1. Is it time to revise the diagnostic criteria for apathy in brain disorders? the 2018 international consensus group
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Robert, P, Lanctôt, K, Agüera-Ortiz, L, Aalten, P, Bremond, F, Defrancesco, M, Hanon, C, David, R, Dubois, B, Dujardin, K, Husain, M, König, A, Levy, R, Mantua, V, Meulien, D, Miller, D, Moebius, H, Rasmussen, J, Robert, G, Ruthirakuhan, M, Stella, F, Yesavage, J, Zeghari, R, Manera, V, Cognition Behaviour Technology (CobTek), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), Sunnybrook Research Institute [Toronto] (SRI), Sunnybrook Health Sciences Centre, Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), School for Mental Health and Neuroscience - Alzheimer Center Limburg (MUMC), Maastricht University [Maastricht], Spatio-Temporal Activity Recognition Systems (STARS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Innsbruck Medical University [Austria] (IMU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), John Radcliffe Hospital [Oxford University Hospital], CIC AP-HP [CHU Pitié-Salpêtrière], Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Agenzia Italiana del Farmaco, Lundbeck SAS, Bracket, Moebius-Consult GmbH, Medcom [Odense], Service d'urologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), University Cote d'Azur, University of Toronto, Hospital Universitario 12 de Octubre & Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Alzheimer Center Limburg, STARS team - INRIA Sophia Antipolis, Innsbruck Medical University, Paris Descartes University, Sorbonne University, Inserm U1171, University of Oxford, Sorbonne Universités, Clinical Research Neurology Lundbeck SAS, moebius-consult GmbH, psi-napse, Université de Rennes 1, Universidade Estadual Paulista (Unesp), Stanford University, Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Troubles cognitifs dégénératifs et vasculaires (U1171), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-INSERM, CIC AP-HP (pitie-Salpetriere)/inserm, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut des Neurosciences Cliniques de Rennes (INCR)-CHU Pontchaillou [Rennes]-Université européenne de Bretagne - European University of Brittany (UEB)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Stanford University School of Medicine [Stanford], Stanford University [Stanford], RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, CHU Lille, CNRS, Inserm, Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U1171, and Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
- Subjects
Emotion ,MILD COGNITIVE IMPAIRMENT ,Brain Diseases ,Motivation ,SYMPTOMS ,MOTOR-ACTIVITY ,International Cooperation ,[SDV]Life Sciences [q-bio] ,Apathy ,DEPRESSION ,Neuropsychiatry ,Social interaction ,ALZHEIMERS-DISEASE ,Treatment ,PARKINSONS-DISEASE ,CLINICAL-PRACTICE ,RATING-SCALE LARS ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Behaviour ,Brain disorders ,Humans ,France ,METAANALYSIS ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Made available in DSpace on 2018-12-11T17:22:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-10-01 Background: Apathy is a very common behavioural and psychological symptom across brain disorders. In the last decade, there have been considerable advances in research on apathy and motivation. It is thus important to revise the apathy diagnostic criteria published in 2009. The main objectives were to: a) revise the definition of apathy; b) update the list of apathy dimensions; c) operationalise the diagnostic criteria; and d) suggest appropriate assessment tools including new technologies. Methods: The expert panel (N = 23) included researchers and health care professionals working on brain disorders and apathy, a representative of a regulatory body, and a representative of the pharmaceutical industry. The revised diagnostic criteria for apathy were developed in a two-step process. First, following the standard Delphi methodology, the experts were asked to answer questions via web-survey in two rounds. Second, all the collected information was discussed on the occasion of the 26th European Congress of Psychiatry held in Nice (France). Results: Apathy was defined as a quantitative reduction of goal-directed activity in comparison to the patient's previous level of functioning (criterion A). Symptoms must persist for at least four weeks, and affect at least two of the three apathy dimensions (behaviour/cognition; emotion; social interaction; criterion B). Apathy should cause identifiable functional impairments (criterion C), and should not be fully explained by other factors, such as effects of a substance or major changes in the patient's environment (Criterion D). Conclusions: The new diagnostic criteria for apathy provide a clinical and scientific framework to increase the validity of apathy as a clinical construct. This should also help to pave the path for apathy in brain disorders to be an interventional target. CoBTeK IA Memory Centre University Cote d'Azur Sunnybrook Research Institute and Departments of Pharmacology/Toxicology and Psychiatry University of Toronto Department of Psychiatry Instituto de Investigación Sanitaria (imas12) Hospital Universitario 12 de Octubre & Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) School for Mental Health and Neuroscience Alzheimer Center Limburg STARS team - INRIA Sophia Antipolis Department of Psychiatry and Psychotherapy Innsbruck Medical University Regional Resource Centre of Old Age Psychiatry Paris Descartes University, Assistance Publique-Hôpitaux de Paris, Corentin-Celton Hospital Memory Center CMRR CHU – CoBTeK lab University Cote d'Azur Centre des Maladies Cognitives et Comportementales (IM2A) Institut du Cerveau et de la Moelle épinière (ICM) UMR-S975 AP-HP Salpêtrière Hospital Sorbonne University Neurology and Movement Disorders Lille University Medical Center Inserm U1171 Nuffield Department of Clinical Neurosciences (John Radcliffe Hospital Oxford OX3 9DU) & Department of Experimental Psychology University of Oxford AP-HP Neurology deparment Salpetriere hospital Inserm U 1127 CNRS UMR 7225 Sorbonne Universités UPMC Univ Paris 06 UMR S 1127 Institut du Cerveau et de la Moelle épinière ICM FRONTlab School of medicine Sorbonne Universités Agenzia Italiana del Farmaco, via del Tritone 181 Clinical Research Neurology Lundbeck SAS Bracket, Wayne moebius-consult GmbH psi-napse EA4712 “Comportement et noyaux gris centraux” Université de Rennes 1 Laboratorio de Neurociencias LIM27 Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo UNESP - Univ Estadual Paulista Biosciences Institute, Campus of Rio Claro Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Stanford University Laboratorio de Neurociencias LIM27 Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo UNESP - Univ Estadual Paulista Biosciences Institute, Campus of Rio Claro
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- 2018