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The role of macrophages (Mo) and their prognostic impact in diffuse large B-cell lymphomas (DLBCL) remain controversial. By regulating the lipid metabolism, Liver-X-Receptors (LXRs) control Mo polarization/inflammatory response, and their pharmacological modulation is under clinical investigation to treat human cancers, including lymphomas. Herein, we surveyed the role of LXRs in DLBCL for prognostic purposes. Comparing bulk tumors with purified malignant and normal B-cells, we found an intriguing association of NR1H3, encoding for the LXR-α isoform, with the tumor microenvironment (TME). CIBERSORTx-based purification on large DLBCL datasets revealed a high expression of the receptor transcript in M1-like pro-inflammatory Mo. By determining an expression cut-off of NR1H3, we used digital measurement to validate its prognostic capacity on two large independent on-trial and real-world cohorts. Independently of classical prognosticators, NR1H3

The first part of the paper presents some basic relationships linking multiple options, i.e. options written on several risky assets and, specifically, options on the maximum and the minimum of n assets. This is followed by a description of the features of currency option bonds, which offer their holders a series of multiple currency options, and of the Fong and Vasicek M.A.P. strategy, which consists in replicating the payoff of a call option on the maximum written on several assets. Subsequently, Johnson's equation for pricing options on the maximum of n assets is presented and adapted to the case of currency options, with a test of the underlying assumptions to see whether they apply to the exchange market of the lira. Call options on the maximum written on the dollar, the yen and the DM are then priced and a simulation carried out to replicate the value of these options with a dynamically adjusted portfolio made up of the three underlying currencies. Lastly, a comparison is made of the results obtained by an equally distributed multicurrency portfolio and by a M.A.P. strategy.

Long-term predictors of survival in essential mixed cryoglobulinemic glomerulonephritis. We report the clinical outcome of 105 essential mixed cryoglobulinemia (EMC) patients with renal involvement collected throughout 25 years in three renal Units of Milan. The median follow-up was 72 months since renal biopsy and 131 months since the clinical onset of EMC. Patient survival was 49% at 10 years after renal biopsy. Forty-two patients died primarily from cardiovascular and liver disease or infection, whereas 15 patients developed chronic renal failure. Two patients had a complete remission of the disease while 15 had a remission only of renal signs. Thirty-one patients are alive with persistent renal and extrarenal manifestations. Anti-HCV antibodies were retrospectively detected in 34 patients and were present in 85% of them. This variable was not included in the statistical evaluation. At multivariate analysis, age older than 50 years, purpura, splenomegaly, cryocrit levels higher than 10%, C3 plasma levels lower than 54 mg/dl, and serum creatinine higher than 1.5 mg/dl were independent risk factors for death or dialysis. In conclusion, several factors may influence the outcome of patients with EMC nephritis. Markers of disease activity and an impaired renal function can herald a bad prognosis. It should be stressed, however, that only a minority of patients eventually develop renal failure, probably because in the most severe cases patients die earlier.

The kidney frequently contains amyloid deposits in the so-called ‘imunocyte dyscrasia-associated systemic amyloidosis’ (IDSA) and renal abnormality is the main presenting feature in most patients [1]. In the literature renal abnormality has been reported for 40–80% of the cases with primary (AL) amyloidosis and it is even more frequent in patients with myeloma associated (MAL) amyloidosis [1, 2, 3]. Progressive renal failure, which is almost invariable in renal amyloidosis, has bad prognostic significance and is one of the main causes of death. In this study we retrospectively analyzed the morphologic and clinical features of 99 patients with AL or MAL renal amyloidosis.