19 results on '"Adler, L."'
Search Results
2. Tratamiento no quirúrgico de la osteonecrosis relacionada a medicación asociada a un implante dental
- Author
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Flück, Giacco C A, Adler L I, and Gandolfo M S
- Subjects
Periodontal treatment ,QH301-705.5 ,business.industry ,Science ,medicine.medical_treatment ,Osteoporosis ,Dentistry ,medicine.disease ,Ibandronic acid ,Conservative treatment ,Antiresorptive Drugs ,stomatognathic system ,medicine ,In patient ,Biology (General) ,Osteonecrosis maxilar asociada a bifosfonatos, implante dental, clorhidrato de minociclina y tratamiento conservador ,business ,Osteonecrosis of the jaw ,Dental implant ,medicine.drug - Abstract
espanolLa osteonecrosis de los maxilares es un serio efecto adverso asociado a medicamentos antirresortivos especialmente en pacientes con osteoporosis y neoplasias malignas. En este manuscrito, presentamos un caso clinico de una mujer caucasica de 56 anos, con antecedentes de osteoporosis, medicada con bisfosfonatos, que curso con osteonecrosis del maxilar inferior en relacion con un implante dental. El tratamiento se baso fundamentalmente en la administracion de terapia antibiotica, enjuagues bucales antibacterianos y en el tratamiento periodontal. El objetivo de esta presentacion fue comunicar un caso de osteonecrosis de la mandibula alrededor de un implante dental relacionado con el uso de acido ibandronico tratado con exito mediante un tratamiento conservador que incluia la aplicacion local de minociclina. EnglishOsteonecrosis of the jaws is a serious adverse effect related with antiresorptive drugs, especially in patients with osteoporosis and malignant tumors. This article presents a case report of a 56-year-old caucasian woman with a history of osteoporosis treated with bisphosphonates who developed osteonecrosis of the lower jaw associated with a dental implant. Treatment was mainly based on the administration of antibiotictherapy, antibacterial mouthwashes and periodontal treatment. The aim of this paper was to report a case of osteonecrosis of the jaw around a dental implant related to the use of ibandronic acid successfully treated with conservative treatment including local application of minocycline.
- Published
- 2021
3. Mammary mechanobiology - investigating roles for mechanically activated ion channels in lactation and involution
- Author
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Felicity M. Davis, Alexander J. Stevenson, Katherine Hughes, Teneale A. Stewart, Michael Morehead, Adler L. Ju, and Natascia Marino
- Subjects
Programmed cell death ,Involution ,Offspring ,Mammary gland ,Biophysics ,Biology ,Mechanotransduction, Cellular ,Ion Channels ,03 medical and health sciences ,Mechanobiology ,Mice ,0302 clinical medicine ,Mammary Glands, Animal ,Lactation ,medicine ,Animals ,Mechanotransduction ,Ion channel ,030304 developmental biology ,0303 health sciences ,PIEZO1 ,Cell Biology ,Cell biology ,medicine.anatomical_structure ,Calcium ,Female ,030217 neurology & neurosurgery - Abstract
A mother's ability to produce a nutritionally-complete neonatal food source has provided a powerful evolutionary advantage to mammals. Milk production by mammary epithelial cells is adaptive, its release is exquisitely-timed and its own glandular stagnation with the permanent cessation of suckling triggers the cell death and tissue remodeling that enables female mammals to nurse successive progeny. Both chemical and mechanical signals play a role in this process. Despite this duality of input, however, much remains unknown about the nature and function of mechanical forces in this organ. Here, we characterize the force landscape in the functionally-mature gland and the capacity of luminal and basal cells to experience and exert force. We explore molecular instruments for force-sensing, in particular channel-mediated mechanotransduction, revealing increased expression of Piezo1 in mammary tissue in lactation and confirming functional expression in luminal cells. We also reveal, however, that lactation and involution proceed normally in mice with luminal-specific Piezo1 deletion. These findings support a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival.
- Published
- 2020
4. Mammary mechanobiology: mechanically-activated ion channels in lactation and involution
- Author
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Katherine Hughes, Felicity M. Davis, Adler L. Ju, Natascia Marino, Michael Morehead, Alexander J. Stevenson, and Teneale A. Stewart
- Subjects
0303 health sciences ,Programmed cell death ,Offspring ,Mammary gland ,PIEZO1 ,Biology ,Cell biology ,03 medical and health sciences ,Mechanobiology ,0302 clinical medicine ,medicine.anatomical_structure ,Tissue remodeling ,030220 oncology & carcinogenesis ,Lactation ,medicine ,Ion channel ,030304 developmental biology - Abstract
A mother’s ability to produce a nutritionally-complete neonatal food source has provided a powerful evolutionary advantage to mammals. Milk production by secretory mammary epithelial cells is adaptive, its release is exquisitely timed and its own glandular stagnation with the permanent cessation of suckling triggers the programmed cell death and tissue remodeling that enables female mammals to nurse successive progeny. Both chemical and mechanical signals control epithelial expansion, function and remodeling. Despite this duality of input, however, the nature and function of mechanical forces in the mammary gland remain unknown. Here, we characterize the mammary force landscape and the capacity of luminal and basal epithelial cells to experience and exert force. We explore the molecular instruments for force-sensing in the mammary gland and the physiological requirement for PIEZO1 in lactation and involution. Our study supports the existence of a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival.
