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We report on a new synthesis pathway for Mg

All-solid-state lithium (Li) metal and lithium-ion batteries (ASSLBs) with inorganic solid-state electrolytes offer improved safety for electric vehicles and other applications. However, current inorganic ASSLB manufacturing technology suffers from high cost, excessive amounts of solid-state electrolyte and conductive additives, and low attainable volumetric energy density. Such a fabrication method involves separate fabrications of sintered ceramic solid-state electrolyte membranes and ASSLB electrodes, which are then carefully stacked and sintered together in a precisely controlled environment. Here we report a disruptive manufacturing technology that offers reduced manufacturing costs and improved volumetric energy density in all solid cells. Our approach mimics the low-cost fabrication of commercial Li-ion cells with liquid electrolytes, except that we utilize solid-state electrolytes with low melting points that are infiltrated into dense, thermally stable electrodes at moderately elevated temperatures (~300 °C or below) in a liquid state, and which then solidify during cooling. Nearly the same commercial equipment could be used for electrode and cell manufacturing, which substantially reduces a barrier for industry adoption. This energy-efficient method was used to fabricate inorganic ASSLBs with LiNi0.33Mn0.33Co0.33O2 cathodes and both Li4Ti5O12 and graphite anodes. The promising performance characteristics of such cells open new opportunities for the accelerated adoption of ASSLBs for safer electric transportation. All-solid-state lithium-ion batteries provide improved safety but typically suffer from high cost and low volumetric energy density. An electrolyte melt-infiltration approach offering reduced manufacturing costs and improved volumetric energy density in all solid cells is proposed.

This work draws from a larger research project that centres a youth summer writing programme. In this article, the author recounts the multiliteracy experiences of a white student who found creativ...

Entanglements among humans, nonhuman objects, and spatial matter in a research site necessitate greater attention to the interwoven and sometimes invisible connections across relational bodies. This piece comments on how reevaluating approaches to participant observations in qualitative research can lead to better understandings of the dynamic interconnectedness among participants, researchers, and observational tools. Drawing from the theory of thinking without method, this research explores the complexity of documentation in an out-of-school literacy setting and argues that ethico-onto-epistemology can highlight intersections between literacy researchers and technological attachments.

Technologically important composites with enhanced thermal and mechanical properties rely on the reinforcement by the high specific strength ceramic nanofibers or nanowires (NWs) with high aspect ratios. However, conventional synthesis routes to produce such ceramic NWs have prohibitively high cost. Now, direct transformation of bulk Mg-Li alloys into Mg alkoxide NWs is demonstrated without the use of catalysts, templates, expensive or toxic chemicals, or any external stimuli. This mechanism proceeds through the minimization of strain energy at the boundary of phase transformation front leading to the formation of ultra-long NWs with tunable dimensions. Such alkoxide NWs can be easily converted in air into ceramic MgO NWs with similar dimensions. The impact of the alloy grain size and Li content, synthesis temperature, inductive and steric effects of alkoxide groups on the diameter, length, composition, ductility, and oxidation of the produced NWs is discussed.

Metal fluoride conversion cathodes offer a pathway towards developing lower-cost Li-ion batteries. Unfortunately, such cathodes suffer from extremely poor performance at elevated temperatures, which may prevent their use in large-scale energy storage applications. Here we report that replacing commonly used organic electrolytes with solid polymer electrolytes may overcome this hurdle. We demonstrate long-cycle stability for over 300 cycles at 50 °C attained in high-capacity (>450 mAh g−1) FeF2 cathodes. The absence of liquid solvents reduced electrolyte decomposition, while mechanical properties of the solid polymer electrolyte enhanced cathode structural stability. Our findings suggest that the formation of an elastic, thin and homogeneous cathode electrolyte interphase layer on active particles is a key for stable performance. The successful operation of metal fluorides at elevated temperatures opens a new avenue for their practical applications and future successful commercialization. Metal fluoride conversion cathodes are promising for low-cost Li-ion batteries but suffer from poor performance at elevated temperatures. By replacing organic electrolytes with solid polymer electrolytes, long-cycle stability at 50 °C with high-capacity FeF2 cathodes is demonstrated.

