290 results on '"Andersen L"'
Search Results
2. Molecular basis and design principles of switchable front-rear polarity and directional migration in Myxococcus xanthus
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Carreira, L., Szadkowski, D., Lometto, S., Hochberg, G., https://orcid.org/0000-0002-7155-0451, Søgaard-Andersen, L., and https://orcid.org/0000-0002-0674-0013
- Abstract
During cell migration, front-rear polarity is spatiotemporally regulated; however, the underlying design of regulatory interactions varies. In rod-shaped Myxococcus xanthus cells, a spatial toggle switch dynamically regulates front-rear polarity. The polarity module establishes front-rear polarity by guaranteeing front pole-localization of the small GTPase MglA. Conversely, the Frz chemosensory system, by acting on the polarity module, causes polarity inversions. MglA localization depends on the RomR/RomX GEF and MglB/RomY GAP complexes that localize asymmetrically to the poles by unknown mechanisms. Here, we show that RomR and the MglB and MglC roadblock domain proteins generate a positive feedback by forming a RomR/MglC/MglB complex, thereby establishing the rear pole with high GAP activity that is non-permissive to MglA. MglA at the front engages in negative feedback that breaks the RomR/MglC/MglB positive feedback allosterically, thus ensuring low GAP activity at this pole. These findings unravel the design principles of a system for switchable front-rear polarity.
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- 2023
3. Inline cryogenically cooled radio-frequency ion trap as a universal injector for cold ions into an electrostatic ion-beam storage ring:Probing and modeling the dynamics of rotational cooling of OH−
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Pedersen, H. B., Juul, H., Mikkelsen, F. K., Rasmussen, A. P., and Andersen, L. H.
- Abstract
We describe the setup and characterization of a cryogenic multipole radio-frequency (RF) ion trap that enables the accumulation and cooling of mass-selected ions before injection into the SAPHIRA storage ring. To characterize the RF trap setup, we use OH- anions and explore the threshold photodetachment cross section measured after storage in SAPHIRA as a probe of the rotational temperature. Beyond the temperature of the ion trap assembly, cooled to 6 K, the final rotational temperature of the OH- ions is strongly influenced by the density of cooled He and the actual number of trapped ions while much less affected (possibly unaffected) by the time-varying field of the trap. To obtain rotationally cold OH- ions, the RF trap must be operated with low He density and a low number of ions. High He densities, corresponding to a strong coupling of the trapped ions and He gas, lead to a significant rotational heating of the trapped ion ensemble, and the He density seems to limit the actual reachable rotational temperature. We demonstrate that cold ions in the RF trap remain cold for at least 30 ms in the SAPHIRA (300 K) storage ring at a base pressure of ∼8×10-9mbar.
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- 2022
4. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis
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Allotey, J., Whittle, R., Snell, K. I. E., Smuk, M., Townsend, R., von Dadelszen, P., Heazell, A. E. P., Magee, L., Smith, G. C. S., Sandall, J., Thilaganathan, B., Zamora, J., Riley, R. D., Khalil, A., Thangaratinam, S., Coomarasamy, A., Kwong, A., Savitri, A. I., Salvesen, K. A., Bhattacharya, S., Uiterwaal, C. S. P. M., Staff, A. C., Andersen, L. B., Olive, E. L., Redman, C., Sletner, L., Daskalakis, G., Macleod, M., Abdollahain, M., Ramirez, J. A., Masse, J., Audibert, F., Magnus, P. M., Jenum, A. K., Baschat, A., Ohkuchi, A., Mcauliffe, F. M., West, J., Askie, L. M., Mone, F., Farrar, D., Zimmerman, P. A., Smits, L. J. M., Riddell, C., Kingdom, J. C., van de Post, J., Illanes, S. E., Holzman, C., van Kuijk, S. M. J., Carbillon, L., Villa, P. M., Eskild, A., Chappell, L., Prefumo, F., Velauthar, L., Seed, P., van Oostwaard, M., Verlohren, S., Poston, L., Ferrazzi, E., Vinter, C. A., Nagata, C., Brown, M., Vollebregt, K. C., Takeda, S., Langenveld, J., Widmer, M., Saito, S., Haavaldsen, C., Carroli, G., Olsen, J., Wolf, H., Zavaleta, N., Eisensee, I., Vergani, P., Lumbiganon, P., Makrides, M., Facchinetti, F., Sequeira, E., Gibson, R., Ferrazzani, S., Frusca, T., Norman, J. E., Figueiro, E. A., Lapaire, O., Laivuori, H., Lykke, J. A., Conde-Agudelo, A., Galindo, A., Mbah, A., Betran, A. P., Herraiz, I., Trogstad, L., Smith, G. G. S., Steegers, E. A. P., Salim, R., Huang, T., Adank, A., Zhang, J., Meschino, W. S., Browne, J. L., Allen, R. E., Costa, F. D. S., Klipstein-Grobusch Browne, K., Crowther, C. A., Jorgensen, J. S., Forest, J. -C., Rumbold, A. R., Mol, B. W., Giguere, Y., Kenny, L. C., Ganzevoort, W., Odibo, A. O., Myers, J., Yeo, S. A., Goffinet, F., Mccowan, L., Pajkrt, E., Teede, H. J., Haddad, B. G., Dekker, G., Kleinrouweler, E. C., Lecarpentier, E., Roberts, C. T., Groen, H., Skrastad, R. B., Heinonen, S., Eero, K., Anggraini, D., Souka, A., Cecatti, J. G., Monterio, I., Pillalis, A., Souza, R., Hawkins, L. A., Gabbay-Benziv, R., Crovetto, F., Figuera, F., Jorgensen, L., Dodds, J., Patel, M., Aviram, A., Papageorghiou, A., Khan, K., Clinicum, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital, Allotey, J, Whittle, R, Snell, K, Smuk, M, Townsend, R, von Dadelszen, P, Heazell, A, Magee, L, Smith, G, Sandall, J, Thilaganathan, B, Zamora, J, Riley, R, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, A, Salvesen, K, Bhattacharya, S, Uiterwaal, C, Staff, A, Andersen, L, Olive, E, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramirez, J, Masse, J, Audibert, F, Magnus, P, Jenum, A, Baschat, A, Ohkuchi, A, Mcauliffe, F, West, J, Askie, L, Mone, F, Farrar, D, Zimmerman, P, Smits, L, Riddell, C, Kingdom, J, van de Post, J, Illanes, S, Holzman, C, van Kuijk, S, Carbillon, L, Villa, P, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, van Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, C, Nagata, C, Brown, M, Vollebregt, K, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, J, Figueiro, E, Lapaire, O, Laivuori, H, Lykke, J, Conde-Agudelo, A, Galindo, A, Mbah, A, Betran, A, Herraiz, I, Trogstad, L, Steegers, E, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, W, Browne, J, Allen, R, Costa, F, Klipstein-Grobusch Browne, K, Crowther, C, Jorgensen, J, Forest, J, Rumbold, A, Mol, B, Giguere, Y, Kenny, L, Ganzevoort, W, Odibo, A, Myers, J, Yeo, S, Goffinet, F, Mccowan, L, Pajkrt, E, Teede, H, Haddad, B, Dekker, G, Kleinrouweler, E, Lecarpentier, E, Roberts, C, Groen, H, Skrastad, R, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, J, Monterio, I, Pillalis, A, Souza, R, Hawkins, L, Gabbay-Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K, Tampere University, Obstetrics and Gynaecology, APH - Quality of Care, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, APH - Digital Health, and Obstetrics and gynaecology
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Calibration (statistics) ,Perinatal Death ,Overfitting ,Cohort Studies ,Fetal Development ,0302 clinical medicine ,Discriminative model ,3123 Gynaecology and paediatrics ,Models ,Pregnancy ,GROWTH RESTRICTION ,Statistics ,Medicine ,Prenatal ,030212 general & internal medicine ,Ultrasonography ,RISK ,030219 obstetrics & reproductive medicine ,PRETERM ,Radiological and Ultrasound Technology ,LOW-DOSE ASPIRIN ,DIAGNOSIS TRIPOD ,Obstetrics and Gynecology ,General Medicine ,Statistical ,Stillbirth ,Prognosis ,Pregnancy Complication ,external validation ,individual participant data ,intrauterine death ,prediction model ,stillbirth ,Female ,Humans ,Infant, Newborn ,Models, Statistical ,Pregnancy Complications ,Regression Analysis ,Risk Assessment ,Ultrasonography, Prenatal ,3. Good health ,PREECLAMPSIA ,Meta-analysis ,Human ,Cohort study ,Prognosi ,MEDLINE ,Regression Analysi ,WEEKS GESTATION ,03 medical and health sciences ,VELOCIMETRY ,Radiology, Nuclear Medicine and imaging ,RECURRENCE ,business.industry ,Infant ,Newborn ,R1 ,HYPERTENSIVE DISORDERS ,Reproductive Medicine ,Sample size determination ,Cohort Studie ,RG ,business ,RA ,Predictive modelling - Abstract
Objective Stillbirth is a potentially preventable complication of pregnancy. Identifying women at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of delivery in order to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none has yet been validated externally. In this study, we externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis to assess their predictive performance. Methods MEDLINE, EMBASE, DH-DATA and AMED databases were searched from inception to December 2020 to identify studies reporting stillbirth prediction models. Studies that developed or updated prediction models for stillbirth for use at any time during pregnancy were included. IPD from cohorts within the International Prediction of Pregnancy Complications (IPPIC) Network were used to validate externally the identified prediction models whose individual variables were available in the IPD. The risk of bias of the models and cohorts was assessed using the Prediction study Risk Of Bias ASsessment Tool (PROBAST). The discriminative performance of the models was evaluated using the C-statistic, and calibration was assessed using calibration plots, calibration slope and calibration-in-the-large. Performance measures were estimated separately in each cohort, as well as summarized across cohorts using random-effects meta-analysis. Clinical utility was assessed using net benefit. Results Seventeen studies reporting the development of 40 prognostic models for stillbirth were identified. None of the models had been previously validated externally, and the full model equation was reported for only one-fifth (20%, 8/40) of the models. External validation was possible for three of these models, using IPD from 19 cohorts (491 201 pregnant women) within the IPPIC Network database. Based on evaluation of the model development studies, all three models had an overall high risk of bias, according to PROBAST. In the IPD meta-analysis, the models had summary C-statistics ranging from 0.53 to 0.65 and summary calibration slopes ranging from 0.40 to 0.88, with risk predictions that were generally too extreme compared with the observed risks. The models had little to no clinical utility, as assessed by net benefit. However, there remained uncertainty in the performance of some models due to small available sample sizes. Conclusions The three validated stillbirth prediction models showed generally poor and uncertain predictive performance in new data, with limited evidence to support their clinical application. The findings suggest methodological shortcomings in their development, including overfitting. Further research is needed to further validate these and other models, identify stronger prognostic factors and develop more robust prediction models. (c) 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
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- 2022
5. Progesterone levels measured on the day of blastocyst transfer in modified natural cycle frozen-thawed embryo transfer (mNC-FET) cycles: a sub-study of an ongoing RCT
- Author
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Saupstad, M., Bogstad, J. W., Bergenheim, S. J., Petersen, M. R., Klajnbard, A., Freiesleben, N. L. C., Andersen, L. F., Knudsen, U. B., Englund, A. L., Husth, M., Alsbjerg, B., Pinborg, A., and Lossl, K.