- Published
- 2019
5. The cross-sectional GRAS sample: A comprehensive phenotypical data collection of schizophrenic patients
- Author
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Ribbe, K., Friedrichs, H., Begemann, M., Grube, S., Papiol, S., Kästner, A., Gerchen, M., Ackermann, V., Tarami, A., Treitz, A., Flögel, M., Adler, L., Aldenhoff, J., Becker-Emner, M., Becker, T., Czernik, A., Dose, M., Folkerts, H., Freese, R., Guenther, R., Herpertz, S., Hesse, D., Kruse, G., Kunze, H., Franz, M., Lohrer, F., Maier, W., Mielke, A., Müller-Isberner, R., Oestereich, C., Pajonk, F., Pollmächer, T., Schneider, U., Schwarz, H., Kröner-Herwig, B., Havemann-Reinecke, U., Frahm, J., Stühmer, W., Falkai, P., Brose, N., Nave, K., and Ehrenreich, H.
- Subjects
Adult ,Male ,573.8 ,Adolescent ,lcsh:RC435-571 ,612.8 ,Neuropsychological Tests ,Basal Ganglia Diseases ,lcsh:Psychiatry ,Databases, Genetic ,Humans ,Genetic Association Studies ,Aged ,Data Collection ,Middle Aged ,Psychiatry and Mental health ,Cross-Sectional Studies ,Phenotype ,Schizophrenia ,Female ,Schizophrenic Psychology ,Cognition Disorders ,Antipsychotic Agents ,Research Article - Abstract
Background Schizophrenia is the collective term for an exclusively clinically diagnosed, heterogeneous group of mental disorders with still obscure biological roots. Based on the assumption that valuable information about relevant genetic and environmental disease mechanisms can be obtained by association studies on patient cohorts of ≥ 1000 patients, if performed on detailed clinical datasets and quantifiable biological readouts, we generated a new schizophrenia data base, the GRAS (Göttingen Research Association for Schizophrenia) data collection. GRAS is the necessary ground to study genetic causes of the schizophrenic phenotype in a 'phenotype-based genetic association study' (PGAS). This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia. Methods For this purpose, 1085 patients were recruited between 2005 and 2010 by an invariable team of traveling investigators in a cross-sectional field study that comprised 23 German psychiatric hospitals. Additionally, chart records and discharge letters of all patients were collected. Results The corresponding dataset extracted and presented in form of an overview here, comprises biographic information, disease history, medication including side effects, and results of comprehensive cross-sectional psychopathological, neuropsychological, and neurological examinations. With >3000 data points per schizophrenic subject, this data base of living patients, who are also accessible for follow-up studies, provides a wide-ranging and standardized phenotype characterization of as yet unprecedented detail. Conclusions The GRAS data base will serve as prerequisite for PGAS, a novel approach to better understanding 'the schizophrenias' through exploring the contribution of genetic variation to the schizophrenic phenotypes.
- Published
- 2010
6. [Cortisol in night-urine: Introduction of a research method in psychoneuroendocrinology]
- Author
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Stephan Doering, Wedekind, D., Pilz, J., Bandelow, B., Adler, L., and Huether, G.
- Subjects
Adult ,Male ,Hypothalamo-Hypophyseal System ,Hydrocortisone ,Reference Values ,Humans ,Pituitary-Adrenal System ,Female ,Arousal ,Stress, Psychological ,Circadian Rhythm - Abstract
Cortisol is one of the major parameters investigated in psychoneuroendocrinological research, but the methods employed for sample collecting are often unsatisfactory. A suitable method of sample collection should allow for the integrative assessment of long-term changes of the HPA-system, should be non-invasive, and should not exceed the subject's compliance. The assessment of cortisol in night-urine fulfils these demands; although this method has been occasionally employed, it has not yet been described systematically. For the first time a detailed description is given here that allows for a standardized replication. In ten previous studies and three investigations of our own this method has been successfully applied to detect changes in the cortisol excretion of patients with endocrinological and psychiatric disorders as well as in subjects under conditions of psychosocial stress. The determination of cortisol in night-urine represents an ideal method for the assessment of changes in the basal HPA-activity in numerous areas of psychoneuroendocrinological research, e.g. field and screening studies in natural environment, clinical studies in psychiatry and especially follow-up studies in psychotherapy research.