Since the first commercialization of lithium-ion batteries (LIBs) in the early 1990s, previous research has been extensive on electrode material development. Due to its high volumetric energy and power densities and its low cost, the LIBs have aided in the widespread adoption of advanced mobile electronic devices, slowly spurred the market penetration of electric vehicles (EVs) globally and been incorporated in household energy storage systems to promote efficient use of renewable energy1,2. Unfortunately, after rapid improvements in LIB technology, the present progress in increasing energy density and reducing the costs of LIBs has been slow. To overcome the performance limitations on the material side, increasing the nickel (Ni) content of layered lithium nickel cobalt aluminum oxide (NCA) and lithium nickel cobalt manganese oxide (NCM) cathode materials and blending silicon with graphite anode materials have shown promise3,4,5. On the manufacturing side, there is a push to use thicker and denser electrodes and increase areal capacity loadings from 3-4 mAh/cm2 to 5-7 mAh/cm2 to reduce the mass and volume fraction of inactive materials and thus reduce costs and improve the energy density and specific energy of LIB cells beyond about 700 Wh/L and 250 Wh/kg, respectively6.-8 . Unfortunately, the characteristic Li+ ion diffusion time is proportional to the square of the average diffusion path through the electrode, which depends on both the electrode thickness and the tortuosity. As a result, the charging time and power performance characteristics in high-loading, dense electrodes may become undesirably poor. Herein, we report on several manufacturing pathways to create straight channel pores within electrodes to accelerate electrolyte wetting and facilitate rapid ion transport to overcome these rate limitations. References: Armand, M. & Tarascon, J.-M. Building Better Batteries. Nature 451, 652–657 (2008). Larcher, D. & Tarascon, J.-M. Towards greener and more sustainable batteries for Electrical Energy Storage. Nature Chemistry 7, 19–29 (2014). Manthiram, A., Knight, J. C., Myung, S.-T., Oh, S.-M. & Sun, Y.-K. Nickel-rich and lithium-rich layered oxide cathodes: Progress and perspectives. Advanced Energy Materials 6, 1501010 (2015). Liu, W. et al. Nickel-rich layered lithium transition-metal oxide for high-energy lithium-ion batteries. Angewandte Chemie International Edition 54, 4440–4457 (2015). Eshetu, G. G. et al. Production of high-energy Li-ion batteries comprising silicon-containing anodes and insertion-type cathodes. Nature Communications 12, (2021). Kuang, Y., Chen, C., Kirsch, D. & Hu, L. Thick electrode batteries: Principles, opportunities, and challenges. Advanced Energy Materials 9, 1901457 (2019). Patry, G., Romagny, A., Martinet, S. & Froelich, D. Cost modeling of lithium‐ion battery cells for Automotive Applications. Energy Science & Engineering 3, 71–82 (2014). Turcheniuk, K., Bondarev, D., Amatucci, G. G. & Yushin, G. Battery materials for low- cost electric transportation. Materials Today 42, 57–72 (2021).

Natural killer (NK) cells are a subset of innate lymphoid cells playing an important role in immune surveillance and early defense against infection and cancer. They recognize and directly kill infected or transformed cells. At the same time, they produce various cytokines and chemokines to regulate other immune cells. NK cell activity can be a useful marker for health screenings because impaired NK cell functions may indicate a more susceptible environment for infection or tumor development. Currently, most NK cell activity assays are focused on measuring either cytokine secretion, in particular, interferon γ (IFN-γ), or cytotoxicity against target cells such as K562, thus only providing partial information on NK cell activity. In order to develop a comprehensive test for measuring NK cell function, cytotoxicity and cytokine secretion ability should be measured simultaneously. In addition, current NK cell assays are performed by stimulating NK cells with cocktails of cytokines, antibody-coated beads, or live target cells. In this study, we developed multifunctional microparticles for NK cell activity assay (MNAs) that allow simultaneous stimulation and sensing various NK cell activities, including cytokine secretion and cytotoxicity. The surfaces of MNAs are decorated with multiple functional biomolecules, including antibodies that stimulate NK cells by engaging NK cell activating receptors, antibodies that can capture cytokines secreted by NK cells, and a peptide sensor that reacts with granzyme B, a key molecule released by NK cells for cytotoxicity. The performances of MNAs are assessed using flow cytometry and live cell imaging. NK cell activity is measured by simply mixing MNAs with NK cells and performing flow cytometry, and the results are comparable to those measured by standard NK cell activity assays.

Kokumi taste substances exemplified by g-glutamyl peptides and Maillard Peptides modulate salt and umami tastes. However, the underlying mechanism for their action has not been delineated. Here, we investigated the effects of a kokumi taste active and inactive peptide fraction (500-10,000 Da) isolated from mature (FIIm) and immature (FIIim) Ganjang, a typical Korean soy sauce, on salt and umami taste responses in humans and rodents. Only FIIm (0.1&ndash, 1.0%) produced a biphasic effect in rat chorda tympani (CT) taste nerve responses to lingual stimulation with 100 mM NaCl + 5 mM benzamil, a specific epithelial Na+ channel blocker. Both elevated temperature (42 &deg, C) and FIIm produced synergistic effects on the NaCl + benzamil CT response. At 0.5% FIIm produced the maximum increase in rat CT response to NaCl + benzamil, and enhanced salt taste intensity in human subjects. At 2.5% FIIm enhanced rat CT response to glutamate that was equivalent to the enhancement observed with 1 mM IMP. In human subjects, 0.3% FIIm produced enhancement of umami taste. These results suggest that FIIm modulates amiloride-insensitive salt taste and umami taste at different concentration ranges in rats and humans.

