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Contains fulltext : 235785.pdf (Publisher’s version ) (Open Access)

Somatic mutations in patients with myelodysplastic syndromes (MDS) undergoing allogeneic hematopoietic stem cell transplantation (HSTC) are associated with adverse outcome, but the role of chronic graft-versus-host disease (cGVHD) in this subset of patients remains unknown. We analyzed bone marrow samples from 115 patients with MDS collected prior to HSCT using next-generation sequencing. Seventy-one patients (61%) had at least one mutated gene. We found that patients with a higher number of mutated genes (more than 2) had a worse outcome (2years overall survival [OS] 54.8% vs. 31.1%, p = 0.035). The only two significant variables in the multivariate analysis for OS were TET2 mutations (p = 0.046) and the development of cGVHD, considered as a time-dependent variable (p 0.001), correlated with a worse and a better outcome, respectively. TP53 mutations also demonstrated impact on the cumulative incidence of relapse (CIR) (1year CIR 47.1% vs. 9.8%, p = 0.006) and were related with complex karyotype (p = 0.003). cGVHD improved the outcome even among patients with more than 2 mutated genes (1-year OS 88.9% at 1year vs. 31.3%, p = 0.02) and patients with TP53 mutations (1-year CIR 20% vs. 42.9%, p = 0.553). These results confirm that cGVHD could ameliorate the adverse impact of somatic mutations in patients with MDS with HSCT.

Se han estudiado 8.700 cráneos de Micromamíferos procedentes de egagrópilas de Tyto alba y 135 ejemplares en piel de diversas localidades de Navarra. Se citan 24 especies pertenecientes a los órdenes Insectivora y Rodentia, de los que se da su distribución. Se puede observar una relación entre las condiciones climáticas, geográficas y de vegetación, y la presencia de determinadas especies en las distintas comarcas. Finalmente se muestra la abundancia en que cada especie está representada en las diversas zonas geográficas consideradas, mediante el análisis de egagrópilas de lechuza (Tyto alba).