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- 2022
6. Design considerations in clinical trials with adaptive stopping, arm-dropping and randomisation
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Granholm, A., Benjamin Skov Kaas-Hansen, Lange, T., Schjorring, O., Andersen, L., Perner, A., Jensen, A., and Møller, M.
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- 2022
7. Importance of frequency and intensity of strength training for work ability among physical therapists
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Calatayud J, Morera A, Ezzatvar Y, Lopez-Bueno R, Andersen L, Cuenca-Martinez F, Suso-Marti L, Sanchis-Sanchez E, Lopez-Bueno L, and Casana J
- Abstract
The aim of the study was to evaluate the association between frequency and intensity of strength training participation and work ability among physical therapists (PTs). The Work Ability Index questionnaire (WAI) and a questionnaire about participation in strength training during leisure time were administered to a sample of Spanish PTs. In addition, participants provided information on gender, age, body mass index, education, substance use, working experience and working hours per week. The odds for having excellent WAI (score 44-49) as a function of intensity or frequency of strength training participation were determined using binary logistic regression controlled for various confounders. Data from 981 PTs were analysed. High-intensity strength training (> 80% 1 RM) showed strong associations with excellent WAI (odds ratio = 9.7; 95% confidence interval, 2.9-31.6). In addition, performing strength training more than 3 times per week was associated with excellent WAI (odds ratio = 1.79; 95% confidence interval, 1.24-2.59), however, no significant associations were found with lower levels of frequency and intensities. High-intensity strength training 3 times per week is associated with excellent WAI among PTs. Training programs meeting these features may importantly contribute to maintain or improve WAI.
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- 2022
8. Past genomic diversity and population structure within Atlantic walrus (Odobenus rosmarus rosmarus) shaped by climate and human activities
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Emily Ruiz Puerta, Xenia Keighley, Star, B., Sanne Boessenkool, Sean Desjardins, Andersen, L. W., Born, E. W., Barrett, J. H., Anne Birgitte Gotfredsen, Lesley Howse, Paul Szpak, Pálsson, S., Malmquist, H. J., Peter Jordan, Morten Tange Olsen, and Arctic and Antarctic studies
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- 2022
9. An alternative and conserved cell wall enzyme that can substitute for the lipid II synthase MurG
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Zhang, L., Ramijan, K., Carrion Bravo, V.J., Aart, L.T. van der, Willemse, J.J., Wezel, G.P. van, Claessen, D., S{ø}gaard-Andersen L, and S{ø}gaard-Andersen L
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morphology switch ,peptidoglycan ,N-Acetylglucosaminyltransferases ,Microbiology ,cell wall biosynthesis ,Cell wall ,MurG ,03 medical and health sciences ,chemistry.chemical_compound ,Bacterial Proteins ,Cell Wall ,Virology ,Gene cluster ,Peptide sequence ,030304 developmental biology ,L-form ,0303 health sciences ,CRISPR interference ,ATP synthase ,biology ,Lipid II ,030306 microbiology ,Streptomyces coelicolor ,biology.organism_classification ,Lipid Metabolism ,Lipids ,QR1-502 ,Actinobacteria ,chemistry ,Biochemistry ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Peptidoglycan ,Research Article ,Bacterial Outer Membrane Proteins - Abstract
Almost all bacteria are surrounded by a cell wall, which protects cells from environmental harm. Formation of the cell wall requires the precursor molecule lipid II, which in bacteria is universally synthesized by the conserved and essential lipid II synthase MurG., The cell wall is a stress-bearing structure and a unifying trait in bacteria. Without exception, synthesis of the cell wall involves formation of the precursor molecule lipid II by the activity of the essential biosynthetic enzyme MurG, which is encoded in the division and cell wall synthesis (dcw) gene cluster. Here, we present the discovery of a cell wall enzyme that can substitute for MurG. A mutant of Kitasatospora viridifaciens lacking a significant part of the dcw cluster, including murG, surprisingly produced lipid II and wild-type peptidoglycan. Genomic analysis identified a distant murG homologue, which encodes a putative enzyme that shares only around 31% amino acid sequence identity with MurG. We show that this enzyme can replace the canonical MurG, and we therefore designated it MglA. Orthologues of mglA are present in 38% of all genomes of Kitasatospora and members of the sister genus Streptomyces. CRISPR interference experiments showed that K. viridifaciens mglA can also functionally replace murG in Streptomyces coelicolor, thus validating its bioactivity and demonstrating that it is active in multiple genera. All together, these results identify MglA as a bona fide lipid II synthase, thus demonstrating plasticity in cell wall synthesis.
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- 2021
10. Corrigendum to 'Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women' [Diab. Res. Clin. Pract. 168 (2020) 108378](S0168822720306318)(10.1016/j.diabres.2020.108378)
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Immanuel, J., Simmons, D., Desoye, G., Corcoy, R., Adelantado, J. M., Devlieger, R., Lapolla, A., Dalfra, M. G., Bertolotto, A., Harreiter, J., Wender-Ozegowska, E., Zawiejska, A., Dunne, F. P., Damm, P., Mathiesen, E. R., Jensen, D. M., Andersen, L. L. T., Hill, D. J., Jelsma, J. G. M., Snoek, F. J., Scharnagl, H., Galjaard, S., Kautzky-Willer, A., VAN Poppel, M. N. M., Public and occupational health, Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), and APH - Quality of Care
- Abstract
The authors regret that a few lines in Tables 1 and 2 were formatted incorrectly in the published version of the article with numbers all appearing in one line instead of being in separate lines. The correctly formatted tables are shown below. The authors would like to apologise for any inconvenience caused.
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- 2021
11. Progesterone supplementation in modified natural frozen embryo transfer (mNC-FET) does not cause mental health adverse effects - A sub-study of a multicenter RCT
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Pistoljevic, N, Saupstad, M, Mizrak, I, Andersen, L F, Englund, A L, Freiesleben, N L Cou., Husth, M, Klajnbard, A, Knudsen, U B, Løssl, K, Schmidt, L, and Pinborg, A
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- 2021
12. Interaction between rs10830962 polymorphism in MTNR1B and lifestyle intervention on maternal and neonatal outcomes: secondary analyses of the DALI lifestyle randomized controlled trial
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Van Poppel, M. N. M., Corcoy, R., Hill, D., Simmons, D., Mendizabal, L., Zulueta, M., Simon, L., Desoye, G., Adelantado Perez, J. M., Kautzky-Willer, A., Harreiter, J., Damm, P., Mathiesen, E., Jensen, D. M., Andersen, L. L. T., Dunne, F., Lapolla, A., Dalfra, M. G., Bertolotto, A., Van Poppel, M., Jelsma, J. G. M., Snoek, F. J., Galjaard, S., Wender-Ozegowska, E., Zawiejska, A., Devlieger, R., Public and occupational health, Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), APH - Quality of Care, and Medical Psychology
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Lifestyle intervention ,Blood Glucose ,Leptin ,medicine.medical_treatment ,Medicine (miscellaneous) ,law.invention ,Randomized controlled trial ,law ,Pregnancy ,Insulin ,Gestational diabetes ,Melatonin ,Nutrition and Dietetics ,C-Peptide ,Diabetes ,Pregnancy Outcome ,Prenatal Care ,Insulin sensitivity ,Fetal Blood ,Gestational Weight Gain ,Cord blood ,Gestational ,Female ,medicine.symptom ,Diet, Healthy ,Receptor ,Adult ,medicine.medical_specialty ,Genotype ,Melatonin receptor 1B ,Polymorphism ,Alleles ,Diabetes, Gestational ,Exercise ,Humans ,Infant, Newborn ,Insulin Resistance ,Receptor, Melatonin, MT2 ,Life Style ,Polymorphism, Genetic ,Insulin resistance ,Genetic ,Internal medicine ,medicine ,Healthy ,business.industry ,MT2 ,Infant ,medicine.disease ,Newborn ,Diet ,business ,Weight gain - Abstract
Background: Interactions between polymorphisms of the melatonin receptor 1B (MTNR1B) gene and lifestyle intervention for gestational diabetes have been described. Whether these are specific for physical activity or the healthy eating intervention is unknown. Objectives: The aim was to assess the interaction between MTNR1B rs10830962 and rs10830963 polymorphisms and lifestyle interventions during pregnancy. Methods: Women with a BMI (in kg/m2) of ≥29 (n = 436) received counseling on healthy eating (HE), physical activity (PA), or both. The control group received usual care. This secondary analysis had a factorial design with comparison of HE compared with no HE and PA compared with no PA. Maternal outcomes at 24-28 wk were gestational weight gain (GWG), maternal fasting glucose, insulin, insulin resistance (HOMA-IR), disposition index, and development of GDM. Neonatal outcomes were cord blood leptin and C-peptide and estimated neonatal fat percentage. The interaction between receiving either the HE or PA intervention and genotypes of both rs10830962 and rs10830963 was assessed using multilevel regression analysis. Results: GDM risk was increased in women homozygous for the G allele of rs10830962 (OR: 2.60; 95% CI: 1.34, 5.06) or rs10830963 (OR: 2.83; 95% CI: 1.24, 6.47). Significant interactions between rs10830962 and interventions were found: in women homozygous for the G allele but not in the other genotypes, the PA intervention reduced maternal fasting insulin (β: -0.16; 95% CI: -0.33, 0.02; P = 0.08) and HOMA-IR (β: -0.17; 95% CI: -0.35, 0.01; P = 0.06), and reduced cord blood leptin (β: -0.84; 95% CI: -1.42, -0.25; P = 0.01) and C-peptide (β: -0.62; 95% CI: -1.07, -0.17; P = 0.01). In heterozygous women, the HE intervention had no effect, whereas in women homozygous for the C allele, HE intervention reduced GWG (β: -1.6 kg; 95% CI: -2.4, -0.8 kg). No interactions were found. Conclusions: In women homozygous for the risk allele of MTNR1B rs10830962, GDM risk was increased and PA intervention might be more beneficial than HE intervention for reducing maternal insulin resistance, cord blood C-peptide, and cord blood leptin.
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- 2021
13. Reliability of shoulder abduction muscle endurance measured using isokinetic dynamometry
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Micheletti, J. K., Andersen, L. L., Machado, A. F., Lopes, J. S.S., Souto, L. R., and Pastre, C. M.