- Published
- 2001
7. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction
- Author
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Van de Werf, F., Armstrong, P. W., Granger, C., Wallentin, L., Adgey, A. A. J., Aylward, P., Binbrek, A. S., Califf, R., Cassim, S., Diaz, R., Fanebust, R., Fioretti, P. M., Huber, K., Husted, S., Lindahl, B., Lopez-Sendon, J. L., Makijarvi, M., Meyer, J., Navarro Robles, J., Pfisterer, M., Seabra-Gomes, R., Soares-Piegas, L., Sugrue, D., Tendera, M., Theroux, P., Toutouzas, P., Vahanian, A., Verheugt, F., Sarelin, H., Goetz, G., Bluhmki, E., Daclin, V., Danays, T., Houbracken, K., Kaye, J., Reilly, P., Hacke, W., von Kummer, R., Lesaffre, E., Bogaerts, K., Peeters, C., Fox, K. A. A., Brower, R., Hirsh, J., Maggioni, A., Tijssen, J., Weaver, D., Beernaert, A., Beysen, N., Broos, K., De Prins, E., D'Hollander, K., Dupon, L., Fomyna, N., Fransen, A., Genesse, D., Goffin, L., Hendrickx, R., Jansen, B., Jorissen, F., Luys, C., Luyten, A., Marschal, C., Moreira, M., Munsters, K., Salerno, R., Schoovaerts, C., Sinnaeve, P., Schildermans, C., Vandenberghe, K., Vandeschoot, K., Van Gucht, H., Van Rompaey, P., Vlassak, S., Watzeels, M., Wittockx, H., Galan, K., Humeniuk, L., Seidel, A., Molina, M., Hafley, G., Alexander, J., Pascual, A., Bestilny, S., Temple, T., Ahuad Guerrero, R., Albisu, J. P., Bassani Arrieta, C. A., Bono, J., Caccavo, A., Cagnolatti, A., Cartasegna, L. R., Castellanos, R., Chekerdemian, S., Covelli, G., Cuello, J. L., Cuneo, C. A., Fernandez, A., Ferrara, C., Ferro-Queirel, E., Gambarte, A., Garcia-Duran, R., Hasbani, E., Hrabar, A., Keller, L., Lobo Marquez, L. L., Luciardi, H., Macin, S. M., Marinig, A., Marzetti, E., Muntaner, J., Nordaby, R., Orlandini, A. D., Piombo, A. C., Pomposiello, J. C., Quijano, R. A., Amerena, J., Aroney, G., Buckmaster, N., Carroll, P., Fitzpatrick, M., Newman, R., Rowe, M., Singh, B., Thomson, A., Winter, C., Eber, B., Gaul, G. B., Klein, W., Leisch, F., Mayr, H., Mlczoch, J., Niessner, H., Pachinger, O., Pall, H., Pichler, M., Roggla, G., Schaflinger, E., Schreiber, W., Slany, J., Traindl, O., Zenker, G., Beckers, J., Bekaert, I., Berthe, C., Bodur, G., Carlier, B., Carlier, M., Carpentier, J., Celen, H., Charlier, F., Clement, A., Coenen, A., Crochelet, L., De Keyser, F., De Man, F., de Meester, A., Dendale, P., Dhondt, E., Dhooghe, G., El Allaf, D., Elshot, S., Emmerechts, C., Foret, F., Gatera, E., Geraedts, J., Gerardy, A. C., Gysbrechts, M., Hallemans, R., Hellemans, S., Herssens, H., Huygens, L., Janssens, L., Lalmand, J., Maamar, R., Marechal, P., Mertens, D., Michel, P., Morandini, E., Nannan, M., Nguyen, D., Odeurs, W., Peerenboom, P., Pirenne, B., Quinonez, M., Raymenants, E., Renard, M., Silance, P. G., Standaert, A. M., Striekwold, H., Thiels, H., Valadi, D., van Brabandt, H., Van Dormael, M., Van Iseghem, P., Van Walleghem, U., Vanden Bosch, H., Vandenbossche, J. L., Vermylen, J., Verstraete, S., Vo Ngoc, P., Willems, P., Zenner, R., Campos de Albuquerque, D., Coutinho, M., de Camargo Carvalho, A. C., Fernandes Manenti, E. R., Ferreira Azevedo, A., Golin, V., Gun, C., Marin Neto, J. A., Marino, R. L., Miranda Abrantes, J. A., Nicolau, J. C., Porto Alegre Dancini, E. M., Rabelo, A., Ramos, R. F., Rizzi Coelho, O., Alexander, D., Bata, I. R., Bhargava, R. K., Bogaty, P., D'Amours, G., Darcel, I., Finnie, K. J. C., Fowlis, R., Gupta, M. K., Henderson, M., Howlett, M. K., Javier, J. J., Kieu, C. V., Kumar, G., Lebouthillier, P., Leduc, F., Lepage, S., Mcavinue, T., Mcgillen, J. E., Mcmeekin, J. D., Morse, J. W., Pistawka, K., Raimondo, E. F., Sandrin, F., Smith, H., Smylie, P. C., Tran, K., Turabian, M., Wagner, K. R., Winkler, L. H., Woo, K. S., Falstie-Jensen, N., Lind