1. Ｎ置換グルコサミン誘導体の合成とそれらのアンジオテンシン I 変換酵素阻害能
- Author
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Kawakami, A, Kayahara, H, Ajiro, H, and Tadasa, K
- Subjects
inhibitor ,Angiotensin I converting enzyme ,glucosamine - Abstract
Inhibitory activity of glucosamine derivatives against angiotensin I converting enzyme (ACE) was investigated. Many N-substituted glucosamine derivatives were synthesized via 1,3,4,6-tetra-O-acetyl-glucosamine hydrochloride. Among them, N-(phenylalanyl-alanyl-prolyl)-glucosamine was found to be the most effective for ACE inhibition, and the half inhibitory concentrations (IC50_) was estimated as 300μM. Furthermore, N-(3,7-dimethyl-2(E/Z), 6-hexadien-carbonyl)-glucosamine and N-(p-dimethylamino benzoyl)-glucosamine were found to be effective for the inhibition of ACE, and their IC50 values were estimated as 5 mM and 8 mM, respectively., Article, 信州大学農学部紀要. 31(1): 45-54 (1994)
- Published
- 1994