Red pepper flakes are often contaminated with various microorganisms; however, any technologies aiming to decontaminate the flakes should also maintain their quality properties. This study investigated the effect of microwave-combined cold plasma treatment (MCPT) at different microwave power densities on microbial inactivation and preservation of red pepper flakes. Red pepper flake samples inoculated with spores of Bacillus cereus or Aspergillus flavus and without inoculation were subjected to MCPT at 900 W for 20 min at either low microwave power density (LMCPT, 0.17 W m-2 ) or high microwave power density (HMCPT, 0.25 W m-2 ).; Results: The numbers of B. cereus and A. flavus spores on red pepper flakes after LMCPT and HMCPT were initially reduced by 0.7 ± 0.1 and 1.4 ± 0.3 log spores cm-2 and by 1.5 ± 0.3 and 1.5 ± 0.2 log spores cm-2 respectively and remained constant for 150 days at 25 °C. Immediately after HMCPT, the concentrations of capsaicin and ascorbic acid in the flakes were significantly lower than in untreated samples; however, no difference in concentration was detected during storage. Neither LMCPT nor HMCPT affected the antioxidant activity or color of the flakes during storage. LMCPT also did not affect the sensory properties and the concentrations of capsaicin and dihydrocapsaicin of the flakes, indicating its suitability in preserving their quality properties.; Conclusion: MCPT may provide an effective non-thermal treatment for food preservation which can improve the microbial safety and stability of red pepper flakes while maintaining intact their qualitative properties. © 2018 Society of Chemical Industry.; © 2018 Society of Chemical Industry.

Films containing microencapsulated cinnamon oil (CO) were developed using a large‐scale production system to protect against the Indian meal moth (Plodia interpunctella). CO at concentrations of 0%, 0.8%, or 1.7% (w/w ink mixture) was microencapsulated with polyvinyl alcohol. The microencapsulated CO emulsion was mixed with ink (47% or 59%, w/w) and thinner (20% or 25%, w/w) and coated on polypropylene (PP) films. The PP film was then laminated with a low‐density polyethylene (LDPE) film on the coated side. The film with microencapsulated CO at 1.7% repelled P. interpunctellamost effectively. Microencapsulation did not negatively affect insect repelling activity. The release rate of cinnamaldehyde, an active repellent, was lower when CO was microencapsulated than that in the absence of microencapsulation. Thermogravimetric analysis exhibited that microencapsulation prevented the volatilization of CO. The tensile strength, percentage elongation at break, elastic modulus, and water vapor permeability of the films indicated that microencapsulation did not affect the tensile and moisture barrier properties (P> 0.05). The results of this study suggest that effective films for the prevention of Indian meal moth invasion can be produced by the microencapsulation of CO using a large‐scale film production system. Low‐density polyethylene‐laminated polypropylene films printed with ink incorporating microencapsulated cinnamon oil using a large‐scale film production system effectively repelled Indian meal moth larvae. Without altering the tensile and moisture barrier properties of the film, microencapsulation resulted in the release of an active repellent for extended periods with a high thermal stability of cinnamon oil, enabling commercial film production at high temperatures. This anti‐insect film system may have applications to other food‐packaging films that use the same ink‐printing platform.

This article argues for expanded opportunities for metalinguistic dialogue and written response rounds in order to better understand students' needs. Encouraging students to reflect on their compositions can invite multiple stylistic approaches and inform a more participatory composition process. The writing explores theoretical underpinnings, makes a case for metalinguistic dialogue, and remarks on the use of written exchanges between students and teachers.

Natural killer (NK) cells are key effectors in cancer immunosurveillance and can be used as a prognostic biomarker in diverse cancers. Nonetheless, the role of NK cells in pancreatic cancer (PC) remains elusive, given conflicting data on their association with disease prognosis. In this study, using conventional K562 target cells and complementary engineered target cells providing defined and synergistic stimulation for NK cell activation, a correlation between impaired NK cell cytotoxic degranulation and PC progression was determined. Peripheral blood mononuclear cells (PBMCs) from 31 patients with newly diagnosed PC, 24 patients with non-malignant tumors, and 37 healthy controls were analyzed by flow cytometry. The frequency, phenotype, and effector functions of the NK cells were evaluated, and correlations between NK cell functions and disease stage and prognosis were analyzed. The results demonstrated that effector functions, but not frequency, of NK cells was progressively decreased on a per-cell basis during PC progression. Impaired cytotoxic degranulation, but not IFN-γ production, was associated with clinical features indicating disease progression, such as high serum CA19-9 and high-grade tumors. Significantly, this impairment correlated with cancer recurrence and mortality in a prospective analysis. Furthermore, the impaired cytotoxic degranulation was unrelated to NKG2D downregulation but was associated with increased circulating and tumor-associated TGF-β1 expression. Thus, NK cell cytotoxic activity was associated with PC progression and may be a favorable biomarker with predictive and prognostic value in PC.

Effects of lemongrass oil (LO) droplet size in the LO/chitosan emulsion on the emulsion's coating effectiveness in improving microbiological safety and preserving grape berries ( Vitis vinifera L. × V. labruscana Bailey) were investigated. LO was homogenized with a chitosan solution (1 g/100 g) and Tween 20 (0.25 g/100 g) by high shear mixing (HSM; 10,000 rpm, 1 min) or dynamic high pressure processing (DHP; 103–172 MPa, 1–3 passes), forming LO coating emulsions. The particle sizes of the HSM and DHP emulsions were 461.9–632.6 nm and 204.2–378.8 nm, respectively. DHP emulsions were more stable than HSM emulsions. Compared with the HSM emulsion, the DHP emulsion coating resulted in higher initial inhibition of Salmonella typhimurium ; greater growth inhibition of total mesophilic aerobes, yeasts, and molds; and retention of color, total soluble solid content, and antioxidant activity during storage at 25 °C ( P Salmonella and preserving grape berries, compared with the coating with larger droplets.