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Reproducibility of results ,Muscle strength dynamometer ,Fatigue ,Resistance training - Abstract
Objective: To evaluate reliability of performance and metabolic expenditure during a shoulder abduction endurance test with isokinetic dynamometer. Methods: A total of 28 healthy adults participated in 4 sessions (Orientation, Familiarization, Test and Retest). The muscle endurance test was performed using 50% of the individual maximal isometric voluntary contraction strength (21.9 ± 5.8 Nm). Participants performed repeated 0–90° shoulder abductions until exhaustion in the isokinetic dynamometer at a velocity of 60°/s. Values of time, repetition, rhythm and total work were analyzed. Results: For test and retest, respectively, time to fatigue (seconds) was 95.5 ± 37.6 and 91.1 ± 32.8 (P = 0.27), and repetitions were 31.4 ± 12.1 and 29.9 ± 10.6 (P = 0.23). Reliability was satisfactory [Time: ICC = 0.83 (95% CI = 0.66; 0.92); Repetition: ICC = 0.83 (95% CI = 0. 67; 0.92); Rhythm: ICC = 0.55 (95% CI = 0.24; 0.77); Total work: ICC = 0.85 (95% CI = 0.69; 0.93)]. Conclusion: The isokinetic test for shoulder muscle endurance at 50% of maximal muscle strength has good reliability.
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- 2021
14. The Nordic Monitoring System: Basis for decision on 3rd data collection
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Fagt, Sisse, Andersen, L. F., Enghardt Barbieri, H., Borodulin, K., Thorgeirsdóttir, H., Trolle, Ellen, and Matthiessen, Jeppe
- Abstract
A Nordic working group was established in 2007 with the aim to describe a future Nordic Monitoring System on diet, physical activity and overweight. The system was validated in 2009 and in 2011 and 2014, the first data collections took place. The Nordic Monitoring Group has discussed future developments of the monitoring system based on experience from the first two data collections. The Nordic Monitoring Group has described how results from the monitoring have been communicated and used for several purposes.The current Nordic working paper sums up the deliveries from the Nordic Monitoring System and points forward to a new data collection.
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- 2021
15. Science aspirations of urban Latino students: A study in East Los Angeles, California
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Andersen, L, Childs, A, Wong, B, Hillier , J, and Strand, S
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Science education - Abstract
Latinos are now the largest racial and ethnic minority group in the United States. However, despite the size of the population, Latinos have historically been underrepresented in the sciences. While interventions have been implemented across the U.S. in order to raise aspirations towards a future in the sciences, the proportion of Latino youth choosing to enter the science pipeline remains low. This suggests that intervention programs designed generally might not take into account important factors influencing Latino science aspirations specifically. This study systematically investigated factors that impact the science aspirations of U.S. Latinos in secondary school (ages 11 to 14), filling a gap in knowledge and addressing a critical section of the ‘science pipeline’ from middle school to high school. Survey data was collected from a sample of 539 6th grade science and 428 9th grade science students attending six public middle schools and five public high schools in East Los Angeles, California. More than nine in ten of the students were Latino, reflecting the demographic composition of the neighbourhood schools. This thesis details science aspirations among this group of students, analysing variation according to gender, home language use, immigration generation, and socioeconomic status. Predictors of science aspirations included attitudinal constructs generated from survey data by principal components analyses. The results of hierarchical multivariate regression analyses suggest that most of these students were detached from science, their science aspirations strongly influenced by family, school experiences, and neighbourhood conditions. Comparisons of results show significant differences in science aspirations by age and gender: the 6th grade students held significantly higher science aspirations than the 9th grade students; 9th grade girls held the lowest science aspirations. Post analysis teacher interviews and an extended 6th grade sample provide valuable context for the results of the survey analyses. The results and findings are discussed in relation to sociocultural theories which stress the structuring effect of U.S. society on aspirations. The main contribution to knowledge of this study was to establish a detailed understanding of the influences on the science aspirations and science-related attitudes of urban Latino youth, based on empirical data from a large and representative East Los Angeles sample.
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- 2020
16. Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD)
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Wijndaele, Katrien, White, Thomas, Andersen, Lars Bo, Bugge, Anna, Kolle, Elin, Northstone, Kate, Wedderkopp, Niels, Ried-Larsen, Mathias, Kriemler, Susi, Page, Angie S., Puder, Jardena J., Reilly, John J., Sardinha, Luis B., Van Sluijs, Esther M. F., Sharp, Stephen J., Brage, Søren, Ekelund, Ulf, Andersen, L. B., Anderssen, S., Atkin, A. J., Cardon, G., Davey, R., Ekelund, U., Esliger, D. W., Hallal, P., Hansen, B. H., Janz, K. F., Kriemler, S., Møller, N., Northstone, K., Page, A., Pate, R., Puder, J. J., Reilly, J. J., Salmon, J., Sardinha, L. B., Sherar, L. B., Timperio, A., Van Sluijs, E. M. F., Wijndaele, Katrien [0000-0003-2199-7981], and Apollo - University of Cambridge Repository
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Iso-temporal ,ICAD ,Cardio-metabolic ,Physical activity ,Research ,Prolonged sitting ,ALSPAC - Abstract
Background: Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children. Methods: Cross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed. Results: Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg). Conclusions: Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.
- Published
- 2020
- Full Text
- View/download PDF
17. Consensus Guidelines for Perioperative Care in Neonatal Intestinal Surgery: Enhanced Recovery After Surgery (ERAS
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Brindle, Mary E., McDiarmid, Caraline, Short, Kristin, Miller, Kathleen, MacRobie, Ali, Lam, Jennifer Y.K., Brockel, Megan, Raval, Mehul V., Harreiter, Alexandra, Kautzky-Willer, A., Damm, P., Mathiesen, E. R., Jensen, D. M., Andersen, L. L., Tanvig, M., Lapolla, A., Dalfra, M. G., Bertolotto, A., Wender-Ozegowska, E., Zawiejska, A., Hill, D. J., Snoek, F. J., Jelsma, J. G.M., Desoye, G., and van Poppel, M. N.M.
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medicine.medical_specialty ,Consensus ,Population ,MEDLINE ,Perioperative Care ,03 medical and health sciences ,0302 clinical medicine ,Anti-Infective Agents ,medicine ,Humans ,030212 general & internal medicine ,education ,Intensive care medicine ,Digestive System Surgical Procedures ,Societies, Medical ,Postoperative Care ,education.field_of_study ,Scientific Review ,Evidence-Based Medicine ,business.industry ,Gastroenterology ,Infant, Newborn ,Foundation (evidence) ,Guideline ,Evidence-based medicine ,Vascular surgery ,Antibiotic Prophylaxis ,Systematic review ,Cardiothoracic surgery ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Surgery ,Interdisciplinary Communication ,Neonatology ,business ,Enhanced Recovery After Surgery - Abstract
BackgroundEnhanced Recovery After Surgery (ERAS®) Society guidelines integrate evidence-based practices into multimodal care pathways that have improved outcomes in multiple adult surgical specialties. There are currently no pediatric ERAS®Society guidelines. We created an ERAS®guideline designed to enhance quality of care in neonatal intestinal resection surgery.MethodsA multidisciplinary guideline generation group defined the scope, population, and guideline topics. Systematic reviews were supplemented by targeted searching and expert identification to identify 3514 publications that were screened to develop and support recommendations. Final recommendations were determined through consensus and were assessed for evidence quality and recommendation strength. Parental input was attained throughout the process.ResultsFinal recommendations ranged from communication strategies to antibiotic use. Topics with poor-quality and conflicting evidence were eliminated. Several recommendations were combined. The quality of supporting evidence was variable. Seventeen final recommendations are included in the proposed guideline.DiscussionWe have developed a comprehensive, evidence-based ERAS guideline for neonates undergoing intestinal resection surgery. This guideline, and its creation process, provides a foundation for future ERAS guideline development and can ultimately lead to improved perioperative care across a variety of pediatric surgical specialties.