Rasmussen, S., Lomholt, P., Markenvard, J., Nielsen, H., Petersen, J., Romer, F., Ahonen, J., Huttunen, M., Kokkonen, L., Luukkonen, J., Mantyla, P., Melin, J., Mustonen, J., Valli, J., Voutilainen, S., Agraou, B., Allam, S., Baradat, G., Battistella, P., Bazin, P., Bouvier, J. -M., Destrac, S., Fouche, R., Fournier, P. -Y., Funck, F., Garnier, H., Grall, J. -Y., Gully, C., Lallement, P. -Y., Loiselet, P., Mycinsky, C., Page, A., Parisot, M., Range, G., Rocher, R., Tafani, C., Thisse, J. -Y., Tibi, T., Tissot, M., Wahl, P., Backenkohler, U., Bavastro, P., Beckmann-Hiss, H., Behnke, M., Bermes, M., Bernsmeier, R., Bethge, K. P., Bethge, H., Block, M., Burkhardt, W., Cieslinski, G., Claus, G., Deetjen, A., Diefenbach, A., Diehm, C., Dietz, A., Dippold, W. G., Eichner, A., Erckenbrecht, J. F., Gawlick, L., Gerber, V., Goppel, L., Gottwik, M., Grosch, B., Hammer, B., Hanheide, M., Hanrath, P., Haspel, J., Hennersdorf, F., Hermanns, M., Hoffmeister, H. M., Holzapfel, P., Hubner, H., Jansen, W., Jung, S., Kaddatz, J., Kienbock, H., Klein, H. H., Konz, K. H., Kulschbach, M., Leschke, M., Liebau, G., Linnartz, M., Lockert, G., Loesbrock, R., Lollgen, H., Ludwig, N., Mudra, H., Munzer, K., Nebel, B., Nellessen, U., Neu, C., Olbrich, H. G., Pfeffer, A., Pfeiffer, P., Plate, V., Pollock, B., Rapp, H., Rommele, U., Sauer, K., Scheffler, N., Schlotterbeck, K., Schmidt-Salzmann, A., Schnitzler, G., Schumann, H., Schuster, C. J., Schuster, P., Schweizer, P., Seitz, K., Simon, R., Spes, C., Szabo, S., Terhardt-Kasten, E., Theuerkauf, B., Tigges, R., Tinnappel, J., Topp, H., Trockel, P., Unland, N., Veth, V., Vom Dahl, J., Vossbeck, G., Weindel, K., Weib, D., Wiewel, D., Wirtz, P., Zipp, C., Apostolou, T., Chalkidis, C., Exadaktylos, N., Foussas, S., Hatseras, D., Karas, S., Karydis, K., Lambrou, S., Louridas, G., Manolis, A., Nanas, J., Novas, I., Panagiotidou, T., Papadopoulos, C., Papakonstantinou, D., Papasteriadis, E., Pavlidis, P., Pyrgakis, V., Skoufas, P., Stavrati, A., Tyrologos, A., Vardas, P., Vrouchos, G., Zacharoulis, A., Zarifis, J., Brown, A., Daly, K., Fennell, W., Horgan, J., Mccann, H., Mcdonald, K., O'Reilly, M., Sullivan, P., Altamura, G., Ambrosio, G., Auteri, A., Aveta, P., Azzarito, M., Badano, L. P., Barbiero, M., Barletta, C., Biscosi, C., Boccanelli, A., Bottero, M., Brizio, E., Brunazzi, M. C., Brunelli, C., Bugatti, U., Capozi, A., Capucci, A., Carfora, A., Caronna, A., Carrone, M., Casazza, F., Cauticci, A., Ceci, V., Ciconte, V., Circo, A., Ciricugno, S., Comito, F., Cornacchia, D., Corsini, G., D'Andrea, F., De Rosa, P., De Simone, M., Del Citerna, F., Del Pinto, M., Dell'Ali, C., Della Casa, S., Della Monica, R., Delogu, G., Di Biase, M., Di Chiara, A., Di Guardo, G., Di Marco, S., Di Mario, F., Di Napoli, T., Di Palma, F., Fadin, B. M., Fazzari, M., Ferraiuolo, G., Fiaschetti, R., Fontanelli, A., Fresco, C., Gambelli, G., Gasbarri, F., Gemelli, M., Giani, P., Gigantino, A., Giomi, A., Giorgi, G., Greco, C., Gregorio, G., Guagnozzi, G., Guiducci, U., Guzzardi, G., Izzo, A., La Rosa, A., Leone, F., Leone, G., Lo Bianco, F., Locuratolo, N., Maggiolini, S., Malinconico, M., Mancone, C., Mangiameli, S., Marchi, S. M., Maresta, A., Mauri, F., Mazzini, C. A., Michisanti, M., Miracapillo, G., Modena, M. G., Morgagni, G. L., Mossuti, E., Nascimbeni, F., Negrelli, M., Notaristefano, A., Pardi, S., Peci, P., Pettinati, G., Pietropaolo, F., Pirelli, S., Pretolani, M., Prinzi, D., Proietti, F., Raganelli, L., Rapino, S., Re, F., Ricci, R., Rinaldi, G., Rusticali, G., Severi, S., Spallarossa, P., Tartagni, F., Terrosu, P., Tortorella, G., Tota, F., Tritto, I., Tuccilo, B., Turco, V., Uscio, G., Valagussa, F., Vergoni, W., Verzuri, M. S., Vetrano, A., Villani, R., Zanini, R., Boisante, L., Niclou, R., Alcocer, L., Castro, A., Fragoso, J., Gonzalez, V., Gonzalez-Pacheco, H., Hernandez-Santamaria, I., Huerta, R., Huerta, D., Martinez, A., Mendoza, M., Moguel, R., Navarro, J., Portos, J. M., Rodriguez, I., Sierra, L., Valencia, S., Vazquez, A., Arnold, A. E. R., Boehmer, A. G., de