Ginsenosides are the principal active components of ginseng and are considered attractive candidates for combination cancer therapy because they can kill tumors and have favorable safety profiles. However, the overall benefit of ginsenosides remains unclear, particularly in cancer immunosurveillance, considering the controversial results showing repression or promotion of immune responses. Here we identify a potentiating role of ginsenoside F1 (G-F1) in cancer surveillance by natural killer (NK) cells. Among 15 different ginsenosides, G-F1 most potently enhanced NK cell cytotoxicity in response to diverse activating receptors and cancer cells. G-F1 also improved cancer surveillance in mouse models of lymphoma clearance and metastatic melanoma that rely on NK cell activity. G-F1-treated NK cells exhibited elevated cytotoxic potential such as upregulation of cytotoxic mediators and of activation signals upon stimulation. NK cell potentiation by G-F1 was antagonized by insulin-like growth factor (IGF)-1 blockade and recapitulated by IGF-1 treatment, suggesting the involvement of IGF-1. Thus, our results suggest that G-F1 enhances NK cell function and may have chemotherapeutic potential in NK cell-based immunotherapy. We anticipate our results to be a starting point for further comprehensive studies of ginsenosides in the immune cells mediating cancer surveillance and the development of putative therapeutics.

This study identified 8-azaguanine (8-AG) as a novel immunomodulatory drug (IMiD) through a high-throughput screen of the Preswick Chemical Library in a model of human NK cell cytotoxicity against blood cancer cells. 8-AG, originally developed as an antineoplastic agent, significantly increased the cytotoxicity of NK cells and was superior in this activity to previously known IMiDs, such as fluoxetine and amphotericin B, identified from the same library. IFN-γ expression was also slightly increased by 8-AG. Mechanistically, 8-AG increased conjugate formation between NK and target cells and subsequent cytolytic granule polarization, but not calcium mobilization, regulation of activating receptors, or expression of perforin or granzyme B. Thus, the antineoplastic activity of 8-AG should be re-evaluated in light of this novel potentiating effect on NK cells.

Red pepper flakes are often contaminated with various microorganisms; however, any technologies aiming to decontaminate the flakes should also maintain their quality properties. This study investigated the effect of microwave-combined cold plasma treatment (MCPT) at different microwave power densities on microbial inactivation and preservation of red pepper flakes. Red pepper flake samples inoculated with spores of Bacillus cereus or Aspergillus flavus and without inoculation were subjected to MCPT at 900 W for 20 min at either low microwave power density (LMCPT, 0.17 W mThe numbers of B. cereus and A. flavus spores on red pepper flakes after LMCPT and HMCPT were initially reduced by 0.7 ± 0.1 and 1.4 ± 0.3 log spores cmMCPT may provide an effective non-thermal treatment for food preservation which can improve the microbial safety and stability of red pepper flakes while maintaining intact their qualitative properties. © 2018 Society of Chemical Industry.

The effects of cold plasma (CP) treatment on the physicochemical and biodegradable properties of polylactic acid (PLA) films were studied. The PLA films were exposed to CP for 40 min at 900 W and 667 Pa using oxygen as the plasma-forming gas. The tensile, optical, and dynamic mechanical thermal properties, surface morphology, printability, water contact angle, chemical structure, weight change, and biodegradability properties of the films were evaluated during storage for up to 56 d. The tensile and optical properties of the PLA films were not significantly affected by CP treatment (CPT; P > 0.05). The surface roughness and water contact angle of PLA films increased by CPT and further increased during storage for 56 d. The printability of the PLA films increased following CPT and remained stable throughout the storage period. CP-induced hydrophilicity was also sustained during the storage period. The PLA films lost 1.9% of their weight after CPT, but recovered 99.5% of this loss after 14 d in storage. Photodegradation, thermal, and microbial biodegradable properties of the films were significantly improved by CPT (P < 0.05). Accelerated biodegradation of CP-treated PLA sachets with and without cheese was observed in compost. These results demonstrate the potential of CPT for modifying the stiffness, water contact angle, and chemical structure of PLA films and improving the printability and biodegradability of the films for food packaging.

Cold plasma treatment (CPT) was investigated for inhibition of foodborne pathogens and extension of fresh lettuce storage life. Lettuce samples were treated with CP at 400 W and 900 W for 10 min for assessment of the effects of CPT on inhibition of Escherichia coli O157:H7 and Salmonella Typhimurium, and on physicochemical and sensory properties of lettuce. N2, an N2-O2 mixture, and He effectively formed CP against both pathogens. CPT inhibited both pathogens on lettuce by up to 2.8 log CFU/g. The Weibull model adequately described the degree of microbial inhibition using CPT. N2-CPT did not affect the sensory properties of lettuce. N2-CPT resulted in a bacteriostatic effect against growth of E. coli O157:H7 but did not affect physicochemical properties of lettuce during storage. CPT demonstrated potential for improving the microbial safety of vegetables without loss of physicochemical or sensory properties.