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- 2020
18. Variations in accelerometry measured physical activity and sedentary time across Europe - harmonized analyses of 47,497 children and adolescents
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Steene-Johannessen, Jostein, Hansen, Bjørge Herman, Dalene, Knut Eirik, Kolle, Elin, Northstone, Kate, Møller, Niels Christian, Grøntved, Anders, Wedderkopp, Niels, Kriemler, Susi, Page, Angie S., Puder, Jardena J., Reilly, John J., Sardinha, Luis B., Van Sluijs, Esther M. F., Andersen, Lars Bo, Van Der Ploeg, Hidde, Ahrens, Wolfgang, Flexeder, Claudia, Standl, Marie, Shculz, Holger, Moreno, Luis A., De Henauw, Stefaan, Michels, Nathalie, Cardon, Greet, Ortega, Francisco B., Ruiz, Jonatan, Aznar, Susana, Fogelholm, Mikael, Decelis, Andrew, Olesen, Line Grønholt, Hjorth, Mads Fiil, Santos, Rute, Vale, Susana, Christiansen, Lars Breum, Jago, Russ, Basterfield, Laura, Owen, Christopher G., Nightingale, Claire M., Eiben, Gabriele, Polito, Angela, Lauria, Fabio, Vanhelst, Jeremy, Hadjigeorgiou, Charalambos, Konstabel, Kenn, Molnár, Dénes, Sprengeler, Ole, Manios, Yannis, Harro, Jaanus, Kafatos, Anthony, Anderssen, Sigmund Alfred, Ekelund, Ulf, Andersen, L. B., Anderssen, S., Atkin, A. J., Cardon, G., Davey, R., Ekelund, U., Esliger, D. W., Hallal, P., Hansen, B. H., Janz, K. F., Kriemler, S., Møller, N., Northstone, K., Pate, R., Puder, J. J., Reilly, J., Salmon, J., Sardinha, L. B., Sherar, L. B., Van Sluijs, E. M. F., Steene-Johannessen, Jostein [0000-0002-3710-9021], Apollo - University of Cambridge Repository, Université de Lille, LillOA, Norwegian School of Sport Sciences = Norges idrettshøgskole [Oslo] (NIH), University Hospitals Bristol, University of Southern Denmark (SDU), Universität Zürich [Zürich] = University of Zurich (UZH), University of Bristol [Bristol], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), University of Strathclyde [Glasgow], Universidade de Lisboa = University of Lisbon (ULISBOA), University of Cambridge [UK] (CAM), Western Norway University of Applied Sciences, VU University Medical Center [Amsterdam], Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Helmholtz Zentrum München = German Research Center for Environmental Health, German Research Center for Environmental Health - Helmholtz Center München (GmbH), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Universiteit Gent = Ghent University (UGENT), Universidad de Granada = University of Granada (UGR), Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Malta [Malta], University of Copenhagen = Københavns Universitet (UCPH), Universidade Católica Portuguesa [Porto], Polytechnic Institute of Porto, Newcastle University [Newcastle], University of London [London], St George's, University of London, University of Skövde [Sweden], Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), Institute of Sciences of Food Production (ISPA), Consiglio Nazionale delle Ricerche (CNR), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University of Cyprus [Nicosia] (UCY), Tallinn University, University of Pecs, Harokopio University of Athens, University of Tartu, University of Crete [Heraklion] (UOC), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Universidade de Lisboa (ULISBOA), Helmholtz-Zentrum München (HZM), Universiteit Gent = Ghent University [Belgium] (UGENT), Universidad de Granada (UGR), Universidad de Castilla-La Mancha (UCLM), University of Helsinki, University of Copenhagen = Københavns Universitet (KU), Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), University of Cyprus [Nicosia], Université de Lille, Inserm, CHU Lille, Norwegian School of Sport Sciences = Norges idrettshøgskole [Oslo] [NIH], University of Southern Denmark [SDU], Centre Hospitalier Universitaire Vaudois [Lausanne] [CHUV], Universidade de Lisboa = University of Lisbon [ULISBOA], University of Cambridge [UK] [CAM], Universiteit Gent = Ghent University [UGENT], Universidad de Granada = University of Granada [UGR], Universidad de Castilla-La Mancha = University of Castilla-La Mancha [UCLM], University of Copenhagen = Københavns Universitet [UCPH], Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics [CREA], Institute of Sciences of Food Production [ISPA], Lille Inflammation Research International Center - U 995 [LIRIC], University of Cyprus [Nicosia] [UCY], University of Crete [Heraklion] [UOC], Department of Food and Nutrition, Nutrition Science, Repositório Científico do Instituto Politécnico do Porto, Public and occupational health, and APH - Health Behaviors & Chronic Diseases
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Male ,DANISH CHILDREN ,RECOMMENDED LEVELS ,FITNESS ,Physical Therapy ,[SDV]Life Sciences [q-bio] ,Medicine (miscellaneous) ,Acceleometry ,RA773 ,Motor activity ,0302 clinical medicine ,Accelerometry ,Medicine and Health Sciences ,Faculty of Science ,Medicine ,adolescents ,030212 general & internal medicine ,Child ,lcsh:RC620-627 ,National data ,CALIBRATION ,Nutrition and Dietetics ,lcsh:Public aspects of medicine ,Public Health, Global Health, Social Medicine and Epidemiology ,Accelerometry measured ,[SDV] Life Sciences [q-bio] ,Europe ,lcsh:Nutritional diseases. Deficiency diseases ,Child, Preschool ,Female ,3143 Nutrition ,BEHAVIOR ,Adolescent ,sedentary time ,PARTICIPATION ,Physical activity ,Behavioural sciences ,Physical Therapy, Sports Therapy and Rehabilitation ,Sports Therapy and Rehabilitation ,Clinical nutrition ,VALIDATION ,VDP::Samfunnsvitenskap: 200::Samfunnsvitenskapelige idrettsfag: 330::Aktivitetslære: 332 ,Wear time ,03 medical and health sciences ,children ,Humans ,Exercise physiology ,Physical activity & health ,Exercise ,Sedentary time ,business.industry ,Research ,lcsh:RA1-1270 ,030229 sport sciences ,BODY-MASS INDEX ,accelerometer ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,SCHOOL ,Commentary ,MODERATE ,SPS Exercise, Nutrition and Health Sciences ,Sedentary Behavior ,business ,Body mass index ,Demography - Abstract
Funder: Ministero delle Politiche Agricole Alimentari e Forestali; doi: http://dx.doi.org/10.13039/501100005401, Funder: ZonMw; doi: http://dx.doi.org/10.13039/501100001826, Funder: The Research Council of Norway, Division for Society and Health., Background: Levels of physical activity and variation in physical activity and sedentary time by place and person in European children and adolescents are largely unknown. The objective of the study was to assess the variations in objectively measured physical activity and sedentary time in children and adolescents across Europe. Methods: Six databases were systematically searched to identify pan-European and national data sets on physical activity and sedentary time assessed by the same accelerometer in children (2 to 9.9 years) and adolescents (≥10 to 18 years). We harmonized individual-level data by reprocessing hip-worn raw accelerometer data files from 30 different studies conducted between 1997 and 2014, representing 47,497 individuals (2–18 years) from 18 different European countries. Results: Overall, a maximum of 29% (95% CI: 25, 33) of children and 29% (95% CI: 25, 32) of adolescents were categorized as sufficiently physically active. We observed substantial country- and region-specific differences in physical activity and sedentary time, with lower physical activity levels and prevalence estimates in Southern European countries. Boys were more active and less sedentary in all age-categories. The onset of age-related lowering or leveling-off of physical activity and increase in sedentary time seems to become apparent at around 6 to 7 years of age. Conclusions: Two third of European children and adolescents are not sufficiently active. Our findings suggest substantial gender-, country- and region-specific differences in physical activity. These results should encourage policymakers, governments, and local and national stakeholders to take action to facilitate an increase in the physical activity levels of young people across Europe.
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- 2020
19. Effectiveness of a Group-Based Progressive Strength Training in Primary Care to Improve the Recurrence of Low Back Pain Exacerbations and Function: A Randomised Trial
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Calatayud J, Guzman-Gonzalez B, Andersen L, Cruz-Montecinos C, Morell M, Roldan R, Ezzatvar Y, and Casana J
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endurance ,multi-site ,chronic low back pain ,core ,resistance training - Abstract
Low back pain (LBP) is the leading cause of disability and one of the most common reasons for physician visits in primary care, with a 33% rate of recurrence during the first year. However, the most optimal exercise program in this context remains unknown. The objective was to evaluate the effectiveness of a group-based progressive strength training program in non-specific chronic LBP (CLBP) patients in primary care on pain recurrence and physical function. Eighty-five patients with non-specific CLBP were separated into two groups (Intervention group: completed a progressive strength training program 3 days per week for 8 weeks; Control group: received the usual care). The intervention group showed a recurrence rate of 8.3%, while the control group had a recurrence rate of 33.3% and a shorter time until the first recurrent episode. The intervention group showed increased lumbar extensor strength, left-hand handgrip strength, and reduced the number of pain sites compared with the control group. Results also showed greater odds for reducing LBP intensity and disability in the intervention group. In conclusion, a group-based progressive strength training program is a more effective and efficient alternative than Back-School programs and can easily be carried out in the primary health care context.
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- 2020
20. Cross‐sectional and prospective associations between physical activity, body mass index and waist circumference in children and adolescents
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Dalene, K. E., Anderssen, S. A., Andersen, L. B., Steene‐Johannessen, J., Ekelund, U., Hansen, B. H., and Kolle, E.
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Accelerometer ,physical activitysedentary timewaist circumference ,Original Article ,body mass index ,Original Articles - Abstract
Summary Objective To study the cross‐sectional and prospective associations between physical activity (PA) of different intensities, body mass index (BMI) and waist circumference (WC) in children and adolescents using isotemporal substitution modelling. Methods Physical activity (accelerometry), BMI and WC were assessed in 6‐ (n = 970), 9‐ (n = 2,423) and 15‐year‐olds (n = 1,544) in 2005/2006 and 2011/2012. Participants aged 9 years in 2005/2006 were followed prospectively to 2011/12 (age 15). Associations between PA of different intensities (light, moderate and vigorous), BMI and WC were examined using isotemporal substitution models. Results Substituting 10 min per day of sedentary time with light PA was associated with higher WC (0.17 to 0.29 cm, p ≤ 0.003)) in all age groups. Substituting 10 min per day of sedentary time with moderate PA was associated with lower WC in 6‐ and 9‐year‐olds (−0.32 to −0.47 cm, p ≤ 0.013)). Substituting 10 min per day of sedentary time with vigorous PA was associated with lower WC in 9‐ and 15‐year‐olds (−1.08 to −1.79 cm, p ≤ 0.015)). Associations were similar with BMI as the outcome. In prospective analyses, substituting sedentary time with light, moderate or vigorous PA at age 9 was not associated with BMI or WC at age 15. Conclusion Substituting sedentary time with moderate PA appears favourably associated with adiposity in children, whereas vigorous PA may be required in adolescents. Cross‐sectional associations were not replicated in prospective analyses.
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- 2017
21. Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)
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Wijndaele, Katrien, White, Thomas, Andersen, Lars Bo, Bugge, Anna, Kolle, Elin, Northstone, Kate, Wedderkopp, Niels, Ried-Larsen, Mathias, Kriemler, Susi, Page, Angie S., Puder, Jardena J., Reilly, John J., Sardinha, Luis B., van Sluijs, Esther M. F., Sharp, Stephen J., Brage, Søren, Ekelund, Ulf, Andersen, L. B., Atkin, A. J., Cardon, G., Davey, R., Ekelund, U., Esliger, D. W., Hallal, P., Hansen, B. H., Janz, K. F., Kriemler, S., Møller, N., Northstone, K., Page, A., Pate, R., Puder, J. J., Reilly, J. J., Salmon, J., Sardinha, L. B., Sherar, L. B., Timperio, A., van Sluijs, E. M. F., International Children's Accelerometry Database (ICAD) Collaborators, Andersen, L.B., Anderssen, S., Atkin, A.J., Cardon, G., Davey, R., Ekelund, U., Esliger, D.W., Hallal, P., Hansen, B.H., Janz, K.F., Kriemler, S., Møller, N., Northstone, K., Page, A., Pate, R., Puder, J.J., Reilly, J.J., Salmon, J., Sardinha, L.B., Sherar, L.B., Timperio, A., van Sluijs, EMF, Wijndaele, Katrien [0000-0003-2199-7981], and Apollo - University of Cambridge Repository
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Iso-temporal ,Waist ,Adolescent ,RJ101 ,ICAD ,Accelerometry ,Blood Pressure/physiology ,Cardiovascular Diseases/epidemiology ,Child ,Child, Preschool ,Cholesterol, HDL/blood ,Cross-Sectional Studies ,Exercise/physiology ,Humans ,Risk Factors ,Sedentary Behavior ,Waist Circumference/physiology ,ALSPAC ,Cardio-metabolic ,Physical activity ,Prolonged sitting ,Medicine (miscellaneous) ,Physical Therapy, Sports Therapy and Rehabilitation ,Blood Pressure ,Clinical nutrition ,computer.software_genre ,Sitting ,03 medical and health sciences ,0302 clinical medicine ,Linear regression ,Medicine ,030212 general & internal medicine ,lcsh:RC620-627 ,Exercise ,Nutrition and Dietetics ,Database ,business.industry ,Research ,lcsh:Public aspects of medicine ,Cholesterol, HDL ,lcsh:RA1-1270 ,030229 sport sciences ,3. Good health ,lcsh:Nutritional diseases. Deficiency diseases ,Blood pressure ,Cardiovascular Diseases ,Meta-analysis ,Waist Circumference ,business ,computer - Abstract
Background Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children. Methods Cross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed. Results Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg). Conclusions Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.
- Published
- 2019
22. Maturity onset diabetes of the young type 3and pregnancy: Spontaneous hypoglycaemia and different pregnancy courses in two sisters with anHNF1amutation
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Skaugen, J. T., Fredriksen, A. L., Brusgaard, K., Schou, A. J., Christesen, H. T., Andersen, L. L. T., and Jensen, D. M.