Graaf, J. J., Funke Kupper, A. J., Gobel, E. J. A. M., Janus, C. L., Linssen, G. C. M., Sedney, M. I., Slegers, L. C., Spierenburg, H. A. M., Strikwerda, S., Tans, J. G. M., Twisk, S. P. M., van der Heijden, R., van Kalmthout, P. M., Verheugt, F. W. A., Holt, E., Skogsholm, A., Thorshaug, R., Thybo, N. K., Wang, H., Maciejewicz, J., Piotrowski, W., Pluta, W., Ruminski, W., Skura, M., Smielak-Korombel, W., Carranca, J., Carvalho, M., Catarino, C., Cunha, D., Ferreira, D., Ferreira, J., Ferreira da Costa, A. F., Lopes de Carvalho, J., Martins, L., Mourao, L., Oliveira Carrageta, M., Prazeres de Sa, E., Puig, J., Ramalho Dos Santos, M. J. J., Resende, M., Seabra Gomes, R., Baig, M. M. E., Bayat, J., Benjamin, J. D., Ranjith, N., Routier, R., Wittmer, H., Abizanda Campos, R., Alonso Garcia, M. A., Amaro Cendon, A., Arboleda Sanchez, J. A., Blanco Varela, J., Bruguera I Cortada, J., Carpintero Avellaneda, J. L., Caturla Such, J., Civeira Murillo, E., Fernandez Aviles, F., Fernandez Fernandez, R., Figueras Bellot, J., Fiol Sala, M., Froufe Sanchez, J., Garcia Calabozo, R., Garcia Palacios, J. L., Gonzalez Maqueda, I., Kallmeyer Martin, C., Lopez Sendon, J. L., Manzano Ramirez, A., Marine Rebull, J., Monton Rodriguez, A., Pique Gilart, M., Reina Toral, A., Rodriguez Llorian, A., Ruano Marco, M., Sanchez Miralles, A., Sanjose Garagarza, J. M., Santalo Bel, M., Torres Ruiz, J. M., Valentin Segura, V., Ahlstrom, P., Ahremark, U., Bandh, S., Bellinetto, A., Dahlberg, A., Hansen, O., Hurtig, U., Jonasson, L., Karlsson, J. E., Larsson, L. E., Moller, B., Ohlin, H., Persson, H., Sandstedt, L., Soderberg, S., Svennberg, L., Swahn, E., Tygesen, H., Broccard, A. F., Estlinbaum, W., Follath, F., Frutiger, A., Hess, N., Maggiorini, M., Marti, D., Muller, P., Rickenbacher, P., Schaller, M. D., Weinbacher, M., Abdulali, S., Ahmad, G., George, S., Ghazi, A., Rao, K. N., Bishop, A., Bridges, A., Canepa-Anson, R., Cave, M., Clarck, R., Cooper, I., de Belder, A., Farrer, M., Kendall, J. M., Ludman, P., Mattu, R., Mcglinchey, P., Moriarty, A. J., Muthusamy, S., Nee, P. A., Nolan, J., Papouchado, M., Rose, E. L., Shahi, M., Stephens, J., Trevelyan, J., Abdul-Karim, A., Adler, L., Arunasalam, S., Avington, D., Baron, S., Beel, T., Bellamy, B., Bennett, J., Berndt, T., Berrick, A., Bersin, R. M., Bethala, V., Bharath, S., Bouchard, A., Boulet, J. E., Bowerman, R., Boyek, T., Brar, R. S., Brodell, G., Bryant, B., Buckner, J. K., Cage, J., Cannon, J. D., Carducci, B., Carr, K., Chang, M., Chelliah, N., Chin, W. L., Chin, J., Church, D. H., Clark, R., Coulis, L., Dadkhah, S., Dearing, B., Defranco, A., Dharawat, M., Dharawat, R., Dhruva, N., Dicola, J., Dykstra, G., Eisenberg, S., El-Bialy, A., Fera, S., Ford, K., Foreman, R. D., Friedman, S., Friedman, V., Garibian, G., Gelormini, J., Geninatti, M. R., Genovese, R., Ghazi, F., Gilchrist, I., Gitler, B., Glover, R., Gonzalez, J., Goulah, R., Graham, B., Gray, R., Grodman, R., Habib, G. B., Hack, T., Hamroff, G., Hanna, G., Hart, M., Haught, H., Hawkins, J., Hempel, R., Hiremath, Y., Hiser, W., Holland, E., Jaffe, N., Jamal, N., James, K. F., Kalla, S., Kates, M., Kemper, A. J., Kennedy, J. J., Kerut, E. K., Killpack, M., King, J., T. Y., Ko, Kollar, K., Kontos, M., Kugelmassluu, A., Kumar, A., Kutscher, A. H., Lambrecht, C., Lancaster, L., Layden, J., Lazar, A., Lebow, M., Lee, C., Lee, A. B., Lehr, J., Levin, F. L., Levitt, R., Levy, R. M., Lieberman, A., Litman, G. I., Lui, H., Luu, M. Q., Macdonald, G., Madyoon, H., Mancherje, C., Marmulstein, M., Mclaurin, B. T., Mcnellis, M., Mendelson, R., Micale, P. J., Miller, M. J., Miller, M. S., Miller, J., Millman, A., Millsaps, R., Minor, S., Modica, J., Morse, H., Moskovits, N., Nester