de este artículo es proponer una justificación teórica y práctica sobre el trabajo para la interiorización del esquema corporal en relación a la neuromotricidad. Para ello se establece una revisión bibliográfica sobre las variables perceptivo-motrices relacionadas con la elaboración del esquema corporal, como son la actitud, control postural, estructuración espacial, estructuración temporal, equilibrio y coordinación con ejercicios prácticos de percusión corporal para su aplicación en las ciencias de la educación física. de este modo, aplicando recursos prácticos focalizados en el trabajo de las funciones cognitivas y ejecutivas, ofrecemos un método psicopedagógico innovador en el ámbito de la motricidad humana.

We present a novel strategy to assemble diverse metal ions and organic linkers into metal–organic polyhedra (MOPs). It involves use of a pre-assembled complex of a parent MOP to replicate this cage with a multicomponent character.

The steric properties of the tetradentate ligand influences the reactivities of the Fe(v)O units in a number of tautomeric Fe(v)(O)(OH) complexes.

To assess the incidence of severe perioperative anaphylaxis, the mechanisms involved, the value of laboratory/skin tests, and the most effective treatments.A historical cohort study conducted in a tertiary public hospital in Spain. Patients that had undergone anaesthesia during the 20-year period were included. In these patients, 66 cases of severe anaphylaxis were found. In patients with suspicion of severe anaphylaxis, levels of blood histamine at less than 15 minutes and serum tryptase at 2, 6, and 24 hours following the reaction were determined. Skin and specific IgE tests were performed between 4 and 8 weeks later.Over the 20-year period, 288 594 anaesthetic procedures were performed. We observed cases of 66 severe anaphylaxis reaction (59% men; age, 60.8 ± 17.3 years. Symptoms observed were cardiovascular (86%), respiratory (73%), and mucocutaneous (56%). Elevated serum tryptase levels were associated with degree of severity at 2 (P 0.0001) and 6 hours (P = 0. 026) and were highest in IgE-mediated reactions (P = 0.020). All patients required treatment, and 3 events were fatal. In 84.8% of patients, skin and/or specific IgE tests were positive for antibiotics (35.8%), non-steroidal anti-inflammatory drugs (23.1%), neuromuscular blocking agents (15.4%) and latex (15.4%).The incidence of severe anaphylaxis in our hospital was 1 in 4.373 anaesthetic procedures, with a death rate of 4.5%. All cases required treatment. Serum tryptase was a good predictor of reaction severity. The most frequent causative agents were antibiotics, non-steroidal anti-inflammatory drugs, neuromuscular blocking agents and latex.

Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2022-2023. Tutor/Director: Gutiérrez Gálvez, Agustí, Sánchez Vives, Maria V., Manasanch Berengué, Arnau, Slow oscillations, which are the default mode of the cortex and the main oscillation in slow-wave sleep, may be affected by aging. In this project, aging effect on the properties of the cortical slow oscillation is studied in 3, 7, 15 and 20 months of age sedated mice with Slowpy, a specialized pipeline for slow oscillations. Results show that aging affects the duration of Ups and Downs, as they slightly decrease with age, as well as the is an increase of the firing rate of the Up states with age. These effects can be explained by several biological and physiological reasons, such as changes in neuronal excitability and network connectivity. However, the effects of aging in functional connectivity remain unclear with this project, as this relationship has not been directly addressed in this study.

We present a new class of Lipschitz operators on Euclidean lattices that we call lattice Lipschitz maps, and we prove that the associated McShane and Whitney formulas provide the same extension result that holds for the real valued case. Essentially, these maps satisfy a (vector-valued) Lipschitz inequality involving the order of the lattice, with the peculiarity that the usual Lipschitz constant becomes a positive real function. Our main result shows that, in the case of Euclidean space, being lattice Lipschitz is equivalent to having a diagonal representation, in which the coordinate coefficients are real-valued Lipschitz functions. We also show that in the linear case the extension of a diagonalizable operator from the values in their eigenvectors coincide with the operator obtained both from the McShane and the Whitney formulae. Our work on such extension/representation formulas is intended to follow current research on the design of machine learning algorithms based on the extension of Lipschitz functions.

Corticosteroid-mediated stress responses require the activation of complex brain circuits involving mitochondrial activity, but the underlying cellular and molecular mechanisms are scantly known. The endocannabinoid system is implicated in stress coping, and it can directly regulate brain mitochondrial functions via type 1 cannabinoid (CB1) receptors associated with mitochondrial membranes (mtCB1). In this study, we show that the impairing effect of corticosterone in the novel object recognition (NOR) task in mice requires mtCB1 receptors and the regulation of mitochondrial calcium levels in neurons. Different brain circuits are modulated by this mechanism to mediate the impact of corticosterone during specific phases of the task. Thus, whereas corticosterone recruits mtCB1 receptors in noradrenergic neurons to impair NOR consolidation, mtCB1 receptors in local hippocampal GABAergic interneurons are required to inhibit NOR retrieval. These data reveal unforeseen mechanisms mediating the effects of corticosteroids during different phases of NOR, involving mitochondrial calcium alterations in different brain circuits.

BACKGROUND Hand eczema is a common inflammatory skin disorder. Health care providers need continuously updated information about the management of hand eczema to ensure best treatment for their patients. OBJECTIVES To update the European Society of Contact Dermatitis guideline on the diagnosis, prevention, and treatment on of hand eczema. METHOD The Guideline Development Group (GDG) was established on behalf of the ESCD. A call for interest was launched via the ESCD website and via the ESCD members' mailing list. Appraisal of the evidence for therapeutic and preventive interventions was applied and a structured method of developing consensus was used and moderated by an external methodologist. The final guideline was approved by the ESCD executive committee and was in external review on the ESCD webpage for 1 month. RESULTS Consensus was achieved for several statements and management strategies. CONCLUSION The updated guideline should improve management of hand eczema.

La introducción de videotutoriales interactivos (VTI) en las clases prácticas de laboratorio de grados en ciencias e ingenierías como complemento a los tradicionales protocolos experimentales escritos ha sido analizada mediante encuestas de satisfacción al alumnado. Los resultados muestran un alto grado de aceptación en el uso de los vídeos y la mejora del aprendizaje autónomo, pero también reflejan una percepción del aumento de la carga de trabajo debido a la inclusión de preguntas en los vídeos, que es valorado de forma muy negativa por parte del alumnado.

Chronic spontaneous urticaria (CSU) is a debilitating skin disease characterized by intensely itchy wheals, angioedema, or both. Symptoms recur spontaneously, on a near-daily basis, over >6 weeks; many patients experience flare-ups over several years and, consequently, reduced quality of life. Differences between the inflammatory profiles of the skin of CSU patients (wheals and nonlesional sites) and healthy controls indicate that key drivers such as mast cells, eosinophils, and basophils interact, release vasoactive mediators, and prime the skin, leaving patients predisposed to symptoms. Many cytokines and chemokines involved in these inflammatory networks and their corresponding intracellular signaling cascades have been identified. These insights informed the development of therapies such as omalizumab, dupilumab, and Bruton's tyrosine kinase (BTK) inhibitors, marking a renewed focus on pathogenesis in CSU clinical research. Despite progress, current therapies provide symptomatic control but do not appear to redress the inflammatory balance in the skin permanently. A deeper understanding of CSU pathogenesis will permit a more targeted approach to developing novel treatments with curative intent. Here, we review what is known about the pathogenesis of CSU and consider how this can be used to identify rational targets to improve patient care further.