By subjecting amorphous titanium dioxide (TiO2) colloidal spheres as a scaffold to a two-step external template-free hydrothermal treatment, anatase TiO2 hollow spheres with an average diameter of 410 nm and shell thickness of 65 nm were successfully yielded. Such hollow TiO2 nanostructures possessed a large surface area, abundant active sites and reduced Li ion diffusion path and thus were highly favorable for use in TiO2-based lithium ion batteries (LIB). Electrochemical measurements revealed that as-prepared TiO2 hollow spheres exhibited specific discharge capacities of 296, 185, 118, 66 and 37 mA h g−1 at 0.1 C, 1 C, 2 C, 5 C and 10 C, respectively. This is in sharp contrast to the considerably lower values obtained in TiO2 solid nanoparticles (i.e., 182, 119, 81, 43 18 mA h g−1 at discharge rates of 0.1 C, 1 C, 2 C, 5 C and 1 0 C, respectively). Interestingly, TiO2 hollow spheres showed a large irreversible capacity loss and relatively low cycling performance due to the residual chemisorbed water in TiO2 and hydroxyl groups present on the TiO2 surface. A solid electrolyte interface (SEI) layer composed primarily of Li2CO3, lithium alkyl carbonates and organic phosphates was thus formed on the surface of hollow TiO2 spheres, thereby leading to an increased internal cell impedance and the decreased rate and cycling performance. The subsequent high-temperature annealing effectively removed chemisorbed water and hydroxyls on the TiO2 surface. As a consequence, annealed TiO2 hollow spheres rendered markedly improved rate stability and cycle performance in the resulting TiO2-based LIBs. The specific discharge capacities at rates of 5 C and 10 C were 77 mA h g−1 and 50 mA h g−1, which are considerably larger than those obtained from as-prepared TiO2 hollow spheres. Moreover, compared to only 42.1% for as-prepared hollow TiO2 spheres, a capacity retention as high as 93.5% over 200 cycles at 1 C was achieved for annealed hollow TiO2 spheres.

Films containing microencapsulated cinnamon oil (CO) were developed using a large-scale production system to protect against the Indian meal moth (Plodia interpunctella). CO at concentrations of 0%, 0.8%, or 1.7% (w/w ink mixture) was microencapsulated with polyvinyl alcohol. The microencapsulated CO emulsion was mixed with ink (47% or 59%, w/w) and thinner (20% or 25%, w/w) and coated on polypropylene (PP) films. The PP film was then laminated with a low-density polyethylene (LDPE) film on the coated side. The film with microencapsulated CO at 1.7% repelled P. interpunctella most effectively. Microencapsulation did not negatively affect insect repelling activity. The release rate of cinnamaldehyde, an active repellent, was lower when CO was microencapsulated than that in the absence of microencapsulation. Thermogravimetric analysis exhibited that microencapsulation prevented the volatilization of CO. The tensile strength, percentage elongation at break, elastic modulus, and water vapor permeability of the films indicated that microencapsulation did not affect the tensile and moisture barrier properties (P0.05). The results of this study suggest that effective films for the prevention of Indian meal moth invasion can be produced by the microencapsulation of CO using a large-scale film production system.Low-density polyethylene-laminated polypropylene films printed with ink incorporating microencapsulated cinnamon oil using a large-scale film production system effectively repelled Indian meal moth larvae. Without altering the tensile and moisture barrier properties of the film, microencapsulation resulted in the release of an active repellent for extended periods with a high thermal stability of cinnamon oil, enabling commercial film production at high temperatures. This anti-insect film system may have applications to other food-packaging films that use the same ink-printing platform.

Objective To investigate three-dimensional angular changes of the pelvis and lower extremities during trunk axial rotation in subjects with and without chronic low back pain (LBP). Design Repeated-measures design. Participants Thirty volunteers participated in the study (15 with LBP, 15 without LBP). The mean age of the subjects was 44 (standard deviation 15.8) years (range 27 to 63 years). Main outcome measures All participants were asked to perform five sets of axial trunk rotation activities with a bar in a standing position. The outcome measures included three-dimensional rotational angles of the pelvis and lower extremities (foot, calf and thigh). Results The angular change of the pelvis in the sagittal plane differed between subjects with and without LBP ( P = 0.03). There were no significant differences in angular changes of the lower extremities in the frontal and transverse planes between groups. Conclusions The angular change of the pelvis in the sagittal plane differed significantly between groups. Further research is needed to investigate the three-dimensional characteristics of biomechanical and neuromuscular aspects in subjects with LBP.

