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30 results on '"Ana Isabel Sanchez-Fructuoso"'

1. Role of mTOR inhibitor in the cellular and humoral immune response to a booster dose of SARS-CoV-2 mRNA-1273 vaccine in kidney transplant recipients

Author

Isabel Pérez-Flores, Ignacio Juarez, Arianne S. Aiffil Meneses, Ana Lopez-Gomez, Natividad Calvo Romero, Beatriz Rodriguez-Cubillo, María Angeles Moreno de la Higuera, Belen Peix-Jiménez, Raquel Gonzalez-Garcia, Elvira Baos-Muñoz, Ana Arribi Vilela, Manuel Gómez Del Moral, Eduardo Martínez-Naves, and Ana Isabel Sanchez-Fructuoso

Subjects
Immunology, Immunology and Allergy
Abstract

BackgroundImmunocompromised patients have an increased risk of developing severe COVID disease, as well as a tendency to suboptimal responses to vaccines. The objective of this study was to evaluate the specific cellular and humoral adaptive immune responses of a cohort of kidney transplant recipients (KTR) after 3 doses of mRNA-1273 vaccine and to determinate the main factors involved.MethodsProspective observational study in 221 KTR (149 non infected), 55 healthy volunteers (HV) and 23 dialysis patients (DP). We evaluated anti-spike (by quantitative chemiluminescence immunoassay) and anti-nucleocapsid IgG (ELISA), percentage of TCD4+ and TCD8+ lymphocytes producing IFNγ against S-protein by intracellular flow cytometry after Spike-specific 15-mer peptide stimulation and serum neutralizing activity (competitive ELISA) at baseline and after vaccination.ResultsAmong COVID-19 naïve KTR, 54.2% developed cellular and humoral response after the third dose (vs 100% in DP and 91.7% in HV), 18% only showed cell-mediated response, 22.2% exclusively antibody response and 5.6% none. A correlation of neutralizing activity with both the IgG titer (r=0.485, p1000/mm3 [4.68 (1.72-12.73, p=0.003], eGFR>30 mL/min [7.34(2.72-19.84), pConclusionsKTR presented poor cellular and humoral immune responses following vaccination with mRNA-1273. The immunosuppression degree and kidney function of these patients play an important role, but the only modifiable factor with a high impact on humoral immunogenicity after a booster dose was an immunosuppressive therapy including a mTOR inhibitor. Clinical trials are required to confirm these results.

Published
2023
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2. Response to circulatory death determination in uncontrolled organ donors: a panel viewpoint

Author

Ana Isabel Sanchez Fructuoso, Beatriz Domínguez-Gil, Alonso Mateos rodriguez, and Piedad Ussetti

Subjects
medicine.medical_specialty, Time Factors, Tissue and Organ Procurement, business.industry, Circulatory death, Tissue Donors, Heart Arrest, Death, Emergency Medicine, Tissue and Organ Harvesting, Medicine, Humans, business, Intensive care medicine
Published
2013

3. Changes in donor and recipient

Author

Ana Isabel Sanchez Fructuoso

Subjects
Aged, 80 and over, Male, Transplantation, Tissue and Organ Procurement, Waiting Lists, Cold Ischemia, Graft Survival, Age Factors, Infant, Middle Aged, Kidney Transplantation, Tissue Donors, Postoperative Complications, Renal Dialysis, Child, Preschool, Humans, Kidney Failure, Chronic, Female, Immunosuppressive Agents, Aged
Published
2006

4. [BK virus in kidney allografts: a search for histologic evidence of the infection]

Author

Arias, Lf, Alvarez, T., Gonzalez, L., Sanz, J., Ana Isabel Sanchez Fructuoso, Marques, M., Prats, D., Saiz-Pardo, M., Saez, Mc, Hernandez, S., Barrientos, A., and Blanco, J.

Subjects
Adult, Male, Polyomavirus Infections, Incidence, Transplants, Middle Aged, Kidney, Kidney Transplantation, Polymerase Chain Reaction, Tumor Virus Infections, BK Virus, DNA, Viral, Humans, Nephritis, Interstitial, Female
Abstract

BK virus (BKV) associated interstitial nephritis is a complication in renal transplantation recipients. Its incidence is controversial. The aim of the present study is to determine the incidence of histopathologic evidence of BKV-infection in a single centre.Renal allograft tissue samples (n = 838) from 526 patients undergoing renal transplant were evaluated by light microscopy. Polymerase chain reaction (PCR) assay for BKV DNA was performed in 41 microdissected cell populations from cases with viral inclusions, cases with other nuclear changes, and cases without nuclear changes.Polyomavirus-inclusions were identified in six cases (five with interstitial nephritis and other one with only urothelial infection). In one case with interstitial nephritis the DNA was degraded. PCR confirmed BKV infection in the other five and was negative in cases without inclusions.Five patterns of inclusions bodies are observed and they appear to be characteristic. PCR assay seemingly have a high specificity for BKV detection and it does not usually detect latent viral infection.

Published
2005

5. Non-heart-beating donors: experience from the Hospital Clinico of Madrid

Author

Ana Isabel, Sanchez-Fructuoso, Maria, de Miguel Marques, Dolores, Prats, and Alberto, Barrientos

Subjects
Adult, Graft Rejection, Male, Time Factors, Incidence, Graft Survival, Middle Aged, Kidney, Kidney Transplantation, Tissue Donors, Heart Arrest, Spain, Creatinine, Humans, Female, Retrospective Studies
Abstract

Non-heart-beating donors (NHBD) have received attention in the last few years as an alternative source to increase the pool of kidney donors. The majority of reports focus on NHBD from controlled donors, i.e. patients who die in hospital. This report focuses on our experience using uncontrolled NHBD, i.e. patients who die outside of hospital and are transported to hospital for organ donation. We evaluated 188 renal transplantations performed in two periods 1989-1992 and 1995-2000. As to the latter period, renal transplantations from NHBD were compared to those from 345 heart-beating donor (HBD). Graft survival at 7 years shows a better tendency in NHBD group, with no statistical significance. When patients over 60 years of age were excluded from the group of patients receiving HBD kidneys, results were the same. At 2 years renal function post-transplantation was better in NHBD organs, as evaluated by serum creatinine and creatinine clearance, while after 2 years it was similar. The incidence of acute renal rejection was lower in NHBD; however, delayed graft function, as expected, was more prevalent in NHBD, although interestingly it did not influence long-term survival. In conclusion NHBD from deaths outside the hospital may be a good source of donor kidneys and also a way to successfully increase the pool for organ transplantation.

Published
2003

10. Practical clinical management of sirolimus

Author

Oppenheimer, F., Alonso, A., Arias, M., Campistol, J. M., Gonzalez Molina, M., Gonzalez Posada, J. M., Grinyo, J. M., Morales, J. M., Ana Isabel Sanchez Fructuoso, Sanchez-Plumed, J., and Ruiz, J. C.

16. Sirolimus use in the 'de novo' patient

Author

Grinyo, J. M., Alonso, A., Arias, M., Campistol, J. M., Gonzalez Molina, M., Gonzalez Posada, J. M., Morales, J. M., Oppenheimer, F., Ana Isabel Sanchez Fructuoso, Sanchez-Plumed, J., and Ruiz, J. C.

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