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- 2019
23. Treatment of hypercholesterolaemia with PCSK-9 Inhibitors in Denmark. Assessment of real-life data; safety an extent of adverse effects after the first years of clinical use
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Mulverstedt, S., Klausen, I. C., Martinsen, M. H., Kanstrup, H., Thomsen, K. K., Knold, J., Henriksen, F. L., Andersen, L. J., Schmidt, E. B., Theilade, J., Clausen, J., Yafasov, K. M., Egstrup, K., Jensen, J. S., and Heitmann, M.
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- 2019
24. A Mobile Electronic Record for Lifestyle Coaches in Gestational Diabetes Prevention
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Simmons, David, Daniels, Tosin, Simmons, Daniel J, Poppel, Mireille Nm Van, Harreiter, Jürgen, Desoye, G, Simmons, D, Corcoy, R, Damm, Peter, Mathiesen, E R, Jensen, D M, Andersen, L L, van Poppel, M N, Kautzky-Willer, A, and Dunne, F P
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- 2019
25. Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Template for In-Hospital Cardiac Arrest: A Consensus Report From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia)
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Nolan, J. P., Berg, R. A., Andersen, L. W., Bhanji, F., Chan, P. S., Donnino, M. W., Lim, S. H., M. H. -M., Ma, Nadkarni, V. M., Starks, M. A., Perkins, G. D., Morley, P. T., Soar, J., Aickin, R., Atkins, D. L., Berg, K. M., Bingham, R., Bottiger, B. W., Brooks, S. C., Callaway, C. W., Castren, M., Chung, S. P., Considine, J., Couto, T. B., de Caen, A. R., Deakin, C. D., Drennan, I. R., Escalante, R., Gazmuri, R. J., Guerguerian, A. -M., Hazinski, M. F., Kudenchuk, P. J., Lofgren, B., Maconochie, I., Mancini, M. E., Meaney, P. A., Neumar, R. W., K. -C., Ng, Nicholson, T. C., Nishiyama, C., Nuthall, G. A., Olasveengen, T. M., Paiva, E. F., Parr, M. J., Reis, A. G., Reynolds, J. C., Ristagno, G., Sandroni, Claudio, Schexnayder, S. M., Scholefield, B. R., Smyth, M. A., Stanton, D., Tijssen, J. A., Vaillancourt, C., Van de Voorde, P., Wang, T. -L., and Welsford, M.
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AHA Scientific Statements ,sudden ,cardiac ,death ,Settore MED/41 - ANESTESIOLOGIA ,cardiac arrest ,cardiopulmonary resuscitation ,death, sudden, cardiac ,in-hospital cardiac arrest - Published
- 2019
26. Unravelling the scientific debate on how to address wolf-dog hybridization in Europe
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Donfrancesco, V., Ciucci, P., Salvatori, V., Benson, D., Andersen, L. W., Bassi, E., Blanco, J. C., Boitani, L., Caniglia, R., Canu, A., Capitani, C., Chapron, G., Czarnomska, S. D., Fabbri, E., Galaverni, M., Galov, A., Giménez, O., Godinho, R., Greco, C., Hindrikson, M., Huber, D., Hulva, P., and López Bao, José Vicente
- Abstract
Ramon & Cajal research contract (RYC-2015-18932) from the Spanish Ministry of Economy, Industry and Competitiveness
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- 2019
27. Implications of Teacher Life–Work Histories for Conceptualisations of ‘Care’: Narratives from Rural Zimbabwe
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Coultas, C, Broaddus, E, Campbell, C, Andersen, L, Mutsikiwa, A, Madanhire, C, Nyamukapa, C, Gregson, S, Wellcome Trust, and The World Bank Group
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narrative ,Zimbabwe ,H Social Sciences (General) ,Social Psychology ,HIV‐affected learners ,education ,11 Medical And Health Sciences ,17 Psychology And Cognitive Sciences ,16 Studies In Human Society ,LG Individual institutions (Asia. Africa) ,care ,teacher role ,Research Articles ,Research Article - Abstract
Schools are increasingly seen as key sites for support to HIV‐affected and other vulnerable children, and teachers are assigned the critical role of identifying and providing psychosocial support. Drawing on the life–work history narratives of 12 teachers in Zimbabwe, this paper explores the psychosocial processes underpinning teachers' conceptualisations of these caring roles. The influence of prolonged adversity, formative relationships, and broader patterns of social and institutional change in teacher identity formation processes speak to the complex and embodied nature of understandings of ‘care’. In such extreme settings teachers prioritise the material and disciplinary aspects of ‘care’ that they see as essential for supporting children to overcome hardship. This focus not only means that emotional support as envisaged in international policy is commonly overlooked, but also exposes a wider ideological clash about childrearing. This tension together with an overall ambivalence surrounding teacher identities puts further strain on teacher–student relationships. We propose the current trainings on providing emotional support are insufficient and that more active focus needs to be directed at support to teachers in relation with their students. © 2015 The Authors. Journal of Community & Applied Social Psychology published by John Wiley & Sons Ltd.
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- 2015
28. The Role of Himawari Rainfall Data for Indonesia Fire Danger Rating System (Ina-FDRS)
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Andersen L. Panjaitan, Reni Sulistyowati, Arief Darmawan, Lena Sumargana, and Evie Avianti
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Satellite rainfall ,Peat ,Remote sensing (archaeology) ,Climatology ,Satellite remote sensing ,Environmental science ,Fire weather index ,Rating system ,Land area ,Wind speed - Abstract
The 2015 fire period and 2018 non-fire period in South Sumatera, Indonesia, will be studied by using satellite rainfall data from HIMAWARI-8 AHI. The rainfall data from satellite remote sensing and surface meteorological data will be used as an input for Canadian Forest Fire Weather Index System and compare during those two different seasons. In this study, the satellite rainfall data will be applied to the peat land area at South Sumatera Province. During 2015, rainfall conditions less than 3 mm/day and South Sumatera’s condition very dry compare with the conditions on 2018.
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- 2018
29. Efficient finite-element analysis of the influence of structural modifications on traffic-induced building vibrations
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Peter Persson and Andersen, L. V.
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- 2018
30. One year follow-up of a nationwide cohort of patients with inflammatory arthritis, who switched from originator to biosimilar etanercept, focusing on patients who switched back to originator. An observational DANBIO study
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Glintborg, B., Sorensen, I. J., Omerovic, E., Mehnert, F., Manilo, N., Danebod, K., Jensen, D. V., Nordin, H., Hendricks, O., Loft, A. G., Chrysidis, S., Andersen, B. L., Raun, J. L., Lindegaard, H., Espesen, J., Jakobsen, S. H., Hansen, I. J., Dalgaard, E. B., Pedersen, D. D., Kristensen, S., Linauskas, A., Andersen, L. S., Grydehoj, J., Krogh, N. S., and Merete Lund Hetland
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- 2018
31. Probabilistic assessment of ground-vibration transfer in layered soil
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Andersen, L. V., Bucinskas, P., Peter Persson, Cardoso, Antonio S., Borges, Jose L., A. Costa, Pedro, Gomes, Antonio T., Marques, Jose C., and Vieira, Castorina S.
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- 2018
32. One-year treatment retention after a nationwide non-medical switch from originator to biosimilar etanercept in 2,061 patients with inflammatory arthritis followed in the DANBIO registry
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Bente Glintborg, Sørensen, I. J., Omerovic, E., Mehnert, F., Manilo, N., Kamilla Danebod, Dorte Vendelbo Jensen, Henrik Nordin, Anne Gitte Loft, Oliver Hendricks, Chrysidis, S., Andersen, B. L., Johnny Lillelund Raun, Hanne Lindegaard, Jakob Espesen, Jakobsen, S. H., Inger Marie Jensen Hansen, Dalsgaard, E. B., Pedersen, D. D., Kristensen, S., Asta Linauskas, Andersen, L. S., Grydehøj, J., Krogh, N., and Merete Lund Hetland
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- 2018
33. Immediate effects of osteopathic treatment versus therapeutic exercise on patients with chronic cervical pain
- Author
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Galindez-Ibarbengoetxea, X., Setuain, I., Robinson Ramírez-Vélez, Andersen, L. L., González-Izal, M., Jauregi, A., and Izquierdo, M.
- Subjects
Pain measurement ,Physiology ,Cervical vertebrae ,Exercise therapy ,Chronic pain ,Pathophysiology ,articular ,Pain threshold ,Cervical vertebra ,Kinesiotherapy ,Neck pain ,Randomized controlled trial ,Joint characteristics and functions ,Humans ,Treatment outcome ,Controlled study ,Range of motion ,Human - Abstract
Context. Alternatives to medication for immediate pain relief are needed because long-term use of pain medication has been associated with adverse effects. High-velocity, low-amplitude (HVLA) manipulation techniques (MTs) and craniocervical flexion (CCF) exercises have been frequently used in the management of chronic cervical pain. Objective. The study intended to compare the immediate effects on pain of a treatment using HVLA manipulation versus one using a CCF exercise protocol. Design. The research team designed a single-blinded, randomized clinical trial. Setting. The study was conducted at osteopathic clinics. Participants. Participants were 25 volunteer patients with chronic neck pain. Intervention. Participants were randomly enrolled in one of 2 groups: the HVLA manipulation group (MT group), n = 12, or the CCF exercise protocol group (CCF group), n = 13. Participants in the CCF group performed the exercise for 10 repetitions of a 10-s duration, with a 10-s rest interval between each contraction, for a total contraction time of 100 s and a total time of the session of 190 s. Outcome Measures • The outcomes were measured at baseline and at 60 s postintervention. The measures included (1) a visual analogue scale (VAS) completed during range of motion (ROM) measurement, (2) an evaluation of the ROM of the cervical spine, (3) a test of pressure pain thresholds (PPTs), and (4) electromyographic (EMG) activation of sternocleidomastoid muscle during a craniocervical flexion test. Results • Following both interventions, significant changes were found between baseline and immediately postintervention in the VAS score during ROM measurement for both groups, with P =.004 and P =.015, respectively. In the MT group, the measures for flexion (P =.001), right-side bending (P =.002), and left rotation (P =.005) changed significantly between baseline and postintervention; however, only flexion (P =.026) and extension (P =.040) ROM changed significantly between baseline and postintervention in the CCF group. Significant changes were observed in upper trapezius PPT following both interventions—MT group, P =.043, and CCF group, P =.005. In addition, significant changes in C5 PPT had occurred in the CCR group (P =.020). Between-group differences were significant for extension and right-side-bending ROM, with P =.019 and P =.012, respectively, and the changes between baseline and postintervention were greater in the MT group. None of the interventions led to changes in EMG. Conclusions • Although both interventions were associated with immediately improved ROM and pain after treatment, HVLA manipulation was more effective than CCF exercise in improving ROM and VAS during ROM. None of the interventions led to changes in EMG. © 2018, InnoVision Communications. All rights reserved.