N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTAP) lipid molecules were used to drive the self-assembly of pre-fabricated Fe 3 O 4 nanoparticles (∼10 nm in size) into a tightly packed hexagonal array by spin coating. In spite of the relatively wide particle size distribution of the pre-fabricated nanoparticles, the nanoparticles encapsulated by the DOTAP lipid molecules were self-assembled into a two-dimensional superlattice over a large area because the monolayer of DOTAP molecules attached to the particles surface provided the force necessary to anchor the nanoparticles on the substrate surface during spin coating as well as the force necessary to hold the particles together. It is expected that the proposed method can be easily scalable to an industrial process and be also adapted to different nanoparticle systems by appropriate selection of the encapsulating lipid molecules.

This paper describes the synthesis and magnetic properties of multifunctional Fe3O4-AuPt core-shell nanoparticles. The Fe3O4-AuPt core-shell nanoparticles were synthesized by a one-pot polyol process in two consecutive steps from Fe, Au, and Pt precursors. The structural characterization and property analysis proves the formation of the core-shell nanostructure fusing the multifunctionality in a single entity. The TEM observation shows that the Fe3O4-AuPt core-shell nanoparticles are highly crystalline and uniform in size distribution, with an averaged particle size of ~12.5 nm in diameter, whereas the X-ray diffraction patterns provide further substantiation. The surface plasmon resonance arising from the AuPt nano-shell was revealed by UV-vis spectroscopy, while the magnetic measurements by VSM and PPMS demonstrate the well-defined superparamagnetic and/or soft-ferromagnetic behavior of the Fe3O4-AuPt core-shell nanoparticles.

Mountain-grown ginseng (Panax ginseng C. A. Meyer; Sansam in Korean) is believed to possess more potent biological activity than red ginseng. This study examined the endothelium-dependent vasorelaxant effects and possible mechanisms of crude ginsenosides from adventitious roots of Korean mountain-grown ginseng (GS-ARMG) and red ginseng (GS-RG) in isolated rat aorta pre-contracted with norepinephrine. GS-ARMG (0.03–3.0 mg/mL) produced transient acute relaxation in a concentration-dependent manner, with a maximum relaxation (mean ± SEM) of 90 ± 9% and a median effective concentration (EC50) of 0.09 ± 0.07 mg/mL. GS-ARMG displayed about 25-fold more potent activity than GS-RG (maximum relaxation 50 ± 4%, EC50 2.34 ± 1.30 mg/mL). Relaxations induced by both GS-ARMG (1.0 mg/mL) and GS-RG (1.0 mg/mL) were nearly abolished by endothelial ablation or pre-treatment with N G -nitro-l-arginine, a nitric oxide synthase inhibitor, or by methylene blue, a soluble guanylate cyclase inhibitor. These inhibitory effects, however, revealed different sensitivity of GS-ARMG and GS-RG; the maximum relaxations attained were 30–38% and 13–17% that of untreated preparations, respectively, but indomethacin and cyclooxygenase inhibitors did not affect the response. None of the receptor antagonists, atropine, diphenhydramine, [D-Pro2, D-Trp7, 9]-substance P, or propranolol, caused any significant inhibition to GS-ARMG-induced relaxation; however, atropine or propranolol caused a 10% reduction in the relaxation, suggesting possible involvement of a muscarinic receptor or a β-adrenoceptor in the GS-ARMG-induced relaxation. These results demonstrate that GS-ARMG produces endothelium-dependent relaxation of isolated rat aorta similar to that of GS-RG; increased nitric oxide production and increased vascular levels of cGMP in endothelial cells could contribute to the relaxation. However, GS-ARMG has more potent activity than GS-RG to relax isolated rat aorta though an active substance(s), which might be higher in mountain-grown ginseng due to the growing conditions on mountains or the processing during manufacture of GS-ARMG. These factors may contribute to understanding the biological beneficial effects of mountain-grown ginseng.

The effects of cold plasma (CP) treatment on the physicochemical and biodegradable properties of polylactic acid (PLA) films were studied. The PLA films were exposed to CP for 40 min at 900 W and 667 Pa using oxygen as the plasma-forming gas. The tensile, optical, and dynamic mechanical thermal properties, surface morphology, printability, water contact angle, chemical structure, weight change, and biodegradability properties of the films were evaluated during storage for up to 56 d. The tensile and optical properties of the PLA films were not significantly affected by CP treatment (CPT; P0.05). The surface roughness and water contact angle of PLA films increased by CPT and further increased during storage for 56 d. The printability of the PLA films increased following CPT and remained stable throughout the storage period. CP-induced hydrophilicity was also sustained during the storage period. The PLA films lost 1.9% of their weight after CPT, but recovered 99.5% of this loss after 14 d in storage. Photodegradation, thermal, and microbial biodegradable properties of the films were significantly improved by CPT (P0.05). Accelerated biodegradation of CP-treated PLA sachets with and without cheese was observed in compost. These results demonstrate the potential of CPT for modifying the stiffness, water contact angle, and chemical structure of PLA films and improving the printability and biodegradability of the films for food packaging.