, B. A., Newton, A. S., Niazi, I., Niederman, A., Oatfield, R., Painter, J. A., Pamfilis, S. M., Pamulapati, K. M., Patel, N., Payne, R., Pearson, C., Peizner, D. S., Petrovich, L., Piriz, J., Pollack, M., Pollock, S., Popkave, A., Puma, J. A., Quesada, R., Quigley-Malcolm, D., Raby, K., Ravindran, K., Rees, A. P., Reiner, J., Rivera, E., Rogers, F., Rosenthal, A., Rowe, W. W., Ryan, P. F., Ryman, K., Salacata, A., Santolin, C., Saucedo, J., Savage, R., Savage, W., Schumacher, R., Segarra, S., Sharkey, S., Shonkoff, D., Silver, M., Silver, S. L., Singh, G., Sinyard, R. D., Sporn, D., Srivastava, N. K., Stomel, R., Suresh, D. P., Tallman, M., Togioka, T., Varma, S., Verant, R. P., Wallach, R., Weinberg, M., Weinberg, D., Weinstein, J. M., Wesley, G., Westerman, J. H., Wheeling, J., Whitaker, J., Widmer, M., Yasin, M., and Zakrzewski, M. J.
- Subjects
Male ,medicine.medical_specialty ,Abciximab ,Ischemia ,Myocardial Infarction ,Tenecteplase ,Injections ,Immunoglobulin Fab Fragments ,Reperfusion therapy ,Fibrinolytic Agents ,Recurrence ,Internal medicine ,medicine ,Humans ,Myocardial infarction ,Enoxaparin ,Aged ,Intention-to-treat analysis ,Chi-Square Distribution ,business.industry ,Heparin ,Antibodies, Monoclonal ,General Medicine ,Middle Aged ,medicine.disease ,Survival Analysis ,Regimen ,Treatment Outcome ,Anesthesia ,Tissue Plasminogen Activator ,Cardiology ,Drug Therapy, Combination ,Female ,business ,Platelet Aggregation Inhibitors ,medicine.drug - Abstract
BACKGROUND: Current fibrinolytic therapies fail to achieve optimum reperfusion in many patients. Low-molecular-weight heparins and platelet glycoprotein IIb/IIIa inhibitors have shown the potential to improve pharmacological reperfusion therapy. We did a randomised, open-label trial to compare the efficacy and safety of tenecteplase plus enoxaparin or abciximab, with that of tenecteplase plus weight-adjusted unfractionated heparin in patients with acute myocardial infarction. METHODS: 6095 patients with acute myocardial infarction of less than 6 h were randomly assigned one of three regimens: full-dose tenecteplase and enoxaparin for a maximum of 7 days (enoxaparin group; n=2040), half-dose tenecteplase with weight-adjusted low-dose unfractionated heparin and a 12-h infusion of abciximab (abciximab group; n=2017), or full-dose tenecteplase with weight-adjusted unfractionated heparin for 48 h (unfractionated heparin group; n=2038). The primary endpoints were the composites of 30-day mortality, in-hospital reinfarction, or in-hospital refractory ischaemia (efficacy endpoint), and the above endpoint plus in-hospital intracranial haemorrhage or in-hospital major bleeding complications (efficacy plus safety endpoint). Analysis was by intention to treat. FINDINGS: There were significantly fewer efficacy endpoints in the enoxaparin and abciximab groups than in the unfractionated heparin group: 233/2037 (11.4%) versus 315/2038 (15.4%; relative risk 0.74 [95% CI 0.63-0.87], p=0.0002) for enoxaparin, and 223/2017 (11.1%) versus 315/2038 (15.4%; 0.72 [0.61-0.84], p
- Published
- 2001
8. An international study of student' (self)positioning in L1 and Math education
- Author
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Adler, L., Braathe, H.J., Harrington, S., Ongstad, S., Ven, P.H.M. van de, Rijlaarsdam, G., and Rijlaarsdam, G.
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Het vakspecifiek functioneren van docenten - Abstract
Item does not contain fulltext Third Conference
- Published
- 2001
9. Implementing PET-guided biopsy: Integrating functional imaging data with digital x-ray mammography cameras
- Author
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Weinberg, I. N., Zawarzin, V., Pani, R., Williams, R., Freimanis, R. L., Lesko, N. M., Levine, E. A., Perrier, N., Berg, W. A., and Adler, L. P.