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- 2018
34. Associations between rash, treatment outcome, and SNPs in HNSCC patients receiving EGFR-inhibition
- Author
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Brøndum, L., Alsner, J., Sørensen, B. Singers, Maare, C., Johansen, J., Primdahl, H., Evensen, J. Folkvard, Kristensen, C. Andrup, Andersen, L. Juhler, Overgaard, J., and Eriksen, J. Grau
- Published
- 2018
35. Darbepoetin alfa and radiotherapy in the treatment of SCCHN - the DAHANCA 10 randomized trial
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Overgaard, J., Hoff, C., Hansen, H., Specht, L., Overgaard, M., Lassen, P., Andersen, E., Johansen, J., Andersen, L., Evensen, J., Alsner, J., and Grau, C.
- Published
- 2018
36. 'Just imagine that…': A solution focused approach to doctoral research supervision in health and social care
- Author
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Kenneth Walsh, Kathleen Doherty, Andersen, L., Bingham, S., Crookes, P., Ford, K., and Mcsherry, R.
- Abstract
Effective supervision in doctoral research is critical to successful and timely completion. However, supervision is a complex undertaking with structural as well as relational challenges for both students and supervisors. This instructional paper describes an internationally applicable approach to supervision that we have developed in the health and social care disciplines that offers structure, but is also dynamic and responsive to the needs of students and supervisors and aims to develop the research competency of students. Our approach called Solution Focused Research Supervision (SFRS) is based on solution focused approaches, adapted from Solution Focused Brief Therapy and questioning techniques derived from coaching. This approach has enabled our supervision teams to effectively develop focused research questions and decide on appropriate research methodologies and methods. We offer the SFRS approach as a way of working that seeks to recognize and build upon strengths, foster engagement and openness to learning as well as build trust between students and supervisors. The authors, from (countries deleted for peer review), are supervisors and students who have developed the approach and provide practical examples of its application.
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- 2018
37. The management and survival outcomes of nasopharyngeal cancer in the Nordic countries
- Author
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Makitie, A., Ruuskanen, M., Bentzen, J., Brun, E., Gebre-Medhin, M., Friesland, S., Marsk, E., Hammarstedt-Nordenvall, L., Gille, E., Reizenstein, J., Adell, G., Farnebo, L., Rzepecki, J., Haugen, H., Söderström, K., Zackrisson, B., Bergstrom, S., Loden, B., Cederblad, L., Laurell, G., Smeland, E., Evensen, J. Folkvard, Lund, J. A., Tondel, H., Karlsdottir, A., Johannsson, J., Johansen, J., Kristensen, C. A., Jensen, K., Andersen, L. J., Koivunen, P., Korpela, M., Voutilainen, L., Wigren, T., Minn, H., Joensuu, H., Overgaard, J., Saarilahti, K., Clinicum, Korva-, nenä- ja kurkkutautien klinikka, University of Helsinki, Heikki Joensuu / Principal Investigator, Department of Oncology, HUS Head and Neck Center, and HUS Comprehensive Cancer Center
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CARCINOMA ,education ,3122 Cancers ,3125 Otorhinolaryngology, ophthalmology ,GUIDELINES - Published
- 2018
38. 37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)
- Author
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Karavana, V., Smith, I., Kanellis, G., Sigala, I., Kinsella, T., Zakynthinos, S., Liu, L., Chen, J., Zhang, X., Liu, A., Guo, F., Liu, S., Yang, Y., Qiu, H., Grimaldi, D. G., Kaya, E., Acicbe, O., Kayaalp, I., Asar, S., Dogan, M., Eren, G., Hergunsel, O., Pavelescu, D., Grintescu, I., Mirea, L., Guanziroli, M., Gotti, M., Marino, A., Cressoni, M., Vergani, G., Chiurazzi, C., Chiumello, D., Gattinoni, L., Spano, S., Massaro, F., Moustakas, A., Johansson, S., Larsson, A., Perchiazzi, G., Zhang, X. W., Guo, F. M., Chen, J. X., Xue, M., Qiu, H. B., Yang, L., Fister, M., Knafelj, R., Suzer, M. A., Kavlak, M. E., Atalan, H. K., Gucyetmez, B., Cakar, N., Weller, D., Grootendorst, A. F., Dijkstra, A., Kuijper, T. M., Cleffken, B. I., Regli, A., De Keulenaer, B., Van Heerden, P., Hadfield, D., Hopkins, P. A., Penhaligon, B., Reid, F., Hart, N., Rafferty, G. F., Grasselli, G., Mauri, T., Lazzeri, M., Carlesso, E., Cambiaghi, B., Eronia, N., Maffezzini, E., Bronco, A., Abbruzzese, C., Rossi, N., Foti, G., Bellani, G., Pesenti, A., Bassi, G. Li, Panigada, M., Ranzani, O., Kolobow, T., Zanella, A., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Girardis, M., Barbagallo, M., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Torres, A., Ranzani, O. T., Umbrello, M., Taverna, M., Formenti, P., Mistraletti, G., Vetrone, F., Baisi, A., Garnero, A. G., Novotni, D. N., Arnal, J. A., Urner, M., Fan, E., Dres, M., Vorona, S., Brochard, L., Ferguson, N. D., Goligher, E. C., Leung, C., Joynt, G., Wong, W., Lee, A., Gomersall, C., Poels, S., Casaer, M., Schetz, M., Van den Berghe, G., Meyfroidt, G., Holzgraefe, B., Von Kobyletzki, L. B., Cianchi, G., Becherucci, F., Batacchi, S., Cozzolino, M., Franchi, F., Di Valvasone, S., Ferraro, M. C., Peris, A., Phiphitthanaban, H., Wacharasint, P., Wongsrichanalai, V., Lertamornpong, A., Pengpinij, O., Wattanathum, A., Oer-areemitr, N., Boddi, M., Cappellini, E., Ciapetti, M., Di Lascio, G., Bonizzoli, M., Lazzeri, C., Katsin, M. L., Hurava, M. Y., Dzyadzko, A. M., Hermann, A., Schellongowski, P., Bojic, A., Riss, K., Robak, O., Lamm, W., Sperr, W., Staudinger, T., Buoninsegni, L. Tadini, Parodo, J., Ottaviano, A., Cecci, L., Corsi, E., Ricca, V., de Garibay, A. Perez Ruiz, Ende-Schneider, B., Schreiber, C., Kreymann, B., Turani, F., Resta, M., Niro, D., Castaldi, P., Boscolo, G., Gonsales, G., Martini, S., Belli, A., Zamidei, L., Falco, M., Lamas, T., Mendes, J., Galazzi, A., Benco, B., Binda, F., Masciopinto, L., Lissoni, A., Adamini, I., Thamjamrassri, T., Watcharotayangul, J., Numthavaj, P., Kongsareepong, S., Higuera, J., Cabestrero, D., Rey, L., Narváez, G., Blandino, A., Aroca, M., Saéz, S., De Pablo, R., Mohamed, A., Sklar, M., Munshi, L., Alban, L., Turrini, C., Taccone, P., Marenghi, C., Spadaro, S., Volta, C., Alonso, D. Cabestrero, González, L. Rey, Franci, A., Stocchi, G., Cappuccini, G., Socci, F., Guetti, C., Rastrelli, P., Nestorowicz, A., Glapinski, J., Fijalkowska-Nestorowicz, A., Wosko, J., Duprez, F., Bonus, T., Cuvelier, G., Mashayekhi, S., Ollieuz, S., Reychler, G., Kuchyn, I., Bielka, K., Sergienko, A., Jones, H., Day, C., Park, S. C., Yeom, S. R., Myatra, S. N., Gupta, S., Rajnala, V., Divatia, J., Silva, J. Villalobos, Olvera, O. Aguilera, Schulte, R. Cavazos, Bermudez, M. Castañeda, Zorrilla, L. Pariente, Ferretis, H. Lopez, García, K. Trejo, Balciuniene, N., Ramsaite, J., Kriukelyte, O., Krikscionaitiene, A., Tamosuitis, T., Terragni, P., Brazzi, L., Falco, D., Pistidda, L., Magni, G., Bartoletti, L., Mascia, L., Filippini, C., Ranieri, V., Kyriakoudi, A., Rovina, N., Koltsida, O., Konstantellou, E., Kardara, M., Kostakou, E., Gavriilidis, G., Vasileiadis, I., Koulouris, N., Koutsoukou, A., Van Snippenburg, W., Kröner, A., Flim, M., Buise, M., Hemler, R., Spronk, P., Noffsinger, B., Singh, B., Hockings, L., Spina, C., Magni, F., Di Giambattista, C., Vargiolu, A., Citerio, G., Scaramuzzo, G., Waldmann, A. D., Böhm, S. H., Ragazzi, R., Volta, C. A., Heines, S. J., Strauch, U., Van de Poll, M. C., Roekaerts, P. M., Bergmans, D. C., Sosio, S., Gatti, S., Punzi, V., Asta, A., Mroczka, J., Yaroshetskiy, A. I, Rezepov, N. A., Mandel, I. A., Gelfand, B. R., Ozen, E., Karakoc, E., Ayyildiz, A., Kara, S., Ekemen, S., Yelken, B. Buyukkidan, Saasouh, W., Freeman, J., Turan, A., Hajjej, Z., Sellami, W., Bousselmi, M., Samoud, W., Gharsallah, H., Labbene, I., Ferjani, M., Vetrugno, L., Barbariol, F., Forfori, F., Regeni, I., Della Rocca, G., Jansen, D., Jonkman, A., Doorduin, J., Roesthuis, L., Van der Hoeven, J., Heunks, L., Marocco, S. Arrigoni, Bottiroli, M., Pinciroli, R., Galanti, V., Calini, A., Gagliardone, M., Fumagalli, R., Ippolito, D., Sala, V. L., Meroni, V., Elbanna, M., Nassar, Y., Abdelmohsen, A., Yahia, M., Mongodi, S., Mojoli, F., Via, G., Tavazzi, G., Fava, F., Pozzi, M., Iotti, G. A., Bouhemad, B., Ruiz-Ferron, F., Simón, J. Serrano, Gordillo-Resina, M., Chica-Saez, V., Garcia, M. Ruiz, Vela-Colmenero, R., Redondo-Orts, M., Gontijo-Coutinho, C., Ozahata, T., Nocera, P., Franci, D., Santos, T., Carvalho-Filho, M., Fochi, O., Nacoti, M., Signori, D., Bonacina, D., Bonanomi, E., Bonvecchio, E., Stella, A., Roldi, E., Orlando, A., Luperto, M., Trunfio, D., Licitra, G., Martinelli, R., Vannini, D., Giuliano, G., Näslund, E., Lindberg, L. G., Lund, I., Frithiof, R., Nichols, A., Pentakota, S., Kodali, B., Pranskunas, A., Kiudulaite, I., Simkiene, J., Damanskyte, D., Pranskuniene, Z., Arstikyte, J., Vaitkaitis, D., Pilvinis, V., Brazaitis, M., Pool, R., Haugaa, H., Botero, A., Escobar, D., Maberry, D., Tønnessen, T., Zuckerbraun, B., Pinsky, M., Gomez, H., Lyons, H., Trimmings, A., Domizi, R., Scorcella, C., Damiani, E., Pierantozzi, S., Tondi, S., Monaldi, V., Carletti, A., Zuccari, S., Adrario, E., Pelaia, P., Donati, A., Kazune, S., Grabovskis, A., Volceka, K., Rubins, U., Bol, M., Suverein, M., Delnoij, T., Driessen, R., Heines, S., Delhaas, T., Vd Poll, M., Sels, J., Jozwiak, M., Chambaz, M., Sentenac, P., Richard, C., Monnet, X., Teboul, J. L., Bitar, Z., Maadarani, O., Al