Battery energy storage has become a critical component of civil and military operations because of the rapidly growing demands in consumer electronics, electric vehicles and the power-consuming systems carried by soldiers on the battlefield. Currently utilized batteries are flammable and suffer from an insufficient high specific energy, which poses major safety issues creating a tactical burden for the soldiers. The use of solid state batteries may offer enhanced safety and increased energy density. Previous modeling studies of the superionic lithium-rich anti-perovskites conductors focused on Li3OX (X = Cl, Br) structures and reported a variety of the charge transport mechanisms ranging from the low-barrier three-atom hop mechanism involving vacancies, Li hops to the nearest neighbor, Li interstitial dumbbells, and diffusion of the Li+ interstitials in LiCl-deficient Li3OCl that outnumber vacancies by 2–3 orders of magnitude as predicted by the shell model. It is, however, quite challenging to completely remove protons from these anti-perovskite conductors during synthesis, highlighting the importance of understanding the influence of protons on conductivity and electrochemical properties for these superionic lithium-rich anti-perovskite conductors.(1, 2) Born-Oppenheimer molecular dynamics (BOMD) simulations of Li2+xOH1-xCl (0≤x≤1) solid electrolytes were performed in order to gain insights into the mechanism of lithium transport and the influence of H concentration, complementing previous modeling studies of H-free antiperovskites. The simulation cell was comprised of 320 atoms. Density Functional Theory (DFT) calculations were performed with the QUICKSTEP module of the CP2K code, which implements the dual Gaussian and Plane Waves (GPW) method. The gamma point supercell approach was used in combination with 3-dimensioanl Periodic Boundary Conditions (PBC). Calculations were performed using the spin-polarized Perdew-Burke-Ernzerhof (PBE) exchange correlation functional with Grimme’s D3 dispersion correction. BOMD simulations predicted a significant enhancement of the lithium diffusion with the increased fraction of protons in agreement with experimental data. The lithium transport mechanism was found to be closely coupled with the rotation of a relatively short OH-group within the protonated electrolytes. Moreover, lithium jump events were found to be highly-correlated. Figure 1a shows a snapshot of the simulation box. In order to gain further insight into the transport mechanics, the motion of the fastest lithium cations in Li2.5OH0.5Cl solid electrolyte are highlighted with different colors. Overlap between trajectories of the fastest lithium cations shown by red arrows is indicative of the highly-correlated fashion of the lithium jumps.(2) We will also discuss changes of band gaps and band alignments that were calculated using DFT hybrid functionals as markers for electrochemical stability. We anticipate that our findings will reduce the existing confusions and show new avenues for tuning solid electrolyte compositions for further improved Li-ion conductivities. Different aspects of this work were supported by NASA Minority University Research and Education Project (MUREP; NASA grant NNX15AP44A and interagency agreement NND16AA29I with ARL for modeling) and ARPA-E (grant DE-AR0000779). References 1. Y. Li, W. Zhou, S. Xin, S. Li, J. Zhu, X. Lü, Z. Cui, Q. Jia, J. Zhou, Y. Zhao and J. B. Goodenough, Angew. Chem. Int. Ed., 55, 9965 (2016). 2. A.-Y. Song, Y. Xiao, K. Turcheniuk, A. Ramanujapuram, J. Benson, A. Magasinski, M. Oguin, L. Meda, O. Borodin and G. Yushin, (submitted)(2017). Figure 1. A snapshot from MD simulations of Li2.5(OH)0.5Cl (a). Trajectories of the fastest Li+ cations during 10 ps BOMD run of Li2.5OH0.5Cl SSE using different colors to denote distinct Li+ (b). Red arrows show overlap between the Li+ trajectories that is indicative of the Li+ correlated motion for the fastest moving Li+. Figure 1

Insect-resistant laminate films containing microencapsulated cinnamon oil (CO) were developed to protect food products from the Indian meal moth (Plodia interpunctella). CO microencapsulated with polyvinyl alcohol was incorporated with a printing ink and the ink mixture was applied to a low-density polyethylene (LDPE) film as an ink coating. The coated LDPE surface was laminated with a polypropylene film. The laminate film impeded the invasion of moth larvae and repelled the larvae. The periods of time during which cinnamaldehyde level in the film remained above a minimum repelling concentration, predicted from the concentration profile, were 21, 21, and 10 d for cookies, chocolate, and caramel, respectively. Coating with microencapsulated ink did not alter the tensile or barrier properties of the laminate film. Microencapsulation effectively prevented volatilization of CO. The laminate film can be produced by modern film manufacturing lines and applied to protect food from Indian meal moth damage.The LDPE-PP laminate film developed using microencapsulated cinnamon oil was effective to protect the model foods from the invasion of Indian meal moth larvae. The microencapsulated ink coating did not significantly change the tensile and barrier properties of the LDPE-PP laminate film, implying that replacement of the uncoated with coated laminate would not be an issue with current packaging equipment. The films showed the potential to be produced in commercial film production lines that usually involve high temperatures because of the improved thermal stability of cinnamon oil due to microencapsulation. The microencapsulated system may be extended to other food-packaging films for which the same ink-printing platform is used.