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Biopsy ,Positron ,Applied Mathematics ,Electronic ,Image fusion ,Computer Science Applications1707 Computer Vision and Pattern Recognition ,Breast ,Optical and Magnetic Materials ,Electrical and Electronic Engineering ,Mammography ,Minimally invasive therapy ,Electronic, Optical and Magnetic Materials ,Condensed Matter Physics - Published
- 2001
10. Testing for New Couplings in Top Quark Decay
- Author
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Nelson, Charles A. and Adler, L. J.
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High Energy Physics - Phenomenology (hep-ph) ,High Energy Physics::Phenomenology ,FOS: Physical sciences ,High Energy Physics::Experiment - Abstract
Tests of the Lorentz structure of t --> W b decay will be carried out at the Tevatron, and later at the LHC and at a NLC. To quantitatively assay future measurements of competing observables, we consider the (V-A) coupling values of the helicity decay parameters versus "(V-A) + Single Additional Lorentz Structures". Three phase-type ambiguities exist, but measurement of the sign of the large interference between the W boson longitudinal/transverse amplitudes could exclude the two due dynamically to additional (S+P) and (f_M + f_E) couplings. Sizable T-violation signatures can occur for low-effective mass scales, < 320 GeV, but in most cases can be more simply excluded by 10% precision measurement of the probabilities P(W_L) and P(b_L). Signatures for the presence of T-violation associated with the dynamical phase-type ambiguities, CP-violation signatures, and Lambda_b polarimetry are also discussed., Reason for Replacement: To supply larger figures and correct some typos. Contributed Paper for ICHEP2000. 3 tables; 8 sets of figures; no macros
- Published
- 2000
- Full Text
- View/download PDF
11. On Measurement of Helicity Parameters in Top Quark Decay
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Nelson, Charles A. and Adler, L. J.
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High Energy Physics - Phenomenology (hep-ph) ,FOS: Physical sciences - Abstract
To enable an evaluation of future measurements of the helicity parameters for " t --> W b " decay in regard to " T_FS violation", this paper considers the effects of an additional pure-imaginary coupling, (i g/2 Lambda) or (i g), associated with a specific, single additional Lorentz structure, i = S, P, S + P, ... Sizable " T_FS violation" signatures can occur for low-effective mass scales (< 320 GeV), but in most cases can be more simply excluded by 10% precision measurement of the probabilities P(W_L) and P(b_L). Signatures for excluding the presence of " T_FS violation" associated with the two dynamical phase-type ambiguities are investigated., 15 pages, 1 table, 7 figures, no macros
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- 2000
- Full Text
- View/download PDF
12. Physician management of hypercholesterolemia. A randomized trial of continuing medical education
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Browner, W S, Baron, R B, Solkowitz, S, Adler, L J, and Gullion, D S
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Male ,Evaluation Studies as Topic ,education ,Hypercholesterolemia ,Practice Guidelines as Topic ,Humans ,Education, Medical, Continuing ,Female ,Practice Patterns, Physicians' ,Research Article - Abstract
To determine the effect of continuing medical education (CME) on compliance with the recommendations of the National Cholesterol Education Program Expert Panel on high serum cholesterol levels in adults, we randomly assigned primary physicians in 174 practices to 3 groups, 2 that underwent either standard or intensive CME and a control group. The standard CME group was offered a free 3-hour seminar on high serum cholesterol levels; the intensive CME group was offered in addition follow-up seminars and free office materials. After 18 months, we audited 13,099 medical records from the 140 practices that remained in the study. There were no significant differences (P > .15) in screening for high serum cholesterol or compliance with guidelines between the groups receiving continuing medical education (51% screening; 33% compliance) and the control group (57% screening; 37% compliance). In the prespecified subgroup of patients with hypercholesterolemia, there was a trend toward a modest benefit from the continuing medical education interventions: compliance was 21% in the control group, 23% in the standard CME group, and 27% in the intensive CME group (P = .07 overall). These results emphasize the need for better ways to change behavior in practicing physicians and the importance of studying the implementation of preventive health recommendations.
