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139 results on '"Adam R. Renslo"'

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1. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6

4. Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

5. Mutation of the conserved Asp‐Asp pair impairs the structure, function, and inhibition of CTX‐M Class A β‐lactamase

6. Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2

7. Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

8. Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro)biology and antibacterial therapy

9. Systematic Exploration of Passive Permeability in Tetrapeptides with Hydrogen-Bond-Accepting Amino Acid Side Chains

10. Structure-Based Ligand Design Targeting

11. Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis

12. Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

17. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

18. Author response: A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

19. Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron

20. Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine

21. Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor

22. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors

23. Ferrous Iron-Dependent Pharmacology

24. Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

25. An Empirical Study of Amide-Heteroarene π-Stacking Interactions Using Reversible Inhibitors of a Bacterial Serine Hydrolase

26. Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies

27. Antimalarial Trioxolanes with Superior Drug-Like Properties and In vivo Efficacy

28. Exploiting KRAS-Driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

29. USP7 small-molecule inhibitors interfere with ubiquitin binding

30. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases

31. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane

32. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases

33. Targeting Mobilization of Ferrous Iron in

34. Small molecule inhibitors of a human recombination-associated ATPase, RAD54

35. Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery

36. Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography

37. Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound

38. Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome

39. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models

40. Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery

41. A reactivity-based probe of the intracellular labile ferrous iron pool

42. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response

43. Abstract 6419: Novel ferrous iron-dependent prodrug strategy for KRAS-driven pancreatic cancer: The preclinic efficacy and safety test

44. Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels

45. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates

46. Cilia-associated oxysterols activate smoothened

47. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease

48. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

49. Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions

50. Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography

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