Even though a number of studies have evaluated postural adjustments based on kinematic changes in subjects with low back pain (LBP), kinematic stability has not been examined for abnormal postural responses during the one leg standing test. The purpose of this study was to evaluate the relative kinematic stability of the lower extremities and standing duration in subjects with and without chronic LBP. In total, 54 subjects enrolled in the study, including 28 subjects without LBP and 26 subjects with LBP. The average age of the subjects was 37.8 ± 12.6 years and ranged from 19 to 63 years. The outcome measures included normalized holding duration and relative kinematic stability. All participants were asked to maintain the test position without visual input (standing on one leg with his/her eyes closed and with the contra lateral hip flexed 90°) for 25 s. The age variable was used as a covariate to control confounding effects for the data analyses. The control group demonstrated significantly longer holding duration times (T = −2.78, p = 0.007) than the LBP group (24.6 ± 4.2 s vs. 20.5 ± 6.7 s). For the relative kinematic stability, there was a difference in dominance side (F = 9.91, p = 0.003). There was a group interaction between side and lower extremities (F = 11.79, p = 0.001) as well as an interaction between age and dominance side (F = 7.91, p = 0.007). The relative kinematic stability had a moderate negative relationship with age (r = −0.60, p = 0.007) in subjects without LBP. Clinicians need to understand the effects of age and relative stability, which decreased significantly in the single leg holding test, in subjects with LBP in order to develop effective rehabilitation strategies.

This work investigates the intrinsic cell labeling efficiency of the Fe3O4 nanoparticles prepared by a modified thermal decomposition method using nontoxic precursors and a biocompatible polymer surfactant. This method eliminates the current need for additional step of surface modification. The structural analysis reveals the highly crystalline feature of the nanoparticles, while the magnetic measurement shows their superparamagnetic behavior at room temperature. Fe3O4 nanoparticles were efficiently incorporated into the murine macrophage cells (RAW264.7) without visible cytotoxicity. Cell labeling efficiency was found to be over 90% as measured by magnetically activated cell sorting and physical property measurement system. Therefore, such Fe3O4 nanoparticles could provide a useful magnetic cell labeling tool for macrophage cells using their phagocytic/endocytic activity and further apply to the other relevant biomedical applications.

We report the nonaqueous synthesis and magnetic properties of narrowly size distributed ZnFe2O4 nanocrystals of two different particle sizes by nanoemulsion, of which structure and properties were investigated by transmission electron microscopy, x-ray diffraction, vibrating sample magnetometry, and physical property measurement system. The morphological and structural characterization show the high crystallinity and excellent particle size distribution of the ZnFe2O4 nanocrystals in the diameters of 5.37 ± 0.68 nm and 6.44 ± 0.95 nm, separately. Meantime, the corresponding magnetic measurements reveal the strong size dependence and well-defined nanomagnetism of the nanocrystals.

The Fe(3)O(4)-Ca(3)(PO(4))(2) core-shell nanoparticles were prepared by one-pot non-aqueous nanoemulsion with the assistance of a biocompatible triblock copolymer, poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEO-PPO-PEO), integrating the magnetic properties of Fe(3)O(4) and the bioactive functions of Ca(3)(PO(4))(2) into single entities. The Fe(3)O(4) nanoparticles were pre-formed first by thermal reduction of Fe(acac)(3) and then the Ca(3)(PO(4))(2) layer was coated by simultaneous deposition of Ca(2+) and PO(4)(3-). The characterization shows that the combination of the two materials into a core-shell nanostructure retains the magnetic properties and the Ca(3)(PO(4))(2) shell forms an hcp phase (a = 7.490 Å, c = 9.534 Å) on the Fe(3)O(4) surface. The magnetic hysteresis curves of the nanoparticles were further elucidated by the Langevin equation, giving an estimation of the effective magnetic dimension of the nanoparticles and reflecting the enhanced susceptibility response as a result of the surface covering. Fourier transform infrared (FTIR) analysis provides the characteristic vibrations of Ca(3)(PO(4))(2) and the presence of the polymer surfactant on the nanoparticle surface. Moreover, the nanoparticles could be directly transferred to water and the aqueous dispersion-collection process of the nanoparticles was demonstrated for application readiness of such core-shell nanostructures in an aqueous medium. Thus, the construction of Fe(3)O(4) and Ca(3)(PO(4))(2) in the core-shell nanostructure has conspicuously led to enhanced performance and multi-functionalities, offering various possible applications of the nanoparticles.

We present the synthesis and magnetic properties of multifunctional CoPtAu alloy nanoparticles of three compositions, Co0.33Pt0.33Au0.33, Co0.2Pt0.2Au0.6, and Co0.4Pt0.4Au0.2, by a modified polyol process. The x-ray diffraction and transmission electron microscopy analyses confirm the formation of the alloy nanostructure comprising Au-rich and Pt-rich nanophases, with a narrow distribution of particle sizes and provides the detailed structural arrangements. The magnetic study shows the composition dependence of the magnetic properties of the nanoparticles, from superparamagnetic for both Co0.33Pt0.33Au0.33 and Co0.4Pt0.4Au0.2 to soft ferromagnetic for Co0.2Pt0.2Au0.6.