Hamdan, R., Huber, W., Malbrain, M., Chew, M., Mallat, J., Tagami, T., Hundeshagen, S., Wolf, S., Mair, S., Schmid, R., Aron, J., Adlam, M., Dua, G., Mu, L., Chen, L., Yoon, J., Clermont, G., Dubrawski, A., Duhailib, Z., Al Assas, K., Shafquat, A., Salahuddin, N., Donaghy, J., Morgan, P., Valeanu, L., Stefan, M., Provenchere, S., Longrois, D., Shaw, A., Mythen, M. G., Shook, D., Hayashida, D., Munson, S. H., Sawyer, A., Mariyaselvam, M., Blunt, M., Young, P., Nakwan, N., Khwannimit, B., Checharoen, P., Berger, D., Moller, P., Bloechlinger, S., Bloch, A., Jakob, S., Takala, J., Van den Brule, J. M., Stolk, R., Vinke, E., Van Loon, L. M., Pickkers, P., Van der Hoeven, J. G., Kox, M., Hoedemaekers, C. W., Werner-Moller, P., Bertini, P., Guarracino, F., Colosimo, D., Gonnella, S., Brizzi, G., Mancino, G., Baldassarri, R., Pinsky, M. R., Amitrano, D., Goslar, T., Stajer, D., Radsel, P., De Vos, R., Dijk, N. Bussink-van, Stringari, G., Cogo, G., Devigili, A., Graziadei, M. Ceola, Bresadola, E., Lubli, P., Amella, S., Marani, F., Polati, E., Gottin, L., Colinas, L., Hernández, G., Vicho, R., Serna, M., Canabal, A., Cuena, R., Gimenez, J., Mercado, P., Depret, F., Sassi, K., Herner, A., Abded, N., Elghonemi, M., Monir, A., Nikhilesh, J., Apurv, T., Uber, A. U., Grossestreuer, A., Moskowitz, A., Patel, P., Holmberg, M. J., Donnino, M. W., Graham, C. A., Hung, K., Lo, R., Leung, L. Y., Lee, K. H., Yeung, C. Y., Chan, S. Y., Trembach, N., Zabolotskikh, I., Caldas, J., Panerai, R., Camara, L., Ferreira, G., Almeida, J., de Oliveira, G. Queiroz, Jardim, J., Bor-Seng-Shu, E., Lima, M., Nogueira, R., Jatene, F., Zeferino, S., Galas, F., Robinson, T., Hajjar, L. A., Oliveira, M., Norgueira, R., Groehs, R., Ferreira-Santos, L., Oliveira, G., Hajjar, L., Ribeiro, J., Gaiotto, F., Lisboa, L., Fukushima, J., Rizk, S., Osawa, E., Franco, R., Kalil, R., Chlabicz, M., Sobkowicz, B., Kaminski, K., Kazimierczyk, R., Musial, W., Tycińska, A., Siranovic, M., Gopcevic, A., Gavranovic, Z. G., Horvat, A. H., Krolo, H., Rode, B., Videc, L., Trifi, A., Abdellatif, S., Ismail, K. Ben, Bouattour, A., Daly, F., Nasri, R., Lakhal, S. Ben, Beurton, A., Girotto, V., Galarza, L., Guedj, T., Iliæ, M. Karaman, Sakic, L., NN, V., Stojcic, L., Alphonsine, J., Lai, C., Tapanwong, N., Chuntupama, P., Hoellthaler, J., Lahmer, T., Latham, H., Bengtson, C. D., Satterwhite, L., Stites, M., Simpson, S. Q., Skladzien, T., Cicio, M., Garlicki, J., Serednicki, W., Wordliczek, J., Vargas, P., Salazar, A., Espinoza, M., Graf, J., Kongpolprom, N., Sanguanwong, N., Jonnada, S., Gerrard, C., Jones, N., Morley, T., Thorburn, P. T., Musaeva, T., Horst, S., Lipcsey, M., Kawati, R., Pikwer, A., Rasmusson, J., Castegren, M., Shilova, A., Yafarova, A., Gilyarov, M., Stojiljkovic, D. L. Loncar, Ulici, A., Reidt, S., Lam, T., Jancik, J., Ragab, D., Taema, K., Farouk, W., Saad, M., Liu, X., Uber, A., Montissol, S., Donnino, M., Andersen, L. W., Perlikos, F., Lagiou, M., Papalois, A., Kroupis, C., Toumpoulis, I., Carter, D., Sardo, S., Landoni, G., Kongsayreepong, S., Sungsiri, R., Wongsripunetit, P., Marchio, P., Guerra-Ojeda, S., Gimeno-Raga, M., Mauricio, M. D., Valles, S. L., Aldasoro, C., Jorda, A., Aldasoro, M., Vila, J. M., Borg, U. B., Neitenbach, A. M., García, M., González, P. Guijo, Romero, M. Gracia, Orduña, P. Saludes, Cano, A. Gil, Rhodes, A., Grounds, R. M., Cecconi, M., Lee, C., Hatib, F., Jian, Z., Rinehart, J., De Los Santos, J., Canales, C., Cannesson, M., García, M. I. Monge, Scheeren, T., Chantziara, V., Vassi, A., Michaloudis, G., Sanidas, E., Golemati, S., Bateman, R. M., Mokhtar, A., Omar, W., Aziz, K. Abdel, El Azizy, H., Nielsen, D. L. Lykke, Holler, J. G., Lassen, A., Eriksson, M., Strandberg, G., Capoletto, C., Nakamura, R., Risk, S., Park, C., Dias, F., D’Arrigo, N., Fortuna, F., Redaelli, S., Zerman, L., Becker, L., Serrano, T., Cotes, L., Ramos, F., Fadel, L., Coelho, F., Mendes, C., Real, J., Pedron, B., Kuroki, M., Costa, E., and Azevedo, L.
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Critical Care and Intensive Care Medicine ,Meeting Abstracts - Published
- 2017
39. Biosynthesis of acurin A and B in Aspergillus aculeatus
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Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Thomas Isbrandt, Holm, D. K., Uffe Mortensen, Nødvig, C. S., Thomas Ostenfeld Larsen, and Jakob Blæsbjerg Hoof
- Abstract
Aspergillus aculeatus is known for the commercial utilization in production of several enzymes. We have identified two stereoisomeric compounds of mixed polyketide-nonribosomal peptide origin in the extracts of A. aculeatus that we named acurin A and acurin B. The structures of the compounds strongly resemble the structure of the mycotoxin fusarin C produced by several Fusarium species. CRISPR-Cas9 was used to construct a non-homologous end-joining deficient strain of A. aculeatus, which enabled efficient gene deletions in the acurin gene cluster. Using RT-qPCR in combination with metabolite profiling of gene deletion strains, the acurin producing gene cluster was delineated, which allowed us to propose a biosynthetic pathway for formation of acurin. Our results show that acurin, in contrast to fusarin C, is biosynthesized by an individual polyketide synthase and non-ribosomal synthetase. At least six other enzymatic activities are required for the biosynthesis of acurin. This study shows how we exploit the CRISPR-Cas9 system for the rapid construction of fungal host strains that can be readily engineered to generate valuable knowledge.
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- 2017
40. 2016 USA?Norway EK80 Workshop Report: Evaluation of a wideband echosounder for fisheries and marine ecosystem science
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Demer, D. A., Andersen, L. N., Bassett, C., Berger, L., Chu, D., Condiotty, J., Cutter, G. R., Hutton, B., Korneliussen, R., Le Bouffant, N., Macaulay, G., Michaels, W. L., Murfin, D., Pobitzer, A., Renfree, J. S., Sessions, T. S., Stierhoff, K. L., and And T
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- 2017
- Full Text
- View/download PDF
41. Occupational violence and mental health: does frequency and type of violence matter? Prospective cohort study on 2.000 social-educators
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Pihl-Tingvad, Jesper, Brandt, L, Høgh, A, Elklit, Ask, and Andersen, L
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- 2017
42. Harmonising data on the correlates of physical activity and sedentary behaviour in young people: Methods and lessons learnt from the international Children's Accelerometry database (ICAD)
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Atkin, Andrew J., Biddle, Stuart J.H., Broyles, Stephanie T., Chinapaw, Mai, Ekelund, Ulf, Esliger, Dale W., Hansen, Bjorge H., Kriemler, Susi, Puder, Jardena J., Sherar, Lauren B., van Sluijs, Esther M.F., Andersen, L. B., Anderssen, S., Cardon, G., Davey, R., Hallal, P., Janz, K. F., Møller, N., Molloy, L., Page, A., Pate, R., Reilly, J., Salmon, J., Sardinha, L. B., and Timperio, A.
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ICAD ,Physical activity ,Sedentary behaviour ,RA773 ,Adolescents ,Children ,Retrospective harmonisation ,Data pooling - Abstract
Background: Large, heterogeneous datasets are required to enhance understanding of the multi-level influences on children's physical activity and sedentary behaviour. One route to achieving this is through the pooling and co-analysis of data from multiple studies. Where this approach is used, transparency of the methodology for data collation and harmonisation is essential to enable appropriate analysis and interpretation of the derived data. In this paper, we describe the acquisition, management and harmonisation of non-accelerometer data in a project to expand the International Children's Accelerometry Database (ICAD). Method: Following a consultation process, ICAD partners were requested to share accelerometer data and information on selected behavioural, social, environmental and health-related constructs. All data were collated into a single repository for cataloguing and harmonisation. Harmonised variables were derived iteratively, with input from the ICAD investigators and a panel of invited experts. Extensive documentation, describing the source data and harmonisation procedure, was prepared and made available through the ICAD website. Results: Work to expand ICAD has increased the number of studies with longitudinal accelerometer data, and expanded the breadth of behavioural, social and environmental characteristics that can be used as exposure variables. A set of core harmonised variables, including parent education, ethnicity, school travel mode/duration and car ownership, were derived for use by the research community. Guidance documents and facilities to enable the creation of new harmonised variables were also devised and made available to ICAD users. An expanded ICAD database was made available in May 2017. Conclusion: The project to expand ICAD further demonstrates the feasibility of pooling data on physical activity, sedentary behaviour and potential determinants from multiple studies. Key to this process is the rigorous conduct and reporting of retrospective data harmonisation, which is essential to the appropriate analysis and interpretation of derived data. These documents, made available through the ICAD website, may also serve as a guide to others undertaking similar projects.
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- 2017
43. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report
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Malfertheiner, P., Megraud, F., O'Morain, C. A., Gisbert, J. P., Kuipers, E. J., Axon, A. T., Bazzoli, F., Gasbarrini, A., Atherton, J., Graham, D. Y., Hunt, R., Moayyedi, P., Rokkas, T., Rugge, M., Selgrad, M., Suerbaum, S., Sugano, K., El-Omar, E. M., Agreus, L., Andersen, L. P., Axon, A., Coelho, L., Delchier, J. C., Di Mario, F., Dinis-Ribeiro, M., El-Omar, E., Fischbach, W., Flahou, B., Fock, K. M., Gasbarrini, G., Gensini, G., Gisbert, J., Goh, K. L., Herrero, R., Kupcinskas, L., Lanas, A., Leja, M., Machado, J. C., Mahachai, V., Milosavljevic, T., Molina-Infante, J., Niv, Y., O'Morain, C., Ristimaki, A., Tepes, B., Vaira, D., Vieth, M., You, W., Gastroenterology & Hepatology, Malfertheiner, P., Megraud, F., O'Morain, C.A., Gisbert, J.P., Kuipers, E.J., Axon, A.T., Bazzoli, F., Gasbarrini, A., Atherton, J., Graham, D.Y., Hunt, R., Moayyedi, P., Rokkas, T., Rugge, M., Selgrad, M., Suerbaum, S., Sugano, K., El-Omar, E.M., Agreus, L., Andersen, L.P., Axon, A., Coelho, L., Delchier, J.C., Di Mario, F., Dinis-Ribeiro, M., El-Omar, E., Fischbach, W., Flahou, B., Fock, K.M., Gasbarrini, G., Gensini, G., Gisbert, J., Goh, K.L., Herrero, R., Kupcinskas, L., Lanas, A., Leja, M., Machado, J.C., Mahachai, V., Milosavljevic, T., Molina-Infante, J., Niv, Y., O'Morain, C., Ristimaki, A., Tepes, B., Vaira, D., Vieth, M., and You, W.
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Helicobacter pylori infection ,Proton Pump Inhibitor ,Gastroenterology ,0302 clinical medicine ,Fluoroquinolone ,Risk Factors ,HELICOBACTER THERAPY ,Medicine ,Early Detection of Cancer ,Evidence-Based Medicine ,biology ,Microbial Sensitivity Test ,Stomach ,Consensus conference ,Anti-Bacterial Agents ,Nitroimidazoles ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,030211 gastroenterology & hepatology ,Drug Therapy, Combination ,Fluoroquinolones ,Human ,medicine.medical_specialty ,Settore MED/12 - GASTROENTEROLOGIA ,Microbial Sensitivity Tests ,Helicobacter Infections ,03 medical and health sciences ,Stomach Neoplasms ,Stomach Neoplasm ,Internal medicine ,Clarithromycin ,Clarithromycin resistance ,Anti-Bacterial Agent ,Drug Resistance, Bacterial ,Gastroscopy ,Humans ,Dyspepsia ,GASTRITIS ,HELICOBACTER PYLORI ,Helicobacter pylori ,business.industry ,Public health ,Nitroimidazole ,Risk Factor ,Gastriti ,Amoxicillin ,Proton Pump Inhibitors ,biology.organism_classification ,Gastrointestinal Microbiome ,Family medicine ,business ,Bismuth ,Helicobacter Infection - Abstract
Important progress has been made in the management of Helicobacter pylori infection and in this fifth edition of the Maastricht Consensus Report, key aspects related to the clinical role of H. Pylori were re-evaluated in 2015. In the Maastricht V/Florence Consensus Conference, 43 experts from 24 countries examined new data related to H. pylori in five subdivided workshops: (1) Indications/ Associations, (2) Diagnosis, (3) Treatment, (4) Prevention/Public Health, (5) H. pylori and the Gastric Microbiota. The results of the individual workshops were presented to a final consensus voting that included all participants. Recommendations are provided on the basis of the best available evidence and relevance to the management of H. pylori infection in the various clinical scenarios.
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- 2017
44. Work-related threats and violence and post-traumatic symptoms in four high-risk occupations: short and long term symptoms
- Author
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Andersen, L, Høgh, A, Biering, Karin, Andersen, J, and Elklit, Ask
- Published
- 2017
45. Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial
- Author
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Jensen, Jens Ulrik S, Itenov, Theis S., Thormar, Katrin M., Hein, Lars, Mohr, Thomas T., Andersen, Mads H., Løken, Jesper, Tousi, Hamid, Lundgren, Bettina, Boesen, Hans Christian, Johansen, Maria E., Ostrowski, Sisse R., Johansson, Pär I., Grarup, Jesper, Vestbo, Jorgen, Lundgren, Jens D., Steensen, M., Thornberg, K., Bestle, M., Strange, D., Lauritsen, A., Søe-Jensen, P., Reiter, N., Drenck, N. E., Fjeldborg, P., Fox, Z., Kjær, J., Kristensen, D., Rasmussen, M. B., Hallas, C. Sv, Zacho, M., Østergaard, C., Petersen, P. L., Hougaard, S., Mantoni, T., Nebrich, L., Bendtsen, A., Andersen, L. H., Bærentzen, F., Eversbusch, Andreas, Bømler, B., Martusevicius, R., Nielsen, T., Bådstøløkken, P. M., Grevstad, U., Hallas, P., Lindhardt, A., Petersen, J. A., Jensen, C. H., and Nielsen, K.
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ARDS ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,Mechanical ventilation ,0302 clinical medicine ,Intensive care ,Internal medicine ,medicine ,Respiratory function ,030212 general & internal medicine ,Diffuse alveolar damage ,education ,Intensive care medicine ,education.field_of_study ,business.industry ,Research ,Lung damage ,Hazard ratio ,medicine.disease ,Personalized early intervention ,030228 respiratory system ,Cohort ,business ,Biomarkers - Abstract
Background It is unclear whether biomarkers of alveolar damage (surfactant protein D, SPD) or conductive airway damage (club cell secretory protein 16, CC16) measured early after intensive care admittance are associated with one-month clinical respiratory prognosis. If patients who do not recover respiratory function within one month can be identified early, future experimental lung interventions can be aimed toward this high-risk group. We aimed to determine, in a heterogenous critically ill population, whether baseline profound alveolar damage or conductive airway damage has clinical respiratory impact one month after intensive care admittance. Methods Biobank study of biomarkers of alveolar and conductive airway damage in intensive care patients was conducted. This was a sub-study of 758 intubated patients from a 1200-patient randomized trial. We split the cohort into a “learning cohort” and “validating cohort” based on geographical criteria: northern sites (learning) and southern sites (validating). Results Baseline SPD above the 85th percentile in the “learning cohort” predicted low chance of successful weaning from ventilator within 28 days (adjusted hazard ratio 0.6 [95% CI 0.4–0.9], p = 0.005); this was confirmed in the validating cohort. CC16 did not predict the endpoint. The absolute risk of not being successfully weaned within the first month was 48/106 (45.3%) vs. 175/652 (26.8%), p
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- 2016
46. Self-reported previous knee injury and low knee function increase knee injury risk in adolescent female football
- Author
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Clausen, M. B., Tang, Lars, Zebis, M. K., Krustrup, Peter, Hölmich, P., Wedderkopp, Niels, Andersen, L. L., Christensen, K. B., Møller, M., and Thorborg, K.
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musculoskeletal diseases ,relative risk ,risk factor ,KOOS ,SMS ,text message ,musculoskeletal system ,human activities - Abstract
Knee injuries are common in adolescent female football. Self-reported previous knee injury and low Knee injury and Osteoarthritis Outcome Score (KOOS) are proposed to predict future knee injuries, but evidence regarding this in adolescent female football is scarce. The aim of this study was to investigate self-reported previous knee injury and low KOOS subscale score as risk factors for future knee injuries in adolescent female football. A sample of 326 adolescent female football players, aged 15-18, without knee injury at baseline, were included. Data on self-reported previous knee injury and KOOS questionnaires were collected at baseline. Time-loss knee injuries and football exposures were reported weekly by answers to standardized text-message questions, followed by injury telephone interviews. A priori, self-reported previous knee injury and low KOOS subscale scores (
- Published
- 2016
47. Erratum: Bias in protein and potassium intake collected with 24-h recalls (EPIC-Soft) is rather comparable across European populations (European Journal of Nutrition DOI: 10.1007/s00394-011-0279-z)
- Author
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Crispim, S, Geelen, A, De Vries, J, Freisling, H, Souverein, O, Hulshof, P, Ocke, M, Boshuizen, H, Andersen, L, Ruprich, J, De Keyzer, W, Huybrechts, I, Lafay, L, De Magistris, MS, Ricceri, F, Tumino, R, Krogh, V, Bueno-De-Mesquita, H, Beulens, J, Boutron-Ruault, M, Naska, A, Crowe, F, Boeing, H, McTaggart, A, and Kaaks, R
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- 2016
48. Effect of time and micropatterns on the behaviour of preosteoblastic cells
- Author
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Justesen, J., Andersen, L. K., Sonia Contera, Duch, M., Hansen, O., Lorentzen, M., Chevallier, J., Foss, M., Pedersen, F. S., and Besenbacher, F.
- Abstract
The influence of the micropatterning of surfaces (in relation to their spreading and morphology) on the behavior of osteoblasts on different surfaces was investigated. Micropatterns were seen to be etched into silicon plates by photolithograhy and coated with a 250 nm tantalum layer. The samples were analyzed by Cryo-SEM (Scanning Electron Microscopy) (CamScan MaXim 2040). The elongation of cells was observed to be faster on deep line patterns than on shallow line patterns.
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- 2016
49. Children with severe haemophilia have greater functional tests performance comparedwith mild peers
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Pérez Alenda, Sofía, Calatayud, Joaquín, Casaña Granell, José, Ezzatvar de Llago, Yasmin, Andersen, L. L., Carrasco, Juan José, Alonso Roca, D., Cuesta Barriuso, Rubén, Torres Ortuño, Ana, and Querol Fuentes, Felipe
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Niño ,Hemofilia en niños ,Enfermedad - Abstract
Sin financiación 3.569 JCR (2016) Q2, 22/70 Hematology UEM
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- 2016
50. Pattern of failure and disease control in patients treated for glottic cancer in Denmark 1971-2011
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Niels Lyhne, Hanne Primdahl, Kristensen, C., Andersen, E., Jørgen Johansen, Andersen, L., and Overgaard, J.
- Published
- 2016
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