- Published
- 1994
13. More cases of SIADH with fluoxetine
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Cohen Bj, Adler L, and Mahelsky M
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Psychiatry and Mental health ,Fluoxetine ,Text mining ,business.industry ,Medicine ,business ,Bioinformatics ,medicine.drug - Published
- 1990
14. Emission of light charged particles in the reactions of 120 MeV $^{20}$Ne with $^{27}$Al
- Author
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Namboodiri, M.N., Gonthier, P., Ho, H., Natowitz, J.B., Eggers, R., Adler, L., Kasiraj, P., Cerruti, C., Chevarier, A., Chevarier, N., Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Flores, Sylvie
- Subjects
[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] ,[PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] - Published
- 1981
15. Cellular basis of an auto-anti-allotypic mechanism for the maintenance of chronic allotype suppression in the rabbit
- Author
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Adler, L T and Claassen, E
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Aging ,Immune Tolerance ,Animals ,Rabbits ,Antibody-Producing Cells ,Immunoglobulin Allotypes ,Research Article ,Autoantibodies - Abstract
Immunocytochemical identification of antibody-forming cells (AFCs) in situ was used to test the hypothesis that the maintenance of chronic allotype suppression in heterozygous rabbits is the result of an autoimmune B-cell-mediated response. Appreciable numbers of B cells with antibody activity directed against the suppressed allotypic determinant were found in spleen and bone marrow sections of all chronically suppressed rabbits examined. Appropriate double-staining was used to determine that such cells were of the non-suppressed allotype. These cells were indistinguishable from anti-allotypic AFCs found in larger numbers in spleens of normal heterozygous rabbits that had been immunized against a heterologous allotypic determinant. Auto-anti-allotypic AFCs were not found in suppressed rabbits less than 8 week old, nor were they found in normal (non-suppressed) heterozygous rabbits or chimeric rabbits formed by the injection of histocompatible but allotype-mismatched lymphoid cells at birth. The findings reported here support the hypothesis that the long-term maintenance of allotype suppression in the rabbit may result from the suppressive activities of autoimmune B cells. It is suggested that the suppression of an allotype during the first few weeks of life could result in a loss of tolerance to a self-determinant. The kinetics of auto-anti-AFC production support this idea in showing that such cells are generated following the decline of the antibody used to induce suppression. The triggering event may be the emergence of B cells expressing the previously suppressed gene product.
- Published
- 1989
16. I. Der Bau der Uterusschleimhaut des geschlechtsreifen Weibes mit besonderer Berücksichtigung der Menstruation
- Author
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Hitschmann, F. and Adler, L.
- Abstract
n/a
- Published
- 1908
17. A study of the distortion of finite amplitude ultrasonic waves in liquids
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Adler, L. (Laszlo), 1932
- Published
- 1961
- Full Text
- View/download PDF
18. The signalling molecule Autoinducer-2 is not internalised in Campylobacter jejuni
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Adler L, Alter T, Soroush Sharbati, and Gölz G
19. The Validity of the World Health Organization Adult Attention-Deficit/Hyperactivity Disorder Self-Report Screening Scale for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition in Adolescence
- Author
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Lenard A. Adler, Martina Arteconi, Antonella Somma, Elisabetta Cotilli, Andrea Fossati, Giulia Gialdi, Somma, Antonella, Adler, L. A., Gialdi, G., Arteconi, M., Cotilli, E., and Fossati, A.
- Subjects
Adult ,Male ,validity ,genetic structures ,Adolescent ,Psychometrics ,World Health Organization ,behavioral disciplines and activities ,factor structure ,External validity ,03 medical and health sciences ,0302 clinical medicine ,Rating scale ,mental disorders ,Item response theory ,medicine ,Attention deficit hyperactivity disorder ,ADHD ,Humans ,Pharmacology (medical) ,ASRS-5 ,reliability ,Receiver operating characteristic ,Reproducibility of Results ,medicine.disease ,Confirmatory factor analysis ,030227 psychiatry ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,Convergent validity ,Attention Deficit Disorder with Hyperactivity ,Scale (social sciences) ,Pediatrics, Perinatology and Child Health ,adolescence ,Self Report ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Objectives: Short, self-report screening measures for adolescent and adult attention-deficit/hyperactivity disorder (ADHD) would greatly enhance the likelihood of ADHD subjects to be correctly diagnosed and treated. This study aimed at testing the reliability, factor structure, convergent validity, external validity, and diagnostic accuracy of the official Italian translation of the ADHD Self-Report Screening Scale for DSM-5 (ASRS-5) in a sample of community-dwelling adolescents, extending previous data on adult participants to adolescent participants. Methods: Five hundred sixty-four community-dwelling male adolescents (mean age ≅15) were administered the ASRS-5, the Adult ADHD Self-Report Scale 18-item and 6-item versions (ASRS-18 and ASRS-6), the Wender Utah Rating Scale (WURS), and the Structured Clinician Interview for DSM-5-Clinician Version ADHD Module (SCID-5-CV-ADHD). School performance variables were also collected. Results: The item response theory (IRT) reliability of ASRS-5 was adequate. Dimensionality analyses strongly supported the unidimensional structure of ASRS-5 items; confirmatory factor analysis fit indices supported the adequacy of the one-factor model of ASRS-5. In terms of convergent validity, the ASRS-5 total score was significantly and positively associated with self-report and interview-based ADHD dimensional scores, as well as with school performance variables. Roughly 8.0% of our male adolescents met SCID-5-CV-ADHD criteria for categorical ADHD diagnosis. Ten-fold cross-validated receiver operating curve value was 0.843; precision-recall curve analysis suggests that an ASRS-5 total score >12 may be preferred for screening purposes in adolescence. Conclusions: Our data showed that the ASRS-5 may represent a psychometrically sound self-report instrument to reliably screen for DSM-5 ADHD, extending the range of application of ASRS-5 from adulthood to adolescence, suggesting that the ASRS-5 could be safely used for screening purposes also in community-dwelling adolescents, at least in its official Italian translation.
- Published
- 2021
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