1. Human natriuretic peptides exhibit antimicrobial activity
- Author
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Krause A, Liepke C, Meyer M, Adermann K, Wg, Forssmann, and Erik Maronde
- Subjects
Anti-Infective Agents ,Staphylococcus ,Natriuretic Peptide, Brain ,Pseudomonas aeruginosa ,Animals ,Humans ,Microbial Sensitivity Tests ,Saccharomyces cerevisiae ,Atrial Natriuretic Factor ,Peptide Fragments ,Anti-Bacterial Agents ,Bacillus subtilis - Abstract
Here we describe a novel function for members of the well-characterized human natriuretic peptide family. Human "brain-type natriuretic peptide" (hBNP-32) as well as other members of this peptide class are antimicrobially active against Gram-positive and Gram-negative bacteria and yeast in a dose-dependent manner. This activity of natriuretic peptides is comparable to that of known antimicrobial peptides such as casocidins or magainins.